Published in Chem Biol Interact on September 01, 1977
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther (2005) 2.30
Studies on the mechanism of hepatic microsomal N-oxide formation. N-oxidation of NN-dimethylaniline by a reconstituted rabbit liver microsomal cytochrome P-448 enzyme system. Biochem J (1979) 0.82
Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27
p53 mutation hotspot in radon-associated lung cancer. Lancet (1994) 3.11
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3. Biochem Pharmacol (1998) 1.80
Cytodifferentiation of the nonciliated bronchiolar epithelial (Clara) cell during rabbit lung maturation: an ultrastructural and morphometric study. Am J Anat (1983) 1.43
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res (1992) 1.42
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines. Cancer Res (1989) 1.38
Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers. Clin Cancer Res (1995) 1.37
A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal Biochem (1980) 1.36
The stimulation and inhibition of hepatic microsomal drug-metabolizing enzymes with special reference to effects of environmental contaminants. Toxicol Appl Pharmacol (1970) 1.32
The submicrosomal distribution of hepatic uridine diphosphate glucuronyltransferases in the rabbit. Biochem J (1968) 1.20
Stimulation of hepatic microsomal aniline p-hydroxylase activity by dimethyl sulfoxide administration to rats. Toxicol Appl Pharmacol (1970) 1.18
Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans. Environ Health Perspect (1987) 1.14
Effects of storage on hepatic microsomal cytochromes and substrate-induced difference spectra. Biochem Pharmacol (1970) 1.14
Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs. J Pharmacol Exp Ther (1973) 1.14
Quantitation of rabbit cytochrome P-450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxidase-immunostaining procedure. Anal Biochem (1984) 1.11
Some characteristics of hepatic microsomal systems which metabolize aminopyrine in the rat and rabbit. J Pharmacol Exp Ther (1968) 1.08
Further studies on the metabolism of drugs by subfractions of hepatic microsomes. J Pharmacol Exp Ther (1967) 1.07
Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem Biol Interact (1997) 1.07
Isolation and identification of Clara cells from rabbit lung. In Vitro (1980) 1.06
CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid. Biochemistry (1995) 1.06
The pulmonary uptake, accumulation, and metabolism of xenobiotics. Annu Rev Pharmacol Toxicol (1985) 1.06
A comparative study of the hepatic and pulmonary microsomal mixed-function oxidase systems in the rabbit. J Pharmacol Exp Ther (1972) 1.05
An additional 136 SSLP markers typed for the AXB and BXA recombinant inbred mouse strains. Mamm Genome (1997) 1.04
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res (1998) 1.03
In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. J Pharmacol Exp Ther (1982) 1.03
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation. Cancer Res (1994) 1.03
Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver. J Pharmacol Exp Ther (1972) 1.03
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain Res Mol Brain Res (1999) 1.02
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest (1995) 1.01
The metabolism of drugs by hepatic microsomal enzymes. Studies on intramicrosomal distribution of enzymes and relationships between enzyme activity and structure of the hepatic endoplasmic reticulum. Exp Mol Pathol (1966) 1.01
Hepatic lipid droplets. Isolation, morphology and composition. Biochem J (1973) 1.01
Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mol Carcinog (1997) 0.99
Flavin-containing monooxygenase (FMO)-dependent metabolism of methionine and evidence for FMO3 being the major FMO involved in methionine sulfoxidation in rabbit liver and kidney microsomes. J Biol Chem (1994) 0.99
At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice. Genomics (1998) 0.98
Cytochrome p-450: localization in rabbit lung. Science (1980) 0.98
New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther (1998) 0.97
Characterization of the free radical formed in aerobic microsomal incubations containing carbon tetrachloride and NADPH. Biochem Biophys Res Commun (1979) 0.97
Hepatic microsomal mixed-function oxidase activity of several marine species from coastal Maine. Drug Metab Dispos (1975) 0.97
Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes. Proc Natl Acad Sci U S A (1993) 0.97
Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung. Am J Respir Cell Mol Biol (1991) 0.96
Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res (1987) 0.96
Cytochrome P-450 mediated genetic activity and cytotoxicity of seven halogenated aliphatic hydrocarbons in Saccharomyces cerevisiae. Mutat Res (1980) 0.95
The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450. Biochem J (1969) 0.95
Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines. Carcinogenesis (2000) 0.94
The effect of phenobarbital on drug metabolic enzyme activity, ultrastructure and growth of a "minimal deviation" hepatoma (Morris 7800). J Pharmacol Exp Ther (1967) 0.93
Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine. Exp Lung Res (1991) 0.93
Species and sex differences in expression of flavin-containing monooxygenase form 3 in liver and kidney microsomes. Drug Metab Dispos (1999) 0.93
CYP4B1 activates 4-ipomeanol in rat lung. Toxicol Appl Pharmacol (1993) 0.92
Benzo(a)pyrene hydroxylase activity in enriched populations of Clara cells and alveolar type II cells from control and beta-naphthoflavone-pretreated rats. Cancer Res (1982) 0.92
Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Mol Pharmacol (1980) 0.92
Xenobiotic metabolism by isolated pulmonary cells. Pharmacol Ther (1989) 0.92
Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB. Mol Pharmacol (1989) 0.92
The rabbit pulmonary monooxygenase system. Immunochemical and biochemical characterization of enzyme components. J Biol Chem (1979) 0.92
Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations. Drug Metab Dispos (1975) 0.92
Hepatic and extrahepatic metabolism, in vitro, of an epoxide (8-(14) C-styrene oxide) in the rabbit. Biochem Pharmacol (1976) 0.91
Mixed-function oxidases and the alveolar macrophage. Biochem Pharmacol (1972) 0.91
A comparative study of two procedures used in the determination of hepatic microsomal aniline hydroxylation. Toxicol Appl Pharmacol (1972) 0.90
Some studies and comments on hepatic and extrahepatic microsomal toxication-detoxication systems. A limited discussion of some of the heterogeneities of these systems and of their responses to stimulation of enzyme "induction". Environ Health Perspect (1972) 0.90
H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells. Carcinogenesis (1995) 0.89
Xenobiotic metabolism in Clara cells and alveolar type II cells isolated from lungs of rats treated with beta-naphthoflavone. J Pharmacol Exp Ther (1983) 0.89
Interaction of methylenedioxyphenyl (1,3-benzodioxole) compounds with enzymes and their effects on mammals. Drug Metab Rev (1974) 0.89
The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization. Mol Pharmacol (1988) 0.89
Methionine S-oxidation in human and rabbit liver microsomes: evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3. Arch Biochem Biophys (1999) 0.89
Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. Exp Lung Res (1981) 0.89
Effect of pretreatment of rabbits with phenobarbital or 3-methylcholanthrene on the distribution of drug-metabolizing enzyme activity in subfractions of hepatic microsomes. J Pharmacol Exp Ther (1967) 0.89
Use of inactivated foot-and-mouth disease virus antigen in liquid-phase blocking ELISA. J Virol Methods (1990) 0.88
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. Cancer Res (1991) 0.88
Pulmonary cytochrome P450 monooxygenase and Clara cell differentiation in mice. Am J Respir Cell Mol Biol (1997) 0.88
Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors. Mol Carcinog (1995) 0.88
Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalyst. Arch Biochem Biophys (1996) 0.88
Immunohistochemical demonstration of cytochrome P-450 monooxygenase in Clara cells throughout the tracheobronchial airways of the rabbit. Exp Lung Res (1987) 0.87
Purification and structural comparison of pulmonary and hepatic cytochrome P-450 from rabbits. Biochim Biophys Acta (1980) 0.87
Overview of the field: environmental factors affecting chemical or drug effects in animals. Fed Proc (1976) 0.86
Some in vitro assay conditions that affect detection and quantitation of phenobarbital-induced increases in hepatic microsomal drug-metabolizing enzyme activity. Toxicol Appl Pharmacol (1970) 0.86
Isolation of pulmonary cells and use in studies of xenobiotic metabolism. Methods Enzymol (1981) 0.86
Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs. Mol Pharmacol (1988) 0.86
A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species. Drug Metab Dispos (1975) 0.85
Cloning and sequencing of flavin-containing monooxygenases FMO3 and FMO4 from rabbit and characterization of FMO3. J Biol Chem (1994) 0.85
The lack of effects of pretreatment with phenobarbital and chlorpromazine on the acute toxicity of benzene in rats. Toxicol Appl Pharmacol (1974) 0.85
Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. Arch Biochem Biophys (1995) 0.85
Stimulation by chlordane of hepatic drug metabolism in the squirrel monkey. J Lab Clin Med (1965) 0.85
High frequency and heterogeneous distribution of p53 mutations in aflatoxin B1-induced mouse lung tumors. Cancer Res (1999) 0.85
Cytochrome P-450-dependent xenobiotic metabolizing activity in Zymbal's gland, a specialized sebaceous gland of rodents. Cancer Res (1983) 0.85
p53 and K-ras in radon-associated lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev (1996) 0.84
Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis. Exp Toxicol Pathol (2001) 0.84
o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. Carcinogenesis (2003) 0.84
Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization. Drug Metab Dispos (1997) 0.84
The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes. J Biol Chem (1990) 0.84
Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months. Carcinogenesis (1995) 0.84
Alveolar type II and Clara cells: isolation and xenobiotic metabolism. Environ Health Perspect (1984) 0.84
The effect of some biphenyl solubilizing and suspending agents on biphenyl 4-hydroxylase of rabbit liver microsomes. Chem Biol Interact (1973) 0.84
Species-dependent expression and induction of homologues of rabbit cytochrome P-450 isozyme 5 in liver and lung. Mol Pharmacol (1987) 0.84