Published in Mol Biol Cell on June 01, 1993
Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00
The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol (1995) 3.33
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol (1995) 2.45
Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circ Res (2006) 2.08
Syndecans: multifunctional cell-surface co-receptors. Biochem J (1997) 2.04
Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci U S A (1994) 2.02
Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component. Mol Biol Cell (1994) 2.00
Crystal structure of a heparin- and integrin-binding segment of human fibronectin. EMBO J (1999) 1.84
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Mol Biol Cell (1999) 1.64
Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell (1995) 1.53
Design properties of hydrogel tissue-engineering scaffolds. Expert Rev Med Devices (2011) 1.47
Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem J (2002) 1.39
Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Mol Biol Cell (1995) 1.36
The extracellular matrix and blood vessel formation: not just a scaffold. J Cell Mol Med (2007) 1.25
Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice. Proc Natl Acad Sci U S A (1994) 1.23
Protein kinase C regulates the recruitment of syndecan-4 into focal contacts. Mol Biol Cell (1995) 1.18
A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1. J Cell Biol (2001) 1.15
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. PLoS One (2008) 1.14
Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J Clin Invest (1994) 1.12
The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces. Biomaterials (2009) 1.10
Cartilage destruction by matrix degradation products. Mod Rheumatol (2006) 1.08
The receptor-binding domain of pseudorabies virus glycoprotein gC is composed of multiple discrete units that are functionally redundant. J Virol (1996) 0.99
Structural domains of heparan sulphate for specific recognition of the C-terminal heparin-binding domain of human plasma fibronectin (HEPII). Biochem J (1996) 0.93
Changes in the fibronectin-specific integrin expression pattern modify the migratory behavior of sarcoma S180 cells in vitro and in the embryonic environment. J Cell Biol (1995) 0.92
Identification of the active site in the heparin II domain of fibronectin that increases outflow facility in cultured monkey anterior segments. Invest Ophthalmol Vis Sci (2008) 0.91
Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Cell Res (2010) 0.91
Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels. Biomaterials (2010) 0.90
Effect of CD44 binding peptide conjugated to an engineered inert matrix on maintenance of breast cancer stem cells and tumorsphere formation. PLoS One (2013) 0.90
Phosphorylation of a membrane-intercalated proteoglycan, syndecan-2, expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma. Biochem J (1996) 0.90
Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction. PLoS One (2010) 0.87
Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin. Tissue Eng (2005) 0.86
C-terminal heparin-binding domain of fibronectin regulates integrin-mediated cell spreading but not the activation of mitogen-activated protein kinase. Biochem J (2001) 0.84
Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta (2013) 0.83
Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival. Biochem J (2001) 0.82
A synthetic peptide from the heparin-binding domain III (repeats III4-5) of fibronectin promotes stress-fibre and focal-adhesion formation in melanoma cells. Biochem J (2003) 0.82
Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin α5β1. J Biol Chem (2014) 0.81
Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility. Mol Cancer Res (2016) 0.77
Extracellular matrix-derived peptides and myocardial repair. Cell Adh Migr (2011) 0.76
Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway. Sci Rep (2017) 0.75
A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater (2016) 0.75
N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions. Am J Physiol Renal Physiol (2016) 0.75
Mixed Fibronectin-Derived Peptides Conjugated to a Chitosan Matrix Effectively Promotes Biological Activities through Integrins, α4β1, α5β1, αvβ3, and Syndecan. Biores Open Access (2016) 0.75
Regulation of human nucleus pulposus cells by peptide-coupled substrates. Acta Biomater (2017) 0.75
Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu Rev Cell Biol (1988) 14.18
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol (1992) 7.97
Fibronectin and its receptors. Annu Rev Biochem (1988) 7.06
Proteoglycans: structures and interactions. Annu Rev Biochem (1991) 6.53
Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis (1989) 5.88
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (1992) 5.72
Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol (1989) 5.69
Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Annu Rev Cell Biol (1992) 4.37
Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (1992) 3.66
Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments. EMBO J (1986) 3.54
Formation of cell-to-substrate contacts during fibroblast motility: an interference-reflexion study. J Cell Sci (1980) 3.47
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell (1990) 3.46
Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function. Cell (1988) 2.70
Protein kinase C involvement in focal adhesion formation. J Cell Sci (1992) 2.54
Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol (1992) 2.52
Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate. J Biol Chem (1992) 2.20
Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells. J Cell Biol (1986) 2.16
Adhesion, growth, and matrix production by fibroblasts on laminin substrates. J Cell Biol (1983) 1.91
Relationship of heparan sulfate proteoglycans to the cytoskeleton and extracellular matrix of cultured fibroblasts. J Cell Biol (1984) 1.82
Cell surface receptors for extracellular matrix components. Biochim Biophys Acta (1990) 1.73
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly. J Cell Biol (1991) 1.59
Substratum contacts and cytoskeletal reorganization of BALB/c 3T3 cells on a cell-binding fragment and heparin-binding fragments of plasma fibronectin. Exp Cell Res (1986) 1.57
Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata. J Cell Biol (1988) 1.55
Localization and chemical synthesis of fibronectin peptides with melanoma adhesion and heparin binding activities. Biochemistry (1988) 1.49
RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities. J Cell Biol (1990) 1.44
Heparan sulfate proteoglycans of rat embryo fibroblasts. A hydrophobic form may link cytoskeleton and matrix components. J Biol Chem (1985) 1.41
Localization of the major heparin-binding site in fibronectin. J Biol Chem (1991) 1.35
Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts. J Biol Chem (1992) 1.33
Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis. J Biol Chem (1991) 1.33
Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol (1992) 1.25
Fibroblast adhesion to RGDS shows novel features compared with fibronectin. J Cell Biol (1987) 1.23
Focal adhesions and cell-matrix interactions. Coll Relat Res (1988) 1.17
Fibronectins: structure, functions and receptors. Curr Opin Cell Biol (1989) 1.11
1H NMR assignment and secondary structure of the cell adhesion type III module of fibronectin. Biochemistry (1992) 1.11
Recognition of the A chain carboxy-terminal heparin binding region of fibronectin involves multiple sites: two contiguous sequences act independently to promote neural cell adhesion. J Cell Biol (1990) 1.06
Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide. J Cell Biol (1992) 0.99
Heparan sulfate proteoglycans and signalling in cell adhesion. Adv Exp Med Biol (1992) 0.97
Characterization of FN-C/H-V, a novel synthetic peptide from fibronectin that promotes rabbit corneal epithelial cell adhesion, spreading, and motility. Invest Ophthalmol Vis Sci (1993) 0.97
Adhesion defective BHK cell mutant has cell surface heparan sulfate proteoglycan of altered properties. J Cell Physiol (1988) 0.95
Immobilized amines and basic amino acids as mimetic heparin-binding domains for cell surface proteoglycan-mediated adhesion. J Biol Chem (1992) 0.90
Heparin modulates conformational states of plasma fibronectin: an electron spin resonance spin label approach. Arch Biochem Biophys (1986) 0.81
Enhanced assembly of basement membrane matrix by endodermal cells in response to fibronectin substrata. J Cell Sci (1991) 0.79
Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments. EMBO J (1986) 3.54
Lymphocyte-mediated activation of fibroblast proliferation and collagen production. J Immunol (1978) 3.16
The behaviour of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion and growth, and in the distribution of actomyosin and fibronectin. J Cell Sci (1979) 2.88
Protein kinase C involvement in focal adhesion formation. J Cell Sci (1992) 2.54
EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron (2001) 2.53
Bacterial adherence to fibronectin and endothelial cells: a possible mechanism for bacterial tissue tropism. J Lab Clin Med (1984) 2.52
Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin. Dev Biol (1983) 2.48
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol (1995) 2.45
Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide. J Immunol (1979) 2.39
Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans. Fed Proc (1985) 2.27
Control of morphology, cytoskeleton and migration by syndecan-4. J Cell Sci (1999) 2.17
Extracellular matrix proteins (fibronectin, laminin, and type IV collagen) bind and aggregate bacteria. Am J Pathol (1985) 2.08
Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin. J Cell Biol (1983) 2.07
Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component. Mol Biol Cell (1994) 2.00
Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions. Int J Biochem Cell Biol (2000) 1.99
Human fibronectin contains distinct adhesion- and motility-promoting domains for metastatic melanoma cells. J Cell Biol (1986) 1.98
Human fibronectin binding to staphylococcal surface protein and its relative inefficiency in promoting phagocytosis by human polymorphonuclear leukocytes, monocytes, and alveolar macrophages. Infect Immun (1981) 1.97
Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro. J Cell Biol (1984) 1.95
Adhesion, growth, and matrix production by fibroblasts on laminin substrates. J Cell Biol (1983) 1.91
The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci (1999) 1.82
Fibronectin has a dual role in locomotion and anchorage of primary chick fibroblasts and can promote entry into the division cycle. J Cell Biol (1982) 1.74
Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues. Nature (1984) 1.69
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Nat Cell Biol (1999) 1.65
Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts. Arch Biochem Biophys (2000) 1.58
Still more complexity in mammalian basement membranes. J Histochem Cytochem (2000) 1.57
Basement membrane-specific chondroitin sulfate proteoglycan is abnormally associated with the glomerular capillary basement membrane of diabetic rats. J Histochem Cytochem (1994) 1.53
Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration. J Cell Biol (1988) 1.53
Tumor cell invasion, matrix metalloproteinases, and the dogma. Lab Invest (1994) 1.52
Immunological identification of two sulfhydryl-containing fragments of human plasma fibronectin. J Biol Chem (1982) 1.52
Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C. J Biol Chem (1997) 1.51
A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. Am J Pathol (2001) 1.51
Syndecan-4 and focal adhesion function. Curr Opin Cell Biol (2001) 1.49
Localization and chemical synthesis of fibronectin peptides with melanoma adhesion and heparin binding activities. Biochemistry (1988) 1.49
Correlation of CD44S expression in renal clear cell carcinomas with subsequent tumor progression or recurrence. Cancer (1999) 1.49
Synthesis and localization of two sulphated glycoproteins associated with basement membranes and the extracellular matrix. J Cell Biol (1982) 1.45
Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes. J Invest Dermatol (1985) 1.44
Production of laminin and fibronectin by Schwannoma cells: cell-protein interactions in vitro and protein localization in peripheral nerve in vivo. J Cell Biol (1983) 1.44
RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities. J Cell Biol (1990) 1.44
Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C. J Biol Chem (1997) 1.44
Immunocytochemical localization of fibronectin (LETS proteins) on the surface of L6 myoblasts: light and electron microscopic studies. Cell (1978) 1.42
Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts. Cell (1983) 1.42
Heparan sulfate proteoglycans of rat embryo fibroblasts. A hydrophobic form may link cytoskeleton and matrix components. J Biol Chem (1985) 1.41
Immunohistochemical localization of chondroitin sulfate, chondroitin sulfate proteoglycan, heparan sulfate proteoglycan, entactin, and laminin in basement membranes of postnatal developing and adult rat lungs. Am J Respir Cell Mol Biol (1993) 1.41
Control of extracellular matrix assembly by syndecan-2 proteoglycan. J Cell Sci (2000) 1.37
Selective immunoreactivities of kidney basement membranes to monoclonal antibodies against laminin: localization of the end of the long arm and the short arms to discrete microdomains. J Cell Biol (1989) 1.36
Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J Clin Invest (1992) 1.36
Critical factors controlling angiogenesis: cell products, cell matrix, and growth factors. Lab Invest (1986) 1.36
The role of cell adhesion proteins--laminin and fibronectin--in the movement of malignant and metastatic cells. Cancer Metastasis Rev (1985) 1.36
Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5-bisphosphate coordinately regulate protein kinase C activity. J Biol Chem (1998) 1.35
Neuron-specific interactions with two neurite-promoting fragments of fibronectin. J Neurosci (1985) 1.34
CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor. Prostate (1999) 1.34
Evidence for a satellite secretory pathway in neuronal dendritic spines. Curr Biol (2001) 1.30
Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their interaction with fibronectin. J Exp Med (1991) 1.30
A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. J Cell Biol (1992) 1.29
A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the alpha 3 beta 1 integrin. J Cell Biol (1992) 1.27
Adherence of Streptococcus pneumoniae to immobilized fibronectin. Infect Immun (1995) 1.27
Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol (1992) 1.25
A novel synthetic peptide from the B1 chain of laminin with heparin-binding and cell adhesion-promoting activities. J Cell Biol (1988) 1.25
Syndecans: synergistic activators of cell adhesion. Trends Cell Biol (1998) 1.25
Guidance of neurite outgrowth by pathways of substratum-adsorbed laminin. J Neurosci Res (1985) 1.24
Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice. Proc Natl Acad Sci U S A (1994) 1.23
Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences. J Biol Chem (2000) 1.23
Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells. J Biol Chem (2001) 1.23
Extracellular matrix alterations in human corneas with bullous keratopathy. Invest Ophthalmol Vis Sci (1996) 1.21
Controlled induction of focal adhesion disassembly and migration in primary fibroblasts. J Cell Sci (1993) 1.21
The effect of nonenzymatic glucosylation on the binding of the main noncollagenous NC1 domain to type IV collagen. J Biol Chem (1988) 1.21
Organelle-cytoskeleton relationships in fibroblasts: mitochondria, Golgi apparatus, and endoplasmic reticulum in phases of movement and growth. Eur J Cell Biol (1982) 1.21
Fibronectin presence in native collagen fibrils of human fibroblasts: immunoperoxidase and immunoferritin localization. J Histochem Cytochem (1980) 1.20
Spreading and focal contact formation of human melanoma cells in response to the stimulation of both melanoma-associated proteoglycan (NG2) and alpha 4 beta 1 integrin. Cancer Res (1995) 1.20
Basement membrane abnormalities in human eyes with diabetic retinopathy. J Histochem Cytochem (1996) 1.19
Syndecan proteoglycans and cell adhesion. Matrix Biol (1998) 1.18
Transforming growth factor-beta 1 binds to immobilized fibronectin. J Cell Biochem (1989) 1.18
Fibronectin distribution in epithelial and associated tissues of the rat. Arch Dermatol Res (1979) 1.17
Focal adhesions and cell-matrix interactions. Coll Relat Res (1988) 1.17
Localization of three distinct heparin-binding domains of laminin by monoclonal antibodies. J Biol Chem (1988) 1.17
Integrin modulation by lateral association. J Biol Chem (2000) 1.16
Actomyosin organisation for adhesion, spreading, growth and movement in chick fibroblasts. Cell Biol Int Rep (1979) 1.16
CSPG4 in cancer: multiple roles. Curr Mol Med (2010) 1.15
CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. J Clin Invest (1996) 1.15
Characterization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growth. J Immunol (1994) 1.14
Evidence that mitogenic lectins induce changes in lymphocyte membrane fluidity. Nature (1974) 1.14
Selective interaction of peripheral and central nervous system cells with two distinct cell-binding domains of fibronectin. J Cell Biol (1987) 1.13