PubRank

F M Richards

Author PubWeight™ 242.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The interpretation of protein structures: estimation of static accessibility. J Mol Biol 1971 40.24
2 Areas, volumes, packing and protein structure. Annu Rev Biophys Bioeng 1977 16.38
3 Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes. J Mol Biol 1987 10.85
4 The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy. Biochemistry 1992 9.40
5 Relationship between nuclear magnetic resonance chemical shift and protein secondary structure. J Mol Biol 1991 8.38
6 The interpretation of protein structures: total volume, group volume distributions and packing density. J Mol Biol 1974 5.39
7 A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution. Nature 1982 4.92
8 Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature 1994 4.29
9 Chemical cross-linking: reagents and problems in studies of membrane structure. Annu Rev Biochem 1977 4.19
10 The matching of physical models to three-dimensional electron-density maps: a simple optical device. J Mol Biol 1968 3.30
11 Glutaraldehyde as a protein cross-linkage reagent. J Mol Biol 1968 3.18
12 Packing of alpha-helices: geometrical constraints and contact areas. J Mol Biol 1978 2.95
13 Use of the avidin-biotin complex for specific staining of biological membranes in electron microscopy. Proc Natl Acad Sci U S A 1974 2.91
14 Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan. Hum Mutat 1996 2.80
15 The three-dimensional structure of ribonuclease-S. Interpretation of an electron density map at a nominal resolution of 2 A. J Biol Chem 1970 2.77
16 Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Hum Mol Genet 1994 2.65
17 An approach to nearest neighbor analysis of membrane proteins. Application to the human erythrocyte membrane of a method employing cleavable cross-linkages. J Biol Chem 1974 2.53
18 Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype. Hum Mol Genet 1994 2.52
19 1H-15N heteronuclear NMR studies of Escherichia coli thioredoxin in samples isotopically labeled by residue type. Biochemistry 1985 2.39
20 Familial gastric cancer: overview and guidelines for management. J Med Genet 1999 2.38
21 The structure of ribonuclease-S at 3.5 A resolution. J Biol Chem 1967 2.33
22 The HA2 subunit of influenza hemagglutinin inserts into the target membrane prior to fusion. J Biol Chem 1991 2.07
23 Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. J Mol Biol 1991 2.05
24 An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: application to ribonuclease S peptide. J Mol Biol 1979 1.99
25 Crystal structure of hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres. J Mol Biol 1987 1.97
26 Characterization of colicin Ia and colicin Ib. Purification and some physical properties. J Biol Chem 1970 1.93
27 Heat capacity changes for protein-peptide interactions in the ribonuclease S system. Biochemistry 1992 1.91
28 NMR sequential assignment of Escherichia coli thioredoxin utilizing random fractional deuteriation. Biochemistry 1988 1.83
29 Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations. J Med Genet 1996 1.76
30 Protein folding: evaluation of some simple rules for the assembly of helices into tertiary structures with myoglobin as an example. J Mol Biol 1979 1.72
31 Calculation of molecular volumes and areas for structures of known geometry. Methods Enzymol 1985 1.64
32 Anion binding and pH-dependent electrostatic effects in ribonuclease. Biochemistry 1982 1.62
33 Design of a diffractometer and flow cell system for X-ray analysis of crystalline proteins with applications to the crystal chemistry of ribonuclease-S. J Mol Biol 1967 1.56
34 Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. Am J Hum Genet 1997 1.54
35 The crystal structure of a mutant protein with altered but improved hydrophobic core packing. Proc Natl Acad Sci U S A 1994 1.48
36 Thermodynamics of the binding of S-peptide to S-protein to form ribonuclease S.. Biochemistry 1971 1.45
37 Protein structure, ribonuclease-S and nucleotide interactions. Cold Spring Harb Symp Quant Biol 1972 1.44
38 Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. J Mol Biol 1991 1.44
39 Optimal sequence selection in proteins of known structure by simulated evolution. Proc Natl Acad Sci U S A 1994 1.41
40 Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: analysis of allele loss in VHL tumours. Hum Genet 1994 1.41
41 Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Res 2001 1.35
42 Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition. Nat Struct Biol 1994 1.33
43 Replacement of proline-76 with alanine eliminates the slowest kinetic phase in thioredoxin folding. Biochemistry 1987 1.32
44 Protein packing: dependence on protein size, secondary structure and amino acid composition. J Mol Biol 2000 1.28
45 Calcium-induced increase in the radius of gyration and maximum dimension of calmodulin measured by small-angle X-ray scattering. Biochemistry 1985 1.28
46 Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures. Biochemistry 1992 1.26
47 A preliminary study of the use of the Denver development screening test in a health department. Dev Med Child Neurol 1973 1.25
48 Photochemical labeling of the surface proteins of human erythrocytes. Biochemistry 1974 1.25
49 Thermodynamics of protein-peptide interactions in the ribonuclease S system studied by titration calorimetry. Biochemistry 1990 1.24
50 Crystallographic structures of ribonuclease S variants with nonpolar substitution at position 13: packing and cavities. Biochemistry 1992 1.21
51 Increase in apparent compressibility of cytochrome c upon oxidation. Proc Natl Acad Sci U S A 1982 1.20
52 3-Trifluoromethyl-3-phenyldiazirine. A new carbene generating group for photolabeling reagents. J Biol Chem 1980 1.19
53 The structure of ribonuclease-S at 6 A resolution. J Biol Chem 1967 1.18
54 Preparative-scale isolation of isotopically labeled amino acids. Anal Biochem 1982 1.15
55 The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions. Biochemistry 1992 1.14
56 Analysis of membranes photolabeled with lipid analogues. Reaction of phospholipids containing a disulfide group and a nitrene or carbene precursor with lipids and with gramicidin A. J Biol Chem 1980 1.14
57 Hydrogen exchange from identified regions of the S-protein component of ribonuclease as a function of temperature, pH, and the binding of S-peptide. J Mol Biol 1981 1.13
58 Genetic linkage between von Hippel-Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus. Hum Mol Genet 1993 1.10
59 Reactivity and structural role of protein amino groups in tobacco mosaic virus. J Mol Biol 1968 1.08
60 An analysis of phenotypic variation in the familial cancer syndrome von Hippel-Lindau disease: evidence for modifier effects. Am J Hum Genet 1998 1.07
61 Electrostatic field of the large fragment of Escherichia coli DNA polymerase I. J Mol Biol 1985 1.07
62 SEQSEE: a comprehensive program suite for protein sequence analysis. Comput Appl Biosci 1994 1.07
63 Simple techniques for the quantification of protein secondary structure by 1H NMR spectroscopy. FEBS Lett 1991 1.07
64 Unnatural amino acid packing mutants of Escherichia coli thioredoxin produced by combined mutagenesis/chemical modification techniques. Protein Sci 1993 1.06
65 Insertion of apocytochrome c into lipid vesicles. J Biol Chem 1984 1.06
66 Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br J Cancer 1994 1.04
67 Electrostatic orientation during electron transfer between flavodoxin and cytochrome c. Nature 1983 1.04
68 Reaction of dimethyl-3,3'-dithiobispropionimidate with intact human erythrocytes. Cross-linking of membrane proteins and hemoglobin. J Biol Chem 1975 1.04
69 Cyclosporine, FK506, and rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells. Transplantation 1990 1.03
70 Effect of hydrostatic pressure on the solvent in crystals of hen egg-white lysozyme. J Mol Biol 1988 1.03
71 The pH-dependent conformational change of diphtheria toxin. J Biol Chem 1988 1.01
72 Proteolytic and chemical modification of colicin E3 activity. Biochemistry 1976 1.00
73 Unrecognized adult phenylketonuria. Implications for obstetrics and psychiatry. N Engl J Med 1973 0.99
74 Solvents, interfaces and protein structure. Ciba Found Symp 1977 0.98
75 The pH dependence of hydrogen exchange in proteins. J Biol Chem 1983 0.97
76 Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. J Clin Pathol 2004 0.97
77 Mixed disulfide intermediates during the reduction of disulfides by Escherichia coli thioredoxin. Biochemistry 1995 0.95
78 Effects of binding of S-peptide and 2'-cytidine monophosphate on hydrogen exchange from the S-protein component of ribonuclease S. The amide protons of serine 123 and valine 124. J Mol Biol 1982 0.95
79 Behavior of colicins E1, E2, and E3 attached to sephadex beads. Biochemistry 1976 0.95
80 Participation of cysteinyl residues in the structure and function of muscle aldolase. Characterization of mixed disulfide derivatives. Biochemistry 1970 0.94
81 Photochemical labeling of the cytoplasmic surface of the membranes of intact human erythrocytes. J Biol Chem 1975 0.92
82 Thermodynamic and structural consequences of changing a sulfur atom to a methylene group in the M13Nle mutation in ribonuclease-S. Biochemistry 1994 0.92
83 Stability of transmembrane regions in bacteriorhodopsin studied by progressive proteolysis. J Membr Biol 1985 0.92
84 A PCR generated AccI RFLP in the 3' untranslated region of the von Hippel-Lindau disease (VHL) tumour suppressor gene. Hum Mol Genet 1994 0.91
85 Identification of novel VHL targets that are associated with the development of renal cell carcinoma. Oncogene 2006 0.90
86 Presymptomatic diagnosis of von Hippel-Lindau disease with flanking DNA markers. J Med Genet 1992 0.90
87 Human erythrocytes and resealed ghosts. A comparison of membrane topology. J Biol Chem 1974 0.90
88 Interactions in nonnative and truncated forms of staphylococcal nuclease as indicated by mutational free energy changes. Protein Sci 1995 0.89
89 Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem-5. Protein Sci 1994 0.88
90 Mobile unnatural amino acid side chains in the core of staphylococcal nuclease. Protein Sci 1996 0.88
91 The influence of lipid state on the planar distribution of membrane proteins in Acholeplasma laidlawii. J Mol Biol 1976 0.88
92 Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer 2012 0.87
93 Identification of regions of potential flexibility in protein structures: folding units and correlations with intron positions. Biopolymers 1988 0.86
94 Isoelectric point of a protein in the crosslinked crystalline state: beta-lactoglobulin. J Mol Biol 1968 0.86
95 Internal packing and protein structural classes. Cold Spring Harb Symp Quant Biol 1987 0.85
96 Cross-linking of elongation factor EF-G to the 50S ribosomal subunit of Escherichia coli. Biochemistry 1973 0.85
97 MET mutation and familial gastric cancer. J Med Genet 2001 0.85
98 Comparison of straight chain and cyclic unnatural amino acids embedded in the core of staphylococcal nuclease. Protein Sci 1997 0.84
99 Reaction of a lipid-soluble, unsymmetrical, cleavable, cross-linking reagent with muscle aldolase and erythrocyte membrane proteins. J Biol Chem 1977 0.83
100 Dimerization by colicin E3 in the absence of immunity protein. J Biol Chem 1983 0.83
101 Differences in hydrogen exchange behavior between the oxidized and reduced forms of Escherichia coli thioredoxin. Protein Sci 1992 0.83
102 The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity. Oncogene 2006 0.82
103 Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter. J Med Genet 2002 0.82
104 Attachment of metal-chelating functional groups to hen egg white lysozyme. An approach to introducing heavy atoms into protein crystals. J Biol Chem 1968 0.82
105 Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes. Br J Cancer 1998 0.82
106 Reduction of thioredoxin significantly decreases its partial specific volume and adiabatic compressibility. Protein Sci 1992 0.81
107 Improved synthetic methods for the selective deuteration of aromatic amino acids: applications of selective protonation towards the identification of protein folding intermediates through nuclear magnetic resonance. Biochim Biophys Acta 1993 0.80
108 Properties of liquids in small pores. Rates of diffusion of some solutes in cross-linked crystals of beta-lactoglobulin. J Mol Biol 1968 0.80
109 Differential electrostatic stabilization of A-, B-, and Z-forms of DNA. Biopolymers 1984 0.80
110 Chemical modification of protein thiols: formation of mixed disulfides. Methods Enzymol 1995 0.79
111 Public access to X-ray diffraction data. J Comput Aided Mol Des 1988 0.79
112 Reversible inhibition of glucose transport in human erythrocytes by a series of pyridine derivatives. J Biol Chem 1976 0.79
113 Germline mutation analysis of the transforming growth factor beta receptor type II (TGFBR2) and E-cadherin (CDH1) genes in early onset and familial colorectal cancer. J Med Genet 2001 0.79
114 A proton nuclear magnetic resonance assignment and secondary structure determination of recombinant human thioredoxin. Biochemistry 1989 0.78
115 The 1972 nobel prize for chemistry. Science 1972 0.78
116 Synthesis of carriers of differing Stokes radius with activated acyl groups for use as reagents in labeling membrane proteins. J Biol Chem 1981 0.78
117 Differential hydrolysis of immobilized phosphatidylcholines by phospholipases A2 and C. Biochem Biophys Res Commun 1994 0.78
118 Avidin-biotin technology. Reflections. Methods Enzymol 1990 0.78
119 FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. Transplant Proc 1990 0.77
120 The histidyl residues in ribonuclease-S. Photooxidation in solution and in single crystals; the iodination of histidine-12. J Biol Chem 1966 0.76
121 Investigations of the relationship between cell proliferation and differentiation of HL-60 cells induced to differentiate by N-methylformamide. Leuk Res 1988 0.76
122 A Practical Preparation of Ribonuclease-S and the Action of Subtilisin on Ribonuclease-B. Yale J Biol Med 1962 0.75
123 Partitioning the effects of changes in a protein to the folded or unfolded forms by using a thermodynamic cycle: a change in Escherichia coli thioredoxin does not affect the unfolded state. Biochemistry 1993 0.75
124 Christian B. Anfinsen (1916-95). Nature 1995 0.75
125 Folding of the reduced form of the thioredoxin from bacteriophage T4. Biochemistry 1990 0.75
126 Prediction of the pH dependence of the separation of weak electrolytes by ion-exchange: amino acid chromatography with competitive buffer ion eluents. Anal Biochem 1982 0.75
127 The labeling with 8-azido-cyclic adenosine monophosphate of proteins in vesicles of sarcoplasmic reticulum from rabbit skeletal muscle. Biochim Biophys Acta 1981 0.75
128 Comments on some present and future problems in protein structure. Basic Life Sci 1984 0.75
129 Optical matching of physical models and electron density maps: early developments. Methods Enzymol 1985 0.75
130 Measuring thiol-disulfide exchange equilibrium constants for single cysteine-containing proteins. Methods Enzymol 1995 0.75
131 Folding kinetics of phage T4 thioredoxin. Biochemistry 1990 0.75
132 Sex education in the schools--the doctor's role. Can Med Assoc J 1966 0.75
133 Crystallization and preliminary X-ray diffraction studies of colicin E3 immunity protein. J Mol Biol 1984 0.75