One hundred years of schizophrenia: a meta-analysis of the outcome literature.

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Published in Am J Psychiatry on October 01, 1994

Authors

J D Hegarty1, R J Baldessarini, M Tohen, C Waternaux, G Oepen

Author Affiliations

1: Department of Psychiatry, Harvard Medical School, Boston, MA.

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Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex: effects of amphetamine analogues. Neuropharmacology (1973) 1.10

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A sensitive and specific enzymatic isotopic assay for tissue histamine. J Pharmacol Exp Ther (1966) 1.08

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