Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

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Published in Curr Biol on April 01, 1997

Authors

D R Alessi1, S R James, C P Downes, A B Holmes, P R Gaffney, C B Reese, P Cohen

Author Affiliations

1: Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, DD1 4HN, Scotland. dralessi@bad.dundee.ac.uk

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Protein phosphatases: properties and role in cellular regulation. Science (1983) 2.61

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The clinician's illusion. Arch Gen Psychiatry (1984) 2.55

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