Prevention by chlorpromazine of ischemic liver cell death.

PubWeight™: 1.31‹?› | Rank: Top 10%

🔗 View Article (PMC 2032382)

Published in Am J Pathol on September 01, 1977

Authors

K R Chien, J Abrams, R G Pfau, J L Farber

Articles citing this

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J Cell Biol (1982) 2.54

Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. Am J Pathol (1981) 2.28

Lethal myocardial ischemic injury. Am J Pathol (1981) 2.05

Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion. J Clin Invest (1993) 1.66

A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states. Biochem J (1990) 1.42

Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. J Clin Invest (1985) 1.10

Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction. Am J Pathol (1979) 1.01

Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. J Clin Invest (1988) 0.95

Dependence of the carbon-tetrachloride--induced death of cultured hepatocytes on the extracellular calcium concentration. Am J Pathol (1981) 0.92

Pharmacologic modulation of experimental postischemic hepatic function. Ann Surg (1989) 0.92

Lipid peroxidation is a nonparenchymal cell event with reperfusion after prolonged liver ischemia. J Surg Res (1990) 0.86

Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am J Pathol (1989) 0.85

Irreversible ischemic cell injury. Prevention by chlorpromazine of the aggregation of the intramembranous particles of rat liver plasma membranes. Am J Pathol (1978) 0.83

The role of calcium ions in toxic cell injury. Environ Health Perspect (1990) 0.83

Effect of a transitory ischaemia on the structure-linked latency of rat liver acid phosphatase and beta-galactosidase. Biochem J (1981) 0.77

Altered calcium homeostasis in irreversibly injured P388D1 macrophages. Am J Pathol (1990) 0.77

Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke. Mol Neurobiol (2016) 0.76

The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate. Am J Pathol (1980) 0.76

Effects of the phospholipase inhibitor mepacrine on injury in ischemic and metabolically inhibited adult isolated myocytes. Am J Pathol (1991) 0.75

Effects of chloroquine and Nifedipine on the phospholipid content and enzyme activity in the subcellular fraction of ischemic rat liver. Basic Res Cardiol (1982) 0.75

Articles cited by this

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

The membrane actions of anesthetics and tranquilizers. Pharmacol Rev (1972) 11.00

Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol (1968) 3.85

Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation. Am J Pathol (1974) 2.71

The role of cell swelling in ischemic renal damage and the protective effect of hypertonic solute. J Clin Invest (1972) 2.38

Reduction of experimental myocardial infarct size by corticosteroid administration. J Clin Invest (1973) 2.28

Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle. Br J Pharmacol (1969) 2.26

Membrane stabilization by drugs: tranquilizers, steroids, and anesthetics. Int Rev Neurobiol (1966) 2.10

Regulation of intracellular fluid volume and disease. Am J Med (1970) 2.04

Reduction by propranolol of myocardial necrosis following temporary coronary artery occlusion in dogs. Circ Res (1973) 1.65

Biochemical changes in liver in acute thioacetamide intoxication. J Pathol Bacteriol (1956) 1.64

Cell swelling. A factor in ischemic tissue injury. Circulation (1973) 1.62

Propranolol in the treatment of acute myocardial infarction. Effect on myocardial oxygenation and hemodynamics. Circulation (1974) 1.60

ULTRASTRUCTURAL CYTOPLASMIC CHANGES OF LIVER CELLS AFTER REVERSIBLE AND IRREVERSIBLE ISCHEMIA. Exp Mol Pathol (1964) 1.52

Reduction by hyaluronidase of myocardial necrosis following coronary artery occlusion. Circulation (1972) 1.50

The pathogenesis of liver injury in carbon tetrachloride and thioacetamide poisoning. J Pathol Bacteriol (1961) 1.39

THE PHENOTHIAZINETRANQUILIZERS: BIOCHEMICAL AND BIOPHYSICAL ACTIONS. Int Rev Neurobiol (1964) 1.38

Calcium reversal of nerve blockade by alcohols, anesthetics, tranquilizers, and barbiturates. Can J Physiol Pharmacol (1974) 1.31

Effects of local anaesthetics on phospholipases. Biochim Biophys Acta (1976) 1.27

The role of glucose in the survival and 'recovery' of the anoxic isolated perfused rat heart. Biochem J (1972) 1.20

Ventricular arrhythmias and K+ transfer during myocardial ischemia and intervention with procaine amide, insulin, or glucose solution. J Clin Invest (1967) 1.20

On the molecular pathology of ischemic renal cell death. Reversible and irreversible cellular and mitochondrial metabolic alterations. Am J Pathol (1968) 1.19

Effect of propranolol on regional myocardial blood flow in acute ischaemia. Cardiovasc Res (1970) 1.15

Mechanism of cellular damage by virus: a study of antihistamine drugs. I. Murine hepatitis virus and liver explant cultures. Exp Mol Pathol (1962) 1.14

Early, reversible plasma membrane injury in galactosamine-induced liver cell death. Am J Pathol (1975) 1.14

Hyaluronidase-induced reductions in myocardial infarct size. Science (1976) 1.11

The glucose-insulin-potassium (GIK) regimen in the treatment of myocardial ischemia. Circulation (1973) 1.05

Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction. Am J Cardiol (1976) 1.04

MYOCARDIAL FUNCTION AND CONTRACTILE FORCE AFFECTED BY GLUCOSE LOADING OF THE HEART DURING ANOXIA. Surgery (1965) 1.04

Reversible nature of liver cell damage due to carbon tetrachloride as demonstrated by the use of phenergan. Nature (1961) 1.00

Effects of hyaluronidase administration on myocardial ischemic injury in acute infarction. A preliminary study in 24 patients. Ann Intern Med (1975) 0.98

Ventricular fibrillation and myocardial necrosis after transient ischemia. Effect of treatment with oxygen, procainamide, reserpine, and propranolol. Arch Intern Med (1972) 0.97

Microsomal membrane dysfunction in ischemic rat liver cells. Arch Biochem Biophys (1977) 0.95

Role of mitochondria in control of calcium content of liver slices. Nature (1976) 0.93

On the nature of protection by propranolol against myocardial necrosis after temporary coronary occlusion in dogs. Am J Cardiol (1976) 0.93

The biochemical pathology of liver cell necrosis. Am J Pathol (1975) 0.92

Intracellular calcium homeostasis in galactosamine-intoxicated rat liver cells. Active sequestration of calcium by microsomes and mitochondria. Arch Biochem Biophys (1977) 0.92

Blood reflow after renal ischemia. Effects of hypertonic mannitol on reflow and tubular necrosis after transient ischemia in the rat. Arch Pathol (1974) 0.92

Studies of cellular recovery from injury. I. Recovery from anoxia in Ehrlich ascites tumor cells. Lab Invest (1975) 0.89

The relationship between cell viability and changes in mitochondrial ultrastructure, cellular ATP, ion and water content following injury of Ehrlich ascites tumor cells. Virchows Arch B Cell Pathol (1974) 0.88

Mitochondrial biochemical changes and glucose-KCl-insulin solution in cardiac infarct. Am J Physiol (1966) 0.87

Metabolic evaluation of agents designed to protect the ischemic myocardium and to reduce infarct size. Am J Cardiol (1976) 0.86

Methylprednisolone treatment in acute myocardial infarction. Effect on regional and global myocardial function. Am J Cardiol (1976) 0.86

Intravenous injection of hyaluronidase in acute myocardial infarction: preliminary report of clinical and experimental observations. Am Heart J (1959) 0.85

Beneficial metabolic effects of methylprednisolone sodium succinate in acute myocardial ischemia. Am J Cardiol (1976) 0.84

Effects of glucose and nonglucose infusions on myocardial potassium ion transfers and arrhythmias during ischemia. Am J Cardiol (1969) 0.83

Potassium, glucose, and insulin in treatment of myocardial infarction. Br Heart J (1967) 0.81

Effects of hyaluronidase and hydrocortisone on myocardial necrosis after coronary occlusion. Am J Cardiol (1976) 0.80

Experimental myocardial ischemia. III. Protective effect of glucose of myocardial function. J Mol Cell Cardiol (1976) 0.78

Protection against liver injury due to murine hepatitis virus. Nature (1960) 0.77

Articles by these authors

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med (1991) 16.81

High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol (1999) 10.86

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell (1999) 10.08

Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A (1991) 5.60

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science (1994) 4.84

MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell (1997) 4.67

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A (1999) 4.11

Signaling pathways for cardiac hypertrophy and failure. N Engl J Med (1999) 3.97

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem (1998) 3.80

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol (1988) 3.65

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev (1994) 3.54

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Calcium dependence of toxic cell death: a final common pathway. Science (1979) 3.35

Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation (1996) 3.34

A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell (2001) 3.13

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A (1998) 3.05

Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation (2000) 2.94

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development (1998) 2.91

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A (2001) 2.77

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A (1998) 2.76

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med (1994) 2.70

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. J Biol Chem (1990) 2.70

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell (1999) 2.68

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem (1990) 2.64

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med (2001) 2.40

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem (1998) 2.35

Fashioning the vertebrate heart: earliest embryonic decisions. Development (1997) 2.29

Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. Am J Pathol (1981) 2.28

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem (1995) 2.27

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem (1991) 2.12

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A (1995) 2.11

American College of Cardiology/Society for Cardiac Angiography and Interventions Clinical Expert Consensus Document on cardiac catheterization laboratory standards. A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol (2001) 2.09

Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood (2001) 2.09

Race and differences in breast cancer survival in a managed care population. J Natl Cancer Inst (1999) 2.06

Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem (1998) 2.05

Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem (1998) 2.05

Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. Circulation (1997) 2.00

Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem (1994) 1.96

Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. Blood (1990) 1.93

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem (1993) 1.91

Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol (1994) 1.89

A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Mol Cell Biol (1991) 1.88

Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem (2000) 1.86

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development (1997) 1.83

Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J Clin Invest (1999) 1.82

Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen. J Biol Chem (1988) 1.81

Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. J Biol Chem (1986) 1.80

The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy. J Biol Chem (1997) 1.80

Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4. J Immunol (1990) 1.79

Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem (1997) 1.78

APACHE II score does not predict multiple organ failure or mortality in postoperative surgical patients. Arch Surg (1990) 1.76

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci U S A (1993) 1.76

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol (2000) 1.76

Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. J Biol Chem (1996) 1.69

Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression. J Biol Chem (1988) 1.69

The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem (1993) 1.68

Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. J Biol Chem (1989) 1.68

Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Lab Invest (1982) 1.65

Bacterial toxin-induced cytokine production studied at the single-cell level. Immunol Rev (1992) 1.64

Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury. J Biol Chem (1978) 1.64

DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J Biol Chem (1999) 1.62

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Mol Cell Biol (1992) 1.61

Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A (1994) 1.59

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene (2009) 1.58

The role of calcium in cell death. Life Sci (1981) 1.57

Concomitant in vivo production of 19 different cytokines in human tonsils. Immunology (1994) 1.57

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. Proc Natl Acad Sci U S A (1995) 1.56

Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids. Circ Res (1984) 1.55

Fatal and hospitalized injuries resulting from the 1994 Northridge earthquake. Int J Epidemiol (1998) 1.54

Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction. J Biol Chem (1985) 1.52

Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med (2001) 1.51

Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest (2001) 1.51

Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem (1996) 1.48

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J Biol Chem (2000) 1.46

In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J Biol Chem (1993) 1.45

Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res (1996) 1.45

[Laser tonsillectomy in tonsillar hyperplasia of early childhood]. HNO (2002) 1.45

Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest (1995) 1.44

Low-dose combined therapy with fluvastatin and cholestyramine in hyperlipidemic patients. Ann Intern Med (1994) 1.44

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A (1997) 1.42

Nitroglycerin and long-acting nitrates in clinical practice. Am J Med (1983) 1.41

RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest (1996) 1.41

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem (1994) 1.41

The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem (1998) 1.40

Colloid (mucinous noncystic) carcinoma of the pancreas. Am J Surg Pathol (2001) 1.40

Risk factors for postcoital bleeding among women with or at risk for infection with human immunodeficiency virus. J Infect Dis (1995) 1.40

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem (1999) 1.40

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem (1993) 1.39

FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol (2000) 1.39

Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine responses to IL-1 and tumor necrosis factor. J Exp Med (1992) 1.38

tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids. Arch Biochem Biophys (1989) 1.37

Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones. J Immunol (1988) 1.36

Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells. J Immunol (1999) 1.35

Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine. Cancer Res (2001) 1.30