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V Kinzel

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24). EMBO J 1993 2.54
2 Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem 1996 1.45
3 Biosynthesis and membrane topography of the neural cell adhesion molecule L1. EMBO J 1985 1.34
4 Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Structure 1997 1.21
5 Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. J Biol Chem 1991 1.13
6 Protein kinase activity and substrates at the surface of intact HeLa cells. J Biol Chem 1982 1.09
7 Circular dichroic evidence for an ordered sequence of ligand/binding site interactions in the catalytic reaction of the cAMP-dependent protein kinase. Biochemistry 1985 1.04
8 Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation. J Cell Biol 2000 1.04
9 Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry. Protein Sci 2000 1.01
10 Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase. Biochemistry 2001 1.01
11 Direct effects of phosphorylation on the preferred backbone conformation of peptides: a nuclear magnetic resonance study. Biophys J 1999 0.99
12 Induced release of cell surface protein kinase yields CK1- and CK2-like enzymes in tandem. J Biol Chem 1996 0.99
13 Primary structure elements responsible for the conformational switch in the envelope glycoprotein gp120 from human immunodeficiency virus type 1: LPCR is a motif governing folding. Proc Natl Acad Sci U S A 1993 0.98
14 Stimulation of choline incorporation in cell cultures by phorbol derivatives and its correlation with their irritant and tumor-promoting activity. Cancer Res 1979 0.97
15 Substrate-effected release of surface-located protein kinase from intact cells. Proc Natl Acad Sci U S A 1983 0.97
16 Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J 1989 0.97
17 Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode. J Biol Chem 1989 0.97
18 Phorbol esters as a tool in cell research? Eur J Cancer 1972 0.96
19 Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins. Biochemistry 1994 0.92
20 A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci 1998 0.92
21 Secondary structure of the Arg-Gly-Asp recognition site in proteins involved in cell-surface adhesion. Evidence for the occurrence of nested beta-bends in the model hexapeptide GRGDSP. Eur J Biochem 1988 0.92
22 A conformational switch is associated with receptor affinity in peptides derived from the CD4-binding domain of gp120 from HIV I. Biochemistry 1991 0.91
23 Ligand binding site interaction in adenosine cyclic 3',5'-monophosphate dependent protein kinase catalytic subunit: circular dichroic evidence for intramolecular transmission of conformational change. Biochemistry 1984 0.90
24 Early effects of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate on the cell cycle traverse of asynchronous HeLa cells. Cancer Res 1981 0.90
25 Circular dichroic investigations of secondary structure in synthetic peptide inhibitors of cAMP-dependent protein kinase: a model for inhibitory potential. Biochemistry 1987 0.89
26 Mobilization of diacylglycerol in intact HeLa cells by exogenous phospholipase C from Cl. perfringens is accompanied by release of fatty acids including arachidonic acid. Biochim Biophys Acta 1992 0.89
27 Radiation with 1 Gy prevents the activation of the mitotic inducers mitosis-promoting factor (MPF) and cdc25-C in HeLa cells. Cancer Res 1996 0.89
28 Near- and far-ultraviolet circular dichroism of the catalytic subunit of adenosine cyclic 5'-monophosphate dependent protein kinase. Biochemistry 1984 0.87
29 In vivo activation of recombinant cAPK catalytic subunit active site mutants by coexpression of the wild-type enzyme, evidence for intermolecular cotranslational phosphorylation. FEBS Lett 1996 0.86
30 Variation and adaptation of Pseudomonas aeruginosa toxicity to HeLa cells and fibroblasts. J Clin Microbiol 1986 0.86
31 Single step purification of the catalytic subunit(s) of cyclic 3', 5'-adenosine monophosphate-dependent protein kinase(s) from rat muscle. Biochem Biophys Res Commun 1976 0.85
32 Phosphorylation of surface proteins of HeLa cells using an exogenous protein kinase and (gamma-32P)ATP. Biochim Biophys Acta 1973 0.85
33 [Electron microscope study of the origin of premelanosomes in melanoma cells in vitro]. Virchows Arch B Cell Pathol 1969 0.85
34 Chromatographic separation of two heterogeneous forms of the catalytic subunit of cyclic AMP-dependent protein kinase holoenzyme type I and type II from striated muscle of different mammalian species. Arch Biochem Biophys 1987 0.85
35 Clostridium botulinum C2 toxin delays entry into mitosis and activation of p34cdc2 kinase and cdc25-C phosphatase in HeLa cells. Infect Immun 1999 0.85
36 Solvent polarity-dependent structural refolding: a CD and NMR study of a 15 residue peptide. Proteins 1995 0.84
37 Phosphorylation of cytochrome-P-450-dependent monooxygenase components. Carcinogenesis 1983 0.83
38 Structural analysis of hnRNP particles approached by in vitro phosphorylation using exogenous protein kinase and l gamma 32 P1 ATP. Eur J Cell Biol 1981 0.83
39 Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform C beta 2. Biochim Biophys Acta 1996 0.83
40 Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D. Biochem J 1992 0.83
41 Assays of cell surface protein kinase: importance of selecting cytophilic substrates. Eur J Cell Biol 1982 0.83
42 [Observations on the Golgi area of cells of a plasmacytoma from the golden hamster in vitro]. Naturwissenschaften 1966 0.82
43 Catalytic and molecular properties of highly purified phosvitin/casein kinase type II from human epithelial cells in culture (HeLa) and relation to ecto protein kinase. Biol Chem Hoppe Seyler 1987 0.82
44 The human papillomavirus type 16 E5 protein modulates phospholipase C-gamma-1 activity and phosphatidyl inositol turnover in mouse fibroblasts. Oncogene 1999 0.82
45 Isolation of the catalytic subunits of cyclic AMP-dependent protein kinases from different mammalian tissues on the basis of charge differences of their subunits. Hoppe Seylers Z Physiol Chem 1979 0.82
46 Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells. Exp Cell Res 1994 0.81
47 Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells. Biochem J 1996 0.81
48 The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant. Biochem J 2000 0.81
49 Investigation of the structural components governing the polarity-dependent refolding of a CD4-binding peptide from gp120. J Mol Biol 1995 0.81
50 Atrial natriuretic peptide is phosphorylated by intact cells through cAMP-dependent ecto-protein kinase. Eur J Biochem 1992 0.81
51 Catalytic subunit of cAMP-dependent protein kinase from bovine heart: several isoforms demonstrated by high resolution focusing in immobilized pH gradient. Biochem Biophys Res Commun 1989 0.81
52 Cocarcinogenic croton oil factor A1 stimulates lipid synthesis in cell cultures. Experientia 1971 0.81
53 Epidermal growth factor rapidly impairs activation of p34cdc2 protein kinase in HeLa cells at the G2-M boundary. J Cell Physiol 1995 0.81
54 Substrates for the cell surface protein kinase in blood: a calf serum protein and its precursor in plasma. Biochem Int 1987 0.81
55 Phorbol ester stimulates choline incorporation. Naturwissenschaften 1971 0.81
56 A proposed common mechanism by which phorbol esters and epidermal growth factor delay the progression from G2 phase to mitosis of HeLa cells through phospholipid metabolites. Cancer Res 1991 0.81
57 Responses of synchronized HeLa cells to the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate as evaluated by flow cytometry. Cancer Res 1981 0.80
58 Partial inversion of the initiation-promotion sequence of multistage tumorigenesis in the skin of NMRI mice. Science 1985 0.80
59 Rat C alpha catalytic subunit of the cAMP-dependent protein kinase: cDNA sequence and evidence that it is the only isoform expressed in myoblasts. Biochim Biophys Acta 1991 0.80
60 Interaction of protease inhibitors with the catalytic subunit of cAMP-dependent protein kinase. Biochem Biophys Res Commun 1980 0.80
61 Primary alcohols and phosphatidylcholine metabolism in rat brain synaptosomal membranes via phospholipase D. Pharmacol Toxicol 1996 0.80
62 Signal transduction through epidermal growth factor receptor is altered in HeLa monolayer cells during mitosis. Biochem J 1997 0.80
63 Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinase. Biochim Biophys Acta 1992 0.80
64 [Microsporidial infection (nosema cuniculi) in a transplantable plasmocytoma]. Verh Dtsch Ges Pathol 1968 0.79
65 Isolation and elucidation of some functional properties of the "mute" catalytic subunit of cAMP-dependent protein kinase. Arch Biochem Biophys 1983 0.79
66 Serum proteins associated with tissue culture cells as demonstrated by the use of enzymatically radio-phosphorylated serum. Exp Cell Res 1978 0.79
67 Evidence for CKI and CKII at the cell surface. Cell Mol Biol Res 1994 0.79
68 Evidence for a "mute" catalytic subunit of cyclic AMP-dependent protein kinase from rat muscle and its mode of activation. Proc Natl Acad Sci U S A 1980 0.79
69 Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester. J Cell Physiol 1996 0.79
70 Radiomimetic activity of phorbol esters exerted in HeLa cells in comparison with their tumor-promoting capacity. Cancer Res 1984 0.78
71 Early changes in the arachidonic acid metabolism of HeLa cells in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and related compounds. J Cancer Res Clin Oncol 1987 0.78
72 The inhibitor protein of the cyclic AMP-dependent protein kinase-catalytic subunit interaction. Composition of multiple complexes. Biochem J 1988 0.78
73 Lens culinaris lectin immobilized on sepharose: binding and sugar-specific release of intact tissue culture cells. Science 1976 0.78
74 Phosphorylation by cell surface protein kinase of bovine and human fibrinogen and fibrin. Biochim Biophys Acta 1989 0.77
75 Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation. Carcinogenesis 1986 0.77
76 Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells. Science 1980 0.77
77 Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells. Cancer Res 1992 0.77
78 [Exotoxins of Pseudomonas aeruginosa II. Communication: cytostatic and bacteriostatic activity]. Zentralbl Bakteriol Mikrobiol Hyg A 1982 0.77
79 Lectin receptor sites at the cell surface employed for affinity separation of tissue culture cells. Basic requirements as realized by lens culinaris lectin (LCL) immobilized on 2tb-sepharose. Exp Cell Res 1977 0.77
80 Protein kinase assay on isoelectric focusing gels: evaluation of its quantitative potentials. Anal Biochem 1979 0.77
81 Protein kinase activities in mammalian blood fluid. Biochem Biophys Res Commun 1985 0.77
82 Catalytic subunit of adenosine cyclic 2',5'monophosphate-dependent protein kinase from rat muscle: basic properties and factors influencing the activity. Z Naturforsch C 1979 0.76
83 [Exotoxins of Pseudomonas aeruginosa. I. Communication: isolation, purification and biochemical analysis]. Zentralbl Bakteriol Mikrobiol Hyg A 1982 0.76
84 Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis. Proc Natl Acad Sci U S A 1984 0.76
85 Distribution of phorbol ester TPA-induced structural chromosomal aberrations in HeLa cells. Carcinogenesis 1990 0.75
86 Effects of retinoic acid and tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) on the cell cycle of HeLa cells. Int J Cancer 1982 0.75
87 Thymidine incorporation into HeLa cells increased by tumor-producing croton oil factor TPA. Naturwissenschaften 1970 0.75
88 Inactivation of tissue-specific inhibitors by a carcinogen (diethylnitrosamine). Experientia 1969 0.75
89 [Inactivation of tissue-specific inhibitors by a carcinogen]. Verh Dtsch Ges Pathol 1969 0.75
90 Cytogenetic effects caused by phorbol ester tumor promoters in HeLa cells: mechanistic aspects. Carcinogenesis 1989 0.75
91 Phospho-accepting proteins in bovine sera. Blut 1976 0.75
92 [Burkitt's lymphoma]. Dtsch Med Wochenschr 1968 0.75
93 Nosematosis as an accompanying infection of plasmacytoma ascites in Syrian golden hamsters. Pathol Microbiol (Basel) 1971 0.75
94 Rapid microtechnique for incorporation studies in cell cultures. Experientia 1972 0.75
95 Early changes in the cell cycle traverse of HeLa cells induced by tumor promoter TPA resemble irradiation effects. Carcinog Compr Surv 1982 0.75
96 Effect of acetamidofluorene and activated derivatives on "macromolecular synthesis" in single cell cultures. Z Krebsforsch 1970 0.75
97 Solid-state protein kinase. A tool for post-synthetically modifying and radioactively labeling proteins in vitro. Eur J Biochem 1975 0.75
98 Melanoma regression induced by "chalone": a new tumour inhibiting principle acting in vivo. Nature 1968 0.75
99 Extension of the polarity-dependent "switch phenomenon" of the gp120 binding domain as a target for antiviral chemotherapy. Biochemistry 1996 0.75
100 Severe chromosomal damage in mammalian cells induced by pulse labeling with small amounts of [3H]thymidine. Mutat Res 1990 0.75
101 Protein kinases in HeLa cells and in human cervix carcinoma. Z Naturforsch C 1981 0.75
102 [Specific effects of hyperglasiogenic, tumorpromoting croton oil factors and synthetic phorbolesters to cell cultures (author's transl)]. Verh Dtsch Ges Pathol 1971 0.75
103 Interaction of phorbol derivatives with replicating cells. IARC Sci Publ 1984 0.75
104 Generation of pyrophosphate from extracellular ATP at the surface of HeLa cells. Eur J Cell Biol 1980 0.75
105 Interaction of cells with their proximal environment via surface protein kinase. Prog Clin Biol Res 1982 0.75
106 [Tumors in the forestomach of the chinese hamster following administration of diethylnitrosamine. A contribution to the problem of organotropy of a carcinogen]. Eur J Cancer 1967 0.75
107 [Simplified method for the demonstration of toxic effects in hemorrhagic cell suspensions]. Blut 1970 0.75
108 Culture density and age-dependent interactions of 3T3 AND SV3T3 cells with immobilized and soluble Lens culinaris lectin. Z Naturforsch C 1980 0.75
109 On the biochemical mechanism of tumorigenesis in mouse skin. V. Studies of the metabolism of tumor promoting and non promoting phorbol derivatives in vivo and in vitro. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1974 0.75
110 [Adaptation of a rat tumor to Syrian golden hamsters during 150 passages]. Naturwissenschaften 1969 0.75
111 Interference of xanthate compounds with phorbol ester TPA-induced changes of phospholipid metabolism: inhibition of prostaglandin production. Biochem Pharmacol 1991 0.75
112 Carcinogensis and inhibited biosynthesis of soluble mouse skin proteins by actidione. Experientia 1969 0.75
113 Measurement of the response of HELA cells towards the radiomimetic activity of 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett 1982 0.75
114 [A method of epon embedding of cell cultures for the electron microscopic thin section study]. Mikroskopie 1969 0.75
115 Dual effect of the phorbol ester TPA on arachidonic acid release from HeLa cells. FEBS Lett 1988 0.75
116 Structure of the LAV6 peptide: a nucleation site for the correct receptor-induced refolding of the CD4-binding domain of HIV1 gp 120. Proteins 1997 0.75
117 Phosphoproteins of the cell surface as generated by endogenous or exogenous protein kinase: stability of the 32P-labelled product. Biochim Biophys Acta 1976 0.75
118 [Experimental studies on the immunity of plasmacytoma in golden hamsters]. Arch Geschwulstforsch 1968 0.75
119 [Observations on the structure of the Golgi field in living cells of a transplantable plasmacytoma in vitro]. Z Zellforsch Mikrosk Anat 1967 0.75
120 "Geography" of mitoses and cell divisions in the basal cell layer of mouse epidermis. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1971 0.75
121 Biochemical mechanism of tumorigenesis in mouse skin. 3. Decrease in tumor yields by poly I-C administered during initiation of skin b y and intragastric dose of 7,12-dimethyl-benz(a)anthracene. Z Krebsforsch 1970 0.75
122 [Cytolysis of tumor cells in vitro with antiserum]. Z Krebsforsch 1966 0.75
123 Time and dose dependent inhibition and enhancement of thymidine incorporation into fibroplasts by prednisolone. Experientia 1970 0.75
124 Accumulation of ester- and ether-linked phosphatidates by HeLa cells in response to ionophore A23187 through activation of phospholipase D. Biol Chem Hoppe Seyler 1992 0.75
125 Differential sensitivity of monolayer cells compared with suspension cell cultures to treatment with high concentrations of croton oil factor (TPA) and the surfactants tween 80 and triton X-100. Biochem Pharmacol 1973 0.75
126 International symposium: skin carcinogenesis in man and in experimental models. Heidelberg, Federal Republic of Germany, 29-31 October 1991. J Cancer Res Clin Oncol 1992 0.75
127 Mechanistic aspects of the delay in the G2 phase of the cell cycle caused by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in HeLa cells. Carcinogenesis 1985 0.75
128 Inhibitors of the conformational switch involved in CD4 binding by the env glycoprotein gp120 from human immunodeficiency virus type 1 (HIV1). Biochemistry 1994 0.75
129 [Chromosome studies on in vivo and in vitro grown Walker carcinoma 256]. Z Krebsforsch 1968 0.75