| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Structure-activity relationships for some substance P-related peptides that cause wheal and flare reactions in human skin.
|
J Physiol
|
1983
|
2.42
|
|
2
|
Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors.
|
Br J Pharmacol
|
1988
|
1.96
|
|
3
|
The effects of substance P on histamine and 5-hydroxytryptamine release in the rat.
|
J Physiol
|
1982
|
1.88
|
|
4
|
Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.
|
Br J Pharmacol
|
1991
|
1.33
|
|
5
|
Release of acetylcholine and 14 C-glycine from the cat spinal cord in vivo.
|
Br J Pharmacol
|
1971
|
1.30
|
|
6
|
Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function.
|
Neuropeptides
|
1991
|
1.24
|
|
7
|
Pharmacological characterization of 5-hydroxytryptamine-induced hyperpolarization of the rat superior cervical ganglion.
|
Br J Pharmacol
|
1987
|
1.18
|
|
8
|
Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.
|
Br J Pharmacol
|
1970
|
1.15
|
|
9
|
Potent and highly selective neurokinin antagonists.
|
J Med Chem
|
1990
|
1.13
|
|
10
|
Effect of the 5-HT3 receptor antagonist, GR38032F, on responses to injection of a neurokinin agonist into the ventral tegmental area of the rat brain.
|
Eur J Pharmacol
|
1987
|
1.09
|
|
11
|
A study of [D-Pro2, D-Phe7, D-Trp9]-substance P and [D-Trp7,9]-substance P as tachykinin partial agonists in the rat colon.
|
Br J Pharmacol
|
1984
|
1.03
|
|
12
|
Early histological features of small intestinal injury induced by indomethacin.
|
Aliment Pharmacol Ther
|
1993
|
1.00
|
|
13
|
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
|
J Med Chem
|
1994
|
0.98
|
|
14
|
Efficacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled study.
|
Aliment Pharmacol Ther
|
2006
|
0.97
|
|
15
|
Relative activities of substance P-related peptides in the guinea-pig ileum and rat parotid gland, in vitro.
|
Br J Pharmacol
|
1982
|
0.96
|
|
16
|
Interaction of neurotensin with the substance P receptor mediating histamine release from rat mast cells and the flare in human skin.
|
Br J Pharmacol
|
1982
|
0.95
|
|
17
|
Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor.
|
J Med Chem
|
1992
|
0.95
|
|
18
|
An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes.
|
Br J Pharmacol
|
1986
|
0.93
|
|
19
|
Alternative approaches to analgesia: baclofen as a model compound.
|
Br J Pharmacol
|
1975
|
0.93
|
|
20
|
The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040.
|
Br J Pharmacol
|
1995
|
0.89
|
|
21
|
Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat.
|
Br J Pharmacol
|
1990
|
0.88
|
|
22
|
The substance P receptor on rat mast cells and in human skin.
|
Agents Actions
|
1984
|
0.85
|
|
23
|
Profiles of emetic action of cisplatin in the ferret: a potential model of acute and delayed emesis.
|
Eur J Pharmacol
|
1994
|
0.84
|
|
24
|
The action of the NK1 tachykinin receptor antagonist, CP 99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret.
|
Br J Pharmacol
|
1996
|
0.82
|
|
25
|
Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.
|
Oncology
|
1996
|
0.81
|
|
26
|
Role of pepsin in the development of indomethacin-induced antral ulceration in the rat.
|
Aliment Pharmacol Ther
|
1995
|
0.81
|
|
27
|
Synthesis and biological activity of substance P C-terminal hexapeptide analogues: structure-activity studies.
|
J Med Chem
|
1986
|
0.80
|
|
28
|
The effect of chronic dorsal root section on the concentration of free amino acids in the rabbit spinal cord.
|
J Neurochem
|
1974
|
0.79
|
|
29
|
Evidence that the unilateral activation of 5-HT1D receptors in the substantia nigra of the guinea-pig elicits contralateral rotation.
|
Br J Pharmacol
|
1991
|
0.77
|
|
30
|
The novel CCK antagonist L364,718 abolished caerulein- but potentiates morphine-induced antinociception.
|
Eur J Pharmacol
|
1988
|
0.77
|
|
31
|
Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.
|
J Med Chem
|
1992
|
0.77
|
|
32
|
The release of endogenous amino acids from the cat spinal cord in vivo [proceedings].
|
Br J Pharmacol
|
1976
|
0.76
|
|
33
|
Structure-activity studies on the C-terminal hexapeptide of substance P with modifications at the glutaminyl and methioninyl residues.
|
J Med Chem
|
1987
|
0.76
|
|
34
|
Pharmacological modulation of gut mucosal and large vessel blood flow.
|
Aliment Pharmacol Ther
|
2007
|
0.76
|
|
35
|
Binding of [3H]gamma-aminobutyric acid and [3H]muscimol in purified rat brain synaptic plasma membranes and the effects of bicuculline.
|
J Neurochem
|
1982
|
0.76
|
|
36
|
Two types of adrenoreceptor in the isolated frog heart.
|
Br J Pharmacol
|
1969
|
0.75
|
|
37
|
Chronic dorsal root section on free amino acid levels in the rabbit spinal cord.
|
Br J Pharmacol
|
1973
|
0.75
|
|
38
|
Some studies of the action of betahistine at H1 and H2 receptors for histamine.
|
Agents Actions
|
1986
|
0.75
|
|
39
|
Synthesis of a potent agonist of substance P by modifying the methionyl and glutaminyl residues of the C-terminal hexapeptide of substance P. Structure-activity relationships.
|
Int J Pept Protein Res
|
1991
|
0.75
|
|
40
|
The release of acetylcholine in the perfused cat spinal cord in vivo.
|
Neuropharmacology
|
1978
|
0.75
|
|
41
|
Caerulein-induced antinociception: interaction with morphine and opioid antagonists in the rat.
|
Neuropeptides
|
1990
|
0.75
|
|
42
|
Characterization of tachykinin-induced ventral root depolarization in the neonatal rat isolated spinal cord.
|
Neuroscience
|
1992
|
0.75
|
|
43
|
A modified amylase assay, using a fluorescent substrate, and its application to a study of the rat parotid gland in vitro.
|
J Pharmacol Methods
|
1981
|
0.75
|
|
44
|
Descending fibre-mediated release of endogenous glutamate and glycine from the perfused cat spinal cord in vivo.
|
Brain Res
|
1978
|
0.75
|
|
45
|
Histamine release from mast cells by substance P and substance P sequences.
|
Pharmazie
|
1982
|
0.75
|
|
46
|
Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.
|
Int J Pept Protein Res
|
1993
|
0.75
|
|
47
|
Multi-component accumulation of L-[(14)C]glutamate by rat spinal cord slices.
|
Neurosci Lett
|
1978
|
0.75
|
|
48
|
Proceedings: Distribution and localization of tritiated amino acids by autoradiography in the cat spinal cord in vivo.
|
J Physiol
|
1976
|
0.75
|
|
49
|
Synthesis of a potent antagonist of substance P by replacing the CH2SCH3 and the alpha-carboxamide groups of the methionine at [Orn6]-SP6-11 by benzyl ester groups.
|
Int J Pept Protein Res
|
1993
|
0.75
|