PubRank

R B Meyer

Author PubWeight™ 52.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures. Nucleic Acids Res 2000 5.24
2 Efficient priming of PCR with short oligonucleotides conjugated to a minor groove binder. Nucleic Acids Res 1997 2.29
3 Facile preparation of nuclease resistant 3' modified oligodeoxynucleotides. Nucleic Acids Res 1993 1.51
4 Oligodeoxyribonucleotides with conjugated dihydropyrroloindole oligopeptides: preparation and hybridization properties. Bioconjug Chem 1995 1.45
5 Oligonucleotides containing 2-aminoadenine and 2-thiothymine act as selectively binding complementary agents. Biochemistry 1996 1.42
6 Sequence-specific arrest of primer extension on single-stranded DNA by an oligonucleotide-minor groove binder conjugate. Proc Natl Acad Sci U S A 1996 1.35
7 Oligonucleotides with conjugated dihydropyrroloindole tripeptides: base composition and backbone effects on hybridization. Nucleic Acids Res 1997 1.32
8 Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci 1974 1.27
9 Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphate. J Biol Chem 1975 1.16
10 Electromechanical Fredericks effects in nematic gels. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 1999 1.16
11 2' Derivatives of guanosine and inosine cyclic 3',5'-phosphates. Synthesis, enzymic activity, and the effect of 8-substituents. Biochemistry 1976 1.13
12 G/C-modified oligodeoxynucleotides with selective complementarity: synthesis and hybridization properties. Nucleic Acids Res 1996 1.11
13 Solution structure of a highly stable DNA duplex conjugated to a minor groove binder. Nucleic Acids Res 1998 1.03
14 Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5. Nucleic Acids Res 1998 1.03
15 Antiviral activity of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid. Antimicrob Agents Chemother 1977 1.00
16 Acridine- and cholesterol-derivatized solid supports for improved synthesis of 3'-modified oligonucleotides. Bioconjug Chem 1992 1.00
17 Direct, solid phase assembly of dihydropyrroloindole peptides with conjugated oligonucleotides. Bioconjug Chem 1997 0.99
18 Sequence-specific covalent modification of DNA by cross-linking oligonucleotides. Catalysis by RecA and implication for the mechanism of synaptic joint formation. Biochemistry 1995 0.94
19 Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. J Am Chem Soc 1976 0.94
20 Factors influencing the extent and regiospecificity of cross-link formation between single-stranded DNA and reactive complementary oligodeoxynucleotides. Biochemistry 1994 0.87
21 Synthesis and antiviral acticity of some phosphates of the broad-spectrum antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin). J Med Chem 1978 0.87
22 Synthesis and reactivity of aryl nitrogen mustard-oligodeoxyribonucleotide conjugates. Bioconjug Chem 1998 0.87
23 2,5-Anhydro-1-deoxy-1-phosphono-D-altritol, an isosteric analogue of alpha-D-ribofuranose 1-phosphate. J Med Chem 1984 0.87
24 Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides. Nucleic Acids Res 1997 0.86
25 An improved CPG support for the synthesis of 3'-amine-tailed oligonucleotides. Bioconjug Chem 1992 0.86
26 Synthesis and biological activity of several 6-substituted 9- -D-ribofuranosylpurine 3',5',-cyclic phosphates. Biochemistry 1972 0.85
27 Synthesis, intramolecular hydrogen bonding, and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside. J Med Chem 1988 0.85
28 RecA-catalyzed, sequence-specific alkylation of DNA by cross-linking oligonucleotides. Effects of length and nonhomologous base substitutions. Biochemistry 1996 0.84
29 Preparation and hybridization properties of oligonucleotides containing 1-alpha-D-arabinofuranosylthymine. Nucleic Acids Res 1991 0.83
30 Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines. J Med Chem 1980 0.82
31 Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole. Nucleic Acids Res 1996 0.82
32 In vitro antiviral activity of 6-substituted 9-beta-D-ribofuranosylpurine 3', 5'-cyclic phosphates. Antimicrob Agents Chemother 1974 0.81
33 Nucleosides of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogues of enzymes in pyrimidine nucleoside metabolism. J Med Chem 1988 0.81
34 Design and synthesis of tetrahedral intermediate analogues as potential dihydroorotase inhibitors. J Med Chem 1984 0.81
35 Sequence-specific targeting and covalent modification of human genomic DNA. Nucleic Acids Res 1997 0.80
36 Letter: A new class of potent guanine antimetabolites. Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. J Am Chem Soc 1975 0.80
37 Synthesis of fused [1,2,6]thiadiazine 1,1-dioxides as potential transition-state analogue inhibitors of xanthine oxidase and guanase. J Med Chem 1979 0.80
38 Linkers designed to intercalate the double helix greatly facilitate DNA alkylation by triplex-forming oligonucleotides carrying a cyclopropapyrroloindole reactive moiety. Nucleic Acids Res 1999 0.80
39 Synthesis and enzymatic and inotropic activity of some new 8-substituted and 6,8-disubstituted derivatives of adenosine cyclic 3',5'-monophosphate. J Med Chem 1980 0.80
40 Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides. Nucleic Acids Res 1997 0.80
41 Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids. J Med Chem 1984 0.79
42 Irreversible enzyme inhibitors. LXXXIV. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. IX. Derivatives of 2,4-diaminopyrimidine. 3. J Pharm Sci 1967 0.78
43 Enhancement of interferon antiviral action in L-cells by cyclic nucleotides. Proc Soc Exp Biol Med 1974 0.78
44 Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides. J Med Chem 1981 0.78
45 Pyridine nucleosides related to 5-fluorouracil and thymine. J Med Chem 1973 0.77
46 Synthesis of some 1, 8- and 2, 8-disubstituted derivatives of adenosine cyclic 3', 5'-phosphate and their interaction with some enzymes of cAMP metabolism. J Med Chem 1976 0.77
47 Modulation of Cm/T, G/A, and G/T triplex stability by conjugate groups in the presence and absence of KCl. Biochemistry 1997 0.77
48 Effect of modification of the 1-, 2-, and 6-positions of 9-beta-D-ribofuranosylpurine cyclic 3',5'-phosphate on the cyclic nucleotide specificity of adenosine cyclic 3',5'-phosphate- and guanosine cyclic 3',5'-phosphate-dependent protein kinases. Biochem Pharmacol 1981 0.77
49 Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position. J Med Chem 1968 0.76
50 Synthesis and enzymic studies of 5-aminoimidazole and N-1-and N6-substituted adenine ribonucleoside cyclic 3',5'-phosphates prepared from adenosine cyclic 3',5'-phosphate. J Med Chem 1973 0.76
51 Targeted mutagenesis of DNA with alkylating RecA assisted oligonucleotides. Nucleic Acids Res 1999 0.75
52 Transmission studies of Bovine anaplasmosis with the horseflies, Tabanus fuscicostatus and Tabanus nigrovittatus. Am J Vet Res 1966 0.75
53 Genetic testing legislation: a review of the past two years. J Insur Med 1998 0.75
54 Interaction of "aza" and "deaza" analogs of adenosine cyclic 3', 5'-phosphate with some enzymes of adenosine cyclic 3', 5'-phosphate metabolism: evidence that the lone pair electrons of N-3 are involved in the binding of adenosine cyclic 3', 5'-phosphate to type II adenosine cyclic 3', 5'-phosphate-dependent protein kinase. J Cyclic Nucleotide Res 1978 0.75
55 Irrevesible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal sulfonyl fluoride. J Med Chem 1969 0.75
56 Irreversible enzyme inhibitors. CLIV. Some factors in cell wall transport of active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-substituted 2,4-diaminopyrimidines. J Med Chem 1969 0.75
57 Discovery of short, 3'-cholesterol-modified DNA duplexes with unique antitumor cell activity. Cancer Res 1994 0.75
58 2-substituted derivatives of adenosine and inosine cyclic 3',5'-phosphate. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase. Biochemistry 1975 0.75
59 Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride. J Med Chem 1969 0.75
60 Structure of two hydroxylated metabolites of ftorafur. Biochem Pharmacol 1980 0.75
61 Quantitative high-pressure liquid chromatographic procedure for the determination of plasma and tissue levels of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (metoprine) and its application to the measurement of brain capillary permeability coefficients. J Chromatogr 1978 0.75
62 Irreversible enzyme inhibitors. LXXXII. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. VII. Derivatives of 2,4-diaminopyrimidine. I. J Pharm Sci 1967 0.75
63 Irreversible enzyme inhibitors. 133. Studies on differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse. J Med Chem 1969 0.75
64 Synthesis and enzymic activity of 8-acyl and 8-alkyl derivatives of guanosine 3, 5-cyclic phosphate. Biochemistry 1975 0.75
65 Structure-activity relationships of cytotoxic cholesterol-modified DNA duplexes. J Med Chem 1995 0.75
66 2'-O-Acyl-6-thioinosine cyclic 3',5'-phosphates as prodrugs of thioinosinic acid. J Med Chem 1979 0.75
67 [Diagnostic significance of so-called Veraguth's upper lid folds in depressions]. Schweiz Arch Neurol Neurochir Psychiatr 1970 0.75
68 A new purine ring closure and the synthesis of 2-substituted derivatives of adenosine cyclic 3',5'-phosphate. J Am Chem Soc 1974 0.75
69 Irreversible enzyme inhibitors. CXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-substituted 2,4-diamino-5-phenylpyrimidines. 3. J Med Chem 1968 0.75
70 A novel biotinylated adenylate analogue derived from pyrazolo[3,4-d]pyrimidine for labeling DNA probes. Bioconjug Chem 1992 0.75
71 Irreversible enzyme inhibitors. CXLII. Further studies on active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-Aminophenoxypropyl)-2,4,6-triaminopyrimidine bearing a terminal sulfonyl fluoride. J Med Chem 1969 0.75
72 6-aminopyrazolo[4,3-c]pyridin-4(5H)-one, a novel analogue of guanine. J Med Chem 1977 0.75
73 Adenosine cyclic 3',5',-monophosphate phosphodiesterasr inhibitors. 2.3-Substituted 5,7-dialkylpyrazolo [1,5-a]pyrimidines. J Med Chem 1975 0.75