Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage.

PubWeight™: 0.89‹?›

🔗 View Article (PMID 8080818)

Published in Adv Pharmacol on January 01, 1994

Authors

E D Hall1, J M McCall, E D Means

Author Affiliations

1: Upjohn Company, Kalamazoo, Michigan 49001.

Articles citing this

Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx (2004) 1.98

Antioxidant therapies for traumatic brain injury. Neurotherapeutics (2010) 1.73

Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma (2009) 1.67

Pharmacology of traumatic brain injury: where is the "golden bullet"? Mol Med (2008) 1.63

Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta (2011) 1.48

Antioxidant therapies for acute spinal cord injury. Neurotherapeutics (2011) 1.26

Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury. Brain (2010) 1.13

Targeting microvasculature for neuroprotection after SCI. Neurotherapeutics (2011) 0.93

Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo. Free Radic Biol Med (2012) 0.90

Temporal and spatial dynamics of nrf2-antioxidant response elements mediated gene targets in cortex and hippocampus after controlled cortical impact traumatic brain injury in mice. J Neurotrauma (2014) 0.82

Role of animal studies in the design of clinical trials. Front Neurol Neurosci (2009) 0.80

Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. Br J Pharmacol (1995) 0.78

Combination of therapeutic hypothermia and other neuroprotective strategies after an ischemic cerebral insult. Curr Neuropharmacol (2014) 0.76

Articles by these authors

[3H]U-69593 a highly selective ligand for the opioid kappa receptor. Eur J Pharmacol (1985) 1.77

A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg (1998) 1.52

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem (1987) 1.40

Treatment of iatrogenic femoral artery pseudoaneurysms using ultrasound-guided injection of thrombin. Clin Radiol (2000) 1.39

Nervous system lesions after sting by yellow jacket. A case report. Neurology (1973) 1.32

Acute spontaneous subdural hematoma. Surg Neurol (1984) 1.22

Tremorine-tremor, shivering and acute cerebellar ataxia in the adult and child--a comparative study. Brain (1969) 1.16

Uterine fibroleiomyoma: MR imaging appearances before and after embolization of uterine arteries. Radiology (2000) 1.14

Evaluation of a measurement strategy for Parkinson's disease: assessing patient health-related quality of life. Qual Life Res (2000) 1.08

Ultrastructure of retrograde degeneration in thalamus of rat. 1. Neuronal somata and dendrites. J Neuropathol Exp Neurol (1973) 1.04

Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma (1985) 1.03

The efficacy of percutaneous cholecystostomy in critically ill patients. Am Surg (1996) 1.02

Abdominal radical trachelectomy: a new surgical technique for the conservative management of cervical carcinoma. Br J Obstet Gynaecol (1997) 1.01

Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury. J Neurosurg (1987) 0.97

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage. J Pharmacol Exp Ther (1987) 0.97

Neuronophagia by leukocytes in experimental spinal cord injury. J Neuropathol Exp Neurol (1983) 0.96

U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J Pharmacol Exp Ther (1991) 0.94

Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury. Cell Mol Neurobiol (1993) 0.94

Effects of the 21-aminosteroid U74006F on experimental head injury in mice. J Neurosurg (1988) 0.92

Membrane lipid changes in laminectomized and traumatized cat spinal cord. Proc Natl Acad Sci U S A (1985) 0.91

Some factors affecting liver microsomal drug metabolism in the chicken. Biochem J (1972) 0.89

Sulfation of minoxidil by liver sulfotransferase. Biochem Pharmacol (1982) 0.89

Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment. J Neurosurg (1982) 0.89

Spinal cord injury and protection. Ann Emerg Med (1985) 0.89

Thrombin interactions with central nervous system tissue and implications of these interactions. Ann N Y Acad Sci (1986) 0.88

Phase I study of percutaneous cryotherapy for colorectal liver metastasis. Br J Surg (2002) 0.88

Changes in lipid metabolism in traumatized spinal cord. Prog Brain Res (1985) 0.87

Iron-induced lipid peroxidation in spinal cord: protection with mannitol and methylprednisolone. J Free Radic Biol Med (1985) 0.86

Ultrastructure of retrograde degeneration in thalamus of rat. 2. Changes in vascular elements and transvascular migration of leukocytes. Exp Mol Pathol (1974) 0.85

Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue. J Neurochem (1987) 0.85

Spinal cord energy metabolism following compression trauma to the feline spinal cord. J Neurosurg (1980) 0.85

Generation and detection of hydroxyl radical following experimental head injury. Ann N Y Acad Sci (1994) 0.85

Effects of treatment with U-74006F on neurological outcome following experimental spinal cord injury. J Neurosurg (1988) 0.84

Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma. J Med Chem (1990) 0.83

Effect of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg (1981) 0.83

Embolization of uterine arteriovenous malformations associated with cyanotic congenital heart disease. Cardiovasc Intervent Radiol (2009) 0.83

Spinal cord energy metabolism in normal and postlaminectomy cats. J Neurosurg (1980) 0.83

The numb chin in breast cancer. J Neurol Neurosurg Psychiatry (1973) 0.83

Early membrane lipid changes in laminectomized and traumatized cat spinal cord. Neurochem Pathol (1987) 0.81

1-(alkylamino)isochromans: hypotensives with peripheral and central activities. J Med Chem (1982) 0.81

Effects of laminectomy on spinal cord blood flow. J Neurosurg (1978) 0.81

Cerebrospinal fluid lactate and electrolyte levels following experimental spinal cord injury. J Neurosurg (1976) 0.81

Effects of a 21-aminosteroid (U-74006F) on cerebral metabolites and edema after severe experimental head trauma. Adv Neurol (1990) 0.81

Bromocriptine treatment of neuroleptic malignant syndrome. J Clin Psychiatry (1987) 0.80

Histochemical and histological studies of axon reaction in feline motoneurons. J Neuropathol Exp Neurol (1972) 0.80

Liquid-lipquid partition coefficients by high-pressure liquid chromatography. J Med Chem (1975) 0.80

Role of oxygen radicals in stroke: effects of the 21-aminosteroids (lazaroids). A novel class of antioxidants. Prog Clin Biol Res (1990) 0.80

Antioxidant effects in brain and spinal cord injury. J Neurotrauma (1992) 0.79

Comparative neuroanatomical distribution of the kappa and mu opioid receptors in guinea pig brain sections. Eur J Pharmacol (1989) 0.78

Pyrimidine and triazine 3-oxide sulfates: a new family of vasodilators. J Med Chem (1983) 0.78

Effect of delayed administration of U74006F (tirilazad mesylate) on recovery of locomotor function after experimental spinal cord injury. J Neurotrauma (1991) 0.78

Pathology of lacquer thinner induced neuropathy. Ann Clin Lab Sci (1976) 0.78

Stimulation of mono- and diacylglycerol lipase activities by bradykinin in neural cultures. Biochem Biophys Res Commun (1990) 0.77

Pretreatment with alpha tocopherol enhances neurologic recovery after experimental spinal cord compression injury. J Neurotrauma (1988) 0.77

Effects of the lazaroid, tirilazad mesylate, on sepsis-induced acute lung injury in minipigs. Crit Care Med (1998) 0.77

The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat. Brain Res (1991) 0.77

Efficacy of a monothermal warm water caloric screening test. Ann Otol Rhinol Laryngol (1985) 0.77

New pharmacological treatment of acute spinal cord trauma. J Neurotrauma (1988) 0.76

The degradation of phospholipids, formation of metabolites of arachidonic acid, and demyelination following experimental spinal cord injury. Cent Nerv Syst Trauma (1985) 0.76

Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes. Free Radic Biol Med (1994) 0.76

Microvascular perfusion experimental spinal cord injury. Surg Neurol (1978) 0.76

Methylprednisolone and membrane properties of primary cultures of mouse spinal cord. Brain Res (1994) 0.76

Thyrotropin-releasing hormone has profound presynaptic action on cultured spinal cord neurons. Synapse (1990) 0.75

Ligature injury to the accessory nerve. J Neurol Neurosurg Psychiatry (1987) 0.75

A new approach to triaminopyrimidine n-oxides. J Org Chem (1975) 0.75

Tirilazad mesylate protects stored erythrocytes against osmotic fragility. Chem Phys Lipids (1994) 0.75

Arylformamidines with antinociceptive properties. J Med Chem (1988) 0.75

Iron-initiated tissue oxidation: lipid peroxidation, vitamin E destruction and protein thiol oxidation. Inhibition by a novel antioxidant, U-78517F. Biochem Pharmacol (1993) 0.75

Radioimmunoassay of minoxidil in human serum. J Pharm Sci (1977) 0.75

The effect of laminectomy on spinal cord blood flow, energy metabolism and ATPase activity. Paraplegia (1985) 0.75

Mechanical damage to murine neuronal-enriched cultures during harvesting: effects on free fatty acids, diglycerides, Na+,K+-ATPase, and lipid peroxidation. In Vitro Cell Dev Biol (1985) 0.75

Susceptibility of feline spinal cord energy metabolism to severe incomplete ischemia. Neurology (1983) 0.75

Isolation, identification and synthesis of a metabolite of tazadolene succinate. Drug Des Deliv (1987) 0.75

Attenuation of hemorrhagic shock by the non-glucocorticoid 21-aminosteroid U74006F. Eur J Pharmacol (1988) 0.75

Antioxidant action of lazaroids. Methods Enzymol (1994) 0.75

The effects of vincamine on experimental cerebral infarction in Mongolian gerbils: a pilot study. Methods Find Exp Clin Pharmacol (1984) 0.75

Teaching student nurses to use skills analysis. Nurse Educ Today (1985) 0.75

7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. J Med Chem (1986) 0.75

Objectively assessing nursing practices: a curricular development. Nurse Educ Today (1996) 0.75

Tetrahydro-2-benzoxepins: a novel family of hypotensives. J Med Chem (1981) 0.75

Delay in the absolute latency of auditory brainstem response (ABR) component P1 in acute inflammatory demyelinating disease. Scand Audiol (1986) 0.75

Balloon choice for metallic stent dilation. J Vasc Interv Radiol (1993) 0.75

Experimental cerebral infarction in Mongolian gerbils: effects of vincamine on lesion size, survival and behavior. Res Commun Chem Pathol Pharmacol (1985) 0.75

Tremorine tremor, shivering and human "shuddering" tremor: a comparative study. Neurology (1968) 0.75

Antegrade catheterization of the brachial artery for embolizing a sarcoma of the forearm. Br J Radiol (1997) 0.75

Variations in liver-colon anatomic relationship: relevance to interventional radiology. J Vasc Interv Radiol (1994) 0.75

An aspirin-prednisolone combination to modify postadulticide lung disease in heartworm-infected dogs. Am J Vet Res (1984) 0.75

Minoxidil sulfate, a metabolite of minoxidil. Drug Metab Dispos (1983) 0.75

1-[Ethoxyamino)methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins: a new class of antianaphylactic agents. J Med Chem (1980) 0.75