Published in Blood on June 01, 1977
Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume. Blood (2005) 3.77
beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site. Proc Natl Acad Sci U S A (1984) 1.81
Comparison of haematological indices between women of four ethnic groups and the effect of oral contraceptives. J Clin Pathol (1983) 1.09
Alpha-thalassemia in blacks is due to gene deletion. Am J Hum Genet (1979) 0.89
Age- and sex-related blood cell values in healthy black Americans. Public Health Rep (1987) 0.83
Red blood cell indices and prevalence of hemoglobinopathies and glucose 6 phosphate dehydrogenase deficiencies in male Tanzanian residents of Dar es Salaam. Int J Mol Epidemiol Genet (2014) 0.78
Hemoglobin and MCV values in 4,074 healthy black children and adolescents. J Natl Med Assoc (1987) 0.77
Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res (1987) 5.46
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature (1990) 4.53
Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc Natl Acad Sci U S A (1983) 4.05
Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. Proc Natl Acad Sci U S A (1987) 4.03
Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCR. J Mol Biol (2001) 2.97
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood (1999) 2.66
Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector. J Virol (2000) 2.63
Triplicated alpha-globin loci in humans. Proc Natl Acad Sci U S A (1980) 2.61
Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc Natl Acad Sci U S A (1993) 2.46
Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells. Proc Natl Acad Sci U S A (1977) 2.43
G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin. Nature (1985) 2.41
The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 2.09
F-cells in the adult: normal values and levels in individuals with hereditary and acquired elevations of Hb F. Blood (1975) 2.06
Cellular regulation of hemoglobin switching: evidence for inverse relationship between fetal hemoglobin synthesis and degree of maturity of human erythroid cells. Proc Natl Acad Sci U S A (1979) 2.00
A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc Natl Acad Sci U S A (2000) 1.97
Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science (1990) 1.94
Hemophilia A. Detection of molecular defects and of carriers by DNA analysis. N Engl J Med (1985) 1.91
Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants. Proc Natl Acad Sci U S A (1995) 1.74
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice. Proc Natl Acad Sci U S A (1996) 1.74
Negro variant of glucose-6-phosphate dehydrogenase deficiency (A-) in man. Science (1967) 1.68
Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. Mol Cell Biol (1998) 1.67
Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals. Proc Natl Acad Sci U S A (1976) 1.66
Role of gene order in developmental control of human gamma- and beta-globin gene expression. Mol Cell Biol (1993) 1.66
FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes. Mol Cell Biol (1999) 1.57
GATA1 and YY1 are developmental repressors of the human epsilon-globin gene. EMBO J (1995) 1.57
Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice. Blood (1992) 1.56
Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity. Am J Hum Genet (1975) 1.54
Eastern European (delta beta) zero-thalassemia: molecular characterization of a novel 9.1-kb deletion resulting in high levels of fetal hemoglobin in the adult. Blood (1994) 1.54
Analysis of human hemoglobin switching in MEL x human fetal erythroid cell hybrids. Cell (1986) 1.53
Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator. Blood (1994) 1.52
Role of NF-Y in in vivo regulation of the gamma-globin gene. Mol Cell Biol (2001) 1.51
Thalassemia major (homozygous beta-thalassemia). A survey of 138 cases with emphasis on neurologic and muscular aspects. Neurology (1972) 1.49
The linkage relationships of the beta and delta hemoglobin genes. Hemoglobin (1977) 1.47
The molecular defects of alpha-thalassemia in the Filipino. Hemoglobin (1977) 1.47
Beta-globin locus activation regions: conservation of organization, structure, and function. Proc Natl Acad Sci U S A (1990) 1.46
FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes. Blood (2000) 1.46
Genomic footprinting and sequencing of human beta-globin locus. Tissue specificity and cell line artifact. J Biol Chem (1994) 1.41
Neutrophil dysfunction, chronic granulomatous disease, and non-spherocytic haemolytic anaemia caused by complete deficiency of glucose-6-phosphate dehydrogenase. Lancet (1973) 1.38
A new form of hereditary persistence of fetal hemoglobin in blacks and its association with sickle cell trait. Blood (1975) 1.36
Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. EMBO J (1999) 1.36
Further evaluation of intensified and increased total dose of cyclophosphamide for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-25. J Clin Oncol (1999) 1.36
Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics. Science (1984) 1.36
Developmental regulation of human globin genes in transgenic mice. Cold Spring Harb Symp Quant Biol (1985) 1.35
Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study. Ann Intern Med (2000) 1.35
Retroviral-mediated transfer of genomic globin genes leads to regulated production of RNA and protein. Proc Natl Acad Sci U S A (1987) 1.34
Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine. Blood (1984) 1.33
Monoclonal antibodies specific for globin chains. Blood (1983) 1.33
Nephrotic syndrome and acute hepatitis in secondary syphilis. Mil Med (1969) 1.32
On the familial predisposition to favism. Am J Hum Genet (1966) 1.29
Globin gene switching. In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program. J Biol Chem (1996) 1.25
Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines. Proc Natl Acad Sci U S A (1993) 1.25
Erythrocytosis associated with hemoglobin Rainier: oxygen equilibria and marrow regulation. J Clin Invest (1969) 1.23
Hb F production in stressed erythropoiesis: observations and kinetic models. Ann N Y Acad Sci (1985) 1.20
Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture. Science (1978) 1.19
Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism. Blood (1998) 1.18
Fetal Hb production during acute erythroid expansion. I. Observations in patients with transient erythroblastopenia and post-phlebotomy. Br J Haematol (1980) 1.18
Chinese A gamma fetal hemoglobin: C to T substitution at position-196 of the A gamma gene promoter. Blood (1986) 1.17
Group psychotherapy for recently diagnosed breast cancer patients: a multicenter feasibility study. Psychooncology (2000) 1.17
Chromatin structure and developmental expression of the human alpha-globin cluster. Mol Cell Biol (1986) 1.16
Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. N Engl J Med (1985) 1.16
Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons. N Engl J Med (1987) 1.15
Only adult hemoglobin is produced in fetal nonerythroid x MEL cell hybrids. Blood (1986) 1.14
Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Genet (1995) 1.14
Molecular basis of hemoglobin-H disease in the Mediterranean population. Blood (1979) 1.14
Simultaneous purification of DNA and RNA from small numbers of eukaryotic cells. Anal Biochem (1989) 1.10
HbF and HbA production in erythroid cultures from human fetuses and neonates. Blood (1979) 1.10
The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis. J Mol Biol (2001) 1.10
Inclusion-body beta-thalassemia trait. A form of beta thalassemia producing clinical manifestations in simple heterozygotes. N Engl J Med (1974) 1.10
Expression of human factor IX in rat capillary endothelial cells: toward somatic gene therapy for hemophilia B. Proc Natl Acad Sci U S A (1991) 1.09
Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood (2000) 1.09
alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse. Blood (1994) 1.08
Activation of beta-globin promoter by erythroid Krüppel-like factor. Mol Cell Biol (1998) 1.08
Athens variant of glucose-6-phosphate dehydrogenase. Science (1967) 1.07
Genetic correction of sickle cell disease: insights using transgenic mouse models. Nat Med (2000) 1.05
Genetic diversity of the "Mediterranean" glucose-6-phosphate dehydrogenase deficiency phenotype. J Clin Invest (1971) 1.05
Hemoglobin switching in culture: evidence for a humoral factor that induces switching in adult and neonatal but not fetal erythroid cells. Proc Natl Acad Sci U S A (1982) 1.05
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations. Blood (1988) 1.05
DNA methylation: a secondary event in globin gene switching? Genes Dev (1988) 1.04
The distribution of glucose-6-phosphate dehydrogenase deficiency in Greece. Am J Hum Genet (1966) 1.04
Production of transgenic mice with yeast artificial chromosomes. Trends Genet (1997) 1.03
Identification of Haemoglobin S in red cells and normoblasts, using fluorescent anti-Hb S antibodies. Br J Haematol (1976) 1.03
Stimulation of fetal hemoglobin production by short chain fatty acids. Blood (1995) 1.03
Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes. J Clin Invest (1975) 1.03
Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region. Genomics (1999) 1.02
Haemoglobin Rainier: beta-145 (HC2) tyrosine leads to cysteine and haemoglobin Bethesda: beta-145 (HC2) tyrosine leads to histidine. Nat New Biol (1971) 1.01
Adenosine deaminase: racial distribution and report of a new phenotype. J Med Genet (1970) 1.00
LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs. Hum Mol Genet (1998) 1.00
Anti-HEL cell monoclonal antibodies recognize determinants that are also present in hemopoietic progenitors. Blood (1984) 1.00
Folate balance in dietary-induced megaloblastic anemia. N Engl J Med (1971) 1.00
Stochastic expression of fetal hemoglobin in adult erythroid cells. Proc Natl Acad Sci U S A (1981) 0.99
Concordance of a point mutation 5' to the A gamma-globin gene with A gamma beta + hereditary persistence of fetal hemoglobin in Greeks. Blood (1986) 0.99
alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult. Blood (1988) 0.99
Primary structure of the goat beta-globin locus control region. Genomics (1991) 0.99