Inhibition of tumor invasiveness by 1alpha,25-dihydroxyvitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 9062386)

Published in Clin Exp Metastasis on March 01, 1997

Authors

M R Young1, Y Lozano

Author Affiliations

1: Department of Research Services, Hines V.A. Hospital, IL 60141, USA. ryoung@bsd.meddean.luc.edu

Articles cited by this

Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem (1993) 2.77

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem (1989) 2.32

Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol (1994) 2.21

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem (1990) 1.99

Sunlight--can it prevent as well as cause cancer? Cancer Res (1995) 1.48

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem (1994) 1.40

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta (1993) 1.35

Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. J Cell Biol (1989) 1.28

Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer (1994) 1.13

EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochem Pharmacol (1992) 1.08

Metastasis associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours. Anticancer Res (1993) 1.07

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3. Cancer Res (1994) 1.04

The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. J Biol Chem (1995) 0.98

Actin, its associated proteins and metastasis. Cell Motil Cytoskeleton (1995) 0.93

Association of a functional prostaglandin E2-protein kinase A coupling with responsiveness of metastatic Lewis lung carcinoma variants to prostaglandin E2 and to prostaglandin E2-producing nonmetastatic Lewis lung carcinoma variants. Cancer Res (1990) 0.90

Actin cytoskeleton and motility in rat sarcoma cell populations with different metastatic potential. Cell Motil Cytoskeleton (1994) 0.90

Cancer cell motility-inhibitory protein in the Dunning adenocarcinoma model. Cancer Res (1992) 0.85

Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion. Biochem Biophys Res Commun (1995) 0.85

Immunolocalization of desmoglein and intermediate filaments in human oral squamous cell carcinomas. Head Neck (1995) 0.84

Calpain-mediated proteolysis of microtubule-associated protein 2 (MAP-2) is inhibited by phosphorylation by cAMP-dependent protein kinase, but not by Ca2+/calmodulin-dependent protein kinase II. J Neurosci Res (1993) 0.83

Selective responses (actin polymerization, shape changes, locomotion, pinocytosis) to the PKC inhibitor Ro 31-8220 suggest that PKC discriminately regulates functions of human blood lymphocytes. J Leukoc Biol (1995) 0.82

Phenotypic variations and differential migration of NIH:OVCAR-3 ovarian carcinoma cells isolated from athymic mice. Clin Exp Metastasis (1995) 0.81

Inhibition of K1735-M2 melanoma cell invasion in vitro by retinoic acid. Clin Exp Metastasis (1993) 0.81

Protein phosphatases limit tumor motility. Int J Cancer (1993) 0.80

Regulation of cytoskeletal organization in tumor cells by protein phosphatases-1 and -2A. Int J Cancer (1995) 0.80

Autophosphorylation-dependent protein kinase phosphorylates Ser25, Ser38, Ser65, Ser71, and Ser411 in vimentin and thereby inhibits cytoskeletal intermediate filament assembly. J Protein Chem (1994) 0.80

A variant actin (beta m) reduces metastasis of mouse B16 melanoma. Int J Cancer (1994) 0.79

Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants. Int J Cancer (1994) 0.79

Inhibition of tumor production of granulocyte-macrophage colony-stimulating factor by 1 alpha, 25-dihydroxyvitamin D3 reduces tumor motility and metastasis. Invasion Metastasis (1993) 0.79

Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects. Int J Cancer (1995) 0.79

Application of molecular genetic techniques to the cAMP-dependent protein kinase system. Methods Enzymol (1988) 0.79

Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells. J Biol Chem (1991) 0.78

pp125FAK in human melanocytes and melanoma: expression and phosphorylation. Exp Cell Res (1995) 0.78

Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells. Invasion Metastasis (1992) 0.78

Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones. Int J Cancer (1991) 0.77

Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J Neurochem (1985) 0.77

Intracellular localization and biochemical function of variant beta-actin, which inhibits metastasis of B16 melanoma. Jpn J Cancer Res (1994) 0.76

Rat myoblastic sarcoma cell lines. A model for the study of invasion, metastasis, and myogenic differentiation. Lab Invest (1994) 0.75

1,25-Dihydroxyvitamin D3 attenuates adenylyl cyclase activity in rat thyroid cells: reduction of thyrotropin receptor number and increase in guanine nucleotide-binding protein Gi-2 alpha. Endocrinology (1994) 0.75

Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis. Clin Exp Metastasis (1996) 0.75

1,25-dihydroxyvitamin D3 alters the effect of cAMP in thyroid cells by increasing the regulatory subunit type II beta of the cAMP-dependent protein kinase. J Biol Chem (1994) 0.75

The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells. Eur J Cell Biol (1995) 0.75

Articles by these authors

Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells. Int J Cancer (1997) 1.46

Mechanisms of immune suppression in patients with head and neck cancer: influence on the immune infiltrate of the cancer. Int J Cancer (1996) 1.21

Association of a functional prostaglandin E2-protein kinase A coupling with responsiveness of metastatic Lewis lung carcinoma variants to prostaglandin E2 and to prostaglandin E2-producing nonmetastatic Lewis lung carcinoma variants. Cancer Res (1990) 0.90

Phenolic composition of litchi fruit pericarp. J Agric Food Chem (2000) 0.89

Treating tumor-bearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence. Cancer Immunol Immunother (1995) 0.89

Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A. Int J Cancer (1995) 0.84

Granulocyte-macrophage colony-stimulating factor stimulates the metastatic properties of Lewis lung carcinoma cells through a protein kinase A signal-transduction pathway. Int J Cancer (1993) 0.84

Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells. Cancer Lett (1997) 0.82

Protein phosphatases limit tumor motility. Int J Cancer (1993) 0.80

Regulation of cytoskeletal organization in tumor cells by protein phosphatases-1 and -2A. Int J Cancer (1995) 0.80

Inhibition of tumor production of granulocyte-macrophage colony-stimulating factor by 1 alpha, 25-dihydroxyvitamin D3 reduces tumor motility and metastasis. Invasion Metastasis (1993) 0.79

Activation of the protein kinase a signal transduction pathway by granulocyte-macrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcinoma variants. Int J Cancer (1994) 0.79

Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells. Invasion Metastasis (1992) 0.78

Stimulation of the metastatic properties of Lewis-lung-carcinoma cells by autologous granulocyte-macrophage colony-stimulating factor. Int J Cancer (1992) 0.78

Regulation of protein kinase A activation and prostaglandin E2-stimulated migration of Lewis lung carcinoma clones. Int J Cancer (1991) 0.77

1alpha,25-dihydroxyvitamin D3 activates T cells of tumor bearers through protein phosphatase 2A. Cancer Immunol Immunother (1997) 0.76

Immune parameters of mice bearing human head and neck cancer. Cancer Immunol Immunother (1995) 0.76

Ineffective immune enhancement by IL-12 in tumor-bearing mice whose immune depression is mediated by suppressive granulocyte-macrophage progenitor cells. Cancer Lett (1995) 0.76

Vitamin D3 treatment of tumor bearers can stimulate immune competence and reduce tumor growth when treatment coincides with a heightened presence of natural suppressor cells. Cancer Lett (1996) 0.75

Immune modulation by interleukin-12 in tumor-bearing mice receiving vitamin D3 treatments to block induction of immunosuppressive granulocyte/macrophage progenitor cells. Cancer Immunol Immunother (1996) 0.75

Tumor responsiveness to the metastasis-stimulatory effects of prostaglandin E2 is restricted by protein phosphatases. Adv Exp Med Biol (1997) 0.75

Bi-directional stimulation of adherence to extracellular matrix components by human head and neck squamous carcinoma cells and endothelial cells. Cancer Lett (1995) 0.75

Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis. Clin Exp Metastasis (1996) 0.75