Published in Anesthesiology on April 01, 1996
Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians. Eur J Pharmacol (2006) 0.79
Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog. Neuromodulation (2012) 0.76
Using remifentanil in mechanically ventilated rats to provide continuous analgosedation. J Am Assoc Lab Anim Sci (2012) 0.75
Direct Effect of Remifentanil and Glycine Contained in Ultiva® on Nociceptive Transmission in the Spinal Cord: In Vivo and Slice Patch Clamp Analyses. PLoS One (2016) 0.75
The clinical pharmacology of remifentanil: a brief review. J Anesth (1998) 0.75
Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods (1994) 23.05
Analgesia mediated by a direct spinal action of narcotics. Science (1976) 2.84
Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci (2001) 2.33
Control of body temperature in the unanaesthetized monkey by cholinergic and aminergic systems in the hypothalamus. J Physiol (1969) 2.23
Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther (1992) 2.17
Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther (1977) 2.11
Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature (1980) 2.08
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science (1992) 2.00
Spinal opiate analgesia: characteristics and principles of action. Pain (1981) 1.97
Intrathecal somatostatin in cat and mouse studies on pain, motor behavior, and histopathology. Anesth Analg (1989) 1.96
Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology (1993) 1.86
Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav (1985) 1.85
Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology (1995) 1.83
In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. J Pharmacol Exp Ther (1984) 1.83
Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods (1997) 1.82
Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology (1981) 1.80
Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Res (1976) 1.66
Release of substance P from the cat spinal cord. J Physiol (1987) 1.52
Thermoregulation around a new set-point' established in the monkey by altering the ratio of sodium to calcium ions within the hypothalamus. J Physiol (1971) 1.51
Long-term spinal analgesic delivery: a review of the preclinical and clinical literature. Reg Anesth Pain Med (2000) 1.51
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther (1997) 1.50
Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. Br J Anaesth (1998) 1.45
Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther (1994) 1.44
Differential cross-tolerance between intrathecal morphine and sufentanil in the rat. Anesthesiology (1990) 1.42
Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J Pharmacol Exp Ther (1980) 1.39
Narcotic analgestics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques. Pain (1978) 1.37
The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain (1997) 1.36
Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther (1998) 1.36
Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. Mayo Clin Proc (1981) 1.35
Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. J Neurosci (1994) 1.34
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science (1979) 1.33
The physiology and pharmacology of spinal opiates. Annu Rev Pharmacol Toxicol (1985) 1.31
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain (1996) 1.27
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain (1993) 1.26
Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, clonidine, and their combination in sheep. Anesthesiology (1995) 1.26
Analgetic actions of intrathecal opiates in cat and primate. Brain Res (1978) 1.24
Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth (1997) 1.23
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci (1995) 1.20
Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur J Pharmacol (1978) 1.19
Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha 2 receptor systems. Anesthesiology (1994) 1.19
Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J Pharmacol Exp Ther (1992) 1.17
Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur J Pharmacol (1985) 1.17
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacol Rev (1993) 1.16
Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol (2010) 1.16
Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res (1984) 1.15
Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology (1992) 1.15
Spinal serotonin terminal system mediates antinociception. J Pharmacol Exp Ther (1979) 1.15
Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain (2000) 1.14
Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat. Brain Res (1986) 1.13
Analgesic and neurotoxic effects of intrathecal corticosteroids in rats. Anesthesiology (1994) 1.12
An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res (1977) 1.11
Micturition in rats: a chronic model for study of bladder function and effect of anesthetics. Am J Physiol (1986) 1.10
Drug effects on urinary bladder tone during spinal morphine-induced inhibition of the micturition reflex in unanesthetized rats. Anesthesiology (1988) 1.10
Epidural injections of bupivacaine, morphine, fentanyl, lofentanil, and DADL in chronically implanted rats: a pharmacologic and pathologic study. Anesthesiology (1986) 1.10
Multiple opioid receptor systems in brain and spinal cord: Part I. Eur J Anaesthesiol (1984) 1.10
Spinal noradrenergic terminal system mediates antinociception. Brain Res (1980) 1.10
Long-term pain relief produced by intrathecal morphine infusion in 53 patients. J Neurosurg (1990) 1.09
Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Res (1979) 1.08
The pharmacokinetics of lignocaine in humans during a computer-controlled infusion. Eur J Pain (1997) 1.08
Sites of action of opiates in production of analgesia. Prog Brain Res (1988) 1.08
Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. J Pharmacol Exp Ther (1995) 1.08
Properties of two unmyelinated fibre tracts of the central nervous system: lateral Lissauer tract, and parallel fibres of the cerebellum. J Physiol (1978) 1.07
Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. Life Sci (1991) 1.06
Epidural ketamine: a useful, mechanistically novel adjuvant for epidural morphine? Reg Anesth (1997) 1.06
Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine. Eur J Pharmacol (1977) 1.06
Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg (1997) 1.06
Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem. Brain Res (1991) 1.06
Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience (2006) 1.05
Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol (1991) 1.05
The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. J Pharmacol Exp Ther (1991) 1.04
An improved method for chronic catheterization of the rat spinal subarachnoid space. Physiol Behav (1981) 1.04
Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology (1997) 1.03
The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats. Br J Pharmacol (1995) 1.03
Changes in body temperature of the unanaesthetized monkey produced by sodium and calcium ions perfused through the cerebral ventricles. J Physiol (1971) 1.02
Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology (2001) 1.02
Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain (1992) 1.02
Dynorphin A and related peptides administered intrathecally in the rat: a search for putative kappa opiate receptor activity. J Pharmacol Exp Ther (1986) 1.02
Vincristine-induced allodynia in the rat. Pain (2001) 1.02
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. Neuroscience (1999) 1.02
Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J Pharmacol Exp Ther (1996) 1.02
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion. J Pharmacol Exp Ther (1989) 1.02
Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB). J Pharmacol Exp Ther (1992) 1.01
Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. J Neurosci (1999) 1.00
Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain (1982) 0.99
Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats. Neurosci Lett (1999) 0.99
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology (1998) 0.99
Monoamine release from cat spinal cord by somatic stimuli: an intrinsic modulatory system. J Physiol (1981) 0.99
Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine. Brain Res (1984) 0.99
Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J Physiol (1985) 0.98
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett (1995) 0.98
Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo. J Neurophysiol (1981) 0.98
Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance. J Pharmacol Exp Ther (1990) 0.98
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications. Anesthesiology (1986) 0.98
Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology (1994) 0.98
An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody. Pain (1997) 0.97
Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist. Neuroscience (2000) 0.96
A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat. Neurosci Lett (1998) 0.96
Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. Brain Res (2000) 0.95