Published in Protein Sci on October 01, 1996
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proc Natl Acad Sci U S A (2008) 2.06
Quantification and rationalization of the higher affinity of sodium over potassium to protein surfaces. Proc Natl Acad Sci U S A (2006) 1.49
Chaperonin filaments: the archaeal cytoskeleton? Proc Natl Acad Sci U S A (1997) 1.10
Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One (2011) 1.07
Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions. Protein Sci (2011) 0.96
Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for Mitochondrial Interactosome. J Bioenerg Biomembr (2009) 0.93
HIV-1 rev depolymerizes microtubules to form stable bilayered rings. J Cell Biol (2000) 0.88
Conformational analysis of the carboxy-terminal tails of human beta-tubulin isotypes. Biophys J (2007) 0.88
Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia. PLoS One (2012) 0.86
Ion-specific modulation of protein interactions: anion-induced, reversible oligomerization of a fusion protein. Protein Sci (2009) 0.86
The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell (2014) 0.83
Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells. Cancer Res (2008) 0.83
Autopalmitoylation of tubulin. Protein Sci (2000) 0.80
Tubulin Dimer Reversible Dissociation: AFFINITY, KINETICS, AND DEMONSTRATION OF A STABLE MONOMER. J Biol Chem (2016) 0.77
Identification of 12Cysbeta on tubulin as the binding site of tubulyzine. Bioorg Med Chem (2005) 0.76
An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance. Int J Mol Sci (2017) 0.75
Microtubule Destabilization Paves the Way to Parkinson's Disease. Mol Neurobiol (2016) 0.75
Cation selective glass electrodes and their mode of operation. Biophys J (1962) 10.25
Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science (1996) 8.34
The periodic association of MAP2 with brain microtubules in vitro. J Cell Biol (1979) 4.97
Taxol binds to polymerized tubulin in vitro. J Cell Biol (1981) 2.86
Ionic and nucleotide requirements for microtubule polymerization in vitro. Biochemistry (1975) 2.43
Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions. Protein Sci (1994) 2.31
The free energy for hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: all of the free energy for hydrolysis is stored in the microtubule lattice. J Cell Biol (1994) 2.20
Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. Biochemistry (1984) 2.04
Polycation-induced assembly of purified tubulin. Proc Natl Acad Sci U S A (1976) 1.99
Common and distinct tubulin binding sites for microtubule-associated proteins. Proc Natl Acad Sci U S A (1986) 1.88
The Na+ binding site of thrombin. J Biol Chem (1995) 1.77
Tubulin subunit carboxyl termini determine polymerization efficiency. J Biol Chem (1985) 1.73
How does taxol stabilize microtubules? Curr Biol (1995) 1.69
Polyglycylation of tubulin: a posttranslational modification in axonemal microtubules. Science (1994) 1.65
Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau. J Biol Chem (1993) 1.53
Polymerization and depolymerization of microtubules in vitro as studied by flow birefringence. FEBS Lett (1974) 1.48
New chain conformations of poly(glutamic acid) and polylysine. Biopolymers (1968) 1.48
The in vitro polymerization of tubulin from beef brain. J Neurobiol (1974) 1.42
Optimization of the electrostatic interactions in proteins of different functional and folding type. Protein Sci (1994) 1.27
Stabilization of a protein by guanidinium chloride. Biochemistry (1993) 1.23
Comparative analysis of tubulin sequences. Comp Biochem Physiol B (1988) 1.23
The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2:tubulin interaction. Eur J Biochem (1984) 1.22
Protein destabilization by electrostatic repulsions in the two-stranded alpha-helical coiled-coil/leucine zipper. Protein Sci (1995) 1.15
Interaction of microtubule-associated proteins with microtubules: yeast lysyl- and valyl-tRNA synthetases and tau 218-235 synthetic peptide as model systems. Biochemistry (1991) 1.03
Charge-shielding and the "paradoxical" stimulation of tubulin polymerization by guanidine hydrochloride. Biochemistry (1996) 0.98
Structure and function in the tubulin dimer and the role of the acidic carboxyl terminus. Subcell Biochem (1995) 0.97
Ribonuclease T1 is stabilized by cation and anion binding. Biochemistry (1988) 0.92
Isolation of microtubule protein from mammalian brain frozen for extended periods of time. Protein Expr Purif (1992) 0.91
Interactions of tubulin and microtubule-associated proteins. Conformation and stability of the oligomeric species from glycerol-cycled microtubule protein of bovine brain. Biochem J (1982) 0.91
Viscometric demonstration of tubulin polymerization. J Biochem (1974) 0.90
Characterization of the in vitro reassembly of tubulin derived from stable Strongylocentrotus purpuratus outer doublet microtubules. Biochemistry (1979) 0.86
Effect of alkaline pH on taxol-microtubule interactions. J Pharmacol Exp Ther (1991) 0.85
Interaction of tubulin with chromatin proteins. H1 and core histones. J Biol Chem (1984) 0.85
In vivo and in vitro effects of diisopropyl phosphorofluoridate (DFP) on the rate of hen brain tubulin polymerization. Neurochem Res (1994) 0.84
The interaction of myelin basic protein with tubulin and the inhibition of tubulin carboxypeptidase activity. Biochem Biophys Res Commun (1986) 0.84
Assembly properties of tubulin after carboxyl group modification. J Biol Chem (1991) 0.83
Reversible dimer dissociation of tubulin S and tubulin detected by fluorescence anisotropy. Biochemistry (1992) 0.82
The effects of elevated pH and high salt concentrations on tubulin. Arch Biochem Biophys (1986) 0.81
Alterations in tubulin immunoreactivity; relation to secondary structure. Eur J Biochem (1983) 0.81
Effect of specific proteolytic cleavages on tubulin polymer formation. Biochem J (1988) 0.80
Interaction of tubulin and microtubule proteins with vanadate oligomers. Biochemistry (1994) 0.77
Evidence based medicine: what it is and what it isn't. BMJ (1996) 66.70
Inpatient general medicine is evidence based. A-Team, Nuffield Department of Clinical Medicine. Lancet (1995) 24.14
Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med (1991) 18.33
The Burlington randomized trial of the nurse practitioner. N Engl J Med (1974) 17.02
Bias in analytic research. J Chronic Dis (1979) 16.40
A controlled trial of teaching critical appraisal of the clinical literature to medical students. JAMA (1987) 14.20
The number needed to treat: a clinically useful measure of treatment effect. BMJ (1995) 13.89
An assessment of clinically useful measures of the consequences of treatment. N Engl J Med (1988) 13.02
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med (1998) 11.27
Increased absenteeism from work after detection and labeling of hypertensive patients. N Engl J Med (1978) 9.29
Controversy in the detection of disease. Lancet (1975) 7.85
How to keep up with the medical literature: V. Access by personal computer to the medical literature. Ann Intern Med (1986) 7.36
Controversy in counting and attributing events in clinical trials. N Engl J Med (1979) 7.25
Randomised clinical trial of strategies for improving medication compliance in primary hypertension. Lancet (1975) 7.22
Users' guides to the medical literature. I. How to get started. The Evidence-Based Medicine Working Group. JAMA (1993) 6.83
A utility maximization model for evaluation of health care programs. Health Serv Res (1972) 6.67
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem (1997) 5.51
Users' guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group. JAMA (1995) 5.28
Problems in the handling of clinical and research evidence by medical practitioners. Arch Intern Med (1983) 5.16
A randomized trial of continuing medical education. N Engl J Med (1982) 4.95
Improvement of medication compliance in uncontrolled hypertension. Lancet (1976) 4.84
The Burlington randomized trial of the nurse practitioner: health outcomes of patients. Ann Intern Med (1974) 4.37
The utility of different health states as perceived by the general public. J Chronic Dis (1978) 3.65
An empirical demonstration of Berkson's bias. J Chronic Dis (1978) 3.48
Can simple clinical measurements detect patient noncompliance? Hypertension (1981) 3.29
Diagnosis and treatment of chronic arterial insufficiency of the lower extremities: a critical review. Circulation (1996) 3.23
Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest (1986) 3.16
p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat Cell Biol (2000) 3.05
Does a mailed continuing education program improve physician performance? Results of a randomized trial in antihypertensive care. JAMA (1986) 3.04
Choosing the best research design for each question. BMJ (1998) 3.03
Continuous intravenous heparin compared with intermittent subcutaneous heparin in the initial treatment of proximal-vein thrombosis. N Engl J Med (1986) 3.00
The measurement iterative loop: a framework for the critical appraisal of need, benefits and costs of health interventions. J Chronic Dis (1985) 2.96
How to keep up with the medical literature: I. Why try to keep up and how to get started. Ann Intern Med (1986) 2.94
Quality-of-care appraisal in primary care: a quantitative method. Ann Intern Med (1975) 2.87
Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest (1992) 2.81
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer (2000) 2.73
Methodologic guidelines for systematic reviews of randomized control trials in health care from the Potsdam Consultation on Meta-Analysis. J Clin Epidemiol (1995) 2.73
The development and application of indices of health: general methods and a summary of results. Am J Public Health (1977) 2.53
Clinical recommendations using levels of evidence for antithrombotic agents. Chest (1995) 2.52
Using research findings in clinical practice. BMJ (1998) 2.40
The rational clinical examination. Does this patient have splenomegaly? JAMA (1993) 2.38
The rational clinical examination. Does this patient have a clinically important carotid bruit? JAMA (1993) 2.38
Hypertension in a family practice. Can Med Assoc J (1977) 2.36
Rules of evidence and clinical recommendations for the management of patients. Can J Cardiol (1993) 2.11
When was a "negative" clinical trial big enough? How many patients you needed depends on what you found. Arch Intern Med (1985) 2.11
Transferring evidence from research into practice: 1. The role of clinical care research evidence in clinical decisions. ACP J Club (1996) 2.10
Cost effectiveness of clinical diagnosis, venography, and noninvasive testing in patients with symptomatic deep-vein thrombosis. N Engl J Med (1981) 2.04
Guidelines for managing raised blood pressure. BMJ (1996) 2.03
Cardiovascular diseases. Lancet (1974) 1.85
Fenoterol and fatal asthma. Lancet (1990) 1.77
Labelling in hypertension: a review of the behavioural and psychological consequences. J Chronic Dis (1984) 1.75
How to keep up with the medical literature: IV. Using the literature to solve clinical problems. Ann Intern Med (1986) 1.75
Cochrane Collaboration. BMJ (1994) 1.74
Educational package on hypertension for primary care physicians. Can Med Assoc J (1984) 1.73
Tubulin subunit carboxyl termini determine polymerization efficiency. J Biol Chem (1985) 1.73
Odds ratios should be avoided when events are common. BMJ (1998) 1.71
Clinical diagnosis and the clinical laboratory. Clin Invest Med (1978) 1.67
Combined use of leg scanning and impedance plethysmography in suspected venous thrombosis. An alternative to venography. N Engl J Med (1977) 1.66
Understanding clinical trials. BMJ (1994) 1.59
How to keep up with the medical literature: II. Deciding which journals to read regularly. Ann Intern Med (1986) 1.57
Tubulin, hybrid dimers, and tubulin S. Stepwise charge reduction and polymerization. J Biol Chem (1985) 1.54
On the need for evidence-based medicine. Health Econ (1996) 1.53
Evaluation of neonatal-intensive-care program. N Engl J Med (1981) 1.52
Cancer risk in ulcerative colitis: scientific requirements for the study of prognosis. Gastroenterology (1980) 1.50
The fall of "clinical research" and the rise of "clinical-practice research". Clin Invest Med (2000) 1.50
The science of the art of the clinical examination. JAMA (1992) 1.48
Self-recording of blood pressure in the management of hypertension. Can Med Assoc J (1978) 1.46
The usefulness of laboratory tests in health-screening programs. Clin Chem (1973) 1.45
Applying the results of trials and systematic reviews to individual patients. ACP J Club (1998) 1.45
Concordance for coronary risk factors among spouses. Circulation (1975) 1.44
Non-use and misuse of measles vaccine. Can Fam Physician (1973) 1.40
1965-1990: 25th anniversary of nurse practitioners. A classic manuscript reprinted in celebration of 25 years of progress. The Burlington randomized trial of the nurse practitioner. 1971-2. J Am Acad Nurse Pract (1990) 1.38
Thrombolytic agents: the science of the art of choosing the better treatment. Ann Intern Med (1994) 1.36
Therapeutic priorities of Canadian internists. CMAJ (1990) 1.33
Patient compliance with antihypertensive regimens. Patient Couns Health Educ (1978) 1.31
Grades of recommendation for antithrombotic agents. Chest (1998) 1.30
Determining causation--a case study: adrenocorticosteroids and osteoporosis. Should the fear of inducing clinically important osteoporosis influence the decision to prescribe adrenocorticosteroids? J Chronic Dis (1984) 1.29
What proportion of primary psychiatric interventions are based on evidence from randomised controlled trials? Qual Health Care (1996) 1.28
Time to put the Canadian Institutes of Health Research on trial. CMAJ (1999) 1.26
Manipulation of the therapeutic regimen to improve compliance: conceptions and misconceptions. Clin Pharmacol Ther (1977) 1.25
Proteolysis of tubulin and the substructure of the tubulin dimer. J Biol Chem (1986) 1.24
Active-control equivalence trials and antihypertensive agents. Am J Med (2001) 1.23
Relation between aortic atherosclerosis and the use of cigarettes and alcohol. An autopsy study. N Engl J Med (1968) 1.23
Compliance with antihypertensive drug therapy. Ann N Y Acad Sci (1978) 1.23
On the need for evidence-based medicine. Therapie (1996) 1.23
Familial aggregation of blood pressure. Preliminary report. JAMA (1966) 1.18
Hypertension II. Finding hypertensives and linking them to clinical care. Can J Public Health (1980) 1.18
Screening in family practice: prevention, levels of evidence, and the pitfalls of common sense. J Fam Pract (1987) 1.16
Pulmonary embolism in outpatients with pleuritic chest pain. Arch Intern Med (1988) 1.14
Teaching critical appraisal: no quick fixes. CMAJ (1998) 1.14
How to keep up with the medical literature: III. Expanding the number of journals you read regularly. Ann Intern Med (1986) 1.14
Effects of labelling on income, work and social function among hypertensive employees. J Chronic Dis (1984) 1.13