Published in Blood on January 01, 1993
How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet (2005) 5.79
Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait. Nat Genet (2005) 4.22
Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J Infect Dis (2005) 3.12
An immune basis for malaria protection by the sickle cell trait. PLoS Med (2005) 2.08
World distribution, population genetics, and health burden of the hemoglobinopathies. Cold Spring Harb Perspect Med (2012) 1.47
Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks. Malar J (2016) 0.75
Correction of sickle cell disease in transgenic mouse models by gene therapy. Science (2001) 3.25
Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa. Proc Natl Acad Sci U S A (1984) 2.86
A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues. Cell (1983) 2.73
Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions. Blood (1991) 2.18
Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood (1994) 2.12
Polymerase chain reaction amplification applied to the determination of beta-like globin gene cluster haplotypes. Am J Hematol (1989) 2.04
Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises. Blood (2000) 1.95
Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. N Engl J Med (1985) 1.90
Ligand-induced conformational dependence of hemoglobin in sickling interactios. J Mol Biol (1971) 1.89
Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients. Proc Natl Acad Sci U S A (1985) 1.85
Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci U S A (1989) 1.79
Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood (2000) 1.77
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo. J Exp Med (2000) 1.71
Membrane knobs are required for the microcirculatory obstruction induced by Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A (1985) 1.68
Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. Am J Physiol Heart Circ Physiol (2000) 1.63
Antigenic characterization of the oligosaccharide portion of the lipooligosaccharide of nontypable Haemophilus influenzae. Infect Immun (1987) 1.59
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria. Am J Hematol (1991) 1.54
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J Exp Med (2001) 1.50
Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proc Natl Acad Sci U S A (1979) 1.50
Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications. Blood Cells (1982) 1.49
Message sequences and short repetitive sequences are interspersed in sea urchin egg poly(A)+ RNAs. Nature (1980) 1.49
Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics. J Clin Invest (1983) 1.48
The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin. J Biol Chem (1971) 1.44
High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc Natl Acad Sci U S A (1992) 1.42
Effect of alpha-thalassemia on sickle-cell anemia linked to the Arab-Indian haplotype in India. Am J Hematol (1997) 1.40
Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD. EMBO J (1991) 1.40
Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine. Am J Trop Med Hyg (1982) 1.39
High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci U S A (1992) 1.37
The -158 site 5' to the G gamma gene and G gamma expression. Blood (1985) 1.34
Structure and properties of hemoglobin C-Harlem, a human hemoglobin variant with amino acid substitutions in 2 residues of the beta-polypeptide chain. J Biol Chem (1967) 1.34
Malaria and red cell genetic defects. Blood (1989) 1.33
Nuclear magnetic relaxation dispersion in protein solutions. IV. Proton relaxation at the active site of carbonic anhydrase. J Biol Chem (1970) 1.32
Volume-dependent and NEM-stimulated K+,Cl- transport is elevated in oxygenated SS, SC and CC human red cells. FEBS Lett (1986) 1.32
Sickling rates of human AS red cells infected in vitro with Plasmodium falciparum malaria. Science (1978) 1.31
The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level. Blood (1987) 1.29
An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells. Blood (1984) 1.27
Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci U S A (1983) 1.25
Water exchange between red cells and plasma. Measurement by nuclear magnetic relaxation. Biophys J (1975) 1.25
Plasmodium falciparum: enhanced gametocyte formation in vitro in reticulocyte-rich blood. Exp Parasitol (1999) 1.24
Specific representation of cloned repetitive DNA sequences in sea urchin RNAs. Cell (1978) 1.22
SC erythrocytes have an abnormally high intracellular hemoglobin concentration. Pathophysiological consequences. J Clin Invest (1982) 1.18
Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism. Blood (1998) 1.18
Morphologic, immunohistochemical, and ultrastructural studies of the production of hepatitis B virus in vitro. Lab Invest (1988) 1.15
In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest (1995) 1.15
Water exchange across red cell membranes: II. Measurements by nuclear magnetic resonance T1, T2, and T12 hybrid relaxation. The effects of osmolarity, cell volume, and medium. J Membr Biol (1978) 1.14
Effect of magnetic susceptibility on nuclear magnetic resonance signals arising from red cells: a warning. Biochemistry (1983) 1.14
The effect of beta 73 Asn on the interactions of sickling hemoglobins. Biochim Biophys Acta (1970) 1.14
Genetic epidemiology of the beta s gene. Baillieres Clin Haematol (1992) 1.14
Second generation knockout sickle mice: the effect of HbF. Blood (2001) 1.14
Beta-chain contact sites in the haemoglobin S polymer. Nature (1980) 1.13
Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia. Am J Hematol (1995) 1.13
Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1. Blood (1997) 1.12
A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. Blood (1995) 1.12
Cerebral malaria in mice: demonstration of cytoadherence of infected red blood cells and microrheologic correlates. Am J Trop Med Hyg (1994) 1.11
Volume-stimulated, Cl(-)-dependent K+ efflux is highly expressed in young human red cells containing normal hemoglobin or HbS. J Membr Biol (1987) 1.10
Glutathione stability and oxidative stress in P. falciparum infection in vitro: responses of normal and G6PD deficient cells. Biochem Biophys Res Commun (1982) 1.09
Vaso-occlusion by sickle cells: evidence for selective trapping of dense red cells. Blood (1986) 1.09
On the mechanism for the red-cell accumulation of mefloquine, an antimalarial drug. Biochim Biophys Acta (1984) 1.09
Multimeric composition of endothelial cell-derived von Willebrand factor. Blood (1989) 1.09
Spectrum of beta thalassemia mutations and their linkage to beta-globin gene haplotypes in the Indo-Mauritians. Am J Hematol (2000) 1.08
Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane. Proc Natl Acad Sci U S A (1990) 1.08
Sulfhemoglobinemia. Clinical and molecular aspects. N Engl J Med (1984) 1.08
Oxidation of spectrin and deformability defects in diabetic erythrocytes. Diabetes (1991) 1.07
The binding of hemoglobin to membranes of normal and sickle erythrocytes. Biochim Biophys Acta (1975) 1.07
Deoxygenation inhibits the volume-stimulated, Cl(-)-dependent K+ efflux in SS and young AA cells: a cytosolic Mg2+ modulation. Blood (1987) 1.07
The sickle gene polymorphism in North Africa. Blood (1981) 1.06
The pathophysiology of vascular obstruction in the sickle syndromes. Blood Rev (1996) 1.06
Accuracy of pulse oximetry in sickle cell disease. Am J Respir Crit Care Med (1999) 1.06
An increased Bohr effect in sickle cell anemia. Blood (1979) 1.06
Sickle gene. Its origin and diffusion from West Africa. J Clin Invest (1981) 1.06
Relation between structure and function in Hemoglobin Chesapeake. Biochemistry (1967) 1.04
Renal nitric oxide synthases in transgenic sickle cell mice. Kidney Int (1996) 1.04
HbS-oman heterozygote: a new dominant sickle syndrome. Blood (1998) 1.03
Biochemical characterization of Plasmodium falciparum hemozoin. Am J Trop Med Hyg (1990) 1.03
The effect of deoxygenation on red cell density: significance for the pathophysiology of sickle cell anemia. Blood (1982) 1.03