Published in Curr Opin Cell Biol on April 01, 1997
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med (2011) 6.21
Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J (1999) 5.05
Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol (2009) 4.07
Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol (1998) 3.46
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J Cell Biol (1999) 2.18
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest (2010) 2.04
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol Biol Cell (2003) 1.80
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79
Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol (2000) 1.77
ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol (1998) 1.73
The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. Proc Natl Acad Sci U S A (2000) 1.71
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci U S A (1999) 1.63
SRC: a century of science brought to the clinic. Neoplasia (2010) 1.58
PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS One (2011) 1.43
Regulation of c-SRC activity and function by the adapter protein CAS. Mol Cell Biol (2000) 1.40
SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol (2009) 1.39
Retracted Gene expression profiles analysis identifies key genes for acute lung injury in patients with sepsis. Diagn Pathol (2014) 1.37
Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B. J Cell Biol (1998) 1.36
Src-dependent ezrin phosphorylation in adhesion-mediated signaling. Mol Biol Cell (2005) 1.35
Turnover of focal adhesions and cancer cell migration. Int J Cell Biol (2012) 1.22
Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells. Infect Immun (2000) 1.19
Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src. Mol Cell Biol (1999) 1.18
Current status of SRC inhibitors in solid tumor malignancies. Oncologist (2011) 1.18
Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts. Proc Natl Acad Sci U S A (2003) 1.13
Regulation of cell motility by tyrosine phosphorylated villin. Mol Biol Cell (2004) 1.06
Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci (1998) 1.04
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest (1999) 1.03
Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase. J Cell Sci (2009) 1.03
Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance. World J Gastroenterol (2002) 1.02
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src. Am J Respir Cell Mol Biol (2007) 0.94
β1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy. Cell Adh Migr (2012) 0.94
Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets. Future Oncol (2012) 0.93
SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol Cell Biol (2001) 0.92
Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clin Cancer Res (2008) 0.92
Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects. Onco Targets Ther (2012) 0.90
Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce focal adhesion kinase autophosphorylation and Src association. Infect Immun (2001) 0.90
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J (2002) 0.90
Erlotinib inhibits growth of a patient-derived chordoma xenograft. PLoS One (2013) 0.90
Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor. Mol Biol Cell (1998) 0.89
Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway. Mol Biol Cell (1999) 0.88
Role of integrin alpha4 in drug resistance of leukemia. Front Oncol (2014) 0.88
RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis. FEBS Lett (2008) 0.87
The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. MAbs (2013) 0.86
Src signaling pathways in prostate cancer. Cancer Metastasis Rev (2014) 0.86
Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell (2013) 0.86
Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells. Clin Exp Metastasis (2011) 0.85
Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth. Transl Oncol (2013) 0.84
Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases. Infect Immun (2010) 0.83
SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell. J Cell Mol Med (2011) 0.82
Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos. PLoS One (2012) 0.82
Mutual cross-talk between fibronectin integrins and the EGF receptor: Molecular basis and biological significance. Cell Logist (2012) 0.82
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation. Cell Signal (2012) 0.80
Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation. Sci Rep (2016) 0.78
A co-association network analysis of the genetic determination of pig conformation, growth and fatness. PLoS One (2014) 0.78
Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism. Hypertension (2013) 0.76
Target points in trastuzumab resistance. Int J Breast Cancer (2012) 0.76
Addressing the functional determinants of FAK during ciliogenesis in multiciliated cells. J Biol Chem (2016) 0.75
Expression of the pRb-binding regions of E1A enables efficient transformation of primary epithelial cells by v-src. J Virol (1998) 0.75
Src-signaling interference impairs the dissemination of blood-borne tumor cells. Cell Tissue Res (2012) 0.75
Phosphatidylinositol 3-Kinase/Akt Mediates Integrin Signaling To Control RNA Polymerase I Transcriptional Activity. Mol Cell Biol (2016) 0.75
Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells. J Ovarian Res (2017) 0.75
Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival. Int J Cancer (2016) 0.75
CXCL12/SDF-1α induces migration via SRC-mediated CXCR4-EGFR cross-talk in gastric cancer cells. Oncol Lett (2017) 0.75
Src family kinases in chronic kidney disease. Am J Physiol Renal Physiol (2017) 0.75
c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem (1999) 3.91
Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci U S A (1999) 3.43
Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin. J Virol (1984) 3.18
A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts. J Cell Biol (1990) 2.41
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers. Proc Natl Acad Sci U S A (1995) 2.29
Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res (2000) 2.14
c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J Cell Biol (1995) 2.06
Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene (2001) 1.89
Transmission of hepatitis C within Australian prisons. Med J Aust (1999) 1.89
A strategy for reducing blood-transfusion requirements in elective orthopaedic surgery. Audit of an algorithm for arthroplasty of the lower limb. J Bone Joint Surg Br (2003) 1.78
c-Src, receptor tyrosine kinases, and human cancer. Adv Cancer Res (1999) 1.71
c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function. Oncogene (2006) 1.69
p60c-src activity detected in the chromaffin granule membrane. Biochem Biophys Res Commun (1986) 1.62
Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src. Mol Cell Biol (1988) 1.59
pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src. Mol Cell Biol (1989) 1.56
Local degradation of fibronectin at sites of expression of the transforming gene product pp60src. Nature (1985) 1.55
Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells. Mol Carcinog (1998) 1.54
Purification and properties of beta-isopropylmalate dehydrogenase. J Biol Chem (1969) 1.41
Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells. Mol Cell Biol (2001) 1.41
Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression. Cancer Res (1999) 1.37
Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Mol Cell Biol (1998) 1.32
Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src. J Virol (1983) 1.31
Role of c-Src tyrosine kinase in EGF-induced mitogenesis. Front Biosci (1997) 1.28
Identification of chromaffin granule-binding proteins. Relationship of the chromobindins to calelectrin, synhibin, and the tyrosine kinase substrates p35 and p36. J Biol Chem (1987) 1.27
Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor. J Biol Chem (1997) 1.22
Effect of butyrolactone I on the producing fungus, Aspergillus terreus. Appl Environ Microbiol (1998) 1.21
Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein. J Virol (1986) 1.19
Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts. J Cell Sci (2001) 1.14
Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway. Oncogene (2006) 1.14
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate. Oncogene (1992) 1.14
Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity. J Biol Chem (1994) 1.12
Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors. Oncogene (1993) 1.12
Immune response to the src gene product in mice bearing tumors induced by injection of avian sarcoma virus-transformed mouse cells. J Virol (1979) 1.11
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. Proc Natl Acad Sci U S A (1992) 1.10
Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells. Oncogene (1988) 1.10
The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src. Mol Cell Biol (1993) 1.06
A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma. Mol Cell Biol (1994) 1.05
Functional interactions between Choline kinase α, epidermal growth factor receptor and c-Src in breast cancer cell proliferation. Oncogene (2011) 1.02
Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation. Proc Natl Acad Sci U S A (1990) 1.01
Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein. J Biol Chem (1995) 0.96
Electroconvulsive treatment induces a rapid and transient increase in tyrosine phosphorylation of a 40-kilodalton protein associated with microtubule-associated protein 2 kinase activity. J Neurochem (1991) 0.96
c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes. Chem Rev (2001) 0.95
Activated 3',5'-cyclic AMP-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line. J Biol Chem (2000) 0.94
Analysis of P210bcr-abl tyrosine protein kinase activity in various subtypes of Philadelphia chromosome-positive cells from chronic myelogenous leukemia patients. Cancer Res (1987) 0.93
Gonadotropin-releasing hormone pulses are required to maintain activation of mitogen-activated protein kinase: role in stimulation of gonadotrope gene expression. Endocrinology (1998) 0.93
Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src. Oncogene (1990) 0.93
Monoclonal antibodies to oncoproteins. Methods Enzymol (1995) 0.92
Monoclonal antibodies specific for the virion polypeptide, p27, of avian retroviruses. Hybridoma (1984) 0.87
Tyrosine kinases are required for catecholamine secretion and mitogen-activated protein kinase activation in bovine adrenal chromaffin cells. J Neurochem (1996) 0.87
Matrix mineralization in hypertrophic chondrocyte cultures. Beta glycerophosphate increases type X collagen messenger RNA and the specific activity of pp60c-src kinase. Bone Miner (1992) 0.87
Modulation of pp60c-src tyrosine kinase activity during secretion in stimulated bovine adrenal chromaffin cells. J Neurosci Res (1989) 0.86
Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus. Proc Natl Acad Sci U S A (1987) 0.85
Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src. J Virol (1987) 0.84
Roles for protein kinase C and mitogen-activated protein kinase in nicotine-induced secretion from bovine adrenal chromaffin cells. J Neurochem (1997) 0.84
Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. Cell Signal (1992) 0.84
Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP. J Virol (1995) 0.83
Activation of Fyn tyrosine kinase upon secretagogue stimulation of bovine chromaffin cells. J Neurosci Res (1996) 0.83
pp60c-src enhances the acetylcholine receptor-dependent catecholamine release in vaccinia virus-infected bovine adrenal chromaffin cells. J Neurochem (1994) 0.81
Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in a loss of GTP binding activity. FEBS Lett (2000) 0.80
Structural and functional motifs of the Rous sarcoma virus src protein. Gene Amplif Anal (1986) 0.80
Phosphotyrosine phosphatase activity associated with c-Src in large multimeric complexes isolated from adrenal medullary chromaffin cells. Biochem J (1997) 0.79
Insulin and phorbol ester induce distinct phosphorylations of pp60c-src in the BC3H-1 murine myocyte cell line. Oncogene (1989) 0.78
Identification of the in vitro phosphorylation sites on Gs alpha mediated by pp60c-src. Biochem J (1995) 0.76
Fidelity of initiation of protein synthesis after premature chain termination in polarity mutants. J Bacteriol (1969) 0.75
Protein-tyrosine kinases, oncogenes, and cancer. Important Adv Oncol (1993) 0.75
A novel negative imaging technique for accurate localization of stainable proteins on complex two-dimensional autoradiograms. Electrophoresis (1997) 0.75