Nature's own pharmacy: the diabetes perspective.

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🔗 View Article (PMID 9168558)

Published in Proc Nutr Soc on March 01, 1997

Authors

A M Gray1, P R Flatt

Author Affiliations

1: School of Biomedical Sciences, University of Ulster at Coleraine.

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(truncated to the top 100)

Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia (1990) 2.75

Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander). Br J Nutr (1999) 1.42

Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr (2007) 1.32

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. Diabetes (1996) 1.26

Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia (1981) 1.24

PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science (1996) 1.22

Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells. J Endocrinol (2006) 1.14

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia (2007) 1.12

Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr (1998) 1.10

Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. Diabet Med (2005) 1.09

The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J Nutr (2000) 1.07

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications. Diabetologia (2009) 1.06

Traditional dietary adjuncts for the treatment of diabetes mellitus. Proc Nutr Soc (1991) 1.04

Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line. J Endocrinol (1996) 1.00

Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia (2007) 0.98

A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine. J Endocrinol (2003) 0.98

Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. Br J Nutr (2006) 0.97

Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe). J Endocrinol (1999) 0.95

Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res (1989) 0.95

Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor. Biosci Rep (1986) 0.93

Engineering cultured insulin-secreting pancreatic B-cell lines. J Mol Med (Berl) (1999) 0.93

Immunoreactive gastric inhibitory polypeptide and K cell hyperplasia in obese hyperglycaemic (ob/ob) mice fed high fat and high carbohydrate cafeteria diets. Acta Endocrinol (Copenh) (1986) 0.92

Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochem J (1990) 0.91

Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. Arch Biochem Biophys (2004) 0.91

Pancreatic cancer cells selectively stimulate islet beta cells to secrete amylin. Gastroenterology (1998) 0.91

Abnormalities of GIP in spontaneous syndromes of obesity and diabetes in mice. Diabetes (1983) 0.91

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Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response. Biochem Biophys Res Commun (1998) 0.89

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. Diabetes Obes Metab (2010) 0.89

Insulin and glucagon during pentobarbitone anaesthesia. Diabete Metab (1980) 0.89

Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne). Br J Nutr (1997) 0.89

Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin. Diabetologia (2003) 0.89

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. J Endocrinol (2006) 0.89

Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells. Diabetes Obes Metab (2014) 0.89

Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycaemic (ob/ob) mice. Horm Metab Res (1981) 0.88

Effects of copper deficiency and experimental diabetes on tissue antioxidant enzyme levels in rats. Ann Nutr Metab (1994) 0.88

Hormonal control of glucose homeostasis during development and ageing in mice. Metabolism (1982) 0.88

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line. Diabetes (1999) 0.88

Influence of genetic background and age on the expression of the obese hyperglycaemic syndrome in Aston ob/ob mice. Int J Obes (1982) 0.88

Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice. Br J Pharmacol (2013) 0.88

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline. Diabetes Obes Metab (2015) 0.86

Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J Endocrinol (2002) 0.86

Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes. Diabetologia (2012) 0.86

Drugs inducing hypoglycemia. Pharmacol Ther (1989) 0.86

Calcium and pancreatic beta-cell function. IX. Demonstration of lanthanide-induced inhibition of insulin secretion independent of modifications in transmembrane Ca2+ fluxes. Endocrinology (1980) 0.86

Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan. J Endocrinol (2012) 0.86

Plasma immunoreactive gastric inhibitory polypeptide in obese hyperglycaemic (ob/ob) mice. J Endocrinol (1984) 0.85

Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol (1998) 0.85

Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide. Eur J Pharmacol (2000) 0.85

Effects of a transplantable insulinoma upon regulatory peptide concentrations in the gastrointestinal tract of the rat. Diabetologia (1986) 0.84

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. Int J Obes (Lond) (2010) 0.84

Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice. Endocrine (2001) 0.84

Comparison of the secretory properties of four insulin-secreting cell lines. Endocr Res (2002) 0.84

Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080. Pharmacol Res (2000) 0.84

Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes. J Biochem Toxicol (1994) 0.83

Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. J Endocrinol (2000) 0.83

Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. Br J Pharmacol (1997) 0.83

Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines. Diabetes Obes Metab (1999) 0.83

Reduced hypothalamic neurotensin concentrations in the genetically obese diabetic (ob/ob) mouse: possible relationship to obesity. Metabolism (1991) 0.83

Anorectic effect of fenfluramine, cholecystokinin and neurotensin in genetically obese (ob/ob) mice. Comp Biochem Physiol A Comp Physiol (1986) 0.83

Defective regulation of glucokinase in rat pancreatic islet cell tumours. Acta Endocrinol (Copenh) (1987) 0.83

Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice. Peptides (2007) 0.83

Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle. J Endocrinol (1998) 0.83

Glycation of insulin in the islets of Langerhans of normal and diabetic animals. Diabetes (1996) 0.83

Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes. Horm Metab Res (2009) 0.83

Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes. Biochem Pharmacol (1992) 0.82

N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo. Biochim Biophys Acta (2000) 0.82

Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas. Br J Cancer (1986) 0.82

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Identification of the site of glycation of human insulin. Peptides (1996) 0.81

Thulium binding to the pancreatic beta-cell membrane. Endocrinology (1981) 0.81

Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed mice. Diabetes Obes Metab (2013) 0.81

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line. Diabetologia (2003) 0.81

Glycation of insulin results in reduced biological activity in mice. Acta Diabetol (1997) 0.81

Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP. Diabetes Obes Metab (2008) 0.81

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo. J Mol Endocrinol (2003) 0.81

Modulation of glucose-induced insulin secretion by cytosolic redox state in clonal beta-cells. Mol Cell Endocrinol (1999) 0.81

Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1. Diabetes Obes Metab (2005) 0.81

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(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy. Br J Pharmacol (2008) 0.80

Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11. Br J Pharmacol (2000) 0.80

Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity. J Endocrinol (2006) 0.80

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Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice. J Endocrinol (2005) 0.79

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Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice. Int J Obes (Lond) (2012) 0.79

A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice. Diabetologia (2013) 0.79

Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion. J Endocrinol (2002) 0.79