Published in Antisense Nucleic Acid Drug Dev on January 01, 1996
Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes. Proc Natl Acad Sci U S A (1998) 1.04
Synthesis and use of synthetic oligonucleotides. Annu Rev Biochem (1984) 4.53
Ribozymes as potential anti-HIV-1 therapeutic agents. Science (1990) 4.49
Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc Natl Acad Sci U S A (1994) 2.12
Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J Virol (1995) 1.90
Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA. Proc Natl Acad Sci U S A (2000) 1.88
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA (1997) 1.84
Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A (1999) 1.80
Direct detection of HIV-1 RNA from AIDS and ARC patient samples. DNA (1988) 1.79
Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1. EMBO J (1994) 1.77
Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene. J Virol (1988) 1.73
Expression of small, therapeutic RNAs in human cell nuclei. Gene Ther (1997) 1.71
Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A (1986) 1.70
Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron. Genes Dev (1991) 1.70
Structure and organization of the two tRNATyr gene clusters on the E. coli chromosome. Cell (1979) 1.68
An alternate method for synthesis of double-stranded DNA segments. J Biol Chem (1982) 1.63
The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA (1999) 1.62
Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors. Mol Ther (2000) 1.61
Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. J Exp Med (1987) 1.57
Rhesus monkey model for fetal gene transfer: studies with retroviral- based vector systems. Mol Ther (2001) 1.53
Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli. J Bacteriol (1977) 1.49
Proline excretion and indirect suppression in Escherichia coli and Salmonella typhimurium. J Bacteriol (1974) 1.41
Differential transcription of Pgk genes during spermatogenesis in the mouse. Dev Biol (1992) 1.41
Detection of drug resistance in human tumors by in vitro enzymatic amplification. Cancer Res (1988) 1.40
Differential recovery of auxotrophs after penicillin enrichment in Escherichia coli. J Bacteriol (1971) 1.39
Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc Natl Acad Sci U S A (1991) 1.37
Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells. Proc Natl Acad Sci U S A (1998) 1.37
Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes. J Virol (1993) 1.36
Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. Proc Natl Acad Sci U S A (1996) 1.36
Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice. Biotechniques (2003) 1.34
Progress and prospects: RNA-based therapies for treatment of HIV infection. Gene Ther (2007) 1.34
Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives. Proc Natl Acad Sci U S A (1983) 1.33
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Ther (2008) 1.32
Carrier detection in the Wiskott Aldrich syndrome. Blood (1988) 1.32
Comparison of the effects of growth factors on retroviral vector-mediated gene transfer and the proliferative status of human hematopoietic progenitor cells. Hum Gene Ther (1990) 1.30
RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts. Nucleic Acids Res (2000) 1.27
Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo. Gene Ther (2009) 1.27
Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation. Hum Gene Ther (1998) 1.25
A test for intron function in the yeast actin gene. Nature (1985) 1.24
Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3' splice site. RNA (1996) 1.24
Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo. Nucleic Acids Res (1992) 1.24
Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3' splice site. EMBO J (1986) 1.22
Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion. Cancer Res (1996) 1.22
Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells. J Virol (1997) 1.22
Improved expression in hematopoietic and lymphoid cells in mice after transplantation of bone marrow transduced with a modified retroviral vector. Blood (1999) 1.22
Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene (1994) 1.13
Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line. J Virol (1997) 1.12
The enhanced green fluorescent protein (eGFP) is minimally immunogenic in C57BL/6 mice. Gene Ther (2001) 1.11
Lentiviral-mediated delivery of siRNAs for antiviral therapy. Gene Ther (2006) 1.11
Growth factors increase amphotropic retrovirus binding to human CD34+ bone marrow progenitor cells. Blood (1993) 1.10
Structural organization of Escherichia coli tRNAtyr gene clusters in four different transducing bacteriophages. J Mol Biol (1979) 1.10
Increased levels of spliced RNA account for augmented expression from the MFG retroviral vector in hematopoietic cells. Gene Ther (1996) 1.10
Allogeneic bone marrow transplantation, zidovudine, and human immunodeficiency virus type 1 (HIV-1) infection. Studies in a patient with non-Hodgkin lymphoma. Ann Intern Med (1989) 1.08
Oligonucleotide probes for the detection of TEM-1 and TEM-2 beta-lactamase genes and their transposons. Can J Microbiol (1987) 1.06
An in vitro model of human red blood cell production from hematopoietic progenitor cells. Blood (1998) 1.05
Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood (1999) 1.05
Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes). Hum Gene Ther (1999) 1.04
Isolation and functional analysis of a Kluyveromyces lactis RAP1 homologue. Gene (1994) 1.02
HIV-1-derived lentiviral vectors and fetal route of administration on transgene biodistribution and expression in rhesus monkeys. Gene Ther (2005) 1.01
High-resolution analysis of cytosine methylation in the 5ĺong terminal repeat of retroviral vectors. Hum Gene Ther (1998) 1.01
Retroviral-mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow. J Clin Invest (1992) 1.01
The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors. Gene Ther (2007) 1.00
Detection of antisense and ribozyme accessible sites on native mRNAs: application to NCOA3 mRNA. Mol Ther (2001) 1.00
Expression of human glucocerebrosidase following retroviral vector-mediated transduction of murine hematopoietic stem cells. Bone Marrow Transplant (1991) 1.00
Kluyveromyces lactis maintains Saccharomyces cerevisiae intron-encoded splicing signals. Mol Cell Biol (1989) 0.98
Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells. Blood (1995) 0.97
Isolation of a mouse pseudo tRNA gene encoding CCA--a possible example of reverse flow of genetic information. Nature (1982) 0.97
Downregulation of the CCR5 beta-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts. Antisense Nucleic Acid Drug Dev (2000) 0.97
Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts. Nucleic Acids Res (1998) 0.97
Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches. Mol Ther (2001) 0.95
Inhibition of HIV-1 replication using a mutated tRNALys-3 primer. J Biol Chem (1997) 0.95
Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line. Blood (1993) 0.95
Current progress in the development of RNAi-based therapeutics for HIV-1. Gene Ther (2011) 0.93
Intracellular applications of ribozymes. Methods Enzymol (2001) 0.92
Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony-stimulating factor. Blood (1996) 0.92
Proline excretion in Escherichia coli: a comparison of an argD+ strain and a proline-excreting argD- derivative. Biochem Genet (1977) 0.91
Biological and functional aspects of catalytic RNAs. Crit Rev Eukaryot Gene Expr (1992) 0.91
Effect of enrichment procedure upon auxotroph recovery in Escherichia coli K-12. Antimicrob Agents Chemother (1975) 0.91
Ribozyme-mediated cleavage of an HIV-1 gag RNA: the effects of nontargeted sequences and secondary structure on ribozyme cleavage activity. Antisense Res Dev (1991) 0.91
Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. Circulation (2001) 0.90
Use of polymerase chain reaction to detect the expression of the Mr 70,000 heat shock genes in control or heat shock leukemic cells as correlated to their heat response. Cancer Res (1990) 0.89
Gene therapy for pediatric AIDS. Ann N Y Acad Sci (2000) 0.89
Expression levels by retroviral vectors based upon the N2 and the MFG backbones. Gene Ther (1996) 0.89
Use of a retroviral vector with an internal opsin promoter to direct gene expression to retinal photoreceptor cells. Curr Eye Res (1996) 0.89
T cell depleted haploidentical bone marrow transplantation for the treatment of children with severe combined immunodeficiency. Arch Immunol Ther Exp (Warsz) (2000) 0.88
Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector. Gene Ther (2010) 0.88
Expression of human glucocerebrosidase in murine long-term bone marrow cultures after retroviral vector-mediated transfer. Blood (1990) 0.88
Myoblast gene therapy in canine mucopolysaccharidosis. I: Abrogation by an immune response to alpha-L-iduronidase. Hum Gene Ther (1996) 0.87
Toward gene therapy for Gaucher disease. Hum Gene Ther (1991) 0.87