Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Cloning of bovine GAP and its interaction with oncogenic ras p21.
|
Nature
|
1988
|
5.56
|
2
|
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.
|
Nature
|
1993
|
4.88
|
3
|
PDGF induction of tyrosine phosphorylation of GTPase activating protein.
|
Nature
|
1989
|
4.36
|
4
|
Sequence dependence of protein isoprenylation.
|
J Biol Chem
|
1991
|
3.10
|
5
|
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.
|
Cell
|
1990
|
3.09
|
6
|
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.
|
Nature
|
1998
|
2.93
|
7
|
CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae.
|
Science
|
1987
|
2.67
|
8
|
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP).
|
J Biol Chem
|
1990
|
2.49
|
9
|
The Differentiation of Hemolytic Streptococci from Various Sources by the Group Precipitin Reaction and by Biochemical Tests.
|
J Bacteriol
|
1940
|
2.24
|
10
|
The ras oncogene--an important regulatory element in lower eucaryotic organisms.
|
Microbiol Rev
|
1989
|
1.79
|
11
|
Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells.
|
J Biol Chem
|
1987
|
1.74
|
12
|
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.
|
J Biol Chem
|
1990
|
1.68
|
13
|
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338.
|
Curr Biol
|
2000
|
1.60
|
14
|
Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain.
|
Cell
|
1991
|
1.57
|
15
|
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
|
Mol Cell Biol
|
1994
|
1.56
|
16
|
Adsorption of Bacteria by Inert Particulate Reagents.
|
J Bacteriol
|
1937
|
1.54
|
17
|
Regulatory function of the Saccharomyces cerevisiae RAS C-terminus.
|
Mol Cell Biol
|
1987
|
1.51
|
18
|
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.
|
Carcinogenesis
|
2000
|
1.51
|
19
|
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.
|
Mol Cell Biol
|
1997
|
1.37
|
20
|
Ras interaction with the GTPase-activating protein (GAP).
|
Proteins
|
1989
|
1.35
|
21
|
Protein isoprenylation in suspension-cultured tobacco cells.
|
Plant Cell
|
1993
|
1.28
|
22
|
Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
|
Biochem Biophys Res Commun
|
2001
|
1.28
|
23
|
Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line.
|
J Biol Chem
|
1995
|
1.20
|
24
|
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.
|
Curr Biol
|
2000
|
1.17
|
25
|
Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase.
|
Biochim Biophys Acta
|
1994
|
1.17
|
26
|
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
|
J Biol Chem
|
1994
|
1.13
|
27
|
Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.
|
Biochem J
|
2000
|
1.10
|
28
|
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
|
Int J Oncol
|
1999
|
1.06
|
29
|
CDC43 and RAM2 encode the polypeptide subunits of a yeast type I protein geranylgeranyltransferase.
|
J Biol Chem
|
1992
|
1.03
|
30
|
Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
|
J Pharmacol Exp Ther
|
2001
|
1.02
|
31
|
Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src.
|
FEBS Lett
|
2001
|
1.01
|
32
|
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.
|
EMBO J
|
1991
|
1.00
|
33
|
Structure/function studies of the ras protein.
|
Cold Spring Harb Symp Quant Biol
|
1988
|
0.96
|
34
|
Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function.
|
Br J Cancer
|
2004
|
0.91
|
35
|
In vitro inhibition of Ras-Raf association by short peptides.
|
Biochem Biophys Res Commun
|
1998
|
0.90
|
36
|
p120 Ras GTPase-activating protein interacts with Ras-GTP through specific conserved residues.
|
J Biol Chem
|
1996
|
0.90
|
37
|
Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.
|
J Biol Chem
|
1995
|
0.85
|
38
|
Use of an enzyme-linked immunosorbent assay to measure antibody responses in turkeys against Pasteurella multocida.
|
Avian Dis
|
1982
|
0.85
|
39
|
Amino acid residues that define both the isoprenoid and CAAX preferences of the Saccharomyces cerevisiae protein farnesyltransferase. Creating the perfect farnesyltransferase.
|
J Biol Chem
|
1998
|
0.82
|
40
|
Structure/function relationships of ras and guanosine triphosphatase-activating protein.
|
Soc Gen Physiol Ser
|
1990
|
0.80
|
41
|
Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.
|
J Biol Chem
|
1992
|
0.80
|
42
|
Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I.
|
Mol Gen Genet
|
1996
|
0.80
|
43
|
Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.
|
J Immunol
|
1995
|
0.80
|
44
|
Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.
|
Blood
|
2001
|
0.79
|
45
|
Ras-Raf complexes in vitro.
|
Methods Enzymol
|
1995
|
0.78
|
46
|
Mutagenesis and biochemical analysis of recombinant yeast prenyltransferases.
|
Methods Enzymol
|
1995
|
0.77
|
47
|
Involvement of H-ras in erythroid differentiation of TF1 and human umbilical cord blood CD34 cells.
|
Blood Cells Mol Dis
|
1998
|
0.77
|
48
|
The ras oncogene protein as a G-protein.
|
Adv Second Messenger Phosphoprotein Res
|
1988
|
0.77
|
49
|
Genetic analysis of the molecular basis for beta-adrenergic receptor subtype specificity.
|
Proteins
|
1989
|
0.76
|
50
|
THE MERTHIOLATE-A NEW ANTISEPTIC.
|
Cal West Med
|
1931
|
0.75
|
51
|
CENTRIFUGING FILTERABLE VIRUSES.
|
Science
|
1927
|
0.75
|
52
|
Spherical particle sizing based on the VanderLugt correlator.
|
Appl Opt
|
1991
|
0.75
|
53
|
Brucella in Commercial Milk Supplies.
|
Cal West Med
|
1931
|
0.75
|
54
|
Immunity in Diphtheria.
|
Cal West Med
|
1932
|
0.75
|
55
|
Serum Preservatives.
|
Cal West Med
|
1934
|
0.75
|
56
|
Control of turkey Alcaligenes rhinotracheitis in Utah with a live vaccine.
|
Avian Dis
|
1982
|
0.75
|
57
|
The teaching laboratories.
|
J Med Educ
|
1973
|
0.75
|
58
|
Ethics, Law, and the Universities.
|
Science
|
1964
|
0.75
|
59
|
The roots of health.
|
Koku Eisei Gakkai Zasshi
|
1972
|
0.75
|
60
|
Bridge sciences.
|
J Med Educ
|
1973
|
0.75
|
61
|
Characterization of the Ras binding domain of the RalGDS-related protein, RLF.
|
Biochem Biophys Res Commun
|
1997
|
0.75
|
62
|
Classicists and Structural Linguists.
|
Science
|
1962
|
0.75
|
63
|
Spherical particle sizing by optical correlation using ternary phase-amplitude filters.
|
Appl Opt
|
1992
|
0.75
|
64
|
The concept of prevention.
|
Koku Eisei Gakkai Zasshi
|
1972
|
0.75
|
65
|
In Vitro Studies of Caries oof the Enamel in the Syrian Hamster.
|
Science
|
1948
|
0.75
|
66
|
The effects of deep physical relaxation and low-frequency-alpha brainwaves on alpha subjective reports.
|
Psychophysiology
|
1976
|
0.75
|
67
|
Letters to the Editor.
|
Science
|
1964
|
0.75
|
68
|
Immunologic.
|
Science
|
1948
|
0.75
|
69
|
Questions and Answers.
|
Science
|
1962
|
0.75
|
70
|
Adjustable standards.
|
J Dent Educ
|
1969
|
0.75
|
71
|
Letter to the Editor.
|
Science
|
1962
|
0.75
|