Published in J Cell Biol on April 01, 1996
Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev (2007) 3.41
p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription. EMBO J (1997) 2.05
Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol Cell Biol (1999) 1.81
Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol (1998) 1.54
Caspase activation and specific cleavage of substrates after coxsackievirus B3-induced cytopathic effect in HeLa cells. J Virol (1998) 1.41
A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol (2000) 1.40
Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle. Mol Cell Biol (2001) 1.32
Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol Cell Biol (2005) 1.27
Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J Virol (2004) 1.18
p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytes. Mol Cell Biol (2003) 1.14
Antisense-mediated depletion of p300 in human cells leads to premature G1 exit and up-regulation of c-MYC. Proc Natl Acad Sci U S A (2001) 1.01
Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation. Stem Cell Res (2014) 0.98
Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity. Proc Natl Acad Sci U S A (2003) 0.96
Enhanced proliferation of monolayer cultures of embryonic stem (ES) cell-derived cardiomyocytes following acute loss of retinoblastoma. PLoS One (2008) 0.94
Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state. Drug Discov Today (2013) 0.90
Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. EMBO J (1998) 0.90
Cell cycle regulation to repair the infarcted myocardium. Heart Fail Rev (2003) 0.84
Transgenic expression in mouse lung reveals distinct biological roles for the adenovirus type 5 E1A 243- and 289-amino-acid proteins. J Virol (2002) 0.83
Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration. Curr Cardiol Rep (2017) 0.75
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell (1993) 20.72
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell (1995) 14.90
G1 phase progression: cycling on cue. Cell (1994) 11.62
Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell (1979) 10.95
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25
The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell (1993) 6.24
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev (1993) 6.02
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A (1994) 5.49
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci U S A (1992) 5.43
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev (1993) 5.33
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell (1993) 4.90
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36
An analysis of myogenesis by the use of fluorescent antimyosin. J Biophys Biochem Cytol (1957) 4.13
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science (1995) 4.06
Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell (1978) 3.96
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24
Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science (1994) 3.05
Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J Virol (1993) 2.92
DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev (1993) 2.88
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev (1994) 2.72
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70
Cell proliferation inhibited by MyoD1 independently of myogenic differentiation. Nature (1990) 2.68
Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment. Cell (1983) 2.37
Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis. Proc Natl Acad Sci U S A (1990) 2.27
Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice. Science (1988) 2.09
MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc Natl Acad Sci U S A (1990) 2.07
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev (1994) 1.99
Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters. Nature (1988) 1.95
Interrelations of the proliferation and differentiation processes during cardiact myogenesis and regeneration. Int Rev Cytol (1977) 1.93
Apoptosis and the cell cycle. Curr Opin Cell Biol (1995) 1.76
The c-myc proto-oncogene regulates cardiac development in transgenic mice. Mol Cell Biol (1990) 1.76
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A (1993) 1.72
Cardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes. Am J Physiol (1992) 1.53
Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. J Clin Invest (1993) 1.51
E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol (1991) 1.41
Regulation of muscle transcription by the MyoD family. The heart of the matter. Circ Res (1993) 1.39
Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice. Am J Physiol (1990) 1.36
Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5. Genes Dev (1992) 1.35
Heart and bone tumors in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.31
The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell Biol (1994) 1.27
Transactivation of the p53 oncogene by E1a gene products. Virology (1990) 1.25
Biochemical aspects of cardiac muscle differentiation. Deoxyribonucleic acid synthesis and nuclear and cytoplasmic deoxyribonucleic acid polymerase activity. J Biol Chem (1975) 1.24
Ability of adenovirus 5 E1A proteins to suppress differentiation of BC3H1 myoblasts correlates with their binding to a 300 kDa cellular protein. Mol Biol Cell (1992) 1.24
Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein. Oncogene (1993) 1.23
Adenovirus E1A represses cardiac gene transcription and reactivates DNA synthesis in ventricular myocytes, via alternative pocket protein- and p300-binding domains. J Biol Chem (1995) 1.23
Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus. Proc Soc Exp Biol Med (1993) 1.20
E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. Mol Cell Biol (1993) 1.13
Heterokaryon analysis of muscle differentiation: regulation of the postmitotic state. J Cell Biol (1987) 1.11
Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block. Oncogene (1994) 1.10
Evolutionarily conserved sequences of striated muscle myosin heavy chain isoforms. Epitope mapping by cDNA expression. J Biol Chem (1989) 1.08
Tumor suppressor gene expression during normal and pathologic myocardial growth. J Biol Chem (1994) 1.04
Adenovirus 5 E1A represses muscle-specific enhancers and inhibits expression of the myogenic regulatory factor genes, MyoD1 and myogenin. Cell Growth Differ (1990) 1.01
Quantitative analysis of regions of adenovirus E1A products involved in interactions with cellular proteins. Biochem Cell Biol (1993) 0.91
Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Mol Cell Biol (1994) 0.88
DNA synthesis and mitosis in well-differentiated mammalian cardiocytes. Science (1974) 0.77
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation (2000) 4.96
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J (2000) 4.09
cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation (1997) 2.54
Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest (1997) 2.31
Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis. J Biol Chem (1999) 2.00
Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res (1995) 1.91
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure. Circ Res (2000) 1.82
NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Am J Physiol (1998) 1.63
The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res (1999) 1.42
Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J Mol Cell Cardiol (2000) 1.37
beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol (1998) 1.35
ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance. Cell Death Differ (2005) 1.23
Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation. Am J Physiol Cell Physiol (2001) 1.17
Behavior of genes directly injected into the rat heart in vivo. Circ Res (1992) 1.08
Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results. Circ Res (1993) 1.04
Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice. Immunology (2001) 0.91
Seeing death in the living. Nat Med (2001) 0.87
Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus. Mol Cell Biol (1996) 0.86
Transcriptional coactivator p300 stimulates cell type-specific gene expression in cardiac myocytes. J Biol Chem (1997) 0.86
GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the beta-myosin heavy chain gene in cardiac myocytes. J Biol Chem (1999) 0.85
Regulation of activity of chromatin receptors for thyroid hormone: possible involvement of histone-like proteins. Proc Natl Acad Sci U S A (1979) 0.84
Peripartum versus idiopathic dilated cardiomyopathy in young women--a comparison of clinical, pathologic and prognostic features. Int J Cardiol (1993) 0.79
Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells. J Biol Chem (2001) 0.78
Imaging hypoxia in diseased tissues. Adv Exp Med Biol (1997) 0.76
Modulation of vascular endothelial gene expression by physical training in patients with chronic heart failure. Ital Heart J (2000) 0.76