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B P Doctor

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 S-Adenosylmethionine and methylation. FASEB J 1996 3.48
2 Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin. Biochem Biophys Res Commun 1976 3.30
3 Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin. Infect Immun 1977 2.94
4 Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins. Protein Sci 1993 2.55
5 Inhibition of protein synthesis in intact HeLa cells by Shigella dysenteriae 1 toxin. Infect Immun 1980 2.47
6 Purification and biological characterization of shiga toxin from Shigella dysenteriae 1. Infect Immun 1982 2.21
7 Nucleotide sequences of transfer ribonucleic acids. Methods Enzymol 1974 1.76
8 RNA codons and protein synthesis. IX. Synonym codon recognition by multiple species of valine-, alanine-, and methionine-sRNA. Proc Natl Acad Sci U S A 1966 1.29
9 Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem Pharmacol 1998 1.26
10 In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact 2005 1.24
11 Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases. Mol Pharmacol 1998 1.17
12 Studies on tyrosine transfer ribonucleic acid, a sulfur-rich species from Escherichia coli. J Biol Chem 1967 1.15
13 Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. Biochemistry 1997 1.07
14 Nucleotide sequence of Escherichia coli tyrosine transfer ribonucleic acid. Science 1969 1.06
15 Shigellosis and Escherichia coli diarrhea: relative importance of invasive and toxigenic mechanisms. Am J Clin Nutr 1979 1.05
16 Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci 1998 1.03
17 Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport 1997 1.02
18 Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase. Biochemistry 1997 1.00
19 Mechanism of inhibition of cholinesterases by huperzine A. Biochem Biophys Res Commun 1992 1.00
20 The role of glutamate-199 in the aging of cholinesterase. Biochem Biophys Res Commun 1993 0.98
21 Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. J Biol Chem 1995 0.97
22 Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice. Biochem Pharmacol 1991 0.97
23 Invasive Escherichia coli. J Am Vet Med Assoc 1978 0.96
24 Isolation and partial characterization of the transfer ribonucleic acid cistrons from Escherichia coli. Nature 1970 0.96
25 Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase. Proc Natl Acad Sci U S A 1983 0.95
26 Bovine brain acetylcholinesterase primary sequence involved in intersubunit disulfide linkages. J Biol Chem 1991 0.94
27 Acetylcholinesterase prophylaxis against organophosphate toxicity. Fundam Appl Toxicol 1987 0.92
28 Acetylcholinesterase from fetal bovine serum. Purification and characterization of soluble G4 enzyme. J Biol Chem 1985 0.92
29 Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning. Biochem Pharmacol 1997 0.92
30 The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study. Biophys J 2004 0.91
31 Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains. Proc Natl Acad Sci U S A 1995 0.91
32 Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring. Bioorg Med Chem Lett 1998 0.91
33 A simplified procedure for the purification of large quantities of fetal bovine serum acetylcholinesterase. Life Sci 1986 0.90
34 Different effects of two peripheral anionic site-binding ligands on acetylcholinesterase active-site gorge topography revealed by electron paramagnetic resonance. Biochim Biophys Acta 1995 0.90
35 Differences in structure and distribution of the molecular forms of acetylcholinesterase. J Cell Biol 1989 0.88
36 The NMDA receptor ion channel: a site for binding of Huperzine A. J Appl Toxicol 2001 0.88
37 Studies on the Escherichia coli Methionine transfer ribonucleic acids. Eur J Biochem 1969 0.88
38 Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase. Chem Biol Interact 2005 0.87
39 The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism. Biochemistry 1998 0.87
40 Conservation of transfer ribonucleic acid and 5S ribonucleic acid cistrons in Enterobacteriaceae. J Bacteriol 1977 0.87
41 Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomedicine 2005 0.87
42 Studies on the topography of the catalytic site of acetylcholinesterase using polyclonal and monoclonal antibodies. J Neurochem 1990 0.87
43 Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases. Protein Sci 1994 0.86
44 Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. Chem Biol Interact 1999 0.85
45 Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase. J Pharmacol Exp Ther 1993 0.84
46 Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy. Biochemistry 1993 0.84
47 Huperzine A as a pretreatment candidate drug against nerve agent toxicity. Life Sci 1994 0.84
48 Protection of rhesus monkeys against soman and prevention of performance decrement by pretreatment with acetylcholinesterase. Toxicol Appl Pharmacol 1992 0.83
49 Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody. Biochemistry 1990 0.83
50 Use of cholinesterases as pretreatment drugs for the protection of rhesus monkeys against soman toxicity. Toxicol Appl Pharmacol 1992 0.83
51 Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Biochemistry 1999 0.81
52 Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study. Biophys J 2005 0.81
53 Purification of two yeast serine transfer ribonucleic acids by countercurrent distribution. J Biol Chem 1966 0.80
54 Isolation of 5S ribonucleic acid cistrons and tRNA cistrons from Escherichia coli. Biochem Biophys Res Commun 1972 0.80
55 The two site model of ribosomal function: a test using degenerate serine codons in bacteriophage f2 mRNA. Biochem Biophys Res Commun 1970 0.79
56 A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme. Biochem Biophys Res Commun 1997 0.79
57 Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice. Biochem Pharmacol 1989 0.79
58 A radioactive assay for acetylcholinesterase using anion-exchange disk. Anal Biochem 1982 0.78
59 Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime. Chem Biol Interact 1999 0.78
60 Membrane-bound acetylcholinesterase: an early differentiation marker for skeletal myoblasts. Biochim Biophys Acta 1992 0.77
61 Fractionation and molecular weight determination of deoxyribonucleic acid fragments using agarose column chromatography. Anal Biochem 1974 0.77
62 Clustering of tRNA cistrons in Escherichia coli DNA. Biochem Biophys Res Commun 1974 0.77
63 Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate. Biophys J 2009 0.77
64 Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases. Chem Biol Interact 1999 0.77
65 A radioimmune assay for human prostatic acid phosphatase-levels in prostatic disease. Clin Biochem 1979 0.77
66 Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal bovine serum acetylcholinesterase. Mol Pharmacol 1993 0.77
67 Behavioral comparison of the oximes TMB-4, 2-PAM, and HI-6 in rats using operant conditioning. Pharmacol Biochem Behav 1997 0.76
68 Organophosphate skin decontamination using immobilized enzymes. Chem Biol Interact 1999 0.76
69 Determination of 5-dimethylaminonaphthalene-1-sulfonyl derivatives of urinary polyamines by ion-pair high-performance liquid chromatography. J Chromatogr 1979 0.76
70 Use of monoclonal antibody to immunochemically characterize variant-specific surface coat glycoprotein from Trypanosoma rhodesiense. J Immunol 1981 0.76
71 Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents. Chem Biol Interact 2005 0.75
72 Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands. Mol Pharmacol 1998 0.75
73 Isolation of transfer ribonucleic acid cistrons and 5 S ribonucleic acid cistrons from Escherichia coli. Methods Enzymol 1974 0.75
74 Desethylaprophen: a metabolite of aprophen with antimuscarinic activities. J Pharm Sci 1988 0.75
75 Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates. J Med Chem 1989 0.75
76 Behavioral and pharmacological assessment of butyrylcholinesterase in rats. Pharmacol Biochem Behav 1995 0.75
77 Arrangement of the helical regions in E. coli tyrosine tRNA. Nature 1969 0.75
78 Postganglionic nicotinic action of anatoxin-a on guinea pig ileum antagonized by thymopentin. Adv Exp Med Biol 1992 0.75
79 Safety and pharmacokinetics of human serum butyrylcholinesterase in guinea pigs. Chem Biol Interact 2005 0.75
80 Enzymatic synthesis of a false cholinergic neurotransmitter: diethylaminoethyl acetate as a muscarinic agonist analog of acetylcholine. Gen Pharmacol 1986 0.75
81 Kinetic investigations into the interactions of aprophen with cholinesterases and a carboxylesterase. Biochem Pharmacol 1986 0.75
82 Studies in the single extraction of amphetamine and phenobarbital from urine using XAD-2 resin. Biochem Med 1973 0.75
83 Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A. Bioorg Med Chem Lett 2000 0.75
84 Countercurrent distribution of rat-liver, "soluble"-fraction ribonucleic acids. 1959. Biochim Biophys Acta 1989 0.75
85 Studies on the effect of 5,5'-diphenylhydantoin on in vitro protein synthesis in rat brain. J Pharmacol Exp Ther 1976 0.75
86 Dodecylglycerol provides partial protection against glutamate toxicity in neuronal cultures derived from different regions of embryonic rat brain. Mol Chem Neuropathol 1997 0.75
87 Ion-pair high-performance liquid chromatographic separation of a multicomponent anticholinergic drug formulation. J Chromatogr 1978 0.75
88 Fighting nerve agent chemical weapons with enzyme technology. Ann N Y Acad Sci 1998 0.75
89 Studies on the species specificity of yeast and E. coli tyrosine tRNAs. Cold Spring Harb Symp Quant Biol 1966 0.75
90 tRNA gene clusters in Escherichia coli DNA. Brookhaven Symp Biol 1975 0.75
91 Disposition of aprophen in rats. J Pharm Pharmacol 1986 0.75
92 Antimuscarinic activity of aprophen. Biochem Pharmacol 1983 0.75
93 Enrichment of tRNA cistrons from Escherichia coli using antibody affinity chromatography. Biochim Biophys Acta 1974 0.75
94 Stability study of HI-6 dichloride in various anticholinergic formulations. J Chromatogr 1984 0.75
95 Studies on the binding of 5,5-diphenyl-hydantoin to nucleic acids in vitro and to rat brain subcellular fractions in vitro and in vivo. J Pharmacol Exp Ther 1976 0.75
96 Allosteric control of acetylcholinesterase activity by monoclonal antibodies. Biochemistry 1998 0.75
97 Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases. J Neurochem 1995 0.75
98 A microtiter assay for determining protein, acetylcholinesterase activity, and G418 (Neomycin) resistance in cultured cells. Anal Biochem 1992 0.75
99 Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies. Chem Biol Interact 1993 0.75
100 Studies on the quantitative extraction of morphine from urine using nonionic XAD-2 resin. Biochem Med 1973 0.75
101 Epitope mapping of form-specific and nonspecific antibodies to acetylcholinesterase. J Neurochem 1993 0.75