Published in J Virol on January 01, 1997
E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. J Virol (1998) 1.83
Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J Virol (1998) 1.72
Replication-selective adenoviruses as oncolytic agents. J Clin Invest (2000) 1.66
p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J Virol (1998) 1.44
SUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoprotein. Proc Natl Acad Sci U S A (2001) 1.26
p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J Virol (1999) 1.25
The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA. J Virol (2000) 1.25
Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism. J Virol (2002) 1.19
Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication. J Virol (1999) 1.16
Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein. J Virol (1999) 1.16
Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J Virol (2009) 1.14
Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev (2009) 1.10
Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background. J Virol (2004) 1.08
Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts. J Virol (2006) 1.08
The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status. J Virol (1999) 1.07
Role of baculovirus IE2 and its RING finger in cell cycle arrest. J Virol (1998) 1.07
Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication. J Virol (2008) 1.05
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection. J Virol (2009) 1.04
An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein function. J Virol (1999) 1.02
Towards predictive computational models of oncolytic virus therapy: basis for experimental validation and model selection. PLoS One (2009) 0.97
E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses. J Virol (2003) 0.96
Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? J Virol (2001) 0.94
Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. J Virol (2004) 0.93
E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein. J Virol (2002) 0.88
Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. J Virol (2001) 0.87
The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells. PLoS Pathog (2012) 0.87
E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus. J Virol (2009) 0.87
Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS One (2008) 0.85
Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants. J Virol (2003) 0.85
Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor. J Virol (2010) 0.83
Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells. J Virol (2012) 0.83
5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells. J Cancer Res Clin Oncol (2004) 0.79
Gene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1-5. Br J Cancer (2003) 0.78
Effects of febrile temperature on adenoviral infection and replication: implications for viral therapy of cancer. J Virol (2005) 0.78
Oncolytic Replication of E1b-Deleted Adenoviruses. Viruses (2015) 0.77
Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein. Virology (2017) 0.75
Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma. BMC Cancer (2016) 0.75
Adenovirus replaces mitotic checkpoint controls. J Virol (2015) 0.75
Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93
Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res (1979) 21.96
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science (1990) 12.88
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature (1983) 11.61
Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell (1979) 10.95
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (1992) 10.28
Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spring Harb Symp Quant Biol (1975) 7.76
Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes. Virology (1983) 7.54
p53: a frequent target for genetic abnormalities in lung cancer. Science (1989) 7.51
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev (1993) 6.02
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 5.97
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev (1993) 5.33
Viral DNA in transformed cells. II. A study of the sequences of adenovirus 2 DNA IN NINE LINES OF TRANSFORMED RAT CELLS USING SPECIFIC FRAGMENTS OF THE VIRAL GENOME;. J Mol Biol (1974) 4.39
Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature (1992) 4.36
Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J Virol (1985) 4.35
Isolation of deletion and substitution mutants of adenovirus type 5. Cell (1978) 4.29
Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A (1987) 4.21
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell (1990) 3.77
Premature of chromosome condensation in a ts DNA- mutant of BHK cells. Cell (1978) 3.55
The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol (1986) 3.36
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol (1985) 3.04
Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J (1993) 3.00
Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology (1987) 2.85
Nuclear PRP20 protein is required for mRNA export. EMBO J (1993) 2.77
Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein. Virology (1983) 2.69
Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. J Cell Biol (1993) 2.67
A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells. Virology (1982) 2.65
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev (1994) 2.54
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Proc Natl Acad Sci U S A (1995) 2.48
Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J Virol (1984) 2.39
Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv (1992) 2.29
A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm. Proc Natl Acad Sci U S A (1992) 2.21
Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. J Cell Biol (1994) 2.17
Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J Virol (1994) 2.14
Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Cancer Res (1986) 2.12
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res (1991) 2.09
Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. Virology (1985) 1.94
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells. Mol Cell Biol (1985) 1.91
Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Science (1995) 1.89
Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins. Virology (1990) 1.85
Interaction of adenoviral E4 and E1b products in late gene expression. Virology (1990) 1.84
Identification of two nuclear subclasses of the adenovirus type 5-encoded DNA-binding protein. J Virol (1986) 1.69
The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J (1989) 1.67
Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. J Virol (1996) 1.65
Effect of adenovirus on host cell DNA synthesis in synchronized cells. Virology (1969) 1.61
DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control. Curr Opin Cell Biol (1994) 1.55
Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology (1994) 1.42
Visualization of nascent RNA transcripts and simultaneous transcription and replication in viral nucleoprotein complexes from adenovirus 2-infected HeLa cells. J Mol Biol (1981) 1.27
Effects of mutant Ran/TC4 proteins on cell cycle progression. Mol Cell Biol (1994) 1.26
Regulation of the cell cycle by viral oncoproteins. Semin Cancer Biol (1995) 1.25
Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1a. Virology (1983) 1.22
Rearrangements of intranuclear structures involved in RNA processing in response to adenovirus infection. J Cell Sci (1994) 1.16
Induction of the cell cycle in baby rat kidney cells by adenovirus type 5 E1A in the absence of E1B and a possible influence of p53. J Virol (1993) 1.16
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. Exp Cell Res (1995) 1.15
Expression and interactions of human adenovirus oncoproteins. Biochem J (1991) 1.10
The replication in vitro of the gammaherpesvirus bovine herpesvirus 4 is restricted by its DNA synthesis dependence on the S phase of the cell cycle. Virology (1995) 1.04
Distribution of viral RNA molecules during the adenovirus type 5 infectious cycle in HeLa cells. J Struct Biol (1993) 1.00
Functions of the adenovirus E1B tumour antigens. Cancer Surv (1986) 0.99
Herpes simplex virus immediate early gene expression in the absence of transinduction by Vmw65 varies during the cell cycle. Virology (1992) 0.97
Changes in metabolic and enzymatic activities of monkey kidney cells after infection with adenovirus 2. Virology (1966) 0.96
Analysis by in situ hybridization and autoradiography of sites of replication and storage of single- and double-stranded adenovirus type 5 DNA in lytically infected HeLa cells. J Struct Biol (1990) 0.95
Localization of simian adenovirus 7 (SA 7) transcription and replication in lytic infection. An ultracytochemical and autoradiographical study. J Gen Virol (1978) 0.95
Deficiencies in DNA replication and cell-cycle progression in polyamine-depleted HeLa cells. Biochem J (1992) 0.92
Replicating single-stranded adenovirus type 5 DNA molecules accumulate within well-delimited intranuclear areas of lytically infected HeLa cells. Eur J Cell Biol (1990) 0.91
Enhanced proliferation, growth factor induction and immortalization by adenovirus E1A 12S in the absence of E1B. Oncogene (1994) 0.89
The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes. Oncogene (1995) 0.86
Virus-lymphocyte interactions: inductive signals necessary to render B lymphocytes susceptible to vesicular stomatitis virus infection. J Virol (1990) 0.85
Ultrastructural study of the replication of human adenovirus type 12 in cultured cells. Pathol Microbiol (Basel) (1968) 0.82
Arrest of cell cycle progression of HeLa cells in the early G1 phase in K(+)-depleted conditions and its recovery upon addition of insulin and LDL. J Cell Biochem (1993) 0.79
Modified method of mammalian cell synchronization improves yield and degree of synchronization. Exp Cell Res (1991) 0.78
Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis. Mol Cell Biol (1986) 1.74
Adenovirus L1 52- and 55-kilodalton proteins are required for assembly of virions. J Virol (1989) 1.71
Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. J Virol (1996) 1.65
Latent species C adenoviruses in human tonsil tissues. J Virol (2008) 1.63
p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J Virol (1998) 1.44
Association of RNA with the cytoskeleton and the nuclear matrix. J Cell Sci Suppl (1986) 1.35
Adenovirus L1 52- and 55-kilodalton proteins are present within assembling virions and colocalize with nuclear structures distinct from replication centers. J Virol (1992) 1.34
The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells. J Virol (1993) 1.20
Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication. J Virol (1999) 1.16
An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein function. J Virol (1999) 1.02
Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia. Br J Cancer (2007) 0.97
Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. Oncogene (2012) 0.96
Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL). Br J Cancer (2010) 0.77
Adenovirus death protein (ADP) is required for lytic infection of human lymphocytes. J Virol (2013) 0.75