Published in Fundam Appl Toxicol on May 01, 1996
Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose. Environ Health Perspect (1997) 0.93
Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. Environ Health Perspect (2008) 0.90
Application of genomics to toxicology research. Environ Health Perspect (2002) 0.89
Animal and human carcinogens. Environ Health Perspect (1999) 0.83
The traditional toxicologic paradigm is correct: dose influences mechanism. Environ Health Perspect (1998) 0.75
Cancer risk assessment of extremely low frequency electric and magnetic fields: a critical review of methodology. Environ Health Perspect (1998) 0.75
DETERMINING DISEASE CAUSALITY FROM EXPERIMENTAL TOXICOLOGY STUDIES. J Law Policy (2005) 0.75
Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect (2000) 5.63
Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst (1993) 2.76
Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics (1988) 2.26
Why not use it all? Environ Health Perspect (1999) 2.04
Risk from low-dose exposures. Science (1994) 1.99
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol (1997) 1.75
Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids. J Steroid Biochem (1977) 1.62
Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis (1993) 1.62
Human exposure estimates for phthalates. Environ Health Perspect (2000) 1.53
Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol (1999) 1.43
Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics (1994) 1.31
Male-mediated developmental toxicity. Annu Rev Public Health (1993) 1.31
Harmonization of cancer and noncancer risk assessment: proceedings of a consensus-building workshop. Toxicol Sci (2001) 1.30
Dose-response assessment for developmental toxicity. II. Comparison of generic benchmark dose estimates with no observed adverse effect levels. Fundam Appl Toxicol (1994) 1.28
Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell (1995) 1.25
TCDD-induced changes in rat liver microsomal enzymes. Environ Health Perspect (1973) 1.24
Multiple DNA adducts in lymphocytes of smokers and nonsmokers determined by 32P-postlabeling analysis. Carcinogenesis (1990) 1.22
Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics (1994) 1.19
Dose-response assessment for developmental toxicity. III. Statistical models. Fundam Appl Toxicol (1994) 1.18
Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments. Cancer Res (1986) 1.18
Temperature and air pollution as risk factors for heat stroke in Tokyo, July and August 1980-1995. Environ Health Perspect (1999) 1.18
A model of acute methyl mercury intoxication in rats. Arch Pathol (1972) 1.15
The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. Environ Health Perspect (1989) 1.15
Ras oncogene mutations in childhood brain tumors. Cancer Epidemiol Biomarkers Prev (1997) 1.12
Stimulating research to improve the scientific basis of risk assessment. Toxicol Sci (1999) 1.11
Medicinal herbs in the United States: research needs. Environ Health Perspect (1999) 1.11
Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Toxicol Sci (2001) 1.10
Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Environ Health Perspect (1998) 1.10
Use of quality-adjusted life year weights with dose-response models for public health decisions: a case study of the risks and benefits of fish consumption. Risk Anal (2000) 1.08
Effects of temperature and air pollutants on cardiovascular and respiratory diseases for males and females older than 65 years of age in Tokyo, July and August 1980-1995. Environ Health Perspect (2001) 1.08
Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res (1994) 1.08
Semen quality of men employed at a lead smelter. Occup Environ Med (1996) 1.07
Receptor mechanisms and dose-response models for the effects of dioxins. Environ Health Perspect (1993) 1.06
Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Toxicol Appl Pharmacol (1991) 1.06
CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis (1993) 1.05
Mercury uptake by renal lysosomes of rats ingesting methyl mercury hydroxide. Ultrastructural observations and energy dispersive x-ray analysis. Arch Pathol (1974) 1.05
Animal models of human response to dioxins. Environ Health Perspect (1998) 1.05
Human variability in mercury toxicokinetics and steady state biomarker ratios. Environ Res (2000) 1.02
Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res (1992) 1.02
Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity. Mol Pharmacol (1987) 1.02
Levels of methyleugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry. Environ Health Perspect (2000) 1.02
Organophosphate pesticide metabolite levels in pre-school children in an agricultural community: within- and between-child variability in a longitudinal study. Environ Res (2011) 1.02
Nature of the enhancement of hepatic uridine diphosphate glucuronyltransferase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Biochem Pharmacol (1975) 1.01
Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis (1996) 1.01
The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments. Math Biosci (1991) 1.00
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol (2002) 1.00
High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead. J Pharmacol Exp Ther (1985) 0.99
Unusually high levels of carcinogenic tobacco-specific nitrosamines in Sudan snuff (toombak). Carcinogenesis (1991) 0.99
Glutathione S-transferase mu in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts. Carcinogenesis (1991) 0.99
Birth and death/differentiation rates of papillomas in mouse skin. Carcinogenesis (1992) 0.99
Microsomal rat liver UDP glucuronyltransferase: effects of piperonyl butoxide and other factors on enzyme activity. Arch Biochem Biophys (1971) 0.99
Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogenesis (1997) 0.97
Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. Drug Metab Dispos (1977) 0.97
Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8,-tetrachlorodibenzofuran in chicks. II. Effects on drug metabolism and porphyrin accumulation. Toxicol Appl Pharmacol (1976) 0.96
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association. Food Chem Toxicol (2002) 0.96
Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis. Environ Health Perspect (1996) 0.96
Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol (1992) 0.96
Hypomethylation of DNA: an epigenetic mechanism involved in tumor promotion. Mol Carcinog (1994) 0.96
Effects of the mechanism of receptor-mediated gene expression on the shape of the dose-response curve. Risk Anal (1993) 0.95
A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol Appl Pharmacol (1993) 0.95
The effects of chronic oral methyl mercury exposure on the lysosome system of rat kidney. Morphometric and biochemical studies. Lab Invest (1975) 0.95
Design of animal carcinogenicity studies for goodness-of-fit of multistage models. Fundam Appl Toxicol (1984) 0.95
The potentiation of barbiturate-induced narcosis by procarbazine. J Pharmacol Exp Ther (1976) 0.95
The exact formula for tumor incidence in the two-stage model. Risk Anal (1994) 0.95
Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Carcinogenesis (1995) 0.94
Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol (2002) 0.94
Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats. Chem Biol Interact (1975) 0.94
Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Biol Interact (1975) 0.93
Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. Cancer Res (2000) 0.93
The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice. Environ Res (1979) 0.93
Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu. Environ Health Perspect (1992) 0.93
Effects of methyl mercury on the cell cycle of primary rat CNS cells in vitro. Toxicol Appl Pharmacol (1994) 0.92
Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Anal (2000) 0.92
Altered sexual differentiation of hepatic uridine diphosphate glucuronyltransferase by neonatal hormone treatment in rats. Biochem J (1979) 0.92
Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. Toxicol Appl Pharmacol (1997) 0.92
The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association. Food Chem Toxicol (1999) 0.91
The role of hepatic microbody and soluble oxidases in the peroxidation of methanol in the rat and monkey. Mol Pharmacol (1968) 0.91
Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis (1995) 0.91
A measure of tumorigenic potency incorporating dose-response shape. Biometrics (1993) 0.90
Infection of rat liver epithelial cells with v-Ha-ras: correlation between oncogene expression, gap junctional communication, and tumorigenicity. Mol Carcinog (1990) 0.89
Altered ontogeny of hepatic steroid-metabolizing enzymes by pure polychlorinated biphenyl congeners. Biochem Pharmacol (1979) 0.89
Sex differences in estrogen binding by cytosolic and nuclear components of rat liver. J Steroid Biochem (1980) 0.89
Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. Chem Res Toxicol (2001) 0.89
Alterations in rat liver microsomal and lysosomal -glucuronidase by compounds which induce hepatic drug metabolizing enzymes. Biochim Biophys Acta (1972) 0.89
Characterizing dose-response: I: Critical assessment of the benchmark dose concept. Risk Anal (1998) 0.89
A mechanistic model of effects of dioxin on thyroid hormones in the rat. Toxicol Appl Pharmacol (1996) 0.89
Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicol Sci (2003) 0.88
Nonlinearity of dose-response functions for carcinogenicity. Environ Health Perspect (1994) 0.88
Mechanism of action of toxic halogenated aromatics. Environ Health Perspect (1985) 0.87
Altered methylation of ras oncogenes in benzidine-induced B6C3F1 mouse liver tumors. Toxicol Appl Pharmacol (1989) 0.87
Consideration of cultural and lifestyle factors in defining susceptible populations for environmental disease. Toxicology (2004) 0.86
Identification of a cardiac sodium channel insensitive to synthetic modulators. J Cardiovasc Pharmacol Ther (2001) 0.86
Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors. Mol Carcinog (1997) 0.86
DNA-purine methylation in hepatic chromatin following exposure to dimethylnitrosamine or methylnitrosourea. Biochem Pharmacol (1984) 0.85