Published in Neuroreport on June 01, 1993
The science of stroke: mechanisms in search of treatments. Neuron (2010) 6.14
Laser speckle contrast imaging in biomedical optics. J Biomed Opt (2010) 4.17
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A (1999) 3.96
Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol (2006) 2.21
Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab (2010) 2.04
Laser speckle contrast imaging of cerebral blood flow. Ann Biomed Eng (2011) 1.67
Heterogeneity in the penumbra. J Cereb Blood Flow Metab (2011) 1.33
Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions. Brain (2010) 1.28
Targeting astrocytes for stroke therapy. Neurotherapeutics (2010) 1.25
Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci (2014) 1.20
Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study. J Cereb Blood Flow Metab (2010) 1.20
Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain (2010) 1.16
Neuroprotection in acute ischemic stroke--current status. J Cell Mol Med (2010) 1.15
Recurrent spontaneous spreading depolarizations facilitate acute dendritic injury in the ischemic penumbra. J Neurosci (2010) 1.13
Recurrent spreading depolarizations after subarachnoid hemorrhage decreases oxygen availability in human cerebral cortex. Ann Neurol (2010) 1.08
Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clin Neurophysiol (2008) 1.06
The impact of anesthetics and hyperoxia on cortical spreading depression. Exp Neurol (2008) 1.05
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability. J Biol Chem (2012) 1.05
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev (2015) 0.99
Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci (2014) 0.97
Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex. Cell Mol Neurobiol (2009) 0.93
Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress. J Neurochem (2012) 0.91
Direct, live imaging of cortical spreading depression and anoxic depolarisation using a fluorescent, voltage-sensitive dye. J Cereb Blood Flow Metab (2007) 0.90
Pathophysiology of the ischemic penumbra--revision of a concept. Cell Mol Neurobiol (1998) 0.90
Neurogenic neuroprotection. Cell Mol Neurobiol (2003) 0.88
Distinct spatiotemporal patterns of spreading depolarizations during early infarct evolution: evidence from real-time imaging. J Cereb Blood Flow Metab (2010) 0.86
Is spreading depolarization characterized by an abrupt, massive release of gibbs free energy from the human brain cortex? Neuroscientist (2012) 0.85
Cytosolic acidification and intracellular zinc release in hippocampal neurons. J Neurochem (2012) 0.84
Glial Hsp70 protects K+ homeostasis in the Drosophila brain during repetitive anoxic depolarization. PLoS One (2011) 0.84
The potential roles of 18F-FDG-PET in management of acute stroke patients. Biomed Res Int (2013) 0.84
Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression. J Cereb Blood Flow Metab (1998) 0.83
Imaging reveals the focal area of spreading depolarizations and a variety of hemodynamic responses in a rat microembolic stroke model. J Cereb Blood Flow Metab (2014) 0.82
Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury? Glia (2015) 0.81
Neuroimaging as a Selection Tool and Endpoint in Clinical and Pre-clinical Trials. Transl Stroke Res (2016) 0.80
The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases. Curr Neuropharmacol (2013) 0.80
Spreading depolarization-induced adenosine accumulation reflects metabolic status in vitro and in vivo. J Cereb Blood Flow Metab (2014) 0.80
A Systematic, Integrated Study on the Neuroprotective Effects of Hydroxysafflor Yellow A Revealed by (1)H NMR-Based Metabonomics and the NF-κB Pathway. Evid Based Complement Alternat Med (2013) 0.78
Perspective of synaptic protection after post-infarction treatment with statins. J Transl Med (2015) 0.76
Temporo-spectral imaging of intrinsic optical signals during hypoxia-induced spreading depression-like depolarization. PLoS One (2012) 0.76
Preconditioning cortical lesions reduce the incidence of peri-infarct depolarizations during focal ischemia in the Spontaneously Hypertensive Rat: interaction with prior anesthesia and the impact of hyperglycemia. J Cereb Blood Flow Metab (2015) 0.76
N-Palmitoylethanolamine Prevents the Run-down of Amplitudes in Cortical Spreading Depression Possibly Implicating Proinflammatory Cytokine Release. Sci Rep (2016) 0.75
Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke. Neuroscience (2016) 0.75
Neurovascular function recovery after focal ischemic stroke by enhancing cerebral collateral circulation via peripheral stimulation-mediated interarterial anastomosis. Neurophotonics (2017) 0.75
Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke. J Cereb Blood Flow Metab (2017) 0.75
Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis. Neural Regen Res (2017) 0.75
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene (1999) 2.22
Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain. J Cereb Blood Flow Metab (1988) 2.03
A giant outburst two years before the core-collapse of a massive star. Nature (2007) 1.82
Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat. Acta Anaesthesiol Scand (1992) 1.77
Pathogenesis of non-familial colorectal carcinomas with high microsatellite instability. J Clin Pathol (2000) 1.75
A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab (1998) 1.58
Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab (1995) 1.52
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. Cancer Res (1999) 1.48
Effects of the external pH on Ca channels: experimental studies and theoretical considerations using a two-site, two-ion model. Proc Natl Acad Sci U S A (1986) 1.48
Reversibility of ischemic brain damage. Arch Neurol (1973) 1.48
Fine structural localization of exudated protein tracers in the brain. Acta Neuropathol (1970) 1.48
Difference in direct charge-parity violation between charged and neutral B meson decays. Nature (2008) 1.46
Membrane currents and their modification by acetylcholine in isolated single atrial cells of the guinea-pig. J Physiol (1985) 1.45
MR imaging of Pellegrini-Stieda disease. Radiat Med (2000) 1.44
Two-stage resuscitation of the cat brain after prolonged cardiac arrest. Intensive Care Med (1991) 1.39
Endothelin type A-antagonist improves long-term neurological recovery after cardiac arrest in rats. Crit Care Med (2000) 1.38
High oxygen delivery and extraction by perfluorocarbon-primed extracorporeal membrane oxygenation do not prevent anaerobic metabolism in rabbits. J Pediatr Surg (1998) 1.37
Evolution of brain infarction after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab (2000) 1.32
Differences in the cerebrovascular anatomy of C57black/6 and SV129 mice. Neuroreport (1998) 1.32
Simultaneous recording of evoked potentials and T2*-weighted MR images during somatosensory stimulation of rat. Magn Reson Med (1999) 1.31
Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. J Gastroenterol (1997) 1.30
Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging. J Cereb Blood Flow Metab (1996) 1.30
Experimental brain infarcts in cats. II. Ischemic brain edema. Stroke (1981) 1.27
Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction. Magn Reson Imaging (1995) 1.25
The effect of transient cerebral ischemia on the vascular permeability to protein tracers. Acta Neuropathol (1971) 1.24
Improved model of thromboembolic stroke and rt-PA induced reperfusion in the rat. Brain Res (1997) 1.23
Simultaneous measurements of microflow and evoked potentials in the somatomotor cortex of the cat brain during specific sensory activation. Pflugers Arch (1979) 1.20
A bioluminescence method for the demonstration of regional glucose distribution in brain slices. J Neurochem (1981) 1.19
The effect of intravascular saline perfusion on the sequelae of transient cerebral ischemia. Light and electron microscopial observations. Acta Neuropathol (1971) 1.18
Measurement of the differential branching fraction and forward-backward asymmetry for B --> K(*)l+l-. Phys Rev Lett (2009) 1.17
Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat. J Cereb Blood Flow Metab (1991) 1.17
Purine nucleotide metabolism in the cat brain after one hour of complete ischemia. J Neurochem (1974) 1.14
Sodium effect of growth on aspartate and genetic analysis of a Bacillus subtilis mutant with high aspartase activity. J Bacteriol (1977) 1.14
Ultrastructural and histochemical investigation of the cerebral cortex of cat during and after complete ischaemia. Acta Neuropathol (1973) 1.14
Reactive microglia in cerebral ischaemia: an early mediator of tissue damage? Neuropathol Appl Neurobiol (1995) 1.13
Protein synthesis in the cat brain after prolonged cerebral ischemia. Brain Res (1971) 1.12
Relationship between specific gravity, water content, and serum protein extravasation in various types of vasogenic brain edema. Acta Neuropathol (1984) 1.12
Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. Pathol Res Pract (2000) 1.11
Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab (2000) 1.10
Transport of tricarboxylic acids in Salmonella typhimurium. J Bacteriol (1973) 1.10
Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab (1994) 1.10
Signal transmission in the parallel fiber-Purkinje cell system visualized by high-resolution imaging. Proc Natl Acad Sci U S A (1994) 1.09
Immunocytochemical study of an early microglial activation in ischemia. J Cereb Blood Flow Metab (1992) 1.09
Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of metabolic recovery. Brain Res (1975) 1.08
Attenuation of muscarinic cholinergic inhibition by islet-activating protein in the heart. Am J Physiol (1985) 1.08
Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system. J Cell Physiol (1995) 1.07
Diffusion nuclear magnetic resonance imaging in experimental stroke. Correlation with cerebral metabolites. Stroke (1994) 1.07
Diffusion- and perfusion-weighted MR imaging of transient focal cerebral ischaemia in mice. NMR Biomed (1999) 1.06
Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice. Neuroreport (1999) 1.06
A specialized transducing phage constructed from Bacillus subtilis phage phi 105. Gene (1980) 1.06
Precision measurement of charged pion and kaon differential cross sections in e+ e- annihilation at sqrt[s]=10.52 GeV. Phys Rev Lett (2013) 1.06
Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice. Neurobiol Dis (1999) 1.06
Microglial reaction in the rat cerebral cortex induced by cortical spreading depression. Brain Pathol (1993) 1.05
Chromosomal loci of genes controlling site-specific restriction endonucleases of Bacillus subtilis. Mol Gen Genet (1981) 1.04
The effect of ischaemia and recirculation on protein synthesis in the rat brain. J Neurochem (1977) 1.04
Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat. Metab Brain Dis (1997) 1.04
[Ultrastructure of human spongioblastomas]. Dtsch Z Nervenheilkd (1965) 1.03
Imaging of the apparent diffusion coefficient for the evaluation of cerebral metabolic recovery after cardiac arrest. Magn Reson Imaging (1995) 1.03
Relationship between metabolic dysfunctions, gene responses and delayed cell death after mild focal cerebral ischemia in mice. Neuroscience (2001) 1.02
Observation of anomalous upsilon(1S)pi+pi(-) and upsilon(2S)pi+pi(-) production near the upsilon(5S) resonance. Phys Rev Lett (2008) 1.02
Cerebral resuscitation from cardiac arrest: pathophysiologic mechanisms. Crit Care Med (1996) 1.02
Suppression and recovery of neuronal function in transient cerebral ischemia. Brain Res (1970) 1.02
Resuscitation of the monkey brain after 1 h complete ischemia. I. Physiological and morphological observations. Brain Res (1974) 1.02
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res (2000) 1.01
Study of e+ e- → π+ π- J/ψ and observation of a charged charmoniumlike state at Belle. Phys Rev Lett (2013) 1.01
Cation activities in reversible ischemia of the cat brain. Stroke (1977) 1.01
Variation of functional MRI signal in response to frequency of somatosensory stimulation in alpha-chloralose anesthetized rats. Magn Reson Med (1996) 1.00
Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment. Lab Invest (1997) 1.00
Neurological effects of microwave exposure related to mobile communication. J Neurol Sci (1997) 1.00
Larger anastomoses in angiotensinogen-knockout mice attenuate early metabolic disturbances after middle cerebral artery occlusion. J Cereb Blood Flow Metab (1999) 1.00
No-reflow after cardiac arrest. Intensive Care Med (1995) 1.00
Immunochemical method for quantitative evaluation of vasogenic brain edema following cold injury of rat brain. Brain Res (1982) 0.99
Immunohistochemical study of NGF and its receptors in the synovial membrane of the ankle joint of adjuvant-induced arthritic rats. Histochem Cell Biol (2000) 0.99
Recovery of neuronal function after prolonged cerebral ischemia. Science (1970) 0.99
Potentiation by nitric oxide of the ATP-sensitive K+ current induced by K+ channel openers in guinea-pig ventricular cells. Br J Pharmacol (1997) 0.98
Experimental brain infarcts in cats. I. Pathophysiological observations. Stroke (1981) 0.98
ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. Cancer (1996) 0.98
Neuronal stress response and neuronal cell damage after cardiocirculatory arrest in rats. J Cereb Blood Flow Metab (1998) 0.98
Prevention of postischemic hyperthermia prevents ischemic injury of CA1 neurons in gerbils. J Cereb Blood Flow Metab (1990) 0.98
A clinicopathological and immunohistochemical study of osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma of long bones. Skeletal Radiol (1992) 0.98
Transient increase of the intracellular Ca2+ concentration during chemotactic signal transduction in Dictyostelium discoideum cells. Differentiation (1988) 0.97
Reperfusion after thrombolytic therapy of embolic stroke in the rat: magnetic resonance and biochemical imaging. J Cereb Blood Flow Metab (1998) 0.97
Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil. J Physiol (1998) 0.97
Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study. Brain Res Cogn Brain Res (2001) 0.97
Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res (2001) 0.97
Cortical steady potential, impedance and excitability changes during and after total ischemia of cat brain. Exp Neurol (1971) 0.96
Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential. Ann Neurol (2000) 0.96
A modified four-vessel occlusion model for inducing incomplete forebrain ischemia in rats. Stroke (1989) 0.96
Ontogenetic increase of the maximal rate of rise of the chick embryonic heart action potential. Relationship to voltage, time, and tetrodotoxin. Circ Res (1979) 0.96
Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG1 2.2) of rat brain. J Neurooncol (1990) 0.96
[14C]leucine incorporation into brain proteins in gerbils after transient ischemia: relationship to selective vulnerability of hippocampus. J Neurochem (1991) 0.95
Repeated negative DC deflections in rat cortex following middle cerebral artery occlusion are abolished by MK-801: effect on volume of ischemic injury. J Cereb Blood Flow Metab (1992) 0.95
Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activating polypeptide-38 (PACAP-38). Neurosci Lett (1997) 0.95
Voltage-sensitive dye versus intrinsic signal optical imaging: comparison of optically determined functional maps from rat barrel cortex. Neuroreport (2001) 0.95
Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: a possible role in direct interaction between osteoclast precursors. Endocrinology (1998) 0.95
Regional assessment of energy-producing metabolism following prolonged complete ischemia of cat brain. J Cereb Blood Flow Metab (1983) 0.95
The effect of ischemia on sensorimotor cortex of cat. Electrophysiological, biochemical and electronmicroscopial observations. Z Neurol (1970) 0.94