K H Weisgraber

Author PubWeight™ 193.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993 4.86
2 Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res 1984 4.12
3 Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. J Biol Chem 1978 3.57
4 Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 1991 3.42
5 Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J Biol Chem 1987 3.04
6 Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem 1981 3.02
7 Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 1994 2.98
8 Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. J Biol Chem 1977 2.86
9 Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci U S A 1986 2.80
10 A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest 1989 2.71
11 Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem 1982 2.71
12 Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 1982 2.64
13 Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem 1990 2.42
14 A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest 1980 2.27
15 Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest 1981 2.27
16 Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc Natl Acad Sci U S A 1995 2.11
17 Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem 1996 2.06
18 Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem 1994 2.04
19 Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry 2000 2.01
20 Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res 1982 2.01
21 Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci U S A 1982 1.96
22 Transthyretin sequesters amyloid beta protein and prevents amyloid formation. Proc Natl Acad Sci U S A 1994 1.94
23 Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci U S A 1987 1.93
24 Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ Res 1974 1.91
25 Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. J Lipid Res 1990 1.90
26 Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol 1994 1.84
27 Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. J Lipid Res 1980 1.84
28 The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. J Biol Chem 1983 1.75
29 Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci U S A 1994 1.74
30 Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. J Biol Chem 1988 1.72
31 The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. J Biol Chem 1983 1.67
32 Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem 1978 1.60
33 Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro. Am J Pathol 1977 1.60
34 Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys. Proc Natl Acad Sci U S A 1980 1.59
35 Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains. J Biol Chem 1988 1.57
36 Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J Clin Invest 1994 1.54
37 Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex. J Biol Chem 1978 1.52
38 Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A 2001 1.51
39 Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry 1975 1.50
40 Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3. J Biol Chem 1986 1.50
41 Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues. Proc Natl Acad Sci U S A 1979 1.48
42 Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100. Lancet 1992 1.46
43 Canine lipoproteins and atherosclerosis. I. Isolation and characterization of plasma lipoproteins from control dogs. Circ Res 1974 1.44
44 Isolation and characterization of apolipoprotein E. Methods Enzymol 1986 1.39
45 Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J Clin Invest 1989 1.35
46 Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J Biol Chem 1994 1.34
47 Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. J Biol Chem 1993 1.33
48 Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors. Biochim Biophys Acta 1979 1.33
49 Human apolipoprotein B-100 heparin-binding sites. J Biol Chem 1987 1.32
50 Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles. J Biol Chem 2001 1.31
51 Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. J Biol Chem 1988 1.31
52 Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E. Proc Natl Acad Sci U S A 1985 1.25
53 Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. J Lipid Res 1992 1.25
54 The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats. Atherosclerosis 1977 1.24
55 Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. J Biol Chem 1983 1.23
56 Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. J Neuropathol Exp Neurol 1994 1.22
57 Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry 2001 1.21
58 Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. J Clin Invest 1989 1.20
59 Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. J Biol Chem 1999 1.19
60 New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. J Biol Chem 2001 1.17
61 Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype. J Clin Invest 1983 1.15
62 Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expr Purif 1999 1.14
63 Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res 1997 1.12
64 Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages. J Clin Invest 1986 1.12
65 In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice. J Biol Chem 1990 1.10
66 Apolipoprotein E;-low density lipoprotein receptor interaction. Influences of basic residue and amphipathic alpha-helix organization in the ligand. J Lipid Res 2000 1.09
67 Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. J Biol Chem 2000 1.09
68 Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. J Biol Chem 1984 1.08
69 Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J 2006 1.08
70 Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nat Struct Biol 1996 1.07
71 Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. J Clin Invest 1983 1.07
72 Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. J Cell Biol 1988 1.07
73 Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey. Biochemistry 1976 1.05
74 A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins. J Clin Invest 1980 1.05
75 The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia. J Biol Chem 1992 1.04
76 Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proc Natl Acad Sci U S A 1984 1.03
77 Apolipoprotein E immunoreactive deposits in inclusion-body muscle diseases. Lancet 1994 1.02
78 Isolation and characterization of an apoprotein from the d less than 1.006 lipoproteins of human and canine lymph homologous with the rat A-IV apoprotein. Biochem Biophys Res Commun 1978 1.01
79 Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor. J Biol Chem 2000 1.01
80 Crosslinking of apolipoprotein E by products of lipid peroxidation. J Neuropathol Exp Neurol 1996 0.99
81 Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism. JAMA 1991 0.98
82 Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins. Ann N Y Acad Sci 1980 0.98
83 Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis. J Lipid Res 1984 0.97
84 Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy. Biochemistry 1999 0.97
85 Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages. Arteriosclerosis 1986 0.97
86 Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure 1994 0.96
87 Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J Biol Chem 1998 0.95
88 Effects of lipid interaction on the lysine microenvironments in apolipoprotein E. J Biol Chem 2000 0.93
89 Structural relationship of human apolipoprotein B48 to apolipoprotein B100. J Clin Invest 1987 0.93
90 Functional domains of apolipoprotein E and apolipoprotein B. Acta Med Scand Suppl 1987 0.92
91 A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1. J Clin Invest 1984 0.92
92 Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling. J Biol Chem 2000 0.91
93 Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey. Biochemistry 1976 0.91
94 An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins. Biochemistry 1974 0.90
95 Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells. Arteriosclerosis 1984 0.90
96 Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. J Lipid Res 1991 0.89
97 Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Ann N Y Acad Sci 1996 0.88
98 Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. J Neurosci 1997 0.86
99 Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127. J Biol Chem 1989 0.86
100 Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci Lett 1994 0.86
101 Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type. J Biol Chem 1984 0.86
102 Effect of apolipoprotein C-I peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteins. J Lipid Res 1994 0.86
103 Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets. Arteriosclerosis 1990 0.86
104 Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia. Ann N Y Acad Sci 1985 0.85
105 Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy. Ann Neurol 1996 0.85
106 Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferase. Biochim Biophys Acta 1989 0.85
107 Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding. Protein Sci 2000 0.85
108 Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions. Cold Spring Harb Symp Quant Biol 1986 0.84
109 Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp Neurol 1996 0.84
110 Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins. Biochemistry 1992 0.84
111 ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci Lett 1995 0.84
112 Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies. Ann Neurol 1996 0.84
113 Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. J Biol Chem 1984 0.84
114 Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels. Anal Biochem 1985 0.83
115 Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E. Biochem Soc Trans 1998 0.83
116 The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity. J Lipid Res 1998 0.82
117 Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate. Biochem Cell Biol 1998 0.82
118 Human low density lipoprotein receptor fragment. Successful refolding of a functionally active ligand-binding domain produced in Escherichia coli. J Biol Chem 1997 0.82
119 Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE. J Lipid Res 2001 0.82
120 Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1997 0.82
121 Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma. Metabolism 1984 0.81
122 Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase. Eur J Biochem 1984 0.81
123 Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Exp Neurol 1995 0.81
124 A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder. J Lipid Res 1993 0.81
125 Pigments of Elsinoe species. VI. A simple synthesis of a related perylenequinone. J Chem Soc Perkin 1 1972 0.81
126 Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice. Biochem Soc Trans 1993 0.80
127 Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall. Am J Physiol 1977 0.79
128 Receptor interactions controlling lipoprotein metabolism. Can J Biochem Cell Biol 1985 0.79
129 Characterization of apolipoprotein E-containing lipoproteins. Methods Enzymol 1986 0.79
130 Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A. Acta Crystallogr D Biol Crystallogr 1999 0.79
131 Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma. J Lipid Res 1993 0.79
132 Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle. Neurology 2002 0.79
133 Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity. J Lipid Res 1990 0.78
134 Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. Cold Spring Harb Symp Quant Biol 1996 0.78
135 Conformation of apolipoprotein E in lipoproteins. J Biol Chem 1993 0.77
136 Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Exp Neurol 1987 0.77
137 Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem 1986 0.77
138 Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity. Arterioscler Thromb Vasc Biol 1997 0.77
139 Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization. Protein Expr Purif 1999 0.77
140 Isolation and characterization of several plasma apolipoproteins of common marmoset monkey. Arteriosclerosis 1990 0.77
141 Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix. Arterioscler Thromb Vasc Biol 1995 0.77
142 Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan. J Biol Chem 2000 0.76
143 Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E. Protein Expr Purif 1999 0.76
144 Identification of homozygosity for a human apolipoprotein A-I variant. J Lipid Res 1986 0.76
145 Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant. J Lipid Res 1994 0.76
146 Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites. Arterioscler Thromb Vasc Biol 1999 0.76
147 Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins. J Lipid Res 1995 0.75
148 Human apolipoprotein E7:lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins. J Lipid Res 2000 0.75
149 Pathology: plasma cholesterol levels determined by lipoprotein interactions with cell surface receptors. West J Med 1986 0.75
150 Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase. Agents Actions Suppl 1984 0.75
151 Animal carotenoids. 7. Carotenes of two colour variants of the aphid Macrosiphum liriodendri--identification of natural gamma, gamma-carotene. Acta Chem Scand 1971 0.75
152 Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100. Atherosclerosis 1993 0.75
153 Comparison of the human, canine and swine E apoproteins. Biochem Biophys Res Commun 1980 0.75
154 Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100. Metabolism 1993 0.75
155 Downstream regulatory elements stimulate expression of the human apolipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice. Trans Assoc Am Physicians 1990 0.75
156 Apolipoprotein E: receptor binding properties. Adv Exp Med Biol 1985 0.75
157 Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol 1988 0.75