PubRank

K Kaushansky

Author PubWeight™ 96.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996 8.41
2 Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000 5.86
3 Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994 2.41
4 Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions. J Clin Invest 1989 2.18
5 Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha. J Immunol 1991 2.09
6 Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A 1986 2.06
7 The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996 1.91
8 A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem 1991 1.83
9 Thrombopoietin signal transduction in purified murine megakaryocytes. Blood 1997 1.75
10 Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995 1.71
11 Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 1996 1.57
12 Secretable human platelet-derived factor V originates from the plasma pool. Blood 1998 1.57
13 In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients. Blood 1991 1.55
14 Mechanisms of cytomegalovirus-mediated myelosuppression: perturbation of stromal cell function versus direct infection of myeloid cells. Proc Natl Acad Sci U S A 1990 1.49
15 Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A 1986 1.46
16 Thrombopoietin: platelets on demand? Ann Intern Med 1997 1.42
17 Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc Natl Acad Sci U S A 1997 1.39
18 Removing the cloud from industry-sponsored, multicentered clinical trials. Blood 2001 1.38
19 The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 1995 1.36
20 Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood 1999 1.34
21 Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996 1.31
22 Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. J Immunol 1987 1.30
23 Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J Biol Chem 2000 1.23
24 The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp Hematol 1995 1.21
25 Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK). Blood 2000 1.19
26 Thrombopoietin signal transduction requires functional JAK2, not TYK2. J Biol Chem 1999 1.18
27 Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. J Exp Med 1991 1.17
28 Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Blood 2000 1.11
29 Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. Proc Natl Acad Sci U S A 1990 1.10
30 Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding. Blood 1999 1.07
31 Human platelets display high-affinity receptors for thrombopoietin. Blood 1997 1.07
32 Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha. Blood 2001 1.02
33 Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors. J Biol Chem 2001 1.02
34 Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions. Blood 1989 1.00
35 Structure and function of the cytokine receptor superfamily. Curr Opin Hematol 1995 0.96
36 Targeted expansion of genetically modified bone marrow cells. Proc Natl Acad Sci U S A 1998 0.95
37 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Exp Hematol 1989 0.94
38 Differential expression of M-CSF, G-CSF, and GM-CSF by human monocytes. J Leukoc Biol 1990 0.93
39 Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995 0.93
40 The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells. FEBS Lett 1993 0.93
41 Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. Exp Hematol 1996 0.92
42 Chronic destructive arthritis in familial Mediterranean fever: the predominance of hip involvement and its management. Clin Orthop Relat Res 1981 0.92
43 Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC). Blood 1988 0.91
44 Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis. Blood 1996 0.90
45 Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995 0.90
46 Hem-1, a potential membrane protein, with expression restricted to blood cells. Biochim Biophys Acta 1991 0.89
47 Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit. Blood 1996 0.88
48 Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. Exp Hematol 1996 0.87
49 Kinetics of endomitosis in primary murine megakaryocytes. J Cell Physiol 2001 0.85
50 Thrombopoietin signal transduction: studies from cell lines and primary cells. Methods 1999 0.85
51 Two neutralizing monoclonal antibodies against human granulocyte-macrophage colony-stimulating factor recognize the receptor binding domain of the molecule. J Immunol 1990 0.84
52 The glycan domain of thrombopoietin enhances its secretion. Biochemistry 2000 0.83
53 Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. J Immunol 1990 0.83
54 Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. Exp Hematol 1989 0.83
55 Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism. FEBS Lett 1995 0.82
56 The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. J Biol Chem 2001 0.82
57 Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies. Blood 1991 0.82
58 Interleukin-1 alpha also induces granulocyte-macrophage colony-stimulating factor in immature normal bone marrow cells. Blood 1990 0.81
59 Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody. Blood 1996 0.81
60 Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts. Blood 1989 0.80
61 In vitro characterization of the human recombinant soluble granulocyte-macrophage colony-stimulating factor receptor. Blood 1995 0.80
62 Granulocyte-macrophage colony-stimulating factor expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line. Exp Hematol 1994 0.80
63 Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996 0.80
64 Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production. J Leukoc Biol 1995 0.80
65 Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release. Blood 1989 0.80
66 CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes. Leukemia 2000 0.80
67 Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor. J Invest Dermatol 2000 0.79
68 Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression. J Biol Chem 1993 0.79
69 Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors. J Clin Invest 1989 0.79
70 Megakaryocytic differentiation of HIMeg-1 cells induced by interferon gamma and tumour necrosis factor alpha but not by thrombopoietin. Cytokine 1998 0.79
71 A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl. J Biol Chem 2000 0.78
72 Mapping of human granulocyte-macrophage-colony-stimulating-factor domains interacting with the human granulocyte-macrophage-colony-stimulating-factor-receptor alpha-subunit. Eur J Biochem 1994 0.78
73 Biology of thrombopoietin. Curr Opin Pediatr 1998 0.78
74 Recombinant antibodies in bioactive peptide design. J Biol Chem 1995 0.78
75 Hematopoietic colony-stimulating factors. Biotechnology 1991 0.77
76 Thrombopoietin from human embryonic kidney cells is the same factor as c-mpl-ligand. Blood 1995 0.76
77 Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro. Am J Hematol 1997 0.75
78 Access to the biomedical literature: a stand against coercion. Blood 2001 0.75
79 Megakaryocyte growth factors and acute myeloid leukemia. Leukemia 1999 0.75
80 Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin. Cytokine 2000 0.75
81 Glossary of molecular biology terminology. Biologicals 1996 0.75
82 Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells. Cell Adhes Commun 1993 0.75
83 [Interferon-alpha directly inhibits thrombopoietin-induced megakaryocyte proliferation and differentiation]. Zhonghua Xue Ye Xue Za Zhi 2001 0.75
84 Defining units for thrombopoietin. Blood 1995 0.75
85 Molecular biology glossary. Rev Invest Clin 1994 0.75
86 Blood: new designs for a new millennium. Blood 2000 0.75
87 A neutralizing monoclonal antibody binds to an epitope near the amino terminus of murine granulocyte-macrophage colony-stimulating factor. Hybridoma 1991 0.75
88 Thrombopoietin and the physiology of platelet production. Leuk Res 1996 0.75