K Fujihashi

Author PubWeight™ 80.47‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol 1995 2.87
2 Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 1993 2.62
3 A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A 1997 2.07
4 Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect Immun 1993 1.78
5 Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J Immunol 1996 1.76
6 Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 1999 1.69
7 Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. J Infect Dis 1996 1.68
8 Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med 1997 1.61
9 Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol 1991 1.58
10 Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion. Reg Immunol 1993 1.56
11 Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol 2000 1.32
12 Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine 1994 1.32
13 Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect Immun 1999 1.30
14 The role of Th1 and Th2 cells for mucosal IgA responses. Ann N Y Acad Sci 1996 1.26
15 A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol 1998 1.24
16 Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5. J Immunol 1993 1.21
17 Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues. J Immunol 1998 1.21
18 Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 2000 1.20
19 Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J Infect Dis 1999 1.20
20 Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. J Immunol 1995 1.18
21 Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections. Mol Med 1997 1.16
22 The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol 2001 1.11
23 Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice. J Immunol 1999 1.08
24 Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res 1998 1.06
25 Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res 1997 1.05
26 Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases. Am J Pathol 1996 1.04
27 Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. J Immunol 2001 1.03
28 Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice. J Immunol 1998 1.03
29 Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis. Infect Immun 2001 1.01
30 Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. Int Immunol 1994 1.00
31 Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. Eur J Immunol 1995 0.99
32 The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev 1994 0.98
33 Evidence for early aging in the mucosal immune system. J Immunol 2000 0.97
34 Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses. J Immunol 2001 0.97
35 Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am J Pathol 2000 0.97
36 Induction of IL-10-producing CD4+ T-cells in chronic periodontitis. J Dent Res 2011 0.96
37 Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. J Infect Dis 1998 0.96
38 Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation. Eur J Immunol 1994 0.95
39 Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnol Bioeng 2001 0.94
40 Role of mucosal antibodies in viral infections. Curr Top Microbiol Immunol 2001 0.94
41 Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. J Immunol Methods 1996 0.93
42 Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol 1991 0.92
43 Comparison of nasal and oral tolerance for the prevention of collagen induced murine arthritis. J Rheumatol 2000 0.91
44 Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. Cell Immunol 1991 0.91
45 Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunol Res 1991 0.90
46 Strategies for mucosal vaccine development. Am J Trop Med Hyg 1999 0.90
47 The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. Eur J Immunol 1993 0.89
48 Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J Immunol 1999 0.89
49 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation. Gene Ther 2005 0.88
50 Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues. Eur J Immunol 1994 0.88
51 Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates. J Immunol 1997 0.87
52 A revisit of mucosal IgA immunity and oral tolerance. Acta Odontol Scand 2001 0.86
53 Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses. J Infect Dis 2000 0.85
54 Induction of T helper cells and cytokines for mucosal IgA responses. Adv Exp Med Biol 1992 0.85
55 Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol 1992 0.84
56 Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes. J Infect Dis 1999 0.84
57 Effects of intranasal immunization on protective immunity against otitis media. Int J Pediatr Otorhinolaryngol 1999 0.84
58 Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies. Vaccine 2001 0.84
59 Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunol Res 1991 0.82
60 Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis. Reg Immunol 1992 0.80
61 Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus. Adv Exp Med Biol 1995 0.79
62 New perspectives in mucosal immunity with emphasis on vaccine development. Semin Hematol 1993 0.79
63 Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology 1998 0.79
64 Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infect Immun 1996 0.78
65 Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine 2001 0.78
66 Role of IL-6 in human antigen-specific and polyclonal IgA responses. Adv Exp Med Biol 1991 0.78
67 A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochem Biophys Res Commun 1997 0.78
68 Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells. J Immunol 1987 0.78
69 Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses. J Immunol 1988 0.78
70 Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities. Eur J Immunol 1992 0.77
71 Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. J Infect Dis 1999 0.77
72 Characterization of T and B cells isolated from mucosa-associated tissues of the rhesus macaque. Cell Immunol 1993 0.76
73 Mucosal immunity: regulation by helper T cells and a novel method for detection. J Biotechnol 1996 0.76
74 Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response. Adv Exp Med Biol 1992 0.75
75 Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses. Int Rev Immunol 1990 0.75
76 Human milk proteins including secretory IgA fail to elicit tolerance after feeding. Int Immunol 1998 0.75
77 Helper T subsets and cytokines for mucosal immunity and tolerance. Behring Inst Mitt 1997 0.75
78 The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens. Reg Immunol 1992 0.75
79 Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes. Adv Exp Med Biol 1995 0.75
80 Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response. Immunol Invest 1989 0.75