PubRank

G M Whitesides

Author PubWeight™ 170.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Geometric control of cell life and death. Science 1997 18.13
2 Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). Anal Chem 1998 15.53
3 Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 2000 9.45
4 Engineering cell shape and function. Science 1994 5.95
5 Patterning proteins and cells using soft lithography. Biomaterials 1999 4.58
6 Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces. Science 1991 4.15
7 Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu Rev Biophys Biomol Struct 1996 2.98
8 Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proc Natl Acad Sci U S A 2000 2.83
9 Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal Chem 2000 2.81
10 How to make water run uphill. Science 1992 2.73
11 Designing a polyvalent inhibitor of anthrax toxin. Nat Biotechnol 2001 2.67
12 Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver. Exp Cell Res 1997 2.52
13 Subcellular positioning of small molecules. Nature 2001 2.49
14 Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim 1999 2.38
15 A strategy for the generation of surfaces presenting ligands for studies of binding based on an active ester as a common reactive intermediate: a surface plasmon resonance study. Anal Chem 1999 2.37
16 Patterning cells and their environments using multiple laminar fluid flows in capillary networks. Proc Natl Acad Sci U S A 1999 2.27
17 Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study. Biochemistry 1989 2.24
18 A self-assembled monolayer for the binding and study of histidine-tagged proteins by surface plasmon resonance. Anal Chem 1996 2.20
19 Fabricating large arrays of microwells with arbitrary dimensions and filling them using discontinuous dewetting. Anal Chem 1998 2.04
20 Micropatterned surfaces for control of cell shape, position, and function. Biotechnol Prog 1998 2.01
21 Submicrometer patterning of charge in thin-film electrets. Science 2001 1.92
22 Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells. Exp Cell Res 1998 1.91
23 Fabrication of submicrometer features on curved substrates by microcontact printing. Science 1995 1.77
24 A trivalent system from vancomycin.D-ala-D-Ala with higher affinity than avidin.biotin. Science 1998 1.69
25 Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups. Insight into mechanism of inhibition. J Med Chem 1995 1.55
26 Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proc Natl Acad Sci U S A 1996 1.53
27 Molecule-mimetic chemistry and mesoscale self-assembly. Acc Chem Res 2001 1.42
28 Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: multivalency and steric stabilization of particulate biological systems. J Med Chem 1994 1.37
29 Electron transport through thin organic films in metal--insulator--metal junctions based on self-assembled monolayers. J Am Chem Soc 2001 1.36
30 Rates of thiol-disulfide interchange reactions involving proteins and kinetic measurements of thiol pKa values. Biochemistry 1980 1.35
31 Self-assembly of 10-microm-sized objects into ordered three-dimensional arrays. J Am Chem Soc 2001 1.34
32 Nonstatistical binding of a protein to clustered carbohydrates. Proc Natl Acad Sci U S A 1999 1.34
33 Biological surface engineering: a simple system for cell pattern formation. Biomaterials 1999 1.29
34 Molecular-Level Control over Surface Order in Self-Assembled Monolayer Films of Thiols on Gold. Science 1988 1.29
35 Regeneration of nicotinamide cofactors for use in organic synthesis. Appl Biochem Biotechnol 1987 1.29
36 Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors. J Med Chem 1994 1.27
37 An integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applications. Anal Chem 2001 1.27
38 Fabrication of a configurable, single-use microfluidic device. Anal Chem 2001 1.19
39 Microfluidic arrays of fluid-fluid diffusional contacts as detection elements and combinatorial tools. Anal Chem 2001 1.18
40 Dynamic, self-assembled aggregates of magnetized, millimeter-sized objects rotating at the liquid-air interface: macroscopic, two-dimensional classical artificial atoms and molecules. Phys Rev E Stat Nonlin Soft Matter Phys 2001 1.16
41 Manipulation of the wettability of surfaces on the 0.1- to 1 -micrometer scale through micromachining and molecular self-assembly. Science 1992 1.15
42 Affinity capillary electrophoresis: a physical-organic tool for studying interactions in biomolecular recognition. Electrophoresis 1998 1.12
43 Correlation between surface free energy and surface constitution. Science 1992 1.11
44 Increasing binding constants of ligands to carbonic anhydrase by using "greasy tails". J Med Chem 1995 1.11
45 Molecular self-assembly of two-terminal, voltammetric microsensors with internal references. Science 1991 1.09
46 On-line detection of nonspecific protein adsorption at artificial surfaces. Anal Chem 1997 1.08
47 Measuring the forces involved in polyvalent adhesion of uropathogenic Escherichia coli to mannose-presenting surfaces. Proc Natl Acad Sci U S A 2000 1.08
48 Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J Med Chem 1995 1.04
49 Use of affinity capillary electrophoresis to determine kinetic and equilibrium constants for binding of arylsulfonamides to bovine carbonic anhydrase. J Med Chem 1993 1.02
50 Optically controlled collisions of biological objects to evaluate potent polyvalent inhibitors of virus-cell adhesion. Chem Biol 1996 1.01
51 Using three-dimensional microfluidic networks for solving computationally hard problems. Proc Natl Acad Sci U S A 2001 1.01
52 A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. Chem Biol 1997 1.00
53 Preparation of a mixture of nucleoside triphosphates suitable for use in synthesis of nucleotide phosphate sugars from ribonucleic acid using nuclease P1, a mixture of nucleoside monophosphokinases and acetate kinase. Appl Biochem Biotechnol 1990 1.00
54 Evaluating electrostatic contributions to binding with the use of protein charge ladders. Science 1996 1.00
55 Orthogonal self-assembled monolayers: alkanethiols on gold and alkane carboxylic acids on alumina. Science 1989 0.99
56 Patterning electro-osmotic flow with patterned surface charge. Phys Rev Lett 2000 0.99
57 Measurement of thiol-disulfide interchange reactions and thiol pKa values. Methods Enzymol 1987 0.98
58 Patterned condensation figures as optical diffraction gratings. Science 1994 0.98
59 Determination of binding constants of ligands to proteins by affinity capillary electrophoresis: compensation for electroosmotic flow. Anal Chem 1994 0.97
60 Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose. Methods Enzymol 1987 0.95
61 Contact adhesion of thin gold films on elastomeric supports: cold welding under ambient conditions. Science 1991 0.94
62 Determination of the effective charge of a protein in solution by capillary electrophoresis. Proc Natl Acad Sci U S A 1994 0.93
63 Fabrication inside microchannels using fluid flow. Acc Chem Res 2000 0.91
64 Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods Mol Biol 2000 0.91
65 Microlithography by using neutral metastable atoms and self-assembled monolayers. Science 1995 0.91
66 Imaging of features on surfaces by condensation figures. Science 1993 0.91
67 Pressure-driven laminar flow in tangential microchannels: an elastomeric microfluidic switch. Anal Chem 2001 0.90
68 Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry. J Med Chem 1996 0.89
69 Self-assembly of an operating electrical circuit based on shape complementarity and the hydrophobic effect. Adv Mater 1998 0.89
70 Monomeric inhibitors of influenza neuraminidase enhance the hemagglutination inhibition activities of polyacrylamides presenting multiple C-sialoside groups. Chem Biol 1996 0.88
71 Binding of a dimeric derivative of vancomycin to L-Lys-D-Ala-D-lactate in solution and at a surface. Chem Biol 1999 0.88
72 Use of affinity capillary electrophoresis to measure binding constants of ligands to proteins. J Med Chem 1992 0.88
73 Using protein charge ladders to estimate the effective charges and molecular weights of proteins in solution. Anal Chem 1997 0.86
74 Covalent immobilization of adenylate kinase and acetate kinase in a polyacrylamide gel: enzymes for ATP regeneration. Methods Enzymol 1976 0.85
75 Reagents for rapid reduction of disulfide bonds. Methods Enzymol 1995 0.85
76 CMP-N-acetylneuraminic acid synthetase of Escherichia coli: high level expression, purification and use in the enzymatic synthesis of CMP-N-acetylneuraminic acid and CMP-neuraminic acid derivatives. Glycobiology 1991 0.84
77 Enzymatic synthesis of S-adenosyl-L-methionine from L-methionine and ATP. Appl Biochem Biotechnol 1983 0.83
78 Cofactor regeneration for enzyme-catalysed synthesis. Biotechnol Genet Eng Rev 1988 0.82
79 Using capillary electrophoresis to follow the acetylation of the amino groups of insulin and to estimate their basicities. Anal Chem 1995 0.82
80 Synthesis of ribulose 1,5-bisphosphate: routes from glucose 6-phosphate (via 6-phosphogluconate) and from adenosine monophosphate (via ribose 5-phosphate). Methods Enzymol 1982 0.81
81 Noncovalent polycationic coatings for capillaries in capillary electrophoresis of proteins. Anal Chem 1997 0.81
82 A Redox Fuel Cell That Operates with Methane as Fuel at 120{degrees}C. Science 1994 0.81
83 Representing primary electrophoretic data in the 1/time domain: comparison to representations in the time domain. Anal Chem 1997 0.80
84 Probing the energetics of dissociation of carbonic anhydrase-ligand complexes in the gas phase. Biophys J 1999 0.80
85 Determination of the binding of ligands containing the N-2,4-dinitrophenyl group to bivalent monoclonal rat anti-DNP antibody using affinity capillary electrophoresis. Anal Chem 1995 0.80
86 Basicity of the amino groups of the aminoglycoside amikacin using capillary electrophoresis and coupled CE-MS-MS techniques. Anal Chem 2001 0.79
87 A structurally biased combinatorial approach for discovering new anti-picornaviral compounds. Chem Biol 2001 0.78
88 X-ray Damage to CF3CO2-Terminated Organic Monolayers on Si/Au: Principal Effect of Electrons. Science 1991 0.78
89 Navenones A-C: trail-breaking alarm pheromones from the marine opisthobrance Navanax inermis. J Am Chem Soc 1977 0.77
90 Studying how different terminal groups change the motion of H2NSO2C6H4CONH(EG)3R when bound to the active site of human carbonic anhydrase II. J Org Chem 1998 0.77
91 Enzyme-catalyzed organic synthesis of sucrose and trehalose with in situ regeneration of UDP-glucose. Appl Biochem Biotechnol 1990 0.77
92 Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes. Int Immunol 1997 0.77
93 Limited nerve impulse blockade by "leashed" local anesthetics. J Med Chem 1987 0.76
94 Affinity separation of enzymes from mixtures containing suspended solids : Comparisons of magnetic and nonmagnetic techniques. Appl Biochem Biotechnol 1982 0.76
95 Neuraminidase-resistant hemagglutination inhibitors: acrylamide copolymers containing a C-glycoside of N-acetylneuraminic acid. J Med Chem 1993 0.76
96 Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B. Anal Chem 1993 0.75
97 Modeling the kinetics of acylation of insulin using a recursive method for solving the systems of coupled differential equations. Biophys J 2000 0.75
98 Large-scale ATP-requiring enzymatic phosphorylation of creatine can be driven by enzymatic ATP regeneration. J Org Chem 1977 0.75
99 Imaging profiles of light intensity in the near field: applications to phase-shift photolithography. Appl Opt 1998 0.75
100 D-lactate dehydrogenase. Substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids. Appl Biochem Biotechnol 1989 0.75
101 Three-dimensional self-assembly of complex, millimeter-scale structures through capillary bonding. J Am Chem Soc 2001 0.75
102 Beam redirection and frequency filtering with transparent elastomeric diffractive elements. Appl Opt 1999 0.75
103 A convenient procedure for transfer blotting of coomassie blue stained proteins from PAGE gels to transparencies. Biotechniques 1993 0.75
104 Fabrication of mid-infrared frequency-selective surfaces by soft lithography. Appl Opt 2001 0.75
105 Synthesis of fatty acids using organocopper (I) ate complexes derived from Grignard reagents. J Org Chem 1975 0.75
106 The enzymic utilization of sucrose in the synthesis of amylose and derivatives of amylose, using phosphorylases. Carbohydr Res 1986 0.75
107 Using capillary electrophoresis to follow the acetylation of the amino groups of insulin and to estimate their basicities. Anal Chem 1996 0.75
108 Applications of cell-free enzymes in organic synthesis. Ciba Found Symp 1985 0.75
109 Large-scale synthesis of beta-L-fucopyranosyl phosphate and the preparation of GDP-beta-L-fucose. Carbohydr Res 1993 0.75
110 Radical isomerization during Grignard reagent formation. A quantitative treatment. J Am Chem Soc 1986 0.75
111 Heterogeneous platinum-catalyzed hydrogenation of dialkyl(diolefin)platinum(II) complexes: A new route to platinum surface alkyls. Proc Natl Acad Sci U S A 1981 0.75
112 Molecular cloning of aldolases for synthetic applications. Ann N Y Acad Sci 1990 0.75
113 Preparation of cytidine 5'-monophospho-N-acetylneuraminic acid and uridine 5'-diphosphoglucuronic acid; syntheses of alpha-2, 6-sialyllactosamine, alpha-2, 6-sialyllactose, and hyaluronic acid. Methods Enzymol 1989 0.75
114 Electron exchange between two electrodes mediated by two electroactive adsorbates. Faraday Discuss 2004 0.75
115 Protein synthesis in cell-free reticulocyte lysates on multi-hour incubation. Appl Biochem Biotechnol 1987 0.75
116 Elastomeric diffraction gratings as photothermal detectors. Appl Opt 1996 0.75
117 Studies on alpha-sialylation using sialyl donors with an auxiliary 3-thiophenyl group. Carbohydr Res 1997 0.75
118 Synthesis of 2-amino-1,2-dideoxy-D-galactitol hydrochloride and 5-amino-1,4-anhydro-5,6-dideoxy-L-galactitol hydrochloride. Carbohydr Res 1992 0.75
119 Wave-front engineering by use of transparent elastomeric optical elements. Appl Opt 1997 0.75
120 Fabrication of photonic crystal lasers by nanomolding of solgel glasses. Appl Opt 1999 0.75