Published in Proteins on May 01, 1996
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5. J Virol (2004) 2.02
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1. Proc Natl Acad Sci U S A (2012) 1.74
Immunoinformatics comes of age. PLoS Comput Biol (2006) 1.35
Structural evolution of glycan recognition by a family of potent HIV antibodies. Cell (2014) 1.28
Chemical generation of bispecific antibodies. Proc Natl Acad Sci U S A (2010) 1.24
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity (2015) 1.18
Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120. J Virol (2005) 1.10
Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibility. Proteins (2009) 1.05
Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab. J Biol Chem (2013) 0.99
The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6. J Mol Recognit (2013) 0.98
Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase. Nucleic Acids Res (2003) 0.95
Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles--part 1: separation-based methods. MAbs (2015) 0.94
A scFv antibody mutant isolated in a genetic screen for improved export via the twin arginine transporter pathway exhibits faster folding. J Mol Biol (2007) 0.93
Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun (2016) 0.92
Directed evolution of single-chain Fv for cytoplasmic expression using the beta-galactosidase complementation assay results in proteins highly susceptible to protease degradation and aggregation. Microb Cell Fact (2004) 0.89
Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262. Proteins (2015) 0.89
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. Proc Natl Acad Sci U S A (2000) 0.89
Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer. Acta Crystallogr D Biol Crystallogr (2015) 0.87
Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies. Nat Protoc (2013) 0.83
Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology (2003) 0.83
Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge. Gene Ther (2010) 0.80
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells. PLoS One (2011) 0.79
Molecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor region. PLoS One (2013) 0.79
Development of scoring functions for antibody sequence assessment and optimization. PLoS One (2013) 0.78
Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526. J Mol Biol (2015) 0.78
Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants. Plant Cell Rep (2003) 0.78
The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling. Acta Crystallogr D Struct Biol (2016) 0.77
Modeling the interactions of a peptide-major histocompatibility class I ligand with its receptors. II. Cross-reaction between a monoclonal antibody and two alpha beta T cell receptors. J Comput Aided Mol Des (2000) 0.77
A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5. Sci Rep (2016) 0.76
Molecular determinants of polyreactive antibody binding: HCDR3 and cyclic peptides. Clin Exp Immunol (2000) 0.76
Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†. Glycobiology (2015) 0.75
Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31. PLoS One (2016) 0.75
Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data. Bioinformation (2010) 0.75
Molecular Basis for the Neutralization of Tumor Necrosis Factor α by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases. Int J Mol Sci (2017) 0.75
Prediction and Reduction of the Aggregation of Monoclonal Antibodies. J Mol Biol (2017) 0.75
Impact of DNA hairpin folding energetics on antibody-ssDNA association. J Mol Biol (2007) 0.75
Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer. PLoS One (2015) 0.75
Expression and characterization of an enantioselective antigen-binding fragment directed against α-amino acids. Protein Expr Purif (2013) 0.75
A method to confer Protein L binding ability to any antibody fragment. MAbs (2015) 0.75
Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains. Sci Rep (2017) 0.75
Structural models of antibody variable fragments: a method for investigating binding mechanisms. J Comput Aided Mol Des (1998) 0.75
Assessment of comparative modeling in CASP2. Proteins (1997) 1.21