Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1861517)

Published in Am J Pathol on April 01, 1996

Authors

P Thorner1, J Squire, S Chilton-MacNeil, P Marrano, J Bayani, D Malkin, M Greenberg, A Lorenzana, M Zielenska

Author Affiliations

1: Department of Pathology, The Hospital for Sick Children, Toronto, Canada.

Articles citing this

Soft tissue tumors associated with EWSR1 translocation. Virchows Arch (2010) 1.50

Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. J Clin Pathol (2003) 1.35

Ewing family of tumours involving the vulva and vagina: report of a series of four cases. J Clin Pathol (2007) 1.23

Perigastric extraskeletal Ewing's sarcoma: a case report. World J Gastroenterol (2009) 1.22

Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia (1999) 1.02

Guidelines for histopathological specimen examination and diagnostic reporting of primary bone tumours. Clin Sarcoma Res (2011) 0.98

Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies. Am J Pathol (1999) 0.97

Diagnosis and classification of the small round-cell tumors of childhood. Am J Pathol (1999) 0.88

Pathobiologic markers of the ewing sarcoma family of tumors: state of the art and prediction of behaviour. Sarcoma (2010) 0.82

Progress in the molecular biology of ewing tumors. Sarcoma (1998) 0.80

Huge peripheral primitive neuroectodermal tumor of the small bowel mesentery at nonage: A case report and review of the literature. World J Clin Cases (2016) 0.75

Diagnosis and classification of small round-cell tumors of childhood. Am J Pathol (1999) 0.75

Ewing's sarcoma family of tumors of the maxillary sinus: a case report of multidisciplinary examination enabling prompt diagnosis. Int J Clin Exp Pathol (2015) 0.75

Is it Askin Tumour? A Question You Must Ask Even in Elderly. J Clin Diagn Res (2014) 0.75

Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma. Gastrointest Tumors (2015) 0.75

Articles cited by this

Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38

High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science (1990) 10.72

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature (1992) 7.68

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet (1993) 5.00

The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med (1994) 4.65

Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell (1983) 4.13

Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol (1991) 3.97

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res (1994) 3.02

Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J (1993) 2.91

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol (1993) 2.84

Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science (1984) 2.46

Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12). Cancer Genet Cytogenet (1988) 2.42

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res (1994) 2.33

Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. Genes Chromosomes Cancer (1992) 2.31

Primitive neuroectodermal tumor and Ewing's sarcoma. Am J Surg Pathol (1993) 2.24

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res (1993) 2.24

MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer (1991) 2.15

A specific chromosomal abnormality in rhabdomyosarcoma. Cytogenet Cell Genet (1987) 1.60

Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes Cancer (1989) 1.59

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours. Oncogene (1993) 1.37

Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses. Am J Pathol (1994) 1.36

Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas. JAMA (1995) 1.21

Cytogenetic studies in subgroups of rhabdomyosarcoma. Genes Chromosomes Cancer (1992) 1.18

In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. Hum Genet (1989) 1.18

Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am J Pathol (1995) 1.13

Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene. Cancer Res (1995) 1.08

EWS rearrangement in Ewing's sarcoma and peripheral neuroectodermal tumor. Molecular detection and correlation with cytogenetic analysis and MIC2 expression. Diagn Mol Pathol (1993) 1.05

Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood. Diagn Mol Pathol (1993) 1.02

Translocation (11;22)(p13;q12): primary change in intra-abdominal desmoplastic small round cell tumor. Genes Chromosomes Cancer (1993) 1.01

Ectomesenchymoma. A malignant tumor of migratory neural crest (ectomesenchyme) remnants showing ganglionic, schwannian, melanocytic and rhabdomyoblastic differentiation. Cancer (1977) 1.00

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas. Cancer Res (1993) 0.97

MDM2 and CDK4 gene amplification in Ewing's sarcoma. J Pathol (1995) 0.96

Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization. Proc Natl Acad Sci U S A (1991) 0.94

MYCN gene amplification in rhabdomyosarcoma. Cancer (1994) 0.93

Cytogenetic and pathologic aspects of Ewing's sarcoma and neuroectodermal tumors. Hum Pathol (1992) 0.92

Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth Differ (1991) 0.91

Neuroepithelioma (primitive neuroectodermal tumor) and Ewing's sarcoma. At least a partial consensus. Arch Pathol Lab Med (1994) 0.80

Intra-abdominal desmoplastic small round cell tumor. Pathology (1993) 0.80

Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20. Cancer Res (1990) 0.77

Articles by these authors

Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med (1996) 5.14

Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol (2000) 4.19

Design and methods of a population-based natural history study of cervical neoplasia in a rural province of Costa Rica: the Guanacaste Project. Rev Panam Salud Publica (1997) 3.67

Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. Nat Genet (1993) 3.08

High-resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc Natl Acad Sci U S A (1992) 2.72

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet (2001) 2.55

Mesothelioma register 1967-68. Br J Ind Med (1974) 2.42

Clinical and immunological responses to enzymes of Bacillus subtilis in factory workers and consumers. Clin Allergy (1973) 2.36

Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr Biol (1998) 2.21

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther (1999) 2.17

Survey of workers exposed to dusts containing derivatives of Bacillus subtilis. Br Med J (1970) 2.12

Sexually transmitted papillomaviral infections. I. The anatomic distribution and pathologic grade of neoplastic lesions associated with different viral types. Am J Obstet Gynecol (1987) 1.97

Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers. Cancer Epidemiol Biomarkers Prev (2001) 1.95

Fine needle aspiration cytology of granulomatous mastitis. Report of a case and review of the literature. Acta Cytol (1990) 1.91

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol (2001) 1.91

Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. N Engl J Med (1990) 1.91

Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2004) 1.86

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol (2001) 1.80

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma. Nature (1983) 1.71

Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. J Immunol (1998) 1.67

Are non-whites at greater risk for occupational cancer? Am J Ind Med (1991) 1.67

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations. Proc Natl Acad Sci U S A (1991) 1.65

Brain tumors in children: long-term survival after radiation treatment. Int J Radiat Oncol Biol Phys (1995) 1.64

Nocturnal cortisol, thyroid stimulating hormone, and growth hormone secretory profiles in depressed adolescents. J Am Acad Child Adolesc Psychiatry (1991) 1.60

An Outbreak of Trichinosis in New York City-With Special Reference to the Intradermal and Precipitin Tests. Am J Public Health Nations Health (1946) 1.60

Identification and characterization of populations living near high-voltage transmission lines: a pilot study. Environ Health Perspect (1993) 1.59

Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1. Hum Mol Genet (2001) 1.58

Collection devices for human papillomavirus. J Fam Pract (1999) 1.57

Screening for germ line TP53 mutations in breast cancer patients. Cancer Res (1992) 1.55

Intracranial germ-cell tumors in children. J Neurosurg (1991) 1.54

HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica. Br J Cancer (2001) 1.52

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense. Oncogene (1987) 1.52

Pediatric onset of Behçet's syndrome with myositis: case report and literature review illustrating unusual features. Arthritis Rheum (1990) 1.51

Brca1 required for T cell lineage development but not TCR loci rearrangement. Nat Immunol (2000) 1.48

Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet (2001) 1.46

Information needs of women with metastatic breast cancer. Cancer Prev Control (1998) 1.46

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest (1995) 1.43

Reduction in tumor burden allowing partial nephrectomy following preoperative chemotherapy in biopsy proved Wilms tumor. J Urol (1991) 1.43

Chromosome 6p amplification and cancer progression. J Clin Pathol (2006) 1.42

Peripheral vs. central blood cultures in patients admitted to a pediatric oncology ward. Pediatr Infect Dis J (1999) 1.41

History of mesothelioma. Eur Respir J (1997) 1.39

Subxiphoid approach for insertion of ICDs after previous median sternotomy. Ann Thorac Surg (1993) 1.39

Metastatic nonfunctional retroperitoneal paraganglioma. Med Pediatr Oncol (1998) 1.38

Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: the Childhood Cancer Survivor Study. Br J Cancer (2004) 1.36

Thawing fresh frozen plasma in a microwave oven. A comparison with thawing in a 37 degrees C waterbath. Am J Clin Pathol (1992) 1.34

Three-dimensional structure of the vertebrate muscle M-region. J Mol Biol (1978) 1.34

Public health and brownfields: reviving the past to protect the future. Am J Public Health (1998) 1.33

High frequency of germline p53 mutations in childhood adrenocortical cancer. J Natl Cancer Inst (1994) 1.33

A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma. Hum Genet (1985) 1.31

Outdoor advertising of addictive products. N J Med (1991) 1.31

Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics (2008) 1.31

Mutational specificity of alkylating agents and the influence of DNA repair. Environ Mol Mutagen (1990) 1.28

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1. Proc Natl Acad Sci U S A (1988) 1.27

Splice-site mutation of the p53 gene in a family with hereditary breast-ovarian cancer. Oncogene (1994) 1.25

Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome. Am J Pathol (1996) 1.24

"Crystalline" myosin cross-bridge array in relaxed bony fish muscle. Low-angle x-ray diffraction from plaice fin muscle and its interpretation. Biophys J (1986) 1.24

The information needs of well, longer-term survivors of breast cancer. Patient Educ Couns (1998) 1.23

Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors. Mol Cell Biol (1988) 1.22

Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg (2000) 1.21

High frequency of de novo mutations in Li-Fraumeni syndrome. J Med Genet (2009) 1.19

The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma (2010) 1.18

The hemagglutinin envelope protein of canine distemper virus (CDV) confers cell tropism as illustrated by CDV and measles virus complementation analysis. J Virol (1995) 1.18

Mutations of the p53 gene do not occur in testis cancer. Cancer Res (1993) 1.17

Genetic predisposition to cancer and familial cancer syndromes. Pediatr Clin North Am (1997) 1.17

Direct and indirect estimates of HIV-1 incidence in a high-prevalence population. Am J Epidemiol (1998) 1.14

Transmission of Chlamydia trachomatis and Neisseria gonorrhoeae among men with urethritis and their female sex partners. J Infect Dis (1998) 1.13

Prognostic impact of chromosomal aberrations in Ewing tumours. Br J Cancer (2002) 1.13

Tumour induction by the retinoblastoma mutation is independent of N-myc expression. Nature (1986) 1.11

Cervical specimens collected in liquid buffer are suitable for both cytologic screening and ancillary human papillomavirus testing. Cancer (1997) 1.10

Fungal antigens as a source of sensitization and respiratory disease in Scottish maltworkers. Clin Allergy (1977) 1.10

Iminodipeptiduria: a genetic defect in recycling collagen; a method for determining prolidase in erythrocytes. Can Med Assoc J (1975) 1.10

Cardiogenic shock due to cardiac free-wall rupture or tamponade after acute myocardial infarction: a report from the SHOCK Trial Registry. Should we emergently revascularize occluded coronaries for cardiogenic shock? J Am Coll Cardiol (2000) 1.09

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer. Hum Mol Genet (1995) 1.08

Differential electrophysiologic properties of decremental retrograde pathways in long RP' tachycardia. Circulation (1987) 1.08

Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res (2008) 1.08

Second malignant neoplasms following childhood Hodgkin's disease: treatment and splenectomy as risk factors. Med Pediatr Oncol (1989) 1.08

Changing trends in US mesothelioma incidence. Occup Environ Med (2005) 1.07

Amplification of a DEAD box protein gene in retinoblastoma cell lines. Proc Natl Acad Sci U S A (1993) 1.07

Canine X chromosome-linked hereditary nephritis: a genetic model for human X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV. Proc Natl Acad Sci U S A (1994) 1.06

Mortality of employed men and women in England and Wales. Am J Ind Med (1991) 1.05

Inescapable shock, neurotransmitters, and addiction to trauma: toward a psychobiology of post traumatic stress. Biol Psychiatry (1985) 1.05

Extrinsic allergic alveolitis in Scottish maltworkers. Br Med J (1976) 1.05

Auscultation of the heart by machine and by physicians. JAMA (1967) 1.05

Knowledge of the health hazard of asbestos prior to the Merewether and Price report of 1930. Soc Hist Med (1994) 1.04

A proportional mortality study of a group of newspaper workers. Br J Ind Med (1972) 1.04

Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization. Hum Genet (1984) 1.04

Detecting disease clusters: the importance of statistical power. Am J Epidemiol (1990) 1.03

Electronic measurement of compliance with mercaptopurine in pediatric patients with acute lymphoblastic leukemia. Med Pediatr Oncol (1998) 1.03

Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma. Cancer Genet Cytogenet (2001) 1.02

Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. Cancer Genet Cytogenet (2003) 1.02

The meaning of menorrhagia: an investigation into the association between the complaint of menorrhagia and depression. J Psychosom Res (1983) 1.02

Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia (1999) 1.02

Impact of universal varicella vaccination on 1-year-olds in Uruguay: 1997-2005. Arch Dis Child (2008) 1.01