Published in Vopr Onkol on January 01, 1977
Metformin for aging and cancer prevention. Aging (Albany NY) (2010) 1.51
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
Do metformin a real anticarcinogen? A critical reappraisal of experimental data. Ann Transl Med (2014) 0.93
Metformin for cancer and aging prevention: is it a time to make the long story short? Oncotarget (2015) 0.92
Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats. Cancer Biol Med (2017) 0.75
Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology (1980) 1.20
Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. J Gerontol A Biol Sci Med Sci (2001) 1.14
Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies. Curr Drug Targets (2011) 1.12
[Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats]. Vopr Onkol (1980) 0.94
[Current approaches to the study of carcinogenic safety, antineoplastic, anticarcinogenic and geroprotective effects of various pharmacologic preparations]. Vopr Onkol (2012) 0.92
Hypothalmic mechanisms of ageing and of specific age pathology--I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system. Exp Gerontol (1979) 0.91
Potentiation of antitumor effect of cyclophosphamide and hydrazine sulfate by treatment with the antidiabetic agent, 1-phenylethylbiguanide (phenformin). Cancer Lett (1979) 0.88
Promotion of skin tumors by 12-O-tetradecanoylphorbol-13-acetate in two generations of descendants of male mice exposed to X-ray irradiation. Mutat Res (1993) 0.88
[Effect of fenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats]. Vopr Onkol (1980) 0.87
Kinase mTOR: regulation and role in maintenance of cellular homeostasis, tumor development, and aging. Biochemistry (Mosc) (2014) 0.87
Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice. Bull Exp Biol Med (2011) 0.86
The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression. Neuro Endocrinol Lett (2001) 0.84
Mammary tumors in HER-2/NEU mice are characterized by low content of estrogen receptors-alpha and absence of progesterone receptors. Bull Exp Biol Med (2003) 0.84
Carcinogenesis and aging. III. The role of age in initiation and promotion of carcinogenesis. Exp Pathol (1982) 0.84
[The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives]. Vopr Onkol (2009) 0.83
[Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice]. Vopr Onkol (2010) 0.83
Pathology of tumours in laboratory animals. Tumours of the rat. Tumours of the vagina, uterus and oviduct. IARC Sci Publ (1990) 0.83
[Metformin slows down ageing processes at the cellular level in SHR mice]. Tsitologiia (2011) 0.82
Carcinogenesis and aging. Adv Cancer Res (1983) 0.82
[Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis]. Adv Gerontol (2007) 0.81
[Inhibition of the blastomogenic effect of 7,12-dimethylbenz(a)anthracene in female rats by buformin, diphenin, a polypeptide pineal extract and L-DOPA]. Biull Eksp Biol Med (1980) 0.80
Effects of melatonin on N-nitroso-N-methylurea-induced carcinogenesis in rats and mutagenesis in vitro (Ames test and COMET assay). Cancer Lett (1999) 0.80
Carcinogenesis and aging. I. Modifying effects of aging on N-methyl-N-nitrosourea-induced carcinogenesis in female rats. Exp Pathol (1981) 0.80
K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors. Cancer Lett (1996) 0.80
[Light-dark conditions, melatonin and risk of cancer]. Vopr Onkol (2006) 0.80
Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice. J Exp Clin Cancer Res (2006) 0.79
[Metformin effect on urethane-induced tumorigenesis in mice]. Vopr Onkol (2012) 0.79
[Increase in longevity and a decrease in the frequency of tumors in C3H/Sn mice under the influence of fenformin and diphenin]. Dokl Akad Nauk SSSR (1979) 0.79
[The effect of the irradiation of male mice on the sensitivity of 2 generations of progeny to the action of the skin tumor promoter 12-0-tetradecanoylphorbol-13-acetate]. Vopr Onkol (1991) 0.78
[Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice]. Vopr Onkol (2015) 0.78
[Effect of an epiphyseal polypeptide preparation on life expectancy and frequency of spontaneous tumors in aged female rats]. Dokl Akad Nauk SSSR (1991) 0.78
[Melatonin inhibits urethane-induced carcinogenesis tumors in murine lung]. Vopr Onkol (2006) 0.78
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea. Int J Cancer (1983) 0.78
[C-reactive protein modulates neutrophil adhesiveness and biocidal activity]. Zh Mikrobiol Epidemiol Immunobiol (1994) 0.78
[Blood estradiol level and G2-chalone content in the vaginal mucosa in rats of different ages]. Probl Endokrinol (Mosk) (1981) 0.78
The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats. Carcinogenesis (1980) 0.78
[An increase in hypothalamic sensitivity to the inhibiting effects of estrogens caused by use of L-DOPA, diphenine, epithalamin and phenformin in old rats]. Biull Eksp Biol Med (1975) 0.78
Effect of light/dark regimen on N-nitrosoethylurea-induced transplacental carcinogenesis in rats. Cancer Lett (2001) 0.78
[Immunologic reactivity of breast cancer patients]. Vopr Onkol (1978) 0.78
Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and the comet assay. Mutat Res (1998) 0.78
[Effect of phenformin on mammary gland tumor induction in rats]. Vopr Onkol (1974) 0.77
[Characteristics of dyslipidemia in cancer patients]. Vopr Onkol (1986) 0.77
[Effects of radiation from video display terminals of personal computers on free radical processes in rats]. Biull Eksp Biol Med (1997) 0.77
Role of age in host sensitivity to carcinogens. IARC Sci Publ (1983) 0.77
[Dynamics of the transplacental penetration of 7,12-dimethylbenz(a)anthracene (DMBA) in mice]. Vopr Onkol (1973) 0.77
[Effect of light regimens and melatonin on the homeostasis, life span and development of spontaneous tumors in female rats]. Adv Gerontol (2007) 0.77
[Chromosomal damage in peripheral blood lymphocytes of rats in nitrosomethylurea-induced carcinogenesis]. Eksp Onkol (1990) 0.77
Microvascular endothelium dysfunction in rats bearing 1,2-dimethylhydrazine-induced colon tumors. Cancer Lett (1999) 0.77
[Susceptibility of wild and knockout p53 FVB/N line mice to benz(a)pyrene-induced subcutaneous sarcoma]. Vopr Onkol (2002) 0.77
[Effect of radiation emitted from personal computer terminal on urethan-induced lung tumors in mice]. Vopr Onkol (1996) 0.77
[Free-radical processes in blood serum, liver and large bowel during 1,2-dimethylhydrazine-induced carcinogenesis in rats]. Vopr Onkol (1997) 0.77
[Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice]. Vopr Onkol (2007) 0.76
Disturbances of diurnal rhythms of biogenic amines contents in hypothalamic nuclei as an evidence of neurotropic effects of enterotropic carcinogen 1,2-dimethylhydrazine. Neuro Endocrinol Lett (2001) 0.76
[Effect of light regimens and melatonin on homeostasis, life span and spontaneous tumorigenesis in male rats]. Vopr Onkol (2008) 0.76
Expression of circadian Per1 and Per2 genes in the liver and breast tumor tissues of HER2/neu transgenic mice of different age. Bull Exp Biol Med (2011) 0.76
Morphology of experimentally induced tumors of the sympathetic nervous system in rats. Exp Toxicol Pathol (2004) 0.76
[Effect of thyroxine on the hypothalamic concentration of biogenic amines in rats of different ages]. Fiziol Zh SSSR Im I M Sechenova (1978) 0.76
[Colon carcinogenesis in rat vs. variable light]. Vopr Onkol (2008) 0.76
[Effect of the enterotropic carcinogen 1,2-dimethylhydrazine on the level of biogenic amines in the hypothalamus of rats]. Biull Eksp Biol Med (1976) 0.76
Long-live euthymic BALB/c-nu mice. I. Survival study suggests body weight as a life span predictor. Mech Ageing Dev (2001) 0.76
[Features of carcinogenesis and aging in knockout male mice PARP-1]. Vopr Onkol (2010) 0.76
Increase in lifespan of rats following polypeptide pineal extract treatment. Exp Pathol (Jena) (1979) 0.76
[The regulation of blood neutrophil functions by C-reactive protein and serum amyloid P]. Fiziol Zh Im I M Sechenova (1997) 0.76
Increase with age in the hypothalamo-hypophyseal threshold to the inhibitory action of estrogens and the effect of pineal extract on this process. Bull Exp Biol Med (1974) 0.76
[Cancer risk in women: a possible connection with geographic and certain economic and social factors]. Vopr Onkol (2011) 0.76
Hypothalamic mechanisms of ageing and of specific age pathology--III. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in energy systems. Exp Gerontol (1979) 0.76
[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice]. Vopr Onkol (2009) 0.76
[Inhibition of the transplacental blastomogenic effect of N-nitrosomethylurea in rats by buformin]. Biull Eksp Biol Med (1980) 0.76
[Age-related characteristics of the effects of epithalamin on serotonin metabolism in the pineal gland of rats]. Biull Eksp Biol Med (1992) 0.76
[Anahormone chimeras. Conjugates of melanocyte-stimulating pituitary hormone (MSH) with human melanoma antigens]. Dokl Akad Nauk SSSR (1974) 0.75
[A decrease in body weight, cholesterol and blood sugar under the influence of phenformin (phenylbiguanide) in patients with cancer and atherosclerosis]. Vopr Onkol (1972) 0.75
[Life span and tumor incidence in animals of various species]. Eksp Onkol (1987) 0.75
[Correction of endocrine-metabolic disorders in oncologic patients. The effect of biguanides (phenformin and adebita), miskleron and diphenin]. Vopr Onkol (1975) 0.75
[Proto-oncogene expression in the liver of male rats of different age]. Biull Eksp Biol Med (1991) 0.75
[Urgent problems of endocrinological oncology]. Vopr Onkol (1979) 0.75
[Decrease in the excretion of antigonadotropic factor in patients with cancer of the uterine cervix and prostate gland. Experimental antitumor effect of an epiphyseal extract]. Vopr Onkol (1976) 0.75
Transformation of the development program in the mechanism of age pathology. An elevational model of age pathology and natural death in man. Hum Physiol (1979) 0.75
[Reduced excretion of total gonadotropins during use of Elipten in breast neoplasms]. Vopr Onkol (1972) 0.75
[Inhibition of growth, fat-mobilization and lactogenic effects of somatotropic hormone with antiserum to anahormone of human placental lactogen]. Biull Eksp Biol Med (1972) 0.75
Age dynamics of regulation in the adaptation homeostat and age pathology. Hum Physiol (1979) 0.75
[The development of research into the role of the neuro-endocrine system in the pathogenesis of cancer (neuro-endocrine mechanisms of aging and cancer)]. Vopr Onkol (1967) 0.75
[The different effects of estrogen and drugs suppressing ovulation on tolerance to carbohydrates]. Akush Ginekol (Mosk) (1972) 0.75
[Improvement of the indicators of cellular immunity under the effect of polypeptide epiphyseal extract (epithalamine)]. Vopr Onkol (1977) 0.75
[Cutaneous fat fold thickness, obesity characteristics and body surface in breast cancer and fibroadenomatosis]. Vopr Onkol (1979) 0.75
[Effect of succinic and glutamic acids on the sensitivity of the hypothalamo-gonadotropic system to inhibitory effect of estrogens in old rats]. Farmakol Toksikol (1977) 0.75
[The effect of eliptene aminoglutethimide on the excretion of gonadotropins and phenol steroids (preliminary study)]. Vopr Onkol (1969) 0.75
[Overcoming artificial tolerance to somatotropin by a human somatotropin anahormone with additional antigenicity]. Biull Eksp Biol Med (1972) 0.75
[Central mechanism of the action of 17-alpha-hydroxy-progesterone capronate in the treatment of endometrial cancer]. Akush Ginekol (Mosk) (1977) 0.75
[Anahormone-chimeras. Hormonally-inactive conjugate of bovine ACTH and human somatotropin, retaining the antigenic properties of the original hormones]. Dokl Akad Nauk SSSR (1972) 0.75
[Antibodies to thyroglobulin in patients with cancer]. Vopr Onkol (1977) 0.75
[Improvements in the methods of diagnosing and treating trophoblastic disease]. Vopr Onkol (1969) 0.75
[The immunologic and hormonal activity of chorionic gonadotropin in patients with trophoblastic disease]. Vopr Onkol (1970) 0.75
[Birth weight and growth of children-cancer patients]. Pediatriia (1977) 0.75
[Age and increase in the sensitivity threshold of the tonic region of the hypothalamic sex center to inhibition by estradiol in female rats]. Biull Eksp Biol Med (1978) 0.75