Published in Br J Pharmacol on June 01, 1996
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J (2001) 2.17
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology (Berl) (2005) 1.51
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) (2005) 1.49
Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms. Pharmacol Rev (2009) 1.40
Autogenic modulation of mechanoreceptor excitability by glutamate release from synaptic-like vesicles: evidence from the rat muscle spindle primary sensory ending. J Physiol (2004) 1.09
Mechanotransduction in the muscle spindle. Pflugers Arch (2014) 0.95
Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs. J Physiol (2001) 0.90
Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system. Br J Pharmacol (2001) 0.81
Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS One (2011) 0.79
Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes. Br J Pharmacol (2000) 0.77
Fear potentiated startle increases phospholipase D (PLD) expression/activity and PLD-linked metabotropic glutamate receptor mediated post-tetanic potentiation in rat amygdala. Neurobiol Learn Mem (2015) 0.76
Synaptic-like vesicles and candidate transduction channels in mechanosensory terminals. J Anat (2015) 0.75
Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Epilepsia (2010) 0.75
The metabotropic glutamate receptors: structure and functions. Neuropharmacology (1995) 5.11
Molecular diversity of glutamate receptors and implications for brain function. Science (1992) 4.90
The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J (1990) 3.44
Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J Biol Chem (1992) 2.21
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett (1993) 2.10
Glutamate stimulates inositol phosphate formation in striatal neurones. Nature (1985) 2.02
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. J Biol Chem (1988) 1.89
Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron (1992) 1.74
Regulation of phospholipase D in HL-60 granulocytes. Activation by phorbol esters, diglyceride, and calcium ionophore via protein kinase- independent mechanisms. J Biol Chem (1989) 1.65
Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci (1993) 1.65
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J Neurosci (1994) 1.59
Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol Sci (1990) 1.53
Feedback regulation of phospholipase C-beta by protein kinase C. J Biol Chem (1990) 1.41
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol Sci (1994) 1.41
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol (1993) 1.30
Receptor regulation of choline phospholipid hydrolysis. A novel source of diacylglycerol and phosphatidic acid. Biochem Pharmacol (1989) 1.27
Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. J Neurochem (1986) 1.26
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J Neurochem (1994) 1.26
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport (1992) 1.20
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature (1990) 1.18
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur J Pharmacol (1994) 1.17
Receptor-coupled phospholipase D and its inhibition. Trends Pharmacol Sci (1991) 1.06
Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology (1995) 1.04
Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C. Biochem Pharmacol (1988) 0.95
Muscarinic acetylcholine receptor regulates phosphatidylcholine phospholipase D in canine brain. J Biol Chem (1989) 0.93
Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist. J Neurochem (1992) 0.91
Desensitization of metabotropic glutamate receptors in neuronal cultures. J Neurochem (1991) 0.91
A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res (1993) 0.90
Pharmacological tools for the investigation of metabotropic glutamate receptors (mGluRs): phenylglycine derivatives and other selective antagonists--an update. Neuropharmacology (1995) 0.90
Subtypes of sodium-dependent high-affinity L-[3H]glutamate transport activity: pharmacologic specificity and regulation by sodium and potassium. J Neurochem (1993) 0.89
Role of phospholipase D activation in nervous system physiology and pathophysiology. J Neurochem (1995) 0.88
Alpha 1-adrenergic receptor-mediated activation of phospholipase D in rat cerebral cortex. J Biol Chem (1992) 0.86
Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. J Neurochem (1992) 0.85
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein. Proc Natl Acad Sci U S A (1992) 0.85
Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation. Neurosci Lett (1992) 0.82
Morphine withdrawal in vitro: potentiation of agonist-dependent polyphosphoinositide breakdown. Eur J Pharmacol (1988) 0.82
L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Mol Pharmacol (1994) 0.82
Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats. J Neurochem (1993) 0.81
Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures. J Neurochem (1988) 0.81
Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus. Neurochem Int (1993) 0.80
Activation of phospholipase D in rabbit neutrophils by fMet-Leu-Phe is mediated by a pertussis toxin-sensitive GTP-binding protein that may be distinct from a phospholipase C-regulating protein. FEBS Lett (1991) 0.78
Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation. J Neurochem (1992) 0.78
Phospholipase C and phospholipase D are independently activated in rat hippocampal slices. Biochem Pharmacol (1994) 0.77
The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders. Trends Neurosci (1997) 2.38
High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. J Neurochem (2007) 1.77
Neurophysiological effects of mobile phone electromagnetic fields on humans: a comprehensive review. Bioelectromagnetics (2007) 1.64
Increased kynurenic acid levels in Huntington's disease. Lancet (1988) 1.43
Presynaptic kynurenate-sensitive receptors inhibit glutamate release. Eur J Neurosci (2001) 1.27
Adenosine decreases aspartate and glutamate release from rat hippocampal slices. Eur J Pharmacol (1984) 1.19
Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Agents Actions (1978) 1.11
Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci (1994) 1.11
Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br J Pharmacol (2001) 1.09
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J Pharmacol Exp Ther (1997) 1.05
Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats. Br J Pharmacol (1986) 1.04
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J Cereb Blood Flow Metab (1999) 1.03
Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid. J Neurochem (2001) 1.02
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience (1994) 0.99
Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci (1990) 0.99
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. Neuroscience (2001) 0.99
The role of T and B cells in human atherosclerosis and atherothrombosis. Clin Exp Immunol (2015) 0.98
Is the brain influenced by a phone call? An EEG study of resting wakefulness. Neurosci Res (2005) 0.97
Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. Neuropharmacology (1999) 0.97
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. J Neurochem (1995) 0.96
The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus. Neurosci Lett (1986) 0.96
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. J Neuroimmunol (2001) 0.95
Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. J Viral Hepat (2006) 0.95
Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase. J Neurochem (1996) 0.95
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. Eur J Neurosci (1999) 0.95
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J Med Chem (1995) 0.94
Electrical stimulation of the stratum radiatum increases the release and neosynthesis of aspartate, glutamate, and gamma-aminobutyric acid in rat hippocampal slices. J Neurochem (1983) 0.92
Effect of associated antiepileptic treatment on valproate-induced hyperammonemia. Ther Drug Monit (1985) 0.92
Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death. Br J Pharmacol (2008) 0.91
Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation. J Neurochem (1988) 0.91
The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain. Brain Res (1984) 0.91
Ureterocalicostomy in the treatment of pyeloplasty failures. Urol Int (1992) 0.91
Fidia and neuroscience. Nature (1993) 0.90
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. Neuropharmacology (1999) 0.90
Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum. Br J Pharmacol (1993) 0.89
Interaction of histamine H1-and H2-receptor antagonists with histamine uptake and metabolism by guinea-pig isolated atrium and mouse neoplastic mast cells cells in vitro. Br J Pharmacol (1975) 0.89
The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells. Agents Actions (1977) 0.88
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound. FEBS Lett (1999) 0.88
Effects of histamine and noradrenaline on contractile force of guinea-pig ventricular strips: antagonism by burimamide and metiamide. Agents Actions (1974) 0.87
General anaesthetics inhibit the responses induced by glutamate receptor agonists in the mouse cortex. Neurosci Lett (1992) 0.87
beta endorphin inhibits ACh turnover in nuclei of rat brain. Nature (1977) 0.86
GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res (1983) 0.86
Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine versus 3, 5-dihydroxyphenylglycine. Mol Pharmacol (1999) 0.86
Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions. J Neurochem (1992) 0.86
Glutamate receptor antagonists protect against ischemia-induced retinal damage. Eur J Pharmacol (1994) 0.86
Clinical findings and follow-up evaluation of an outbreak of mushroom poisoning--survey of Amanita phalloides poisoning. Klin Wochenschr (1986) 0.85
Uptake, disposition and metabolism of histamine in isolated heart preparations. Br J Pharmacol (1973) 0.85
Melatonin is an efficient antioxidant. Arch Gerontol Geriatr (2004) 0.85
Clinical pharmacokinetics of valproic acid--1988. Clin Pharmacokinet (1988) 0.85
Interactions between enkephalinergic and other neuronal systems. Adv Biochem Psychopharmacol (1978) 0.85
Agonists, antagonists and modulators of excitatory amino acid receptors in the guinea-pig myenteric plexus. Br J Pharmacol (1988) 0.85
The release of gamma-aminobutyric acid, glutamate, and acetylcholine from striatal slices: a mass fragmentographic study. J Neurochem (1981) 0.84
Visceral hypersensitivity and intolerance symptoms in lactose malabsorption. Neurogastroenterol Motil (2007) 0.84
Electroencephalographic sleep inertia of the awakening brain. Neuroscience (2010) 0.83
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist. Eur J Neurosci (1997) 0.83
Inhibition of acetylcholine turnover in rat hippocampus by intraseptal injections of beta-endorphin and morphine. Naunyn Schmiedebergs Arch Pharmacol (1977) 0.83
Topical mannitol reduces inflammatory edema in a rat model of arthritis. Pharmacology (2012) 0.83
Morphine withdrawal in vitro: potentiation of agonist-dependent polyphosphoinositide breakdown. Eur J Pharmacol (1988) 0.82
Crystalline silica induces apoptosis in human endothelial cells in vitro. Cell Biol Toxicol (2004) 0.81
Calcium gluconate and hypertonic sodium chloride in a case of massive verapamil poisoning. Clin Toxicol (1980) 0.81
Modulation of ACh turnover in the septal-hippocampal pathway by electrical stimulation and lesioning. Brain Res (1978) 0.81
Studies on the 14C-histamine release induced by histamine in mouse neoplastic mast cells. Agents Actions (1975) 0.81
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase. J Med Chem (1994) 0.81
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices. Br J Pharmacol (1996) 0.81
Modulation of cortical acetylcholine and gamma-aminobutyric acid release in freely moving guinea pigs: effects of clonidine and other adrenergic drugs. J Pharmacol Exp Ther (1983) 0.81
Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis. J Neurochem (1999) 0.81
Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release. Br J Pharmacol (1988) 0.81
Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity. Neuroscience (2002) 0.81
Melatonin regulates the respiratory burst of human neutrophils and their depolarization. J Pineal Res (1998) 0.81
Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. Naunyn Schmiedebergs Arch Pharmacol (1978) 0.80
The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process. Neurosci Lett (1984) 0.80
Food restriction in female Wistar rats. I. Survival characteristics, membrane microviscosity and proliferative response in lymphocytes. Arch Gerontol Geriatr (2004) 0.80
The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J Neurochem (1983) 0.80
Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition. Clin Neuropharmacol (1986) 0.80
Melatonin increases the intensity of respiratory burst and prevents L-selectin shedding in human neutrophils in vitro. Biochem Biophys Res Commun (1998) 0.80
Action of antischizophrenic drugs on the metabolism of gamma-aminobutyric acid and acetylcholine in globus pallidus, striatum and n. accumbens. Fed Proc (1978) 0.80
Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology (1999) 0.80
Combined inhibition of indoleamine 2,3-dioxygenase and nitric oxide synthase modulates neurotoxin release by interferon-gamma-activated macrophages. J Leukoc Biol (2000) 0.80
Release of GABA from the guinea-pig neocortex induced by electrical stimulation of the 'locus coeruleus' or by norepinephrine. Brain Res (1982) 0.80
Increase in kynurenic acid in Huntington's disease motor cortex. J Neurochem (1989) 0.80
A trend in the therapy of Amanita phalloides poisoning. Arch Toxicol (1976) 0.79
MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. Br J Pharmacol (2013) 0.79
Food restriction in female Wistar rats: V. Lipid peroxidation and antioxidant enzymes in the liver. Arch Gerontol Geriatr (2004) 0.79
Proceedings: Definition of the antagonistic action of burimamide and metiamide on the positive inotropic effect of histamine in isolated heart preparations. Br J Pharmacol (1974) 0.79
Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation. Mech Ageing Dev (1993) 0.79
The guinea pig myenteric plexus as a tool to characterize drugs active at the glycine recognition site of the NMDA receptors. Pharmacol Res (1991) 0.79
Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations. Br J Pharmacol (1996) 0.79
Senile dementia and Alzheimer's disease: lack of changes of the cortical content of quinolinic acid. Neurobiol Aging (1986) 0.79
Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. A phase II study. Cancer (1994) 0.79
Food restriction increases the protection of erythrocytes against the hemolysis induced by peroxyl radicals. Mech Ageing Dev (1996) 0.79
Pyrrolidone carboxylic acid in acute and chronic alcoholism. Preclinical and clinical studies. Recenti Prog Med (1989) 0.79
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure. J Neurochem (1986) 0.79
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat. J Pharm Pharmacol (1982) 0.79
Naloxone administration releases catecholamines. N Engl J Med (1983) 0.79
Opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat. J Pharmacol Exp Ther (1978) 0.79
Pharmacological effects of benzodiazepines in the leech; benzodiazepine and GABA receptors and GABA level. Pharmacol Res Commun (1980) 0.78
8-Phenyltheophylline potentiates the electrical activity evoked in hippocampal slices. Eur J Pharmacol (1984) 0.78
Pyroglutamic acid administration modifies the electrocorticogram and increases the release of acetylcholine and GABA from the guinea-pig cerebral cortex. Pharmacol Res Commun (1984) 0.78