Published in Gene Ther on December 01, 1995
Characteristics of Cl- uptake in rat alveolar type I cells. Am J Physiol Lung Cell Mol Physiol (2009) 1.56
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation. Autophagy (2014) 1.21
A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR. Cell Death Differ (2016) 0.83
Assessment of swelling-activated Cl- channels using the halide-sensitive fluorescent indicator 6-methoxy-N-(3-sulfopropyl)quinolinium. Biophys J (1998) 0.82
Prospects for gene therapy in cystic fibrosis. Arch Dis Child (1999) 0.79
New therapeutic approaches for cystic fibrosis lung disease. J R Soc Med (2002) 0.75
Two-, six-, and 12-minute walking tests in respiratory disease. Br Med J (Clin Res Ed) (1982) 7.77
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett (1990) 5.14
Electron transfer by domain movement in cytochrome bc1. Nature (1998) 4.08
Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst (1997) 3.92
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet (2001) 3.65
Oxygen relieves breathlessness in "pink puffers". Lancet (1981) 3.64
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med (1995) 3.61
Ethical consideration of incidental findings on adult brain MRI in research. Neurology (2004) 3.56
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A (2000) 3.44
Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment. Nat Genet (1998) 3.24
Alterations of the PPP2R1B gene in human lung and colon cancer. Science (1998) 3.14
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood (2001) 3.00
Pulmonary fibrosis associated with hypersensitivity to gold salts. Br Med J (1976) 2.91
Progressive airway obliteration in adults and its association with rheumatoid disease. Q J Med (1977) 2.83
Gene therapy progress and prospects: nonviral vectors. Gene Ther (2002) 2.79
The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest (1979) 2.76
Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers. Br Med J (Clin Res Ed) (1981) 2.74
A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun (1991) 2.72
Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol (2001) 2.69
Toxicity of ALS-linked SOD1 mutants. Science (2000) 2.69
Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting. Int J Tuberc Lung Dis (2009) 2.68
Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther (2001) 2.67
Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature (1992) 2.66
Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res (1985) 2.62
Theophylline prescribing, serum concentrations, and toxicity. Lancet (1983) 2.40
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A (1993) 2.35
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28
Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. Br Med J (Clin Res Ed) (1984) 2.19
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes. J Virol (1996) 2.17
Inhaled corticosteroids: benefits and risks. Thorax (1992) 2.17
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol (2001) 2.14
Enzymatic completion of mammalian lagging-strand DNA replication. Proc Natl Acad Sci U S A (1994) 2.11
The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta (1995) 2.10
Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg Infect Dis (2000) 2.08
Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium. Eur Respir J (1994) 2.07
Proteomic analysis of nucleoporin interacting proteins. J Biol Chem (2001) 2.06
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog (1998) 2.06
Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci (2004) 2.03
Transmembrane pH gradient and membrane potential in Clostridium acetobutylicum during growth under acetogenic and solventogenic conditions. Appl Environ Microbiol (1985) 2.02
Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim Biophys Acta (1991) 2.01
Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol (1994) 2.00
Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors. Oncogene (2007) 1.95
Crystal structure of an activated response regulator bound to its target. Nat Struct Biol (2001) 1.95
Effects of dihydrocodeine, alcohol, and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases. N Engl J Med (1981) 1.94
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell (1999) 1.91
New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett (1994) 1.90
Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol (2000) 1.86
Benchmark data and power calculations for evaluating disease outbreak detection methods. MMWR Morb Mortal Wkly Rep (2004) 1.86
Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther (1997) 1.86
Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Ther (2006) 1.84
Patterns of protein synthesis and tolerance of anoxia in root tips of maize seedlings acclimated to a low-oxygen environment, and identification of proteins by mass spectrometry. Plant Physiol (2000) 1.82
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest (2000) 1.82
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease. Ann Neurol (2000) 1.82
Duration of chemotherapy in small cell lung cancer: a Cancer Research Campaign trial. Br J Cancer (1989) 1.81
The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther (1999) 1.81
Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim Biophys Acta (1994) 1.79
A physical map of chromosome 2 of Arabidopsis thaliana. Genome Res (1996) 1.77
Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther (2001) 1.76
Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial. J Clin Oncol (2001) 1.73
Medium term treatment of stable stage cystic fibrosis with recombinant human DNase I. Thorax (1995) 1.72
Efficient gene transfer to airway epithelium using recombinant Sendai virus. Nat Biotechnol (2000) 1.71
A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am J Physiol Renal Physiol (2000) 1.71
alpha 1-antitrypsin phenotypes in fibrosing alveolitis and rheumatoid arthritis. Lancet (1977) 1.70
Absorption of glycine and glycine peptides from the small intestine of the rat. Clin Sci (1968) 1.69
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. Lancet (1999) 1.69
Cationic liposome-mediated gene transfer. Gene Ther (1995) 1.68
Pseudo-steroid resistant asthma. Thorax (1999) 1.67
Nonviral gene therapy: promises and challenges. Gene Ther (2000) 1.65
Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia. J Exp Med (2000) 1.65
Atelectasis and survival after bronchoscopic lung volume reduction for COPD. Eur Respir J (2010) 1.65
Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney. Am J Physiol (1999) 1.61
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res (2000) 1.60
Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry (1996) 1.60
BOOP and COP. Thorax (1991) 1.57
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis (1990) 1.57
Structure and function of lipid-DNA complexes for gene delivery. Annu Rev Biophys Biomol Struct (2000) 1.57
Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons. The Pulmonary Complications of HIV Infection Study Group. Am J Respir Crit Care Med (2000) 1.56
Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat Genet (1993) 1.55
Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence. Eur Respir J (2001) 1.55
Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem (1996) 1.55
Architectural design and tools to support the transparent access to hospital information systems, radiology information systems, and picture archiving and communication systems. J Digit Imaging (1996) 1.54
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism. Thorax (2008) 1.54
DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim Biophys Acta (1994) 1.54
Transcatheter closure of patent ductus arteriosus with severe pulmonary arterial hypertension in adults. Heart (2006) 1.53
Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol (2001) 1.51
An abundant DNA binding protein from the hyperthermophilic archaeon Sulfolobus shibatae affects DNA supercoiling in a temperature-dependent fashion. J Bacteriol (2000) 1.51
In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther (1997) 1.51
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK. J Antibiot (Tokyo) (1999) 1.51
Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim Biophys Acta (1992) 1.50
The calf 5'- to 3'-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. J Biol Chem (1994) 1.49
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther (1996) 1.49