Published in Diabetes on August 01, 1996
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta (2009) 2.05
Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med (2010) 1.93
Early diabetic neuropathy: triggers and mechanisms. World J Gastroenterol (2007) 1.06
Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat. Metabolism (2008) 0.94
Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle. Biochem J (1998) 0.90
Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats. Iran J Basic Med Sci (2013) 0.89
Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial. J Diabetes Res (2015) 0.87
Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation. J Lipid Res (2009) 0.86
Pro-oxidant challenge in vivo provokes the onset of NIDDM in the insulin resistant obese Zucker rat. Br J Pharmacol (1999) 0.84
The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. J Neurodegener Dis (2013) 0.79
A Regenerative Antioxidant Protocol of Vitamin E and α-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats. Evid Based Complement Alternat Med (2011) 0.79
Dietary alpha lipoic Acid improves body composition, meat quality and decreases collagen content in muscle of broiler chickens. Asian-Australas J Anim Sci (2013) 0.78
Alfa-lipoic acid controls tumor growth and modulates hepatic redox state in Ehrlich-ascites-carcinoma-bearing mice. ScientificWorldJournal (2012) 0.77
Phosphorylation of hypothalamic AMPK on serine(485/491) related to sustained weight loss by alpha-lipoic acid in mice treated with olanzapine. Psychopharmacology (Berl) (2014) 0.76
Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials. Nanomaterials (Basel) (2017) 0.75
N-Acetyl-L-Cysteine inhibits the development of glucose intolerance and hepatic steatosis in diabetes-prone mice. Am J Transl Res (2016) 0.75
Dietary Supplementation of Vitamin E and α-Lipoic Acid Upregulates Cell Growth and Signaling Genes in Rat Myocardium. Int J Biomed Sci (2006) 0.75
Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex. J Clin Biochem Nutr (2014) 0.75
Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats. J Diabetes Metab (2015) 0.75
alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med (1995) 3.58
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N Engl J Med (1992) 3.41
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am J Hum Genet (1991) 2.53
The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev (2001) 2.53
31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy. Circulation (1998) 2.06
Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med (1997) 1.99
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Diabetes (1999) 1.84
Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med (1999) 1.51
The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes (1997) 1.48
Insulin-regulated gene expression. Biochem Soc Trans (2001) 1.45
Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev (1999) 1.38
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors (1997) 1.29
Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178. Neurology (1992) 1.29
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res (1999) 1.19
Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilol-metoprolol study. J Hypertens (1996) 1.18
Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med (1998) 1.16
Different mechanisms of increased proteolysis in atrophy induced by denervation or unweighting of rat soleus muscle. Metabolism (1990) 1.13
Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther (1998) 1.07
Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia (2000) 1.06
Exercise training, glucose transporters, and glucose transport in rat skeletal muscles. Am J Physiol (1992) 1.04
Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia (1998) 1.04
31P/1H WALTZ-4 broadband decoupling at 1.5 T: different versions of the composite pulse and consequences when using a surface coil. Magn Reson Imaging (1998) 1.03
Production of single-stranded DNA for sequencing: an alternative approach. Biotechniques (1992) 0.99
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung (1995) 0.99
Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol (1997) 0.99
Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem Pharmacol (1995) 0.98
Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J Neurol Sci (1999) 0.97
Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents? Am J Hypertens (1998) 0.96
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. Diabetes (1999) 0.96
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care (1999) 0.96
Experimental approaches in muscle metabolism: hindlimb perfusion and isolated muscle incubations. Am J Physiol (1994) 0.95
Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol (1985) (1992) 0.95
Decomposition of alpha-lipoic acid derivatives by photoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid-. Biochem Mol Biol Int (1996) 0.94
Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med (1999) 0.94
Palmitate stimulates glucose transport in rat adipocytes by a mechanism involving translocation of the insulin sensitive glucose transporter (GLUT4). Biochem Biophys Res Commun (1991) 0.94
Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol (1997) 0.93
Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci (1997) 0.92
Modulation of the action of insulin in relation to the energy state in skeletal muscle tissue: possible involvement of kinins and prostaglandins. Mol Cell Endocrinol (1982) 0.92
Cytochrome c oxidase deficiency. Pediatr Res (1990) 0.92
Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle. Am J Physiol (1994) 0.92
Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes (1996) 0.91
Efficacy of hypochlorous acid scavengers in the prevention of protein carbonyl formation. Arch Biochem Biophys (1996) 0.91
Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid. Free Radic Biol Med (1997) 0.91
Modulation of cellular reducing equivalent homeostasis by alpha-lipoic acid. Mechanisms and implications for diabetes and ischemic injury. Biochem Pharmacol (1997) 0.91
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats. J Appl Physiol (1985) (2001) 0.90
ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxide. Am J Physiol (1999) 0.90
Biochemical and molecular analysis of cytochrome c oxidase deficiency in Leigh's syndrome. Neurology (1991) 0.90
Glucose transport activity in insulin-resistant rat muscle. Effects of angiotensin-converting enzyme inhibitors and bradykinin antagonism. Diabetes (1996) 0.90
Hypoglycemia in hypertensive diabetic patients treated with sulfonylureas, biguanides, and captopril. N Engl J Med (1988) 0.90
Effects of in vitro antagonism of endocannabinoid-1 receptors on the glucose transport system in normal and insulin-resistant rat skeletal muscle. Diabetes Obes Metab (2010) 0.88
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. Diabetes (1999) 0.87
Microvascular perfusion and transport in the diabetic heart. Microcirculation (2000) 0.87
The blood contribution to early myocardial reperfusion injury is amplified in diabetes. Diabetes (1997) 0.86
Potential role of bradykinin in forearm muscle metabolism in humans. Diabetes (1996) 0.85
Reduction and transport of lipoic acid by human erythrocytes. Biochem Pharmacol (1995) 0.85
Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line. Biochem Biophys Res Commun (1995) 0.85
Alpha-lipoic acid: the metabolic antioxidant. Free Radic Biol Med (1996) 0.85
Spaceflight on STS-48 and earth-based unweighting produce similar effects on skeletal muscle of young rats. J Appl Physiol (1985) (1993) 0.85
Effect of chronic bradykinin administration on insulin action in an animal model of insulin resistance. Am J Physiol (1998) 0.84
Effects of wheel running on glucose transporter (GLUT4) concentration in skeletal muscle of young adult and old rats. Mech Ageing Dev (1993) 0.84
Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem Biophys Res Commun (1994) 0.84
Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for alpha-lipoic acid enantiomers. Biochem Biophys Res Commun (1995) 0.84
Metabolic effects of kinins: historical and recent developments. J Cardiovasc Pharmacol (1990) 0.84
Role of glucocorticoids in increased muscle glutamine production in starvation. Muscle Nerve (1988) 0.83
Improvement of glucose metabolism in patients with type II diabetes after treatment with a hemodialysate. Arzneimittelforschung (1996) 0.83
Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes (2000) 0.83
Differences in cardiac energetics between patients with familial and nonfamilial hypertrophic cardiomyopathy. Circulation (2000) 0.83
Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats. J Appl Physiol (1985) (1997) 0.83
Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol (1993) 0.83
Interactions of exercise training and ACE inhibition on insulin action in obese Zucker rats. J Appl Physiol (1985) (1999) 0.83
Reversible mitochondrial myopathy with cytochrome c oxidase deficiency. Arch Dis Child (1992) 0.82
Prion protein gene analysis in three kindreds with fatal familial insomnia (FFI): codon 178 mutation and codon 129 polymorphism. Am J Hum Genet (1993) 0.82
Stimulation of cardiac glucose transport by thioctic acid and insulin. Horm Metab Res (1999) 0.82
Interactions of captopril and verapamil on glucose tolerance and insulin action in an animal model of insulin resistance. Metabolism (1998) 0.82
Amplified determination of lipoyl groups by lipoamide dehydrogenase in the presence of oxidized glutathione. Biochem Mol Biol Int (1996) 0.81
Thioctic acid--effects on insulin sensitivity and glucose-metabolism. Biofactors (1999) 0.81
Activation of aldose reductase in rat lens and metal-ion chelation by aldose reductase inhibitors and lipoic acid. Free Radic Res (1996) 0.81
The effects of bradykinin and the ischemic isolated rat heart. Horm Metab Res Suppl (1990) 0.81
Skeletal muscle protein content and synthesis after voluntary running and subsequent unweighting. Metabolism (1994) 0.81
Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockers. Blood Press (1999) 0.80
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res Commun (1996) 0.80
Voluntary exercise training enhances glucose transport in muscle stimulated by insulin-like growth factor I. J Appl Physiol (1985) (1997) 0.80
Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle. J Appl Physiol (1985) (2000) 0.79
Insulin attenuates atrophy of unweighted soleus muscle by amplified inhibition of protein degradation. Metabolism (1997) 0.79
Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin. Diabetes (1996) 0.79