Published in Annu Rev Genet on January 01, 1995
A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A (1998) 8.40
The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47
Plant Disease Resistance Genes: Function Meets Structure. Plant Cell (1996) 4.47
A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J (1998) 3.13
Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev (1999) 3.05
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
The Toll pathway is important for an antiviral response in Drosophila. Proc Natl Acad Sci U S A (2005) 2.97
Genetics of mosquito vector competence. Microbiol Mol Biol Rev (2000) 2.19
Maternal control of early mouse development. Development (2010) 2.13
A positional Toll receptor code directs convergent extension in Drosophila. Nature (2014) 1.77
Tracheary element differentiation uses a novel mechanism coordinating programmed cell death and secondary cell wall synthesis Plant Physiol (1999) 1.74
Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae. BMC Genomics (2005) 1.73
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A (1997) 1.67
Nuclear trapping shapes the terminal gradient in the Drosophila embryo. Curr Biol (2008) 1.63
Brassinosteroids and plant steroid hormone signaling. Plant Cell (2002) 1.59
Crystal structure of a clip-domain serine protease and functional roles of the clip domains. EMBO J (2005) 1.58
Pollen tube localization implies a role in pollen-pistil interactions for the tomato receptor-like protein kinases LePRK1 and LePRK2. Plant Cell (1998) 1.55
Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2. Am J Pathol (2010) 1.46
Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate. EMBO J (2001) 1.43
Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem Mol Biol (2005) 1.41
The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily. Proc Natl Acad Sci U S A (1998) 1.40
Activation of a protease cascade involved in patterning the Drosophila embryo. Proc Natl Acad Sci U S A (2001) 1.35
Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology (2002) 1.33
Models of infectious diseases in the fruit fly Drosophila melanogaster. Dis Model Mech (2008) 1.24
Gastrulation defective is a serine protease involved in activating the receptor toll to polarize the Drosophila embryo. Proc Natl Acad Sci U S A (2000) 1.17
members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Genes Dev (2000) 1.16
Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2. Infect Immun (2001) 1.11
Functional genomics of 5- to 8-cell stage human embryos by blastomere single-cell cDNA analysis. PLoS One (2010) 1.10
Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta. FEBS J (2009) 1.09
The origin of dorsoventral polarity in Drosophila. Philos Trans R Soc Lond B Biol Sci (2003) 1.05
The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila. PLoS One (2008) 1.05
Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev (1999) 1.05
Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol (2005) 1.02
Maternal effect for DNA mismatch repair in the mouse. Genetics (2002) 1.02
Interallelic complementation at the Drosophila melanogaster gastrulation defective locus defines discrete functional domains of the protein. Genetics (2001) 1.02
windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum. Genes Dev (1998) 1.02
Proteolytic activation of pro-spätzle is required for the induced transcription of antimicrobial peptide genes in lepidopteran insects. Dev Comp Immunol (2007) 1.01
Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development. Mol Cell Biol (2008) 1.00
18 wheeler regulates apical constriction of salivary gland cells via the Rho-GTPase-signaling pathway. Dev Biol (2007) 0.99
A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFkappaB. Dev Genes Evol (2003) 0.98
Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum. Proc Natl Acad Sci U S A (2000) 0.98
Transcriptome analysis and discovery of genes involved in immune pathways from hepatopancreas of microbial challenged mitten crab Eriocheir sinensis. PLoS One (2013) 0.96
The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis. Genetics (1996) 0.94
Gastrulation defective, a complement factor C2/B-like protease, interprets a ventral prepattern in Drosophila. EMBO Rep (2001) 0.94
A computational statistics approach for estimating the spatial range of morphogen gradients. Development (2011) 0.93
Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes. BMC Dev Biol (2008) 0.92
Proteomic-based identification of maternal proteins in mature mouse oocytes. BMC Genomics (2009) 0.91
Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae. PLoS One (2013) 0.88
Transcriptional analysis of an immune-responsive serine protease from Indian malarial vector, Anopheles culicifacies. BMC Mol Biol (2007) 0.87
The Dorsal Rel homology domain plays an active role in transcriptional regulation. Mol Cell Biol (2002) 0.86
Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe. Development (2009) 0.86
Biochemical defects of mutant nudel alleles causing early developmental arrest or dorsalization of the Drosophila embryo. Genetics (2000) 0.85
DmMyD88 controls dorsoventral patterning of the Drosophila embryo. EMBO Rep (2003) 0.84
Genetics on the Fly: A Primer on the Drosophila Model System. Genetics (2015) 0.83
A Toll-Spätzle pathway in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol (2012) 0.83
The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics (2001) 0.82
Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila. Dev Genes Evol (2011) 0.81
XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. EMBO J (2007) 0.81
Cross talk and interference enhance information capacity of a signaling pathway. Biophys J (2013) 0.79
A ventrally localized protease in the Drosophila egg controls embryo dorsoventral polarity. Curr Biol (2012) 0.78
Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity. Proc Natl Acad Sci U S A (2014) 0.77
Differential expression of toll-like receptors in the human placenta across early gestation. Placenta (2016) 0.75
Ndae1 expression and regulation in Drosophila embryos. PLoS One (2014) 0.75
Toll-tally tubular: A newly identified Toll-like receptor-FoxO pathway regulates dynamics of the neuronal microtubule network. J Cell Biol (2016) 0.75
The 2012 Thomas Hunt Morgan medal: Kathryn V. Anderson. Genetics (2012) 0.75
Preliminary X-ray crystallographic analysis of the catalytic domain of prophenoloxidase activating factor-I. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol (1996) 4.74
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell (1988) 4.36
Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell (1985) 3.24
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature (2001) 3.23
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev (1991) 2.98
Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature (1984) 2.60
Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell (1992) 2.48
The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell (1994) 2.30
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell (1985) 2.22
A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A (1998) 2.18
Rates of synthesis of major classes of RNA in Drosophila embryos. Dev Biol (1979) 2.02
The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase. Genes Dev (2001) 2.01
Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics (1988) 1.99
Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo. Development (1992) 1.95
Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature (1998) 1.86
The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo. Cell (1989) 1.75
A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development (1994) 1.54
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation. Development (1991) 1.49
Changing rates of histone mRNA synthesis and turnover in Drosophila embryos. Cell (1980) 1.49
Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev (1995) 1.49
Activation of the easter zymogen is regulated by five other genes to define dorsal-ventral polarity in the Drosophila embryo. Development (1992) 1.32
Changing rates of DNA and RNA synthesis in Drosophila embryos. Dev Biol (1981) 1.13
Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics (1993) 1.13
Positive and negative regulation of Easter, a member of the serine protease family that controls dorsal-ventral patterning in the Drosophila embryo. Development (1998) 1.11
Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol (2000) 1.11
Drosophila immunity: genes on the third chromosome required for the response to bacterial infection. Genetics (2001) 1.11
Extracellular proteases and embryonic pattern formation. Trends Cell Biol (1992) 1.05
Embryonic patterning mutants of Tribolium castaneum. Development (1996) 1.04
Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. Cell (1990) 0.92
Dorsal-ventral pattern formation in the Drosophila embryo: the role of zygotically active genes. Curr Top Dev Biol (1991) 0.92
fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning. Dev Biol (2001) 0.89
Retinal damage after prolonged exposure to visible light. A light and electron microscopic study. Am J Anat (1972) 0.86
Photoreceptor degeneration in albino rats: dependency on age. Invest Ophthalmol (1974) 0.85
Interaction of tooth pulp and periodontal ligament receptors in a jaw-depression reflex. Exp Neurol (1971) 0.84
Related signaling networks in Drosophila that control dorsoventral patterning in the embryo and the immune response. Cold Spring Harb Symp Quant Biol (1997) 0.84
C-Fiber activity in feline tooth pulp afferents. Exp Neurol (1975) 0.84
Reticular modulation of higher auditory centers in monkey. Exp Neurol (1967) 0.83
Changes in plasma triacylglycerol concentrations among free-living hyperlipidemic men adopting different carbohydrate intakes over 2 y: the Dietary Alternatives Study. Am J Clin Nutr (1995) 0.83
Photically evoked responses in the visual system of rats exposed to continuous light. Exp Neurol (1971) 0.82
The origin of spontaneous, rhythmic potentials in the visual system of rats. Exp Neurol (1971) 0.81
Photoreceptor degeneration after exposure of rats to incandescent illumination. Z Zellforsch Mikrosk Anat (1972) 0.80
Conduction velocities in afferent fibers from feline tooth pulp. Exp Neurol (1974) 0.78
The superior colliculus and higher visual functions in the monkey. Brain Res (1969) 0.78
Altered patterns of gene expression in Tribolium segmentation mutants. Dev Genet (1998) 0.78
Effects of short-term low intensity light on the albino rat retina. An electron microscopic study. Am J Anat (1973) 0.77
Neuronal receptive field properties in feline nucleus reticularis gigantocellularis. Brain Res Bull (1979) 0.77
Response patterns of cells in the feline caudal nucleus reticularis gigantocellularis after noxious trigeminal and spinal stimulation. Exp Neurol (1978) 0.77
Interactions between nucleus centrum medianum and gigantocellular nociceptive neurons. Brain Res Bull (1980) 0.76
Simultaneous demonstration of neuronal somata that innervate the tooth pulp and adjacent periodontal tissues, using two retrogradely transported anatomic markers. Exp Neurol (1984) 0.76
Retinal degeneration produced by low-intensity colored light. Exp Neurol (1972) 0.76
Localization and morphometric analysis of masticatory muscle afferent neurons in the nucleus of the mesencephalic root of the trigeminal nerve in the cat. Acta Anat (Basel) (1985) 0.76
Response properties of cells in the dorsal lateral geniculate nucleus of the albino rat. J Neurosci Res (1977) 0.76
Extraocular muscle degeneration and regeneration after exposure of rats to incandescent radiant energy. J Cell Sci (1975) 0.76
Effect of high-frequency peripheral nerve and dorsal column stimulation on neuronal responses in feline nucleus reticularis gigantocellularis after nociceptive electrical stimulation. Exp Neurol (1977) 0.75
Activation of pain pathways in animals. Am J Anat (1970) 0.75
Jaw depression elicited by tooth pulp stimulation. Exp Neurol (1970) 0.75
Black-white and pattern discrimination in rats without photoreceptors. Exp Neurol (1972) 0.75
Comparison of light-microscopic methods for visualizing horseradish peroxidase granules in stained and unstained tissue. J Neurosci Res (1978) 0.75
Central neurophysiological correlates of constant light-induced retinal degeneration. Exp Neurol (1979) 0.75
Location of feline trigeminal ganglion cells innervating maxillary canine teeth: a horseradish peroxidase analysis. Exp Neurol (1977) 0.75
The use of the Fink-Heimer II technique to stain degenerating peripheral nerve fibers. Stain Technol (1975) 0.75
Peripheral uptake of glucose during sepsis. Surg Forum (1979) 0.75
Behavioral correlates of constant light-induced retinal degeneration. Exp Neurol (1979) 0.75
Spontaneous, rhythmic potentials recorded from the eye of rats. Exp Neurol (1971) 0.75
Interaction of tooth pulp and periodontal ligament receptors in the dog and monkey. Exp Neurol (1971) 0.75
Anatomic evidence revealing extensive transmedian innervation of feline canine teeth. Exp Neurol (1977) 0.75
Response of cells in feline nucleus centrum medianum to tooth pulp stimulation. Brain Res Bull (1980) 0.75
Altered response latencies on visual discrimination tasks in rats with damaged retinas. Physiol Behav (1974) 0.75
Single-cell responses associated with rhythmic slow-wave potentials in rat superior colliculi. J Neurosci Res (1975) 0.75
Behavioral evidence showing the predominance of diffuse pain stimuli over discrete stimuli in influencing perception. J Neurosci Res (1976) 0.75
Transmedian innervation of canine tooth pulp in cats. Exp Neurol (1974) 0.75