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Rank Title Journal Year PubWeight™‹?›
1 Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996 7.15
2 Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine. Xenobiotica 1979 2.07
3 Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J 1998 1.59
4 Characterization of P1-purinoceptors on rat duodenum and urinary bladder. Br J Pharmacol 1992 1.35
5 The ontogeny of purinoceptors in rat urinary bladder and duodenum. Br J Pharmacol 1990 1.16
6 Passage of Japanese encephalitis virus in HeLa cells results in attenuation of virulence in mice. J Gen Virol 1995 1.13
7 Direct effects of adenylyl 5'-(beta,gamma-methylene)diphosphonate, a stable ATP analogue, on relaxant P1-purinoceptors in smooth muscle. Br J Pharmacol 1991 1.11
8 Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain. Prog Neurobiol 2007 1.10
9 Ontogenesis of proenkephalin products in rat striatum and the inhibitory effects of low-level lead exposure. Brain Res 1985 1.04
10 Low-level lead exposure alters morphine antinociception in neonatal rats. Toxicol Lett 1984 1.03
11 Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice. Brain Res 1999 0.99
12 The binding of 1,3-[3H]-dipropyl-8-cyclopentylxanthine to adenosine A1 receptors in rat smooth muscle preparations. Br J Pharmacol 1994 0.96
13 Ontogenesis of delta-opioid receptors in rat brain using [3H][D-Pen2,D-Pen5]enkephalin as a binding ligand. Eur J Pharmacol 1986 0.96
14 Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats. Br J Pharmacol 1992 0.96
15 Opioids and respiration. Prog Neurobiol 1989 0.94
16 Development of opioid systems: peptides, receptors and pharmacology. Brain Res 1987 0.94
17 Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience 2003 0.93
18 Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. Eur J Neurosci 2008 0.93
19 Antinociception opioids and the cholinergic system. Prog Neurobiol 1986 0.93
20 Enzyme-potentiated hyposensitization. 3. Control by sugars and diols of the immunological effect of beta glucuronidase in mice and patients with hay fever. Ann Allergy 1973 0.89
21 Lead neurotoxicity: a review of the biochemical, neurochemical and drug induced behavioural evidence. Prog Neurobiol 1984 0.89
22 Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. Eur J Pharmacol 2001 0.89
23 Swim-stress-induced antinociception in young rats. Br J Pharmacol 1989 0.87
24 Characterization and ontogeny of P1-purinoceptors on rat vas deferens. Br J Pharmacol 1993 0.87
25 Different effects of current strength on inhibitory responses of the mouse vas deferens to methionine- and leucine-enkephalin. Br J Pharmacol 1979 0.86
26 Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A(2A) receptor knockout mice. Br J Pharmacol 2008 0.85
27 Impairment of ketocyclazocine antinociception in rats by perinatal lead exposure. Toxicol Lett 1985 0.85
28 Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: behavioural and autoradiographic studies. Eur J Neurosci 1999 0.85
29 Comparative binding of mu and delta selective ligands in whole brain and pons/medulla homogenates from rat: affinity profiles of fentanyl derivatives. Neuropharmacology 1988 0.85
30 Preprodynorphin mediates locomotion and D2 dopamine and mu-opioid receptor changes induced by chronic 'binge' cocaine administration. J Neurochem 2007 0.84
31 Ontogeny of catecholamine and GABA levels in rat brain: lack of effect of perinatal lead exposure. Toxicol Lett 1986 0.84
32 Perinatal lead exposure alters the development of delta- but not mu-opioid receptors in rat brain. Br J Pharmacol 1988 0.83
33 Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse. Life Sci 1983 0.82
34 The stereotypy-inducing and OCD-like effects of chronic 'binge' cocaine are modulated by distinct subtypes of nicotinic acetylcholine receptors. Br J Pharmacol 2012 0.82
35 Assessment of the hot-plate antinociceptive test in mice. A new method for the statistical treatment of graded data. J Pharmacol Methods 1985 0.82
36 Differences in the effects of mu- and delta-opioid receptor antagonists upon plasma corticosterone levels in stressed mice. Eur J Pharmacol 1984 0.81
37 Behavioural effects of selective mu-, kappa-, and delta-opioid agonists in neonatal rats. Psychopharmacology (Berl) 1989 0.81
38 Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain. Neuroscience 2003 0.81
39 Developmental modulation of cysteine conjugate beta-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain. Eur J Drug Metab Pharmacokinet 1998 0.80
40 Effects of adrenalectomy and hypophysectomy on enkephalin content of the rat hypothalamus. Br J Pharmacol 1980 0.79
41 Effects of neonatal naltrindole treatment on antinociceptive and behavioral responses to mu and kappa agonists in rats. Pharmacol Biochem Behav 1999 0.79
42 Enzyme potentiated hyposensitization: IV. effect of protamine on the immunological behavior of beta glucuronidase in mice and patients with hay fever. Ann Allergy 1975 0.79
43 Modification of an analgesy meter for paw-pressure antinociceptive testing in neonatal rats. J Pharmacol Methods 1984 0.78
44 Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice. Neuroscience 2001 0.78
45 Influence of maternal milk on functional activation of delta-opioid receptors in postnatal rats. J Pharmacol Exp Ther 2001 0.78
46 Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat. Gen Pharmacol 1990 0.78
47 Mechanisms involved in the cardiovascular responses to opioid products of proenkephalin in the anaesthetised rat. Gen Pharmacol 1992 0.77
48 Selective enhancement by an adenosine A1 receptor agonist of agents inducing contraction of the rat vas deferens. Naunyn Schmiedebergs Arch Pharmacol 1996 0.77
49 Behavioural profiles of putative 5-hydroxytryptamine receptor agonists and antagonists in developing rats. Neuropharmacology 1989 0.77
50 Developmental responses to opioids reveals a lack of effect on stress-induced corticosterone levels in neonatal rats. Br J Pharmacol 1987 0.77
51 The ontogenetic profiles of the pre- and postjunctional adenosine receptors in the rat vas deferens. Br J Pharmacol 1996 0.77
52 Differential distribution of adenosine A2 receptors in the epididymal and prostatic portions of the rat vas deferens. Eur J Pharmacol 1996 0.77
53 Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene. Brain Res 2001 0.77
54 Differential loss of biological activity of the enkephalins induced by current. Eur J Pharmacol 1981 0.77
55 Di-isopropylfluorophosphate induced antinociception and its interactions with opioid drugs in the rat. Toxicology 1986 0.77
56 Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia. Br J Pharmacol 2014 0.76
57 Endogenous opioid nomenclature: light at the end of the tunnel. Gen Pharmacol 1985 0.76
58 Morphine treatment during juvenile isolation increases social activity and opioid peptides release in the adult rat. Brain Res 1999 0.76
59 Adaptive changes in the expression of central opioid receptors in mice lacking the dopamine D2 receptor gene. Neuroscience 2008 0.76
60 Weaning-induced development of delta-opioid receptors in rat brain: differential effects of guanine nucleotides and sodium upon ligand-receptor recognition. Br J Pharmacol 1998 0.76
61 Ontogeny of P2-purinoceptors in the longitudinal muscle and muscularis mucosae of the rat isolated duodenum. Br J Pharmacol 1997 0.76
62 Perinatal lead exposure impairs opioid but not non-opioid stress-induced antinociception in developing rats. Br J Pharmacol 1989 0.76
63 Different effects of di-isopropylfluorophosphate on the entry of opioids into mouse brain. Br J Pharmacol 1985 0.76
64 The importance of tachyphylaxis and release of cyclooxygenase products in the modulation of endothelin-1-induced responses in rat and guinea pig tracheal chains. J Cardiovasc Pharmacol 1991 0.76
65 Effect of delayed weaning on opioid receptor control of swim stress-induced antinociception in the developing rat. Br J Pharmacol 1993 0.76
66 Effects of preweanling chronic naltrindole administration on stress-induced antinociceptive responses in rats. Brain Res Dev Brain Res 1998 0.76
67 Neonatal naltrindole and handling differently affect morphine antinociception in male and female rats. Pharmacol Biochem Behav 1999 0.76
68 The effect of acute kainic acid treatment on mu-opioid receptors in rat brain. Brain Res 1998 0.76
69 Differential development of adenosine A1 and A2b receptors in the rat duodenum. Br J Pharmacol 1996 0.75
70 Enkephalin content in rat hypothalamus--effect of adrenalectomy, laparotomy and corticosteroid treatment [proceedings]. Br J Pharmacol 1979 0.75
71 Opioid analgesia: new information from gene knockout studies. Curr Opin Anaesthesiol 1999 0.75
72 Differences in the characteristics of opioid receptor binding in the rat and marmoset. J Pharm Pharmacol 1988 0.75
73 Effect of chronic maternal diazepam treatment on the development of stress-induced antinociception in young rats. Pharmacol Biochem Behav 1994 0.75
74 The effect of perinatal lead administration on the ontogeny of striatal enkephalin levels in the rat. Toxicol Appl Pharmacol 1984 0.75
75 Effects of proenkephalin products on rat cardiac and vascular tissue in-vitro. J Pharm Pharmacol 1988 0.75
76 Interactions between anticholinesterase poisoning and opioid analgesia and locomotion in mice. Neurotoxicol Teratol 1989 0.75
77 A method for the study of swimming stress and stress-induced antinociception in preweanling rats. J Pharmacol Toxicol Methods 1993 0.75
78 Deletion of the adenosine A(2A) receptor in mice enhances spinal cord neurochemical responses to an inflammatory nociceptive stimulus. Neurosci Lett 2011 0.75
79 The rise and fall of endogenous opioid nomenclature. Prog Neurobiol 1984 0.75
80 Congestive heart failure and cardiogenic shock - drug therapy. Nursing (Lond) 1984 0.75
81 Regional changes in 5-HT1A but not in 5-HT2A receptors in mouse brain after Semliki Forest virus infection: radioligand binding and autoradiographic studies. J Neurovirol 1998 0.75
82 Dietary regulation of hepatic and cardiac pyruvate dehydrogenase during the suckling-weaning transition in rats. Biochem Soc Trans 1995 0.75
83 Drugs and mood changes. Nursing (Lond) 1984 0.75
84 Binding characteristics of [D-Ala2-MePhe4-Glyol5] enkephalin and [D-Pen2,D-Pen5] enkephalin in rat brain: inhibition studies with fentanyl-like drugs. NIDA Res Monogr 1986 0.75
85 Genetic deletion of the adenosine A(2A) receptor in mice reduces the changes in spinal cord NMDA receptor binding and glucose uptake caused by a nociceptive stimulus. Neurosci Lett 2010 0.75
86 Differential ontogeny of adenosine receptors in the longitudinal muscle and muscularis mucosae of the rat isolated duodenum. Eur J Pharmacol 1996 0.75
87 Determination of proenkephalin products in brain tissue by high-performance liquid chromatography and a modified bioassay procedure. J Pharmacol Methods 1985 0.75
88 Assessment of 8-OH-DPAT induced spontaneous tailflicks as an in vivo model of 5-HT1A function in young rats. Neuropharmacology 1993 0.75
89 Lack of effect of perinatal lead exposure on kappa-opioid receptor function. Toxicol Lett 1990 0.75
90 The effect of acute kainic acid treatment on dopamine D2 receptors in rat brain. Neurosci Res 1998 0.75
91 Effects of opioid agonists on urine production in neonatal rats. J Pharm Pharmacol 1989 0.75
92 Ontogeny of adenosine receptors in the longitudinal muscle and muscularis mucosae of the rat distal colon. Naunyn Schmiedebergs Arch Pharmacol 1999 0.75
93 Chronic naltrindole administration does not modify the inhibitory effect of morphine on vocalization responses in the tail electric stimulation test in rats. Neurosci Lett 1999 0.75
94 Postnatal naltrindole treatments induce behavioural modifications in preweanling rats. Neurosci Lett 2000 0.75
95 Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors. Neuroscience 2011 0.75
96 A new method for determination of in vivo pA2 using infusions of naloxone to steady-state blood concentrations. J Pharmacol Methods 1988 0.75
97 Regional mapping of low-affinity kainate receptors in mouse brain using [(3)H](2S,4R)-4-methylglutamate autoradiography. Eur J Pharmacol 2001 0.75
98 Effects of beta-funaltrexamine treatment and sexual isolation in the perinatal period on the development of mu-opioid receptors and nociception. Psychoneuroendocrinology 1993 0.75
99 Non-opioid effects of N-methyl levallorphan in the anaesthetised rat. Gen Pharmacol 1990 0.75
100 Bombesin-induced behavior in infant rats. Peptides 1989 0.75
101 Differential displacement of opioids from plasma protein binding sites by di-isopropylfluorophosphate in the mouse. J Pharm Pharmacol 1988 0.75