E J Leonard

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 1988 7.12
2 Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A 1987 6.90
3 A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J Immunol Methods 1980 6.44
4 Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1). J Immunol 1987 5.64
5 Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett 1989 4.75
6 Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A 1991 4.56
7 Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med 1989 3.89
8 Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 1990 3.26
9 Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly. J Immunol Methods 1980 3.12
10 Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/HeN mouse macrophages. J Immunol 1981 2.39
11 Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J Immunol 1989 2.12
12 NAP-1 (IL-8) Immunol Today 1990 2.09
13 Macrophages in resistance to rickettsial infections: characterization of lymphokines that induce rickettsiacidal activity in macrophages. J Immunol 1981 1.94
14 Abnormal monocyte chemotactic response in cancer patients. J Natl Cancer Inst 1974 1.87
15 Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science 1994 1.84
16 Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions. Proc Natl Acad Sci U S A 1989 1.81
17 Solid phase radioimmunoassay of human beta 1C globulin. Immunochemistry 1970 1.77
18 Identification of high affinity receptors for human monocyte chemoattractant protein-1 on human monocytes. J Immunol 1990 1.68
19 Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol 2001 1.58
20 Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Hum Pathol 1993 1.53
21 Secretion by human fibroblasts of monocyte chemoattractant protein-1, the product of gene JE. J Immunol 1990 1.52
22 Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan. J Clin Invest 1990 1.49
23 Tumor-specific antigen solubilized by hypertonic potassium chloride. J Natl Cancer Inst 1971 1.46
24 Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium. Clin Immunol Immunopathol 1993 1.45
25 Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. J Exp Med 1991 1.43
26 Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 1993 1.42
27 Effects of cell concentration on chemotactic responsiveness of mouse resident peritoneal macrophages. J Reticuloendothel Soc 1981 1.41
28 Interaction of BCG-activated macrophages with neoplastic and nonneoplastic cell lines in vitro : quantitation of the cytotoxic reaction by release of tritiated thymidine from prelabeled target cells. J Natl Cancer Inst 1975 1.38
29 Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. Infect Immun 1980 1.27
30 Neutrophil attractant protein-1-immunoglobulin G immune complexes and free anti-NAP-1 antibody in normal human serum. J Clin Invest 1992 1.25
31 Secretion of neutrophil attractant/activation protein by lipopolysaccharide-stimulated lung macrophages determined by both enzyme-linked immunosorbent assay and N-terminal sequence analysis. Am Rev Respir Dis 1990 1.22
32 Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages. J Biol Chem 1994 1.21
33 A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res 1976 1.20
34 Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein. Blood 1995 1.20
35 Characterization of macrophage activation factor, a lymphokine that causes macrophages to become cytotoxic for tumor cells. Cell Immunol 1978 1.20
36 Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Mol Cell Biol 2000 1.19
37 Neutrophil attractant/activation protein-1 (NAP-1) causes human basophil histamine release. Immunol Lett 1989 1.19
38 Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases. J Clin Invest 1996 1.17
39 Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade. J Biol Chem 1994 1.14
40 Chemotaxis by mouse macrophage cell lines. J Immunol 1981 1.14
41 Defective vaccine-induced immunity to Schistosoma mansoni in P strain mice. II. Analysis of cellular responses. J Immunol 1984 1.14
42 Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence. Mol Immunol 1989 1.12
43 Simultaneous generation of tuberculin-type and cutaneous basophilic hypersensitivity at separate sites in the guinea pig. Int Arch Allergy Appl Immunol 1979 1.09
44 Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. J Biol Chem 2000 1.09
45 Neutrophil attractant protein-1 and monocyte chemoattractant protein-1 in human serum. Effects of intravenous lipopolysaccharide on free attractants, specific IgG autoantibodies and immune complexes. J Immunol 1993 1.08
46 Staphylococcus aureus-derived chemoattractant activity for human monocytes. J Leukoc Biol 1986 1.07
47 Isolation of macrophage stimulating protein (MSP) from human serum. Exp Cell Res 1978 1.07
48 Detection of bound C3 by a new immunochemical methods. J Immunol 1971 1.06
49 Synthesis and biological characterization of monocyte-derived neutrophil chemotactic factor. FEBS Lett 1988 1.06
50 Purification of human blood basophils by single step isopycnic banding on Percoll. J Leukoc Biol 1984 1.06
51 Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene 1996 1.06
52 Basophil chemotaxis: augmentation by a factor from stimulated lymphocyte cultures. Immunol Commun 1973 1.06
53 Colony-stimulating factors and regulation of macrophage tumoricidal and microbicidal activities. Cell Immunol 1983 1.05
54 The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein. Proc Natl Acad Sci U S A 1995 1.04
55 Action and target cell specificity of human macrophage-stimulating protein (MSP). J Immunol 1994 1.03
56 A series of six ligands for the human formyl peptide receptor: tetrapeptides with high chemotactic potency and efficacy. Proc Natl Acad Sci U S A 1987 1.02
57 Two neutrophil populations in human blood with different chemotactic activities: separation and chemoattractant binding. Infect Immun 1982 1.00
58 Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples. Genes Chromosomes Cancer 2000 1.00
59 Mouse lymphotoxin. J Immunol 1976 1.00
60 Quantitative study of monocyte chemoattractant protein-1 (MCP-1) in cerebrospinal fluid and cyst fluid from patients with malignant glioma. J Natl Cancer Inst 1993 1.00
61 Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding. J Biol Chem 1999 0.99
62 Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res 1996 0.99
63 Disposable microliter immunoabsorbent columns: construction and operation. J Immunol Methods 1985 0.99
64 The action of the adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine, on phagocytic function of mouse macrophages and human monocytes. Biochem Biophys Res Commun 1978 0.99
65 Human monocyte chemoattractant protein-1: structure and function. Cytokines 1992 0.99
66 Macrophages as effector cells of protective immunity in murine schistosomiasis: macrophage activation in mice vaccinated with radiation-attenuated cercariae. Infect Immun 1984 0.98
67 Kinases involved in MSP/RON signaling. J Leukoc Biol 1999 0.97
68 Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of the kallikrein family. J Biol Chem 1994 0.97
69 Macrophages as effector cells of protective immunity in murine schistosomiasis. IV. Coincident induction of macrophage activation for extracellular killing of schistosomula and tumor cells. Cell Immunol 1982 0.97
70 Chemotactic responses of normal human basophils to C5a and to lymphocyte-derived chemotactic factor. J Immunol 1976 0.97
71 Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain. J Biol Chem 1997 0.97
72 Characterization of macrophage chemotaxins in tumor cell cultures and comparison with lymphocyte-derived chemotactic factors. Cancer Res 1977 0.97
73 Histamine-induced inhibition of normal human basophil chemotaxis to C5a. J Immunol 1977 0.94
74 Cell-mediated tumor immunity measured in vitro and in vivo with soluble tumor-specific antigens. J Natl Cancer Inst 1972 0.93
75 Enhancement of spreading, phagocytosis and chemotaxis by macrophage stimulating protein (MSP). Adv Exp Med Biol 1979 0.92
76 A human serum protein system affecting muscle contractility: characterization of the five components and their reaction sequence. J Cell Physiol 1978 0.92
77 Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. Biochem Biophys Res Commun 1995 0.91
78 Production of monocyte chemoattractant protein-1 by malignant fibrous histiocytoma: relation to the origin of histiocyte-like cells. Exp Mol Pathol 1991 0.91
79 Normal human sweat contains interleukin-8. J Leukoc Biol 1995 0.89
80 Production and characterization of mouse monoclonal antibodies against human monocyte chemoattractant protein-1. J Immunol 1991 0.89
81 Staphylococcus aureus tetrapeptide with high chemotactic potency and efficacy for human leukocytes. J Leukoc Biol 1989 0.88
82 Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury. J Invest Dermatol 1998 0.88
83 alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein. J Biol Chem 2001 0.87
84 Specificity and reversibility of chemotactic deactivation of human monocytes. Infect Immun 1981 0.87
85 Synergistic action of adenosine and fMet-Leu-Phe in raising cAMP content of purified human monocytes. Biochem Biophys Res Commun 1986 0.87
86 Enhanced tumor growth in animals pretreated with complete Freund's adjuvant. J Natl Cancer Inst 1973 0.87
87 Human monocyte chemoattractant protein-1 (MCP-1). Adv Exp Med Biol 1991 0.87
88 Anti-apoptotic action of macrophage stimulating protein (MSP). Apoptosis 2001 0.86
89 Only the chemotactic subpopulation of human blood monocytes expresses receptors for the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine. Infect Immun 1982 0.86
90 Production and characterization of human glioma cell-derived monocyte chemotactic factor. J Natl Cancer Inst 1989 0.86
91 Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. Exp Cell Res 1999 0.85
92 Dynamics of chemotactic peptide-induced superoxide generation by human monocytes. Inflammation 1987 0.85
93 Functional differences between resident and exudate peritoneal mouse macrophages: specific serum protein requirements for responsiveness to chemotaxins. J Reticuloendothel Soc 1980 0.85
94 A method for staining multiple chemotaxis filters. J Immunol Methods 1975 0.84
95 Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors. Histol Histopathol 2001 0.84
96 Interactions of formylmethionyl-leucyl-phenylalanine, adenosine, and phosphodiesterase inhibitors in human monocytes. Effects on superoxide release, inositol phosphates and cAMP. FEBS Lett 1989 0.84
97 Analysis of human monocyte chemoattractant binding by flow cytometry. J Leukoc Biol 1985 0.83
98 Antibodies to macrophage stimulating protein (MSP): specificity, epitope interactions, and immunoassay of MSP in human serum. J Leukoc Biol 1993 0.83
99 Differences in superoxide production by nonmigrating and migrating human monocyte subpopulations. Biochem Biophys Res Commun 1982 0.82
100 N-formylmethionyl-leucyl-[3H]phenylalanine binding, superoxide release, and chemotactic responses of human blood monocytes that repopulate the circulation during leukapheresis. Blood 1983 0.82
101 Molecular weight, isoelectric point, and stability of a murine lymphokine that induces macrophage tumoricidal activity. J Reticuloendothel Soc 1983 0.81
102 Characterization of mouse lymphocyte-derived chemotactic factor. Cell Immunol 1976 0.80
103 The activities of cytokines are pleiotropic and interdependent. Immunol Lett 1987 0.80
104 Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement. Infect Immun 1982 0.80
105 Mode of receptor binding and activation by plasminogen-related growth factors. FEBS Lett 1998 0.80
106 Two populations of human blood basophils: effect of prednisone on circulating numbers. J Allergy Clin Immunol 1987 0.79
107 Relationship between interleukin 1 (IL1), tumor necrosis factor (TNF) and a neutrophil attracting peptide (NAP-1). Agents Actions 1989 0.79
108 Production of mouse lymphotoxin by phytohemagglutinin-stimulated spleen cells requires two cell fractions. Infect Immun 1982 0.78
109 A high molecular weight chemoattractant generated from C5 by ultracentrifugation of mouse serum without activation of complement. Mol Immunol 1983 0.78
110 Extraction of tumor-specific antigen from cells and plasma membranes of line-10 hepatoma. J Natl Cancer Inst 1975 0.78
111 Functional characterization of lymphokines from the EL-4 T cell line that activate macrophages for nonspecific tumor cytotoxicity. J Leukoc Biol 1984 0.77
112 Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family. Ann Hematol 1996 0.77
113 Effect of mouse lymphotoxin on radiation-damaged cells. Cell Immunol 1980 0.77
114 Determination of the primary and secondary structure of NAP-1/IL-8 and a monocyte chemoattractant protein, MCP-1/MCAF. Prog Clin Biol Res 1990 0.77
115 Properties of tumor-specific antigen solubilized by hypertonic potassium chloride. Natl Cancer Inst Monogr 1972 0.76
116 Macrophage activation for tumor cytotoxicity: mechanisms of macrophage activation by lymphokines. Adv Exp Med Biol 1979 0.76
117 Activation of macrophages for killing of rickettsiae: analysis of macrophage effector function after rickettsial inoculation of inbred mouse strains. Adv Exp Med Biol 1983 0.75
118 Effect of C3 inactivator on bound C3 antigen. J Immunol 1972 0.75
119 Functionally distinct subpopulations of human monocytes: receptors for F-Met-Leu-Phe are expressed only on the chemotactically responsive cells. Adv Exp Med Biol 1982 0.75
120 Evaluating antitrust risk in joint provider negotiations with payors. Med Staff Couns 1992 0.75
121 Chemoattractant efficacy: oxidation of stimulus by responding cells. Biochem Biophys Res Commun 1986 0.75
122 Cardioglobulin: separation, characterization, and assay of the individual components. Circ Res 1968 0.75
123 Destruction of syngeneic tumors by tuberculin-stimulated peritoneal exudate cells from guinea pigs immunized to Mycobacterium bovis (strain BCG). J Natl Cancer Inst 1974 0.75
124 Macrophage activation for tumor cytotoxicity: reactivity of peritoneal and bone marrow macrophages. Adv Exp Med Biol 1982 0.75
125 Humoral immune responses to tumor-specific antigens in strain-2 guinea pigs. J Natl Cancer Inst 1974 0.75
126 Electrofocusing-induced alteration in the net charge of human macrophage-stimulating protein. Arch Biochem Biophys 1982 0.75
127 Isolation from rat diaphragm of a calcium-protein complex involved in excitation-contraction coupling. Circ Res 1971 0.75
128 Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein. Arch Biochem Biophys 1999 0.75
129 Cardioglobulin: tissue localization and plasma activity with special reference to cardiovascular disease and lupus erythematosus. Circ Res 1968 0.75
130 Protective tumor immunity induced by potassium chloride extracts of guinea pig hepatomas. J Natl Cancer Inst 1975 0.75
131 C3 in high molecular weight complexes: separation from plasma of nephritic patients and normal subjects by a method that avoids in vitro artifacts. J Immunol 1970 0.75
132 Separation of human basophils into two fractions with different density and histamine content. J Allergy Clin Immunol 1985 0.75
133 A calcium transport system for mammalian cells. Life Sci 1975 0.75
134 Suppression of tumor growth in strain 2 guinea pigs by xenogeneic antitumor antibody. J Natl Cancer Inst 1976 0.75
135 Excitation-contraction coupling and control of cardiac contractility. Circulation 1966 0.75
136 Strategies for nonprofit hospital capital financing in the 1990s. Healthspan 1989 0.75
137 Immunochemical detection of tumor-specific and embryonic antigens of diethylnitrosamine-induced guinea pig tumors. J Natl Cancer Inst 1973 0.75