Experimental models of complete heart block.

On the Innervation of the Heart, with especial reference to the Heart of the Tortoise. J Physiol (1883) 4.01

Experimental atrioventricular block without thoracotomy: a new instrument. Cardiovasc Res (1971) 2.41

Morphology of the human atrioventricular node, with remarks pertinent to its electrophysiology. Am Heart J (1961) 2.06

ANATOMIC BASIS FOR ATRIOVENTRICULAR BLOCK. Am J Med (1964) 2.05

Chronic heart block in dogs; a method for producing experimental heart failure. Circulation (1955) 1.96

The treatment of complete heart block by the combined use of a myocardial electrode and an artificial pacemaker. Surg Forum (1957) 1.81

Hydraulic power associated with pulmonary blood flow and its relation to heart rate. Circ Res (1966) 1.41

Acute complete heart block in dogs. Circulation (1955) 1.40

A simple technique for production of chronic complete heart block in dogs. J Appl Physiol (1968) 1.36

Effect of heart rate on cardiac work, myocardial oxygen consumption and coronary blood flow in the dog. Acta Physiol Scand (1958) 1.35

An artificial conduction system for the management of experimental complete heart block. Surg Forum (1957) 1.31

Studies on the mechanism of ventricular activity. XIV. Clinical and experimental studies of accelerated auriculoventricular conduction. Circulation (1955) 1.31

EFFECT OF PACEMAKER SITE ON CARDIAC OUTPUT AND VENTRICULAR ACTIVATION IN DOGS WITH COMPLETE HEART BLOCK. Am J Cardiol (1964) 1.29

The cardiac conduction tissue and its blood supply in the dog. Am J Pathol (1959) 1.27

ON THE PHYSIOLOGY OF HEART-BLOCK IN MAMMALS, WITH ESPECIAL REFERENCE TO THE CAUSATION OF STOKES-ADAMS DISEASE. J Exp Med (1906) 1.14

Effect of ventricular rate on the cardiac output in the dog with chronic heart block. Circ Res (1962) 1.11

Contractility of the hypertrophied canine heart in chronic volume overload. Cardiovasc Res (1969) 1.10

On the cause of ventricular asystole during vagal stimulation. Circ Res (1967) 1.02

Regulation of cardiac output through stroke volume. Circ Res (1960) 1.02

Architecture of small arteries during vasoconstriction. Circ Res (1962) 1.01

Blood supply to the atrioventricular node and bundle of His: a comparative study in pig, dog, and man. Am J Pathol (1962) 0.94

The peripheral vascular response to severe exercise in untethered dogs before and after complete heart block. J Clin Invest (1971) 0.92

Left ventricular function in ambulatory dogs during experimental Adams-Stokes seizures. Am J Cardiol (1967) 0.86

ANATOMY OF THE A-V NODE OF THE DOG. Anat Rec (1964) 0.84

Production of chronic atrioventricular block in dogs without thoracotomy. J Appl Physiol (1966) 0.84

Haemodynamics of acute and chronic atrioventricular block in dogs. Cardiovasc Res (1969) 0.83

Production of chronic atrioventricular block in dogs without thoractomy. Cardiovasc Res (1968) 0.83

CARDIODYNAMICS OF COMPLETE HEART BLOCK. Am J Cardiol (1965) 0.82

Focal lesions in the canine bundle of His. Their effect on ventricular excitation. Circ Res (1972) 0.81

Use of intracardiac A-V nodal potentials in producing complete heart block in dogs. J Appl Physiol (1969) 0.81

Effect of glucagon on dogs with acute and chronic heart block. Am Heart J (1971) 0.80

The surgical treatment of coronary insufficiency. Dis Chest (1955) 0.80

Experimental production of permanent heart block (total or bundle branch block) without circulatory arrest or extracorporeal circulation. Thorax (1966) 0.80

ATRIO-VENTICULAR BLOCK PRODUCED BY LIGATION OF SEPTAL ARTERIES IN THE DOG=. Jpn Heart J (1965) 0.80

Selective perfusion of the AV node of the dog by cannulation of the posterior septal artery. Rev Can Biol (1965) 0.79

Electrical pathological obervations on the response of the canine heart to cardiac pacing. Br J Surg (1968) 0.79

Response of cardiac output to severe exercise of dogs in complete heart block with and without artificial pacing. J Thorac Cardiovasc Surg (1970) 0.79

Hemodynamic changes during complete heart block in the unanesthetized monkey. Am Heart J (1973) 0.78

Influence of different stimulation frequencies on the cardiac output at rest and during moderate exercise in dogs with chronic atrioventricular heart block. Acta Cardiol (1965) 0.78

Production of heart block in dogs, under direct vision. Surg Forum (1955) 0.77

A method of producing permanent, complete atrioventricular block in the rat. Br J Pharmacol (1972) 0.77

Cardiac function in experimental complete heart block. UCLA Forum Med Sci (1970) 0.76

Cardiac effects of isoproterenol, norepinephrine and epinephrine in complete A-V heart block during experimental acidosis and hyperkalemia. Circ Res (1959) 0.76

Circulatory dynamics and the effects of respiration during ventricular asystole in dogs with complete heart block. Circ Res (1962) 0.76

Digitalis in experimental, surgically induced heart block. Dis Chest (1962) 0.76

Production of complete atrioventricular dissociation. A new experimental technique. Arch Surg (1963) 0.76

REVERSIBLE COLD BLOCK OF THE SPECIALIZED CARDIAC TISSUES OF THE UNANAESTHETIZED DOG. Science (1964) 0.76

Comparison of single and paired electrical heart stimulation on cardiac hemodynamics at rest and during exercise in dogs with atrioventricular heart block. Arch Int Physiol Biochim (1966) 0.76

Subthalamically induced paroxysmal ventricular tachycardia after complete heart block. Am J Physiol (1966) 0.76

Technique for experimental complete heart block. J Appl Physiol (1967) 0.76

A simple method of producing experimental heart block in dogs. J Thorac Cardiovasc Surg (1967) 0.76

Effect of protokylol on the ventricular rate in dogs with experimental A-V heart block. Am Heart J (1969) 0.76

Effects of nicotine injected into the atrioventricular node artery of the dog. J Pharmacol Exp Ther (1969) 0.76

AV block induced by infusion of hypertonic solution into the canine AV node artery in situ. Tohoku J Exp Med (1970) 0.76

The effect of destruction of the bundle of His or the atrioventricular node on cyclopropane-adrenaline cardiac arrhythmias. Can J Physiol Pharmacol (1970) 0.76

A simplified method of producing experimental heart block. Ann Thorac Surg (1970) 0.76

Pharmacologic production of atrioventricular block with and without initial bundle branch block. J Pharmacol Exp Ther (1971) 0.76

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A (1994) 2.28

Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol (1992) 2.24

A redox-based O2 sensor in rat pulmonary vasculature. Circ Res (1993) 1.83

Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs. Circ Res (1976) 1.76

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol (1990) 1.74

Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ Res (1996) 1.74

Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel. J Clin Invest (1996) 1.72

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest (1999) 1.71

O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci U S A (1999) 1.67

Hypoxic ventilatory drive in normal man. J Clin Invest (1970) 1.62

A placebo-controlled trial of prostacyclin in acute respiratory failure in COPD. Chest (1996) 1.52

Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J Clin Invest (1987) 1.50

Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun (1989) 1.46

High-altitude pulmonary edema in the children and young adults of Leadville, Colorado. N Engl J Med (1977) 1.43

Histamine H1- and H2-receptors in pulmonary and systemic vasculature of the dog. Am J Physiol (1975) 1.40

The red cell mass--arterial oxygen relationship in normal man. Application to patients with chronic obstructive airway disease. J Clin Invest (1968) 1.39

Role of endothelin-1 in lung disease. Respir Res (2001) 1.36

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol (2008) 1.35

Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. J Clin Invest (1983) 1.33

Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J Clin Invest (1987) 1.32

Circulatory adaptation to high altitude. Annu Rev Med (1968) 1.32

Endothelial cells in culture produce a vasoconstrictor substance. J Cell Physiol (1987) 1.31

The genetic factor influencing pulmonary hypertension in cattle at high altitude. Cardiovasc Res (1974) 1.30

Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation (1971) 1.27

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Respir Dis (1982) 1.25

Impaired oxygenation during sleep in excessive polycythemia of high altitude: improvement with respiratory stimulation. Sleep (1978) 1.23

Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol (1985) (2001) 1.19

Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther (1986) 1.17

Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation. Am J Physiol (1999) 1.15

Nitric oxide production in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol (2001) 1.15

Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol (1999) 1.14

Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J Clin Invest (1971) 1.14

Redox status in the control of pulmonary vascular tone. Herz (1986) 1.12

Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Proc Natl Acad Sci U S A (1996) 1.11

Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Am J Physiol (1994) 1.11

Subnormal cardiac output at rest and during exercise in residents at 3,100 m altitude. J Appl Physiol (1967) 1.11

Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Biochem Biophys Res Commun (1989) 1.10

Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol (1985) (1994) 1.10

"Maximal" drug therapy is not necessarily optimal in chronic angina pectoris. J Am Coll Cardiol (1984) 1.09

Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. Am J Physiol (1975) 1.09

Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats. Am J Physiol (1974) 1.09

Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol (2001) 1.09

Purulent pericarditis in children: an analysis of 28 cases. Thorax (1977) 1.09

Ventilatory control in the athlete. J Appl Physiol (1971) 1.08

Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol (1992) 1.08

Measurement of cardiac output by electrical impedance at rest and during exercise. J Appl Physiol (1976) 1.08

Reversal of high altitude pulmonary hypertension. Am J Cardiol (1966) 1.08

Coexistent pulmonary and portal hypertension: morphologic and clinical features. J Am Coll Cardiol (1987) 1.07

Physiological effects of high altitude on the pulmonary circulation. Int Rev Physiol (1979) 1.07

Functional capacities of lungs and thorax in beagles after prolonged residence at 3,100 m. J Appl Physiol (1985) (1985) 1.07

Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. Am Rev Respir Dis (1984) 1.06

Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation. Adv Exp Med Biol (2000) 1.06

Fluid retention and relative hypoventilation in acute mountain sickness. Respiration (1982) 1.06

Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res (1990) 1.06

Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res (2001) 1.06

Endotoxin and prevention of hypoxic pulmonary vasoconstriction. J Lab Clin Med (1976) 1.06

Endothelin 1 causes pulmonary vasodilation in rats. Am J Physiol (1990) 1.05

EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am J Physiol (1993) 1.05

Role of red cell 2,3-diphosphoglycerate in the adaptation of man to altitude. J Lab Clin Med (1969) 1.05

Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol (1985) (1993) 1.05

Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation. J Appl Physiol (1985) (1991) 1.04

Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J Appl Physiol (1985) (1988) 1.04

Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Respir Dis (1992) 1.04

Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro. Am J Physiol (1991) 1.03

Comparative pharmacology of rat and porcine endothelin in rat aorta and pulmonary artery. Eur J Pharmacol (1989) 1.03

Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol (1985) (1989) 1.02

Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia. J Clin Invest (1968) 1.02

Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp Physiol (1995) 1.02

Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am J Physiol (1990) 1.01

Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Am J Physiol (1993) 1.01

Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol (1978) 1.01

Reduction of stroke volume during exercise in man following ascent to 3,100 m altitude. J Appl Physiol (1967) 1.01

The non specificity of specific nitric oxide synthase inhibitors. Biochem Biophys Res Commun (1992) 1.00

Cardiopulmonary responses of male and female swine to simulated high altitude. J Appl Physiol (1973) 1.00

Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol (1992) 1.00

Pulmonary circulation in animals and man at high altitude. Ann N Y Acad Sci (1965) 0.99

NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol (1985) (1993) 0.99

Infant birth weight is related to maternal arterial oxygenation at high altitude. J Appl Physiol Respir Environ Exerc Physiol (1982) 0.99

Does normoxic pulmonary vasodilatation rather than hypoxic vasoconstriction account for the pulmonary pressor response to hypoxia? Lancet (1978) 0.99

Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest (1998) 0.98

Release of vasodilator prostaglandin, PGI2, from isolated rat lung during vasoconstriction. Circ Res (1981) 0.97

Capillary recruitment and transit time in the rat lung. J Appl Physiol (1985) (1997) 0.97

Potassium channel diversity in vascular smooth muscle cells. Can J Physiol Pharmacol (1997) 0.96

Cardiovascular abnormalities in cutis laxa. Eur J Cardiol (1977) 0.96

Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc Natl Acad Sci U S A (1995) 0.96

Effect of captopril on uterine blood flow and prostaglandin E synthesis in the pregnant rabbit. J Clin Invest (1983) 0.96

High-altitude pulmonary edema in persons without the right pulmonary artery. N Engl J Med (1980) 0.96

Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia. Am J Physiol (1991) 0.96

Effect of chronic exposure to hypoxia on ventilatory response to CO 2 and hypoxia. J Appl Physiol (1971) 0.96

Acute mountain sickness and the edemas of high altitude: a common pathogenesis? Respir Physiol (1981) 0.95

Hypoxic contraction of isolated rat pulmonary artery. J Pharmacol Exp Ther (1989) 0.95

Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circ Res (1981) 0.95

Lung vessel leak precedes right ventricular hypertrophy in monocrotaline-treated rats. J Appl Physiol Respir Environ Exerc Physiol (1983) 0.95

High altitude-induced pulmonary arterial hypertension in the llama (Lama glama). Am J Physiol (1971) 0.94