Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 8258346)

Published in Eur J Immunol on December 01, 1993

Authors

J M Kelly1, S J Sterry, S Cose, S J Turner, J Fecondo, S Rodda, P J Fink, F R Carbone

Author Affiliations

1: Department of Pathology and Immunology, Monash Medical School, Victoria, Australia.

Articles citing this

T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med (2000) 4.16

The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med (2009) 2.82

Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J (1998) 1.74

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma. Cancer Cell (2015) 1.71

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias. J Virol (1995) 1.40

Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. J Immunol (2007) 1.37

Functional management of an antiviral cytotoxic T-cell response. J Virol (1997) 1.30

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med (2012) 1.15

T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs. J Exp Med (1999) 1.15

Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice. Mol Ther (2010) 1.02

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol (2008) 0.91

In situ activation of antigen-specific CD8+ T cells in the presence of antigen in organotypic brain slices. J Immunol (2008) 0.90

Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS One (2011) 0.86

Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nat Commun (2015) 0.82

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model. PLoS One (2010) 0.80

In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex. J Exp Med (1995) 0.79

On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor beta chain. Proc Natl Acad Sci U S A (1998) 0.78

Loss of T cell-mediated antitumor immunity after construct-specific downregulation of retrovirally encoded T-cell receptor expression in vivo. Cancer Gene Ther (2008) 0.78

Inducible T-cell receptor expression in precursor T cells for leukemia control. Leukemia (2015) 0.77

Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity. J Biol Chem (2015) 0.75

Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes. Vaccines (Basel) (2014) 0.75

Articles by these authors

T cell receptor antagonist peptides induce positive selection. Cell (1994) 18.66

Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature (1998) 11.08

Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol (1998) 11.07

Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell (1988) 8.01

Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med (1997) 5.72

Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med (1996) 5.21

Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol (2001) 5.15

Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med (1997) 4.01

H-2 antigens of the thymus determine lymphocyte specificity. J Exp Med (1978) 3.91

Correlations between T-cell specificity and the structure of the antigen receptor. Nature (1986) 3.83

Measuring the diaspora for virus-specific CD8+ T cells. Proc Natl Acad Sci U S A (2001) 3.51

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature (1996) 3.08

Cross-presentation in viral immunity and self-tolerance. Nat Rev Immunol (2001) 2.76

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med (1993) 2.57

CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med (1997) 2.49

Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol (2001) 2.41

The influence of thymus H-2 antigens on the specificity of maturing killer and helper cells. Immunol Rev (1978) 2.34

Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science (1988) 2.30

Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med (1998) 2.24

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol (2000) 1.98

The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant. J Virol (1999) 1.97

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem (2000) 1.88

Variation in plasma calcium with induced changes in plasma specific gravity, total protein, and albumin. Br Med J (1973) 1.83

Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J Exp Med (1998) 1.83

Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease. Gut (1987) 1.79

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet (1994) 1.77

The role of the LFA-1/ICAM-1 interaction in human leukocyte homing and adhesion. Immunol Rev (1989) 1.75

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J Exp Med (1994) 1.74

Induction of autoimmune diabetes by oral administration of autoantigen. Science (1996) 1.69

ARMS-PCR methodologies to determine IL-10, TNF-alpha, TNF-beta and TGF-beta 1 gene polymorphisms. Transpl Immunol (1999) 1.68

Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules. J Exp Med (1996) 1.66

Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens. J Exp Med (1984) 1.63

Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J Exp Med (1998) 1.57

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes. J Exp Med (1995) 1.57

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc Natl Acad Sci U S A (1999) 1.55

Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes. Nature (1989) 1.52

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J Exp Med (1987) 1.52

Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides. J Immunol (1989) 1.49

The role of psychiatry as a primary care specialty. Arch Gen Psychiatry (1976) 1.48

The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med (1998) 1.47

The CD8 response on autopilot. Nat Immunol (2001) 1.45

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias. J Virol (1995) 1.40

Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3. J Gen Virol (1994) 1.35

Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation. Nature (1985) 1.34

Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma. Genes Immun (2002) 1.32

Treadmill exercise test in short children. Arch Dis Child (1984) 1.31

Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells. J Exp Med (1983) 1.31

RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity (1998) 1.31

The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant. Eur J Immunol (1990) 1.30

Expression of two T cell receptor alpha chains on the surface of normal murine T cells. Eur J Immunol (1995) 1.27

Molecular cloning of the cDNA encoding the T3 gamma subunit of the mouse T3/T cell antigen receptor complex. J Immunol (1987) 1.24

Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Nature (1999) 1.23

Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity (2000) 1.22

T cell receptor alpha-chain pairing determines the specificity of residue 262 within the Kb-restricted, ovalbumin257-264 determinant. Int Immunol (1992) 1.22

V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J Immunol (1994) 1.21

B cells directly tolerize CD8(+) T cells. J Exp Med (1998) 1.20

MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. Immunity (2001) 1.18

The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression. Eur J Immunol (1987) 1.18

Antigen-specific CD8+ T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection. Eur J Immunol (1997) 1.18

IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma. Genes Immun (2001) 1.16

T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs. J Exp Med (1999) 1.15

Fas ligand costimulates the in vivo proliferation of CD8+ T cells. J Immunol (2000) 1.14

Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice. Infect Immun (1993) 1.14

Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue. J Immunol (1997) 1.14

Chronic modulation of the TCR repertoire in the lymphoid periphery. J Immunol (1999) 1.13

Processing of a minimal antigenic peptide alters its interaction with MHC molecules. Nature (1988) 1.12

The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. Cell (1987) 1.11

A functionally compromised intermediate in extrathymic CD8+ T cell deletion. Immunity (1995) 1.11

Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur J Immunol (1994) 1.08

T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones. J Immunol (1990) 1.07

Cytotoxic T lymphocyte activation by cross-priming. Curr Opin Immunol (1999) 1.07

Holding the line against wrong-headed changes. Psychiatr Serv (1995) 1.07

Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection. J Virol (2000) 1.07

Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells. J Exp Med (1992) 1.06

Receptor revision in peripheral T cells creates a diverse V beta repertoire. J Immunol (2000) 1.04

Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism. Cancer Res (2001) 1.04

Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. Eur J Immunogenet (2003) 1.04

TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity. J Immunol (1996) 1.03

The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc Natl Acad Sci U S A (2000) 1.03

Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene. J Virol (2000) 1.03

HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: evidence from a family-based and case-control study. Clin Exp Allergy (1998) 1.02

Conformational difference of T cell antigen receptors revealed by monoclonal antibodies to mouse V beta 5 T cell receptor for antigen determinants. J Immunol (1991) 1.01

A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells. J Immunol (2000) 1.01

Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J Exp Med (1993) 1.01

Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen. J Immunol (1984) 1.01

A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nat Immunol (2001) 1.01

Hypoadrenalism in patients with pulmonary tuberculosis in Tanzania: an undiagnosed complication? Trans R Soc Trop Med Hyg (1991) 1.00

Monoclonal antibodies to horse cytochrome c expressing four distinct idiotypes distribute among two sites on the native protein. J Immunol (1985) 1.00

Effect of cell-bound hyaluronic acid on infectivity of Newcastle disease virus for human synovial cells in vitro. Ann Rheum Dis (1974) 0.99

General psychiatry. A primary-care specialty. JAMA (1976) 0.99

Herpes-simplex virus from trigeminal ganglion. Lancet (1973) 0.96

The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A. Cell Growth Differ (1993) 0.96

Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus. J Gen Virol (2000) 0.96

Studies on the mechanism of suppression of primary cytotoxic responses by cloned cytotoxic T lymphocytes. J Immunol (1984) 0.96

The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant. J Immunol (1988) 0.96

Influence of TNFalpha and LTalpha single nucleotide polymorphisms on susceptibility to and prognosis in cutaneous malignant melanoma in the British population. Eur J Immunogenet (2002) 0.94