Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.

PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc Natl Acad Sci U S A (2003) 4.03

The structural biology of HIV assembly. Curr Opin Struct Biol (2008) 3.71

Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J Virol (2004) 2.65

Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation. Antimicrob Agents Chemother (2001) 1.96

A historical overview of natural products in drug discovery. Metabolites (2012) 1.47

Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564. Antimicrob Agents Chemother (2001) 1.27

Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. J Med Chem (2009) 1.26

Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. J Med Chem (2006) 1.25

Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod (2010) 1.20

Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat. Antimicrob Agents Chemother (2010) 1.18

New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. J Med Chem (2013) 1.16

The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles. Retrovirology (2011) 1.13

Activation and inhibition of the proteasome by betulinic acid and its derivatives. FEBS Lett (2007) 1.12

Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. J Med Chem (2009) 1.12

New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation. Antimicrob Agents Chemother (2009) 1.10

Structural and functional insights into the HIV-1 maturation inhibitor binding pocket. PLoS Pathog (2012) 1.06

Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS One (2007) 1.06

Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. J Med Chem (2010) 1.04

HIV entry inhibitors and their potential in HIV therapy. Med Res Rev (2009) 1.04

High-throughput human immunodeficiency virus type 1 (HIV-1) full replication assay that includes HIV-1 Vif as an antiviral target. Antimicrob Agents Chemother (2005) 1.03

Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer (2010) 1.01

Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors. J Med Chem (2012) 1.00

Proteasome regulators: activators and inhibitors. Curr Med Chem (2009) 0.99

Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Bioorg Med Chem Lett (2007) 0.95

Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy. Mol Med (2003) 0.93

Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorg Med Chem Lett (2012) 0.93

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents. Nat Prod Rep (2009) 0.91

Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses. Proc Natl Acad Sci U S A (2007) 0.91

The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain. Virol J (2008) 0.88

Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complement Altern Med (2011) 0.88

Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorg Med Chem Lett (2009) 0.87

Conjugates of betulin derivatives with AZT as potent anti-HIV agents. Bioorg Med Chem (2010) 0.86

New betulinic acid derivatives as potent proteasome inhibitors. Bioorg Med Chem Lett (2011) 0.84

Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay. PLoS One (2011) 0.82

Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368. Appl Environ Microbiol (2000) 0.81

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry. Tetrahedron Lett (2012) 0.80

A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid. Biochemistry (2013) 0.78

Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors. J Enzyme Inhib Med Chem (2011) 0.77

HIV-1 Capsid Inhibitors as Antiretroviral Agents. Curr HIV Res (2016) 0.76

Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. Bioorg Med Chem Lett (2015) 0.75

Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1. J Med Chem (2016) 0.75

Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. Bioorg Med Chem Lett (2015) 0.75

Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. Evid Based Complement Alternat Med (2013) 0.75

2'-Methyl-pyrazolo[4',3':16,17]androst-5-en-3β-ol. Acta Crystallogr Sect E Struct Rep Online (2009) 0.75

The natural product betulinic acid rapidly promotes amyloid-β fibril formation at the expense of soluble oligomers. ACS Chem Neurosci (2012) 0.75

Applications of mass spectrometry to DNA sequencing. Genet Anal Tech Appl (1991) 7.10

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature (2001) 7.06

Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science (1991) 5.52

The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies. N Engl J Med (1996) 5.06

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Genes Dev (1990) 4.96

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol Cell (1998) 4.73

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation (2001) 3.98

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A (1994) 3.95

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol (2001) 3.74

Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell (1998) 3.69

Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents. J Nat Prod (2000) 3.62

Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation (1999) 3.62

Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease. J Bacteriol (1996) 3.59

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci U S A (2001) 3.28

A role for oestrogens in the male reproductive system. Nature (1997) 2.99

Inhibition of nitrogenase-catalyzed reductions. Biochim Biophys Acta (1973) 2.99

Genetic regulation of storaage protein content in maize endosperm. Biochem Genet (1976) 2.97

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Genes Dev (1992) 2.85

Triplet-to-singlet exciton formation in poly(p-phenylene-vinylene) light-emitting diodes. Phys Rev Lett (2003) 2.74

Iodine-123 MIBG imaging before treatment of heart failure with carvedilol to predict improvement of left ventricular function and exercise capacity. J Nucl Cardiol (2001) 2.70

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative. Mol Cell Biol (1992) 2.67

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice. Mol Cell Biol (1996) 2.62

Thiazole orange: a new dye for reticulocyte analysis. Cytometry (1986) 2.53

Bioassay for trans-activation using purified human immunodeficiency virus tat-encoded protein: trans-activation requires mRNA synthesis. Proc Natl Acad Sci U S A (1989) 2.51

Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. J Clin Oncol (1995) 2.50

Home delivery and neonatal mortality in North Carolina. JAMA (1980) 2.49

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA. Proc Natl Acad Sci U S A (1990) 2.47

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell (1999) 2.46

Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Natl Acad Sci U S A (1999) 2.44

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell (1996) 2.39

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev (1992) 2.36

Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31

The statistical mechanics of complex signaling networks: nerve growth factor signaling. Phys Biol (2004) 2.24

In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry. Am J Physiol (1998) 2.22

Assessment of reducibility of ileocolic intussusception in children: usefulness of color Doppler sonography. Radiology (1994) 2.20

Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci U S A (1998) 2.19

A highly conserved Brassica gene with homology to the S-locus-specific glycoprotein structural gene. Plant Cell (1989) 2.18

The magnitude of the backbone conformational entropy change in protein folding. Proteins (1996) 2.18

A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem (1996) 2.16

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development (1997) 2.14

Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod (1994) 2.12

Abdominal amyloidosis: spectrum of radiological findings. Clin Radiol (2003) 2.10

Features of myocardial injury in severe organophosphate poisoning. Clin Toxicol (Phila) (2014) 2.09

Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissues. J Clin Microbiol (1999) 2.06

Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J Immunol (1992) 2.00

Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem (1998) 1.97

Regulation of vascular cell adhesion molecule 1 on human dermal microvascular endothelial cells. J Immunol (1992) 1.96

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J Biol Chem (1999) 1.94

Idiopathic calcinosis of the scrotum: histopathologic observations of fifty-one nodules. J Am Acad Dermatol (1988) 1.93

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci U S A (2001) 1.91

Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin. J Pharm Sci (1968) 1.90

Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J Biol Chem (1999) 1.87

Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res (2001) 1.87

Activation of phospholipase C isozymes by G protein beta gamma subunits. J Biol Chem (1993) 1.78

Predictors of mortality in patients with pyogenic liver abscess. Neth J Med (2008) 1.77

The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J Biol Chem (1997) 1.76

Surgical treatment of tuberculous spondylitis. 50 patients followed for 2-8 years. Acta Orthop Scand (1995) 1.75

Isolation of a second S-locus-related cDNA from Brassica oleracea: genetic relationships between the S locus and two related loci. Genetics (1991) 1.74

Differentiation of mycobacterial species by PCR-restriction analysis of DNA (342 base pairs) of the RNA polymerase gene (rpoB). J Clin Microbiol (2001) 1.72

Cigarette smoking in China. Prevalence, characteristics, and attitudes in Minhang District. JAMA (1995) 1.72

Single-beat estimation of end-systolic pressure-volume relation in humans. A new method with the potential for noninvasive application. Circulation (1996) 1.71

Cytotoxicity of sesquiterpene lactones. Cancer Res (1971) 1.71

Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. J Med Chem (1998) 1.71

Overexpression of phospholipase D1 in human breast cancer tissues. Cancer Lett (2000) 1.70

Sweet's syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature. Lupus (2005) 1.67

Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. J Immunol (1999) 1.67

Premortem diagnosis of Creutzfeldt-Jakob disease by cerebrospinal fluid analysis. Lancet (1996) 1.66

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds. Bioorg Med Chem (1998) 1.65

Amelioration of alkali soil using flue gas desulfurization byproducts: productivity and environmental quality. Environ Pollut (2007) 1.63

Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther (1999) 1.63

Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents. J Med Chem (1999) 1.62

The Vibrio fischeri-Euprymna scolopes Light Organ Association: Current Ecological Paradigms. Appl Environ Microbiol (1998) 1.62

An improved method for separation of low-molecular-weight polypeptides by electrophoresis in sodium dodecyl sulfate-polyacrylamide gel. Anal Biochem (1983) 1.60

Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients. Brain (2005) 1.60

Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions. Methods Enzymol (1991) 1.59

The bootstrap and identification of prognostic factors via Cox's proportional hazards regression model. Stat Med (1985) 1.59

Brain abnormalities in Sjogren syndrome with recurrent CNS manifestations: association with neuromyelitis optica. Mult Scler (2009) 1.58

Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol (2001) 1.58

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives. Bioorg Med Chem (1997) 1.58

Rapid tranquilization of acutely psychotic patients with intramuscular haloperidol and chlorpromazine. Psychosomatics (1974) 1.57

Intranasal tooth in a patient with a cleft lip and alveolus. Cleft Palate Craniofac J (1996) 1.57

Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A (1993) 1.56

Ventricular pacing with premature excitation for treatment of hypertensive-cardiac hypertrophy with cavity-obliteration. Circulation (1999) 1.56

Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release. Pharm Res (1999) 1.56

Electrochemistry: building on bubbles in metal electrodeposition. Nature (2002) 1.55

Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science (1997) 1.54

Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem (1997) 1.53

Objective evaluation of treatment effects on port-wine stains using L*a*b* color coordinates. Plast Reconstr Surg (2001) 1.52

The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion. J Immunol (1991) 1.51

Pleomorphic adenoma with extensive necrosis: report of two cases. Oral Dis (2004) 1.51

Ipsilesional neglect: behavioural and anatomical features. J Neurol Neurosurg Psychiatry (1999) 1.50

Phenotyping of flavin-containing monooxygenase using caffeine metabolism and genotyping of FMO3 gene in a Korean population. Pharmacogenetics (1999) 1.50

In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J Control Release (2000) 1.50

Genome-wide association study of bipolar I disorder in the Han Chinese population. Mol Psychiatry (2010) 1.49

Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation. Immunity (1998) 1.49