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1
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A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.
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Nat Genet
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1998
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8.02
|
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2
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Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies.
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Circulation
|
1994
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4.32
|
|
3
|
Osteopontin is expressed in human aortic valvular lesions.
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Circulation
|
1995
|
4.16
|
|
4
|
Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis.
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Arterioscler Thromb Vasc Biol
|
1996
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2.60
|
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5
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Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.
|
Diabetologia
|
2007
|
1.97
|
|
6
|
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.
|
Circulation
|
1999
|
1.64
|
|
7
|
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
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Diabetologia
|
2012
|
1.55
|
|
8
|
Association of metabolic syndrome with Alzheimer disease: a population-based study.
|
Neurology
|
2006
|
1.45
|
|
9
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Glomerular filtration rate and parathyroid hormone are associated with 1,25-dihydroxyvitamin D in men without chronic kidney disease.
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J Intern Med
|
2011
|
1.43
|
|
10
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Cognitive function in an elderly population with persistent impaired glucose tolerance.
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Diabetes Care
|
1998
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1.39
|
|
11
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Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects.
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Diabetologia
|
1993
|
1.26
|
|
12
|
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects.
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Diabetologia
|
1995
|
1.13
|
|
13
|
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy.
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Heart
|
2006
|
1.12
|
|
14
|
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.
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J Am Coll Cardiol
|
1998
|
1.12
|
|
15
|
Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.
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J Clin Invest
|
1994
|
1.09
|
|
16
|
Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study.
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Neurosci Lett
|
1996
|
1.05
|
|
17
|
Microalbuminuria precedes the development of NIDDM.
|
Diabetes
|
1994
|
1.04
|
|
18
|
Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias.
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J Intern Med
|
2010
|
1.01
|
|
19
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Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study.
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Nutr Metab Cardiovasc Dis
|
2010
|
1.01
|
|
20
|
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.
|
Diabetes Care
|
2000
|
1.00
|
|
21
|
Apolipoprotein E phenotype alone does not influence survival in Alzheimer's disease: a population-based longitudinal study.
|
Neuroepidemiology
|
2000
|
0.98
|
|
22
|
Detection of Chlamydia pneumoniae in human nonrheumatic stenotic aortic valves.
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J Am Coll Cardiol
|
1997
|
0.96
|
|
23
|
Retroperitoneal fibrosis with antineutrophil cytoplasmic antibodies.
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J Rheumatol
|
1996
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0.94
|
|
24
|
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men.
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J Intern Med
|
2012
|
0.93
|
|
25
|
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
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Diabetologia
|
2010
|
0.93
|
|
26
|
Increased risk of non-insulin-dependent diabetes mellitus in elderly hypertensive subjects.
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J Hypertens
|
1994
|
0.93
|
|
27
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LDL size and risk of coronary heart disease in elderly men and women.
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Arterioscler Thromb Vasc Biol
|
1999
|
0.91
|
|
28
|
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.
|
Diabetologia
|
2010
|
0.91
|
|
29
|
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.
|
Diabetes
|
2001
|
0.91
|
|
30
|
A novel surrogate index for hepatic insulin resistance.
|
Diabetologia
|
2010
|
0.90
|
|
31
|
Type-2 diabetes and cognitive function in a non-demented population.
|
Acta Neurol Scand
|
1999
|
0.88
|
|
32
|
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women.
|
Circulation
|
1995
|
0.87
|
|
33
|
The Ala54Thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects.
|
Diabetes
|
1997
|
0.86
|
|
34
|
Exopolysaccharide-producing bacteria from sugar beets.
|
Appl Environ Microbiol
|
1999
|
0.86
|
|
35
|
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.
|
Atherosclerosis
|
2000
|
0.86
|
|
36
|
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?
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J Intern Med
|
2014
|
0.86
|
|
37
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APOE-epsilon4 is associated with weight loss in women with AD: a population-based study.
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Neurology
|
2001
|
0.85
|
|
38
|
Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus.
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Ann Med
|
1996
|
0.85
|
|
39
|
The association of apolipoprotein E polymorphism with memory: a population based study.
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Neurosci Lett
|
1995
|
0.84
|
|
40
|
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene.
|
J Mol Cell Cardiol
|
2004
|
0.84
|
|
41
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Association between liver insulin resistance and cardiovascular risk factors.
|
J Intern Med
|
2012
|
0.84
|
|
42
|
Can degenerative aortic valve stenosis be related to persistent Chlamydia pneumoniae infection?
|
Ann Intern Med
|
1998
|
0.81
|
|
43
|
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: magnetic resonance imaging study.
|
Heart
|
2006
|
0.81
|
|
44
|
Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.
|
Diabetes Care
|
2000
|
0.81
|
|
45
|
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children.
|
Am J Cardiol
|
1999
|
0.80
|
|
46
|
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.
|
Diabetologia
|
2011
|
0.80
|
|
47
|
Gender differences in left ventricular function at rest and with exercise in asymptomatic aortic stenosis.
|
Am Heart J
|
1996
|
0.80
|
|
48
|
Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin.
|
Int J Obes (Lond)
|
2008
|
0.79
|
|
49
|
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.
|
Diabetologia
|
1995
|
0.79
|
|
50
|
Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.
|
Diabetes Care
|
1998
|
0.79
|
|
51
|
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.
|
Diabetologia
|
2006
|
0.79
|
|
52
|
The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner.
|
Int J Obes (Lond)
|
2008
|
0.78
|
|
53
|
The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome.
|
Diabetes Care
|
1997
|
0.78
|
|
54
|
Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.
|
Diabetes Care
|
1995
|
0.77
|
|
55
|
New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.
|
Diabetologia
|
1997
|
0.77
|
|
56
|
Stability of age-associated memory impairment during a longitudinal population-based study.
|
J Am Geriatr Soc
|
1997
|
0.75
|
|
57
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[Sarcomere gene mutations--a cause of hypertrophic cardiomyopathy].
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Duodecim
|
1999
|
0.75
|
|
58
|
Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus.
|
Am J Otolaryngol
|
1995
|
0.75
|
|
59
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[The pathogenesis of aortic valvular stenosis will soon be known].
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Duodecim
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1997
|
0.75
|
|
60
|
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
|
Diabetes
|
2000
|
0.75
|
|
61
|
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from eastern Finland.
|
J Mol Cell Cardiol
|
1999
|
0.75
|
|
62
|
Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects.
|
Arterioscler Thromb
|
1994
|
0.75
|