A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 9129026)

Published in Blood on May 01, 1997

Authors

R F Kelley1, C J Refino, M P O'Connell, N Modi, P Sehl, D Lowe, C Pater, S Bunting

Author Affiliations

1: Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.

Articles by these authors

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature (1976) 13.19

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. Prostaglandins (1976) 4.54

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins (1976) 4.44

Patient-to-patient transmission of HIV in private surgical consulting rooms. Lancet (1994) 4.12

Modulation of human platelet adenylate cyclase by prostacyclin (PGX). Prostaglandins (1977) 3.80

Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or knee replacement: a randomised study. Br Med J (Clin Res Ed) (1982) 3.71

The chemical structure of prostaglandin X (prostacyclin). Prostaglandins (1976) 3.63

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther (1990) 3.55

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest (1994) 3.11

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83

Access to stroke care in England, Wales and Northern Ireland: the effect of age, gender and weekend admission. Age Ageing (2007) 2.80

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A (2001) 2.77

Continuous negative extrathoracic pressure in neonatal respiratory failure. Pediatrics (1996) 2.75

Evidence for a link between mortality in acute COPD and hospital type and resources. Thorax (2003) 2.63

Imidazole: a selective inhibitor of thromboxane synthetase. Prostaglandins (1977) 2.48

Impact of managed clinical networks on NHS specialist neonatal services in England: population based study. BMJ (2012) 2.44

Acidosis, non-invasive ventilation and mortality in hospitalised COPD exacerbations. Thorax (2010) 2.38

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. Prostaglandins (1976) 2.28

Clinical audit indicators of outcome following admission to hospital with acute exacerbation of chronic obstructive pulmonary disease. Thorax (2002) 2.22

Airborne contamination of wounds in joint replacement operations: the relationship to sepsis rates. J Hosp Infect (1983) 2.20

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J Immunol (1992) 2.09

Tonsillectomy technique as a risk factor for postoperative haemorrhage. Lancet (2004) 2.08

Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation (1995) 2.07

The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings]. Br J Pharmacol (1976) 2.06

Tumour-associated eosinophilia: a review. J Clin Pathol (1981) 2.03

A comparison of outcomes for patients with oral squamous cell carcinoma at intermediate risk of recurrence treated by surgery alone or with post-operative radiotherapy. Oral Oncol (2006) 2.01

Outcomes of rescue therapy in acute severe ulcerative colitis: data from the United Kingdom inflammatory bowel disease audit. Aliment Pharmacol Ther (2013) 2.01

The national sentinel audit for stroke: a tool for raising standards of care. J R Coll Physicians Lond (2000) 1.97

Characterization of factors that direct transcription of rat ribosomal DNA. Mol Cell Biol (1990) 1.93

Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation (1995) 1.92

Audit of acute admissions of COPD: standards of care and management in the hospital setting. Eur Respir J (2001) 1.90

UK National COPD Audit 2003: Impact of hospital resources and organisation of care on patient outcome following admission for acute COPD exacerbation. Thorax (2006) 1.89

Infection and sepsis after operations for total hip or knee-joint replacement: influence of ultraclean air, prophylactic antibiotics and other factors. J Hyg (Lond) (1984) 1.85

Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Br J Cancer (2006) 1.84

Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol (2003) 1.81

Stroke units: research and reality. Results from the National Sentinel Audit of Stroke. Qual Saf Health Care (2005) 1.80

Peptide exosite inhibitors of factor VIIa as anticoagulants. Nature (2000) 1.77

Benign and malignant teratomas in children: analysis of 85 patients. Surgery (1976) 1.71

Transcutaneous bilirubin measurement: a multicenter evaluation of a new device. Pediatrics (2001) 1.70

Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol (1982) 1.66

Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost (2001) 1.64

Intra-prostatic urinary reflux: an aetiological factor in abacterial prostatitis. Br J Urol (1982) 1.64

Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol (1996) 1.63

A randomised trial of peer review: the UK National Chronic Obstructive Pulmonary Disease Resources and Outcomes Project. Clin Med (2010) 1.62

National stroke audit: a tool for change? Qual Health Care (2001) 1.61

Prostacyclin is a circulating hormone. Nature (1978) 1.60

Randomised controlled trial of postnatal sodium supplementation on body composition in 25 to 30 week gestational age infants. Arch Dis Child Fetal Neonatal Ed (2000) 1.60

Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition. Prostaglandins (1976) 1.56

Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors. Proc Natl Acad Sci U S A (1990) 1.55

Predictors of speech and swallowing function following primary surgery for oral and oropharyngeal cancer. Clin Otolaryngol (2005) 1.55

Outbreak of cephalosporin resistant Enterobacter cloacae infection in a neonatal intensive care unit. Arch Dis Child (1987) 1.54

Changes in plasma cortisol and catecholamine concentrations in response to massage in preterm infants. Arch Dis Child (1993) 1.54

A faster-acting and more potent form of tissue plasminogen activator. Proc Natl Acad Sci U S A (1994) 1.52

Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation (1995) 1.51

Assessment of problems with appearance, following surgery for oral and oro-pharyngeal cancer using the University of Washington appearance domain and the Derriford appearance scale. Oral Oncol (2008) 1.51

Gene expression analysis by transcript profiling coupled to a gene database query. Nat Biotechnol (1999) 1.50

Thermodynamic analysis of an antibody functional epitope. Biochemistry (1993) 1.49

Stroke thrombolysis in England, Wales and Northern Ireland: how much do we do and how much do we need? J Neurol Neurosurg Psychiatry (2010) 1.49

Randomised controlled trial of postnatal sodium supplementation on oxygen dependency and body weight in 25-30 week gestational age infants. Arch Dis Child Fetal Neonatal Ed (2000) 1.48

A randomized, controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor in human newborns less than 32 weeks gestation. Pediatrics (1999) 1.48

Direct selection for curing and deletion of Rhizobium plasmids using transposons carrying the Bacillus subtilis sacB gene. Gene (1989) 1.48

Changes in practice and organisation surrounding blood transfusion in NHS trusts in England 1995-2005. Qual Saf Health Care (2008) 1.47

Reliability and validity of the Intercollegiate Stroke Audit Package. J Eval Clin Pract (2001) 1.46

Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens. Protein Eng Des Sel (2008) 1.45

Kistrin, a polypeptide platelet GPIIb/IIIa receptor antagonist, enhances and sustains coronary arterial thrombolysis with recombinant tissue-type plasminogen activator in a canine preparation. Circulation (1991) 1.44

Preliminary report of unexpected local reactions to a progestogen-releasing contraceptive vaginal ring. Eur J Obstet Gynecol Reprod Biol (1993) 1.43

Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay. Appl Environ Microbiol (1985) 1.43

In utero nephropathy, Denys-Drash syndrome and Potter phenotype. Pediatr Nephrol (1998) 1.43

Assessment of total body water using bioelectrical impedance analysis in neonates receiving intensive care. Arch Dis Child Fetal Neonatal Ed (1997) 1.42

Through the endoscope: a novel method of nasogastric tube insertion during oesophagoscopy. Clin Otolaryngol (2008) 1.42

Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis. Prostaglandins (1976) 1.40

Pheochromocytoma, sickle cell disease and pregnancy: a case report. J Matern Fetal Neonatal Med (2003) 1.39

Indirect laryngoscopy - the cold way. Clin Otolaryngol (2007) 1.37

Relationship between anxiety, depression, and morbidity in adult asthma patients. Thorax (2001) 1.37

The regulation of blood vessel growth by vascular endothelial growth factor. Ann N Y Acad Sci (1995) 1.34

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry (2000) 1.34

Stopping rules for clinical trials incorporating clinical opinion. Biometrics (1984) 1.33

Effects of intravenous infusion of prostacyclin (PGI2) in man. Prostaglandins (1980) 1.30

D2 gastrectomy: lessons from a prospective audit of the learning curve. Br J Surg (1996) 1.28

Phototherapy for neonatal hyperbilirubinaemia: the importance of dose. Arch Dis Child (1983) 1.28

Inhibition of phospholipase C dependent processes by U-73, 122. Adv Prostaglandin Thromboxane Leukot Res (1989) 1.27

A review of scaphoid fracture healing in competitive athletes. Am J Sports Med (1985) 1.26

Bacteria isolated from deep joint sepsis after operation for total hip or knee replacement and the sources of the infections with Staphylococcus aureus. J Hosp Infect (1983) 1.23

Hepatitis B and hepatitis C virus infections: risk factors among drug users in Northwest England. J Infect (1998) 1.23

Clinical trials and neonatal intensive care. Arch Dis Child Fetal Neonatal Ed (1994) 1.23

Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb. Am J Physiol (1994) 1.22

Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation (1994) 1.21

Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation (1997) 1.21

Ultraclean air and antibiotics for prevention of postoperative infection. A multicenter study of 8,052 joint replacement operations. Acta Orthop Scand (1987) 1.21

A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N, KHRR 296-299 AAAA). Thromb Haemost (1993) 1.20

The prostacyclin--thromboxane A2 balance: pathophysiological and therapeutic implications. Br Med Bull (1983) 1.20

A monoclonal antibody that inhibits mouse tissue factor function. J Thromb Haemost (2005) 1.19

Caesarean section controversy. Further research is needed on why rates of caesarean section are increasing. BMJ (2000) 1.19

Health-related quality of life and clinical function after primary surgery for oral cancer. Br J Oral Maxillofac Surg (2002) 1.19

Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4. J Biol Chem (1984) 1.18

The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. Comp Biochem Physiol C Toxicol Pharmacol (2007) 1.17

Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man. Br J Clin Pharmacol (1979) 1.16

Prospective study of the quality of life in patients assessed for liver transplantation: outcome in transplanted and not transplanted groups. J R Soc Med (1995) 1.15