PubRank

R M Perlmutter

Author PubWeight™ 168.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996 8.41
2 A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 1985 5.21
3 Subclass restriction of murine anti-carbohydrate antibodies. J Immunol 1978 4.99
4 Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 1990 4.84
5 Early restriction of the human antibody repertoire. Science 1987 3.90
6 Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association. Science 1991 3.84
7 Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J 1990 3.62
8 Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 1991 3.30
9 Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 1992 3.17
10 Developmentally controlled expression of immunoglobulin VH genes. Science 1985 2.96
11 Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol 1988 2.80
12 Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 1996 2.79
13 Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol 1999 2.57
14 Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 1995 2.53
15 Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol 1987 2.52
16 Translational activation of the lck proto-oncogene. Nature 1988 2.41
17 Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol 1989 2.34
18 CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 1997 2.16
19 Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J 1992 2.12
20 Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J 1995 2.02
21 A dominant-negative transgene defines a role for p56lck in thymopoiesis. EMBO J 1993 1.98
22 Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A 1991 1.93
23 Positive and negative selection invoke distinct signaling pathways. J Exp Med 1996 1.86
24 Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int Immunol 1997 1.85
25 Fyn can partially substitute for Lck in T lymphocyte development. Immunity 1996 1.85
26 Developmental regulation of lck gene expression in T lymphocytes. J Exp Med 1991 1.82
27 Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J 1987 1.80
28 Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 1995 1.79
29 Functional dissection of the lck proximal promoter. Mol Cell Biol 1992 1.78
30 Control of B cell development by Ras-mediated activation of Raf. EMBO J 1997 1.76
31 Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity 2000 1.74
32 Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int Immunol 1990 1.72
33 Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol 1988 1.66
34 The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice. Blood 1995 1.61
35 The generation of diversity in phosphorylcholine-binding antibodies. Adv Immunol 1984 1.59
36 An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity 1994 1.55
37 Immunoglobulin subclass-specific immunodeficiency in mice with an X-linked B-lymphocyte defect. J Exp Med 1979 1.54
38 Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol 1997 1.54
39 Structure and evolution of mammalian VH families. Int Immunol 1990 1.53
40 Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck. EMBO J 1993 1.48
41 T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A 1999 1.46
42 Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements. Proc Natl Acad Sci U S A 1988 1.44
43 Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Nature 1993 1.42
44 Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. Proc Natl Acad Sci U S A 1986 1.42
45 Heterogeneity in the human Ig VH locus. J Immunol 1989 1.41
46 A small multigene family encodes Gi signal-transduction proteins. Proc Natl Acad Sci U S A 1987 1.39
47 A pertussis toxin-sensitive process controls thymocyte emigration. Eur J Immunol 1991 1.37
48 Osteoporosis induced in mice by overproduction of interleukin 4. Proc Natl Acad Sci U S A 1993 1.33
49 Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J Biol Chem 2001 1.30
50 Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. Proc Natl Acad Sci U S A 1993 1.27
51 Multiple VH gene segments encode murine antistreptococcal antibodies. J Exp Med 1984 1.26
52 Interleukin 4 expressed in situ selectively alters thymocyte development. J Exp Med 1991 1.25
53 Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha. Immunity 1997 1.22
54 Functional dissection of the murine lck distal promoter. J Immunol 1995 1.22
55 Delayed thymocyte development induced by augmented expression of p56lck. J Exp Med 1991 1.20
56 Augmented expression of a myeloid-specific protein tyrosine kinase gene (hck) after macrophage activation. J Exp Med 1988 1.19
57 Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck). J Immunol 1989 1.19
58 Participation of CD4 coreceptor molecules in T-cell repertoire selection. Nature 1991 1.18
59 Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem 1997 1.18
60 Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development. Adv Immunol 1994 1.17
61 Transformation of NIH 3T3 fibroblasts by an activated form of p59hck. Mol Cell Biol 1989 1.17
62 Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family. J Exp Med 1985 1.15
63 Presenilin-dependent gamma-secretase activity modulates thymocyte development. Proc Natl Acad Sci U S A 2001 1.13
64 p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen. J Virol 1988 1.12
65 Immune response deficiency of BSVS mice. II. Generalized deficiency to thymus-dependent antigens. Eur J Immunol 1979 1.10
66 Regulation of L-selectin-mediated rolling through receptor dimerization. J Exp Med 1998 1.08
67 A signaling pathway governing early thymocyte maturation. Immunol Today 1995 1.07
68 Caspase enzyme activity is not essential for apoptosis during thymocyte development. J Immunol 2000 1.06
69 Complete sharing of light chain spectrotypes by murine IgM and IgG anti-streptococcal antibodies. J Immunol 1977 1.05
70 Analysis of the diversity of murine antibodies to dextran B1355. III. Idiotypic and spectrotypic correlations. Eur J Immunol 1978 1.05
71 Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. J Immunol 1982 1.04
72 Involvement of p59fynT in interleukin-5 receptor signaling. J Exp Med 1995 1.03
73 Molecular dissection of the murine antibody response to streptococcal group A carbohydrate. J Exp Med 1987 1.01
74 Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med 1996 0.99
75 Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development. Mol Cell Biol 1999 0.97
76 Identification and characterization of a transcriptional regulator for the lck proximal promoter. J Biol Chem 2001 0.97
77 Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism. J Exp Med 1985 0.96
78 Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck. Eur J Immunol 1992 0.95
79 Selective expression of alternative lck mRNAs in human malignant cell lines. Mol Cell Biol 1989 0.95
80 Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur J Immunol 1997 0.93
81 Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase. J Exp Med 1995 0.93
82 Insulin-specific murine antibodies of limited heterogeneity. I. Genetic control of spectrotypes. J Immunol 1979 0.92
83 Programmed development of the antibody repertoire. Curr Top Microbiol Immunol 1987 0.90
84 Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages. Blood 1991 0.90
85 Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene. Mol Cell Biol 1994 0.89
86 Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J Immunol 1998 0.89
87 A novel 6:10 chromosomal translocation in the murine plasmacytoma NS-1. Nature 1984 0.88
88 Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor. J Exp Med 1997 0.87
89 Coumermycin-induced dimerization of GyrB-containing fusion proteins. Methods Enzymol 2000 0.87
90 Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes. Proc Natl Acad Sci U S A 1993 0.85
91 Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes. J Immunol 2001 0.85
92 Immunologic memory to phosphocholine. V. Hybridomas representative of group II antibodies utilize V kappa 1-3 gene(s). J Immunol 1984 0.85
93 Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage. Proc Natl Acad Sci U S A 1998 0.85
94 Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells. Eur J Immunol 1991 0.84
95 The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]. J Exp Med 1993 0.84
96 Immunologic memory to phosphocholine. IV. Hybridomas representative of Group I (T15-like) and Group II (non-T15-like) antibodies utilize distinct VH genes. J Immunol 1984 0.84
97 Autoantibodies and the fetal antibody repertoire. Int Rev Immunol 1990 0.82
98 Membrane localization of Raf assists engagement of downstream effectors. J Biol Chem 2000 0.81
99 Light chain diversity of murine anti-streptococcal antibodies: IgCH-linked effects on L chain expression. J Immunol 1978 0.80
100 Cell type and developmental regulation of the fyn proto-oncogene in neural retina. Oncogene 1992 0.79
101 Structure and expression of the murine hck gene. Oncogene 1991 0.77
102 Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis. Int Immunol 1998 0.77
103 CD8 inhibits signal transduction through the T cell receptor in CD4-CD8- thymocytes from T cell receptor transgenic mice reconstituted with a transgenic CD8 alpha molecule. J Immunol 1993 0.77
104 Characterization of molecular heterogeneity and multispecificity in homologous idiotypic antisera. J Immunol 1977 0.76
105 Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes. Int Immunol 1999 0.75
106 Immunodeficiency. Zapping T-cell responses. Nature 1994 0.75
107 Differential involvement of protein tyrosine kinases p56lck and p59fyn in T cell development. Adv Exp Med Biol 1992 0.75
108 Molecular genetics of anti-carbohydrate antibodies. Ann Immunol (Paris) 1984 0.75