Published in Nat Med on September 01, 1996
Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv Drug Deliv Rev (2008) 2.16
Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK. Br J Cancer (2003) 1.46
Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids. Mol Cancer Ther (2008) 1.32
Anti-GD2 antibody therapy for GD2-expressing tumors. Curr Cancer Drug Targets (2010) 1.28
Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu. Br J Cancer (1998) 1.25
Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications. Protein Eng Des Sel (2004) 1.25
High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells. Protein Eng Des Sel (2011) 1.06
High-affinity recombinant phage antibodies to the pan-carcinoma marker epithelial glycoprotein-2 for tumour targeting. Br J Cancer (1998) 1.02
Antigen specificity and tumour targeting efficiency of a human carcinoembryonic antigen-specific scFv and affinity-matured derivatives. Br J Cancer (1998) 0.98
The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies. J Biol Chem (2010) 0.94
Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts. Biochem J (2000) 0.92
Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus. J Mol Biol (2008) 0.85
Immune therapies for neuroblastoma. Cancer Biol Ther (2009) 0.85
Preclinical evaluation of a novel CEA-targeting near-infrared fluorescent tracer delineating colorectal and pancreatic tumors. Int J Cancer (2015) 0.84
Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen. Biomark Insights (2008) 0.84
T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches. Br J Cancer (2003) 0.80
Intrabody and Parkinson's disease. Biochim Biophys Acta (2008) 0.80
Tumour targeting of humanised cross-linked divalent-Fab' antibody fragments: a clinical phase I/II study. Br J Cancer (2002) 0.80
Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites. J Mater Chem B Mater Biol Med (2013) 0.79
Cancer cell-specific internalizing ligands from phage displayed beta-lactamase-peptide fusion libraries. Protein Eng Des Sel (2010) 0.78
Novel beta-lactamase-random peptide fusion libraries for phage display selection of cancer cell-targeting agents suitable for enzyme prodrug therapy. J Drug Target (2010) 0.77
Generation and Characterization of an scFv Directed against Site II of Rabies Glycoprotein. Biotechnol Res Int (2011) 0.77
An improved phage-display panning method to produce an HM-1 killer toxin anti-idiotypic antibody. BMC Biotechnol (2009) 0.76
Cell surface expression of single chain antibodies with applications to imaging of gene expression in vivo. Eur J Nucl Med Mol Imaging (2003) 0.75
The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity. Cancer Immunol Immunother (2017) 0.75
Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study. J Med Genet (1997) 6.85
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science (1997) 6.10
Making antibodies by phage display technology. Annu Rev Immunol (1994) 5.04
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA (2001) 4.75
Carcinoid tumour. Lancet (1998) 4.52
RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase. Nature (1996) 4.04
Relationship between tumour size and uptake of radiolabelled anti-CEA in a colon tumour xenograft. Eur J Nucl Med (1987) 3.16
A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci U S A (1989) 2.81
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
Methods for evaluating the clinical competence of residents in internal medicine: a review. Ann Intern Med (1998) 2.72
Pregnancy and the risk of stroke. N Engl J Med (1996) 2.68
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci U S A (1991) 2.67
Diagnosis of new variant Creutzfeldt-Jakob disease. Ann Neurol (2000) 2.42
Spectinomycin and penicillin G in the treatment of gonorrhea. A comparative evaluation. JAMA (1972) 2.30
A model for the structure and functions of iron-responsive elements. Gene (1988) 2.29
Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell Stress Chaperones (1999) 2.07
Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada. Am J Public Health (1999) 1.99
Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc Natl Acad Sci U S A (1991) 1.93
Retroviral vectors displaying functional antibody fragments. Nucleic Acids Res (1993) 1.87
Duplication of 8p23.1: a cytogenetic anomaly with no established clinical significance. J Med Genet (1998) 1.87
Nocturnal enuresis: an international evidence based management strategy. J Urol (2004) 1.85
The most polymorphic residue on Plasmodium falciparum apical membrane antigen 1 determines binding of an invasion-inhibitory antibody. Infect Immun (2006) 1.85
Assessment methods for alcohol consumption, prevalence of high risk drinking and harm: a sensitivity analysis. Int J Epidemiol (1999) 1.84
Cancer incidence in an area of radioactive fallout downwind from the Nevada Test Site. JAMA (1984) 1.83
Fatal outcome of methemoglobinemia in an infant. JAMA (1987) 1.81
Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology (1998) 1.75
The relative risks and etiologic fractions of different causes of death and disease attributable to alcohol, tobacco and illicit drug use in Canada. CMAJ (2000) 1.68
Cold pressor test in detection of coronary heart-disease and cardiomyopathy using technetium-99m gated blood-pool imaging. Lancet (1979) 1.65
Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease. J Pathol (2001) 1.61
Randomized trial of two physiotherapy interventions for primary care neck and back pain patients: 'McKenzie' vs brief physiotherapy pain management. Rheumatology (Oxford) (2006) 1.55
Homeless youths and young adults in Los Angeles: prevalence of mental health problems and the relationship between mental health and substance abuse disorders. Am J Community Psychol (1997) 1.54
Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen. Mol Cell Biol (1998) 1.53
The economic costs of alcohol, tobacco and illicit drugs in Canada, 1992. Addiction (1998) 1.53
Abatement of toxic levels of carbon monoxide in Seattle ice-skating rinks. Am J Public Health (1975) 1.49
Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial. Br J Cancer (2002) 1.49
Phase III study of 5FU, etoposide and leucovorin (FELV) compared to epirubicin, cisplatin and 5FU (ECF) in previously untreated patients with advanced biliary cancer. Br J Cancer (2005) 1.47
Simulations in the United States Medical Licensing Examination (USMLE). Qual Saf Health Care (2004) 1.46
Post-renal transplant distal limb bone pain. An under-recognized complication of transplantation distinct from avascular necrosis of bone? Transplantation (1995) 1.45
Expedition health and safety: a risk assessment. J R Soc Med (2000) 1.44
Pseudoaneurysm of the brachial artery: a rare complication of blood donation. Transfusion (1994) 1.44
Chlorine and survival of "rugose" Vibrio cholerae. Lancet (1992) 1.43
Genetic basis for clinical expression in multiple sclerosis. Brain (2002) 1.43
Comparison of accuracy of scintimammography and X-ray mammography in the diagnosis of primary breast cancer in patients selected for surgical biopsy. Clin Radiol (1998) 1.41
Training of staff for the delivery of PET/CT services in the UK. Nucl Med Commun (2006) 1.39
Scintigraphic evidence of abnormal ureteric peristalsis following urological surgery. Br J Urol (1994) 1.39
Helping the general physician to improve outcomes after PEG insertion: how we changed our practice. Clin Med (2011) 1.39
Increased expression of c-myc proto-oncogene in biopsies of ulcerative colitis and Crohn's colitis. Gut (1992) 1.38
Fourteen-year follow-up of speech/language-impaired and control children: psychiatric outcome. J Am Acad Child Adolesc Psychiatry (2001) 1.37
The X-linked gene G4.5 is responsible for different infantile dilated cardiomyopathies. Am J Hum Genet (1997) 1.37
Activation of normal neutrophils by anti-neutrophil cytoplasm antibodies. Clin Exp Immunol (1992) 1.37
Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides. Protein Eng (2001) 1.35
High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematol (1990) 1.30
Norwalk virus infection among Desert Storm troops. J Infect Dis (1993) 1.27
Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization. J Biol Chem (1987) 1.26
Loss of heterozygosity in tuberous sclerosis hamartomas. J Med Genet (1996) 1.25
Discovery of antibodies. BMJ (1992) 1.24
Geographic distribution and genetic variability of hepatitis delta virus genotype I. Virology (1997) 1.22
In vivo aggregation of beta-amyloid peptide variants. J Neurochem (1998) 1.22
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging (2001) 1.20
The effect of hypothyroidism on growth, serum growth hormone, the growth hormone-dependent somatomedin, insulin-like growth factor, and its carrier protein in rats. Endocrinology (1979) 1.19
Radioimmunotherapy of metastatic colorectal tumours with iodine-131-labelled antibody to carcinoembryonic antigen: phase I/II study with comparative biodistribution of intact and F(ab')2 antibodies. Br J Cancer (1994) 1.18
Lead poisoning in wild birds from southern Spain: a comparative study of wetland areas and species affected, and trends over time. Ecotoxicol Environ Saf (2006) 1.17
Funding of radiation protection standards research. Am J Public Health (1979) 1.17
Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. J Biol Chem (1992) 1.17
Elevated antihemophilic factor (AHF, factor VIII) procoagulant activity and AHF-like antigen in alcoholic cirrhosis of the liver. J Lab Clin Med (1974) 1.16
The predominance of hepatitis delta virus genotype I among chronically infected Italian patients. Hepatology (1997) 1.16
Plutonium hazard in respirable dust on the surface of soil. Science (1976) 1.15
Liposomally entrapped second antibody improves tumour imaging with radiolabelled (first) antitumour antibody. Lancet (1982) 1.15
Syphilis and neurosyphilis in a human immunodeficiency virus type-1 seropositive population: evidence for frequent serologic relapse after therapy. Am J Med (1995) 1.15
Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol (2000) 1.14
99Tcm-DTPA for the measurement of glomerular filtration rate. Br J Radiol (1976) 1.14
Craniofacial development: the tissue and molecular interactions that control development of the head. Adv Anat Embryol Cell Biol (2003) 1.13
Phage libraries for generation of clinically useful antibodies. Lancet (1994) 1.13
Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer. Br J Cancer (1989) 1.12
Automatic blood pressure monitors. A clinical evaluation of five models in adults. Anaesthesia (1985) 1.12
Rapid-onset dystonia-parkinsonism: a clinical and genetic analysis of a new kindred. Neurology (2000) 1.12
Incontinentia pigmenti--ophthalmological observation of a series of cases and review of the literature. Br J Ophthalmol (2010) 1.11
Injuries resulting in fractures in the Seattle public schools during the school year 1969-70. J Sch Health (1972) 1.11
Black-white differences in stroke risk among young adults. Stroke (1993) 1.10
The 'adenobody' approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther (1997) 1.08
Comparison of high resolution cytogenetics, fluorescence in situ hybridisation, and DNA studies to validate the diagnosis of Prader-Willi and Angelman's syndromes. Arch Dis Child (1995) 1.08
A locus for isolated cleft palate, located on human chromosome 2q32. Am J Hum Genet (1999) 1.07
Prediction of the usefulness of combined mammography and scintimammography in suspected primary breast cancer using ROC curves. J Nucl Med (2001) 1.07
Discovery, purification, and characterization of a temperate transducing bacteriophage for Bordetella avium. J Bacteriol (2000) 1.07
Changes in water level, land use, and hydrological budget in a semi-permanent playa lake, southwest Spain. Environ Monit Assess (2011) 1.06
Captopril radionuclide test in renovascular hypertension: a European multicentre study. European Multicentre Study Group. Eur J Nucl Med (1993) 1.06
Repeated antitumour antibody therapy in man with suppression of the host response by cyclosporin A. Br J Cancer (1988) 1.06
Engineering T cells for cancer therapy. Br J Cancer (2005) 1.05
Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy. Br J Cancer (2005) 1.04
Preparation and properties of mouse monoclonal antibody (W14A) to human chorionic gonadotropin. Int J Cancer (1984) 1.04
Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela. J Gen Virol (2001) 1.04
Efficient transgene regulation from a single tetracycline-controlled positive feedback regulatory system. Gene Ther (1998) 1.03
CEA-like activity in normal colon tissue. Eur J Cancer (1980) 1.02