Published in Bioessays on September 01, 1995
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.00
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry (2008) 0.99
Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry (2007) 0.98
Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani. Nucleic Acids Res (2003) 0.87
Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity. Mol Cell Biol (2000) 0.85
Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide. Br J Cancer (1996) 0.81
Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase II. Nucleic Acids Res (2005) 0.79
Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha. Nucleic Acids Res (2003) 0.79
Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae. Aging (Albany NY) (2017) 0.75
Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres. Mar Drugs (2017) 0.75
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell (1995) 7.20
The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J Cell Biol (1996) 4.72
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell (1999) 4.71
Chromosome dynamics in the yeast interphase nucleus. Science (2001) 4.33
Import of proteins into mitochondria. Energy-dependent uptake of precursors by isolated mitochondria. J Biol Chem (1982) 4.25
Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster. Cell (1986) 4.15
Metaphase chromosome structure. Involvement of topoisomerase II. J Mol Biol (1986) 4.14
SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell (1993) 3.77
Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J (1997) 3.55
Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. J Cell Biol (1992) 3.48
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell (1997) 3.44
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev (2000) 3.40
Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr Biol (1998) 3.13
Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Cell (1997) 3.00
Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression. Genes Dev (1996) 2.85
Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold. Cell (1988) 2.69
Import of proteins into mitochondria. Energy-dependent, two-step processing of the intermembrane space enzyme cytochrome b2 by isolated yeast mitochondria. J Biol Chem (1982) 2.46
Imported mitochondrial proteins cytochrome b2 and cytochrome c1 are processed in two steps. Proc Natl Acad Sci U S A (1982) 2.39
RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML. Cell (1989) 2.32
Nuclear compartments and gene regulation. Curr Opin Genet Dev (1999) 2.30
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol (1995) 2.26
Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J Mol Biol (1993) 2.23
The positioning and dynamics of origins of replication in the budding yeast nucleus. J Cell Biol (2001) 2.05
The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res (1996) 1.98
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J (2001) 1.95
Telomeres and the functional architecture of the nucleus. Trends Cell Biol (1993) 1.77
Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo. EMBO J (1992) 1.76
Chromosome dynamics: the SMC protein family. Curr Opin Genet Dev (1998) 1.70
A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Genes Dev (1999) 1.53
Import of proteins into mitochondria. In vitro studies on the biogenesis of the outer membrane. J Biol Chem (1983) 1.51
Cooperation at a distance between silencers and proto-silencers at the yeast HML locus. EMBO J (1996) 1.50
Long-range silencing and position effects at telomeres and centromeres: parallels and differences. Cell Mol Life Sci (2003) 1.48
Scaffold attachment of DNA loops in metaphase chromosomes. J Mol Biol (1988) 1.48
The dynamics of yeast telomeres and silencing proteins through the cell cycle. J Struct Biol (2000) 1.46
Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure. J Biol Chem (1998) 1.44
Identification and purification of a protein that binds the yeast ARS consensus sequence. Cell (1991) 1.41
Meiotic behaviours of chromosomes and microtubules in budding yeast: relocalization of centromeres and telomeres during meiotic prophase. Genes Cells (1998) 1.38
Nuclear organization and transcriptional silencing in yeast. Experientia (1996) 1.23
MAP kinase signaling induces nuclear reorganization in budding yeast. Curr Biol (2000) 1.21
Turning telomeres off and on. Curr Opin Cell Biol (2001) 1.21
Drosophila scaffold-attached regions bind nuclear scaffolds and can function as ARS elements in both budding and fission yeasts. Mol Cell Biol (1990) 1.20
DNA loops: structural and functional properties of scaffold-attached regions. Mol Microbiol (1992) 1.20
Functional characterization of the N terminus of Sir3p. Mol Cell Biol (1998) 1.17
Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast. Curr Biol (1998) 1.17
Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae. Genetics (2000) 1.17
Ku-deficient yeast strains exhibit alternative states of silencing competence. EMBO Rep (2001) 1.16
Telomeres and telomerase. Genes Dev (1999) 1.12
Preparation and characterization of yeast nuclear extracts for efficient RNA polymerase B (II)-dependent transcription in vitro. Nucleic Acids Res (1990) 1.12
RecQ-like helicases: the DNA replication checkpoint connection. J Cell Sci (2000) 1.09
ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei. Genes Dev (1997) 1.08
Imaging the asymmetrical DNA bend induced by repressor activator protein 1 with scanning tunneling microscopy. J Struct Biol (1995) 1.07
The nucleolus: nucleolar space for RENT. Curr Biol (1999) 1.07
RAP1 stimulates single- to double-strand association of yeast telomeric DNA: implications for telomere-telomere interactions. Nucleic Acids Res (1994) 1.05
Relation of chromosome structure and gene expression. Philos Trans R Soc Lond B Biol Sci (1987) 1.04
Import of polypeptides into isolated yeast mitochondria. Methods Enzymol (1983) 1.04
Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences. Nucleic Acids Res (1999) 1.02
The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane. Cold Spring Harb Symp Quant Biol (1993) 1.01
Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template. J Mol Biol (1998) 1.01
Nuclear scaffold attachment stimulates, but is not essential for ARS activity in Saccharomyces cerevisiae: analysis of the Drosophila ftz SAR. EMBO J (1990) 1.00
From snapshots to moving pictures: new perspectives on nuclear organization. Trends Cell Biol (2001) 0.99
Targeting Sir proteins to sites of action: a general mechanism for regulated repression. Cold Spring Harb Symp Quant Biol (1998) 0.98
Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA. Biochemistry (2001) 0.97
Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner. Cold Spring Harb Symp Quant Biol (2011) 0.97
Regulation of topoisomerase II by phosphorylation: a role for casein kinase II. J Cell Sci (1993) 0.96
New systems for replicating DNA in vitro. Curr Opin Cell Biol (1998) 0.96
Telomere maintenance and gene repression: a common end? Curr Opin Cell Biol (1994) 0.94
Analysis of nuclear organization in Saccharomyces cerevisiae. Methods Enzymol (1999) 0.94
Casein kinase II copurifies with yeast DNA topoisomerase II and re-activates the dephosphorylated enzyme. J Cell Sci (1993) 0.92
Topoisomerase II forms multimers in vitro: effects of metals, beta-glycerophosphate, and phosphorylation of its C-terminal domain. Mol Cell Biol (1994) 0.90
Chromatin: a sticky silence. Curr Biol (1996) 0.90
Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Mol Cell Biol (1999) 0.86
Mutations in the C-terminal domain of topoisomerase II affect meiotic function and interaction with the casein kinase 2 beta subunit. Mol Cell Biochem (1999) 0.83
The yeast protein encoded by PUB1 binds T-rich single stranded DNA. Nucleic Acids Res (1994) 0.83
Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide. Br J Cancer (1996) 0.81
Assessing import of proteins into mitochondria: an overview. Methods Enzymol (1983) 0.81
Ribonuclease H(70) is a component of the yeast nuclear scaffold. J Cell Sci (1990) 0.80
Phosphorylation of the C-terminal domain of yeast topoisomerase II by casein kinase II affects DNA-protein interaction. J Mol Biol (1994) 0.79
In vitro DNA replication in yeast nuclear extracts. Methods (1999) 0.78
The regulation of DNA topoisomerase II by casein kinase II. Cell Mol Biol Res (1994) 0.76
Functional interaction between the estrogen receptor and CTF1: analysis of the vitellogenin gene B1 promoter in yeast. Mol Endocrinol (1998) 0.76
The composition and morphology of yeast nuclear scaffolds. J Cell Sci (1990) 0.76
The cytochrome b5 tail anchors and stabilizes subdomains of human DNA topoisomerase II alpha in the cytoplasm of retrovirally infected mammalian cells. Exp Cell Res (1999) 0.75
Ectopic expression of human topoisomerase IIalpha fragments and etoposide resistance in mammalian cells. Int J Cancer (2000) 0.75
[Telomere-binding activity of Schizosaccharomyces pombe yeasts]. Mol Biol (Mosk) (2000) 0.75
The nucleosome: from wallflower to Queen of the Ball. Genome Biol (2001) 0.75