| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain.
|
J Med Chem
|
1981
|
1.16
|
|
2
|
Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride.
|
Brain Res
|
1993
|
0.97
|
|
3
|
Evaluation of 5-[18F]fluoropropylepidepride as a potential PET radioligand for imaging dopamine D2 receptors.
|
Synapse
|
1993
|
0.93
|
|
4
|
Preparation of 11C-labelled Raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey.
|
Int J Appl Radiat Isot
|
1985
|
0.92
|
|
5
|
High affinity dopamine D2 receptor radioligands. 1. Regional rat brain distribution of iodinated benzamides.
|
J Nucl Med
|
1991
|
0.88
|
|
6
|
Failure of the three compartment model to describe the pharmacokinetics in brain of a high affinity substituted benzamide.
|
Synapse
|
1993
|
0.87
|
|
7
|
High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors.
|
Life Sci
|
1991
|
0.85
|
|
8
|
Characterization of desamino-5-[125I]iodo-3-methoxy-zacopride ([125I]MIZAC) binding to 5-HT3 receptors in the rat brain.
|
Prog Neuropsychopharmacol Biol Psychiatry
|
1998
|
0.85
|
|
9
|
On the topology of the norepinephrine transport carrier in rat hypothalamus. The site of action of tricyclic uptake inhibitors.
|
Mol Pharmacol
|
1978
|
0.83
|
|
10
|
Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine.
|
J Pharmacol Exp Ther
|
1992
|
0.81
|
|
11
|
Aromatic and amine substituent effects on the apparent lipophilicities of N-[(2-pyrrolidinyl)methyl]-substituted benzamides.
|
J Pharm Sci
|
1994
|
0.80
|
|
12
|
Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study.
|
J Med Chem
|
1990
|
0.79
|
|
13
|
Characterization of (S)-des-4-amino-3-[125I]iodozacopride ([125I]DAIZAC), a selective high-affinity radioligand for 5-hydroxytryptamine3 receptors.
|
J Pharmacol Exp Ther
|
1999
|
0.78
|
|
14
|
High affinity dopamine D2 receptor radioligands. 3. [123I] and [125I]epidepride: in vivo studies in rhesus monkey brain and comparison with in vitro pharmacokinetics in rat brain.
|
Life Sci
|
1993
|
0.78
|
|
15
|
Anxiolytic-like effects of DAIZAC, a selective high-affinity 5-HT(3) receptor antagonist, in the mouse elevated plus-maze.
|
Pharmacol Biochem Behav
|
2001
|
0.77
|
|
16
|
Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.
|
J Med Chem
|
1985
|
0.77
|
|
17
|
Pharmacological characterization of morphine-6-sulfate and codeine-6-sulfate.
|
Brain Res
|
1999
|
0.77
|
|
18
|
Dosimetry of iodine-123-epidepride: a dopamine D2 receptor ligand.
|
J Nucl Med
|
1995
|
0.77
|
|
19
|
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.
|
J Med Chem
|
1986
|
0.76
|
|
20
|
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
|
J Med Chem
|
1994
|
0.75
|
|
21
|
Solid state conformations and antidopaminergic effects of remoxipride hydrochloride and a closely related salicylamide, FLA 797, in relation to dopamine receptor models.
|
Mol Pharmacol
|
1986
|
0.75
|
|
22
|
Molecular structure and absolute configuration of the hydrochloride of a novel dopamine receptor antagonist: 2S(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxysalicylamide.
|
Acta Pharm Suec
|
1985
|
0.75
|
|
23
|
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
|
J Med Chem
|
1995
|
0.75
|
|
24
|
Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.
|
J Med Chem
|
1991
|
0.75
|
|
25
|
[A journey in life].
|
Vardfacket
|
1980
|
0.75
|
|
26
|
Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.
|
J Med Chem
|
1990
|
0.75
|
|
27
|
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
|
J Med Chem
|
1989
|
0.75
|
|
28
|
Synthesis and 5-HT-3 receptor binding of 2- and 3-(halo)alkoxyl substituted (S)-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chlorobenzamides as potential radioligands.
|
Nucl Med Biol
|
1998
|
0.75
|
|
29
|
Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
|
J Med Chem
|
1990
|
0.75
|
|
30
|
Synthesis and radiolabeling of (S)-4-amino-5-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide, the active enantiomer of [125I]iodozacopride, and re-evaluation of its 5-HT3 receptor affinity.
|
Chem Pharm Bull (Tokyo)
|
1997
|
0.75
|
|
31
|
Metabolism of zimelidine in rat, dog and man. Identification and synthesis of the principal metabolites.
|
Arzneimittelforschung
|
1981
|
0.75
|
|
32
|
Antidepressant agents. 1. Chemistry and pharmacology of amino-substituted spiro(5H-dibenzo(a,d)cycloheptene-5,1'-cycloalkanes).
|
J Med Chem
|
1974
|
0.75
|