H Watada

Author PubWeight™ 35.11‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 2001 2.19
2 Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest 1997 1.64
3 Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem 1994 1.62
4 Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 2003 1.27
5 Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. J Biol Chem 2000 1.23
6 Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003 1.18
7 Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes Metab 2012 1.17
8 Temporary hyperglycaemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta. Diabetologia 2005 1.09
9 ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs. Kidney Int 2006 1.08
10 Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 2006 1.03
11 Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. J Biol Chem 2000 1.03
12 Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 1997 0.99
13 Identification of amino-acid polymorphism within the leucine zipper motif of mouse transcription factor A1. Gene 1994 0.96
14 Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population. Diabetologia 2011 0.95
15 Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects. Diabetes Obes Metab 2007 0.92
16 Attempted suicide with liraglutide overdose did not induce hypoglycemia. Diabetes Res Clin Pract 2012 0.92
17 Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation. J Biol Chem 1997 0.90
18 Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta. Diabetologia 2011 0.89
19 Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas. Mol Cell Biol 1999 0.88
20 Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia 2006 0.87
21 Effect of sulfonylureas on switching to insulin therapy (twice-daily biphasic insulin aspart 30): comparison of twice-daily biphasic insulin aspart 30 with or without glimepiride in type 2 diabetic patients poorly controlled with sub-maximal glimepiride. Diabetes Res Clin Pract 2009 0.85
22 Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes Obes Metab 2012 0.84
23 Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin. Diabetologia 2008 0.84
24 The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese. Hum Genet 1997 0.84
25 Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells. J Clin Invest 1997 0.84
26 Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 2011 0.83
27 Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells. Diabetologia 1999 0.83
28 Linagliptin provides effective, well-tolerated add-on therapy to pre-existing oral antidiabetic therapy over 1 year in Japanese patients with type 2 diabetes. Diabetes Obes Metab 2013 0.83
29 Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem Biophys Res Commun 1996 0.82
30 Polymorphism of the solute carrier family 12 (sodium/chloride transporters) member 3, SLC12A3, gene at exon 23 (+78G/A: Arg913Gln) is associated with elevation of urinary albumin excretion in Japanese patients with type 2 diabetes: a 10-year longitudinal study. Diabetologia 2005 0.81
31 Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats. Biochem Biophys Res Commun 1995 0.80
32 Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass. Diabetologia 2008 0.80
33 Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion. Diabetologia 2004 0.79
34 Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM. Diabetes 1997 0.76
35 Alpha-glucosidase inhibitor, acarbose, improves glycamic control and reduces body weight in type 2 diabetes: Findings on indian patients from the pooled data analysis. Indian J Endocrinol Metab 2013 0.75
36 Acarbose improves glycemic control and reduces body weight: Subanalysis data of South Asia region. Indian J Endocrinol Metab 2013 0.75
37 Retraction. Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice. Acta Pharmacol Sin 2007 0.75
38 [Transcription factors for the insulin gene]. Nihon Rinsho 1994 0.75
39 Incidence and time course of left ventricular dilation in the early convalescent stage of reperfused anterior wall acute myocardial infarction. Am J Cardiol 1994 0.75