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1
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Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.
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AIDS
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1999
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3.51
|
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2
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Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
|
Proc Natl Acad Sci U S A
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1993
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1.67
|
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3
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Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.
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Structure
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1995
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1.47
|
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4
|
In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine.
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Antimicrob Agents Chemother
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1993
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1.33
|
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5
|
Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH.
|
Protein Sci
|
1999
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1.20
|
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6
|
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate.
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Biochemistry
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1998
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1.05
|
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7
|
Analysis of intracellular trafficking and interactions of cytoplasmic HIV-1 Rev mutants in living cells.
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Virology
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1998
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1.02
|
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8
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New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors.
|
J Med Chem
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1996
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0.90
|
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9
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Dissection of the pH dependence of inhibitor binding energetics for an aspartic protease: direct measurement of the protonation states of the catalytic aspartic acid residues.
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Biochemistry
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1997
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0.88
|
|
10
|
Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae.
|
Acta Crystallogr D Biol Crystallogr
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2004
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0.84
|
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11
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Structure of human cathepsin D: comparison of inhibitor binding and subdomain displacement with other aspartic proteases.
|
Adv Exp Med Biol
|
1995
|
0.81
|
|
12
|
Thermodynamics and proton uptake for pepstatin binding to retroviral and eukaryotic aspartic proteases.
|
Adv Exp Med Biol
|
1998
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0.75
|
|
13
|
Molecular dynamics of HIV-1 protease in complex with a difluoroketone-containing inhibitor: implications for the catalytic mechanism.
|
Adv Exp Med Biol
|
1995
|
0.75
|
|
14
|
Structure of HIV-1 protease with KNI-272: a transition state mimetic inhibitor containing allophenylnorstatine.
|
Adv Exp Med Biol
|
1995
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0.75
|
|
15
|
A novel putative transcription factor protein MYT2 that preferentially binds supercoiled DNA and induces DNA synthesis in quiescent cells.
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FEBS Lett
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2000
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0.75
|