Published in J Gen Virol on June 01, 1993
Prions. Proc Natl Acad Sci U S A (1998) 27.80
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation. Proc Natl Acad Sci U S A (1997) 3.78
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42
Diversity in prion protein oligomerization pathways results from domain expansion as revealed by hydrogen/deuterium exchange and disulfide linkage. Proc Natl Acad Sci U S A (2007) 1.39
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. J Biol Chem (2011) 1.29
The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks. Proc Biol Sci (2000) 1.02
A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC. J Biol Chem (2014) 0.91
A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig. Mamm Genome (2008) 0.86
A robust, low- to medium-throughput prnp genotyping system in sheep. BMC Infect Dis (2004) 0.84
Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest (2015) 0.83
Disulfide mapping reveals the domain swapping as the crucial process of the structural conversion of prion protein. Prion (2011) 0.80
Prions, beta-sheets and transmissible dementias: is there still something missing? Acta Neuropathol (1995) 0.78
Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006 ˜ 2011). J Vet Sci (2013) 0.76
Allelic frequency and genotypes of prion protein at codon 136 and 171 in Iranian Ghezel sheep breeds. Prion (2011) 0.75
Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature (1997) 15.73
Transmission of BSE by blood transfusion in sheep. Lancet (2000) 5.16
A tandem repeats database for bacterial genomes: application to the genotyping of Yersinia pestis and Bacillus anthracis. BMC Microbiol (2001) 3.83
Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation. Lancet (2008) 3.66
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal. Mol Neurobiol (1995) 3.60
Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature (1997) 2.80
PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol (1994) 2.63
Evaluation of a nurse-run hypertension clinic in general practice. Practitioner (1988) 2.49
Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature (1995) 2.38
Distribution of cell-associated prion protein in normal adult blood determined by flow cytometry. Br J Haematol (1999) 2.29
Regulation of glucose production by the liver. Annu Rev Nutr (1999) 2.23
Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent. Nat Genet (1998) 2.23
PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. Neurodegeneration (1994) 2.21
Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Arch Virol (1996) 2.14
Laparoscopic extralevator abdominoperineal excision of the rectum: short-term outcomes of a prospective case series. Tech Coloproctol (2013) 1.99
Transmission of bovine spongiform encephalopathy to sheep and goats. Vet Rec (1993) 1.97
A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy. EMBO J (1999) 1.96
Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon. J Gen Virol (1991) 1.88
The prion protein gene: a role in mouse embryogenesis? Development (1992) 1.87
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol (2004) 1.73
Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases. Neuroreport (1999) 1.68
Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641. J Gen Virol (1999) 1.62
PrP genotypes of atypical scrapie cases in Great Britain. J Gen Virol (2006) 1.59
Biochemical typing of scrapie strains. Nature (1997) 1.59
A centuries-long epidemic of scrapie in British sheep? Trends Microbiol (2001) 1.57
Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats. Vet Rec (2001) 1.53
Linkage of the scrapie-associated fibril protein (PrP) gene and Sinc using congenic mice and restriction fragment length polymorphism analysis. J Gen Virol (1987) 1.48
The genetics of scrapie in sheep and goats. Curr Mol Med (2004) 1.46
Is scrapie solely a genetic disease? Nature (1997) 1.45
The potential size and duration of an epidemic of bovine spongiform encephalopathy in British sheep. Science (2001) 1.42
Site-specific characterization of the N-linked glycans of murine prion protein by high-performance liquid chromatography/electrospray mass spectrometry and exoglycosidase digestions. Biochemistry (1999) 1.40
The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain. J Pathol (1995) 1.40
Conjunctival instillation of scrapie in mice can produce disease. Vet Microbiol (1993) 1.36
Friction in perspective. Am J Orthod Dentofacial Orthop (1999) 1.35
Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme. J Gen Virol (2006) 1.32
Multicentre comparison of the Glasgow Blatchford and Rockall Scores in the prediction of clinical end-points after upper gastrointestinal haemorrhage. Aliment Pharmacol Ther (2011) 1.31
beta-Endorphin in human cerebrospinal fluid. Lancet (1978) 1.26
Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. J Comp Pathol (2005) 1.26
A quantitatively controlled method to study prospectively interstitial cystitis and demonstrate the efficacy of pentosanpolysulfate. J Urol (1993) 1.26
Natural scrapie and PrP genotype: case-control studies in British sheep. Vet Rec (1997) 1.25
The association of a codon 136 PrP gene variant with the occurrence of natural scrapie. Arch Virol (1994) 1.23
Lysosomes as key organelles in the pathogenesis of prion encephalopathies. J Pathol (1992) 1.20
Frequencies of PrP gene variants in healthy cattle and cattle with BSE in Scotland. Vet Rec (1994) 1.19
Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain. J Neurochem (1994) 1.19
Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence. J Virol (1999) 1.16
Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheep. Vet Rec (1989) 1.16
Evaluation of the ID-gel test for antibody screening and identification. Transfus Med (1991) 1.11
Plasminogen binds to disease-associated prion protein of multiple species. Lancet (2001) 1.11
Mice and beef and brain diseases. Nature (1996) 1.09
PrP gene dosage and long term potentiation. Neurodegeneration (1995) 1.09
Validity of questionnaires in population studies on drug use. Acta Psychiatr Scand (1985) 1.08
Application of a time-resolved fluoroimmunoassay for the analysis of normal prion protein in human blood and its components. Vox Sang (1999) 1.08
New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1). J Gen Virol (2002) 1.07
Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene. J Gen Virol (1991) 1.06
A systematic review of patient reported outcomes and patient experience in enhanced recovery after orthopaedic surgery. Ann R Coll Surg Engl (2014) 1.05
Scrapie epidemic in a fully PrP-genotyped sheep flock. J Gen Virol (2002) 1.05
Circadian rest-activity disturbances in seasonal affective disorder. Arch Gen Psychiatry (1997) 1.05
Signal requirements for growth and differentiation of activated murine B lymphocytes. J Immunol (1985) 1.05
Population dynamics of a scrapie outbreak. Arch Virol (2001) 1.02
Preparation of a gap junction fraction from uteri of pregnant rats: the 28-kD polypeptides of uterus, liver, and heart gap junctions are homologous. J Cell Biol (1985) 1.02
The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks. Proc Biol Sci (2000) 1.02
Stimulation of adrenal mitogenesis by N-terminal proopiocortin peptides. Nature (1982) 1.01
Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells. J Gen Virol (2000) 1.01
Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie. J Gen Virol (1994) 0.99
Effects of sampling context on the expressive language of children and adolescents with mental retardation. Ment Retard (1995) 0.99
The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic. J Gen Virol (1998) 0.97
Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations. Biotechnology (N Y) (1995) 0.97
Modelling the spread of scrapie in a sheep flock: evidence for increased transmission during lambing seasons. Arch Virol (2005) 0.95
Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience (2010) 0.95
Purification and characterization of a gamma-melanotropin precursor from frozen human pituitary glands. Biochem J (1980) 0.95
The fine structure of the developing follicle of the rhesus ovary. J Ultrastruct Res (1965) 0.94
Bovine brain acetylcholinesterase primary sequence involved in intersubunit disulfide linkages. J Biol Chem (1991) 0.94
Immunodetection of PrPSc in spleens of some scrapie-infected sheep but not BSE-infected cows. J Gen Virol (1997) 0.94
Structure and biosynthesis of peptides related to corticotropins and beta-melanotropins. Ann N Y Acad Sci (1977) 0.93
Use of antipsychosis and adjunctive medications by an inner urban community psychiatric service. Aust N Z J Psychiatry (1999) 0.93
Transmission of bovine spongiform encephalopathy to sheep, goats, and mice. Ann N Y Acad Sci (1994) 0.93
Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. J Gen Virol (1992) 0.93
Pro-opiocortin related peptides in human pituitary and ectopic ACTH secreting tumours. Clin Endocrinol (Oxf) (1983) 0.92
Folate binding protein from kidney brush border membranes contains components characteristic of a glycoinositol phospholipid anchor. Biochemistry (1992) 0.92
A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease. Blood (1998) 0.91
Nor98-like sheep scrapie in the United Kingdom in 1989. Vet Rec (2007) 0.91
Comparative epidemiology of scrapie outbreaks in individual sheep flocks. Epidemiol Infect (2002) 0.91
Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos. J Gen Virol (1999) 0.91
Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry. Eur J Oral Sci (2000) 0.90
Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo. EMBO J (2000) 0.90
Feline spongiform encephalopathy: fibril and PrP studies. Vet Rec (1992) 0.90