Published in Biophys J on July 01, 1997
Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem (2008) 2.90
Amyloid peptide channels. J Membr Biol (2004) 1.43
Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity. Biophys J (2008) 1.36
Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology. J Cell Biol (2011) 1.33
Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys J (2012) 1.31
Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr Alzheimer Res (2008) 1.26
Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy. Neurotox Res (2009) 1.24
Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels. Biophys J (2009) 1.18
Architecture of the Alzheimer's A beta P ion channel pore. J Membr Biol (2004) 1.16
Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity. Proc Natl Acad Sci U S A (2009) 1.12
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm. Biochim Biophys Acta (2007) 1.11
Diversity of amyloid beta protein fragment [1-40]-formed channels. Cell Mol Neurobiol (2001) 1.10
Structural convergence among diverse, toxic beta-sheet ion channels. J Phys Chem B (2010) 1.08
Antimicrobial properties of amyloid peptides. Mol Pharm (2011) 1.02
Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity. PLoS One (2012) 1.02
Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses. Int J Alzheimers Dis (2011) 1.01
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry (2012) 1.00
Insertion of Alzheimer's A beta 40 peptide into lipid monolayers. Biophys J (2004) 0.99
Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells. J Am Chem Soc (2013) 0.98
Direct observation of single amyloid-β(1-40) oligomers on live cells: binding and growth at physiological concentrations. PLoS One (2011) 0.98
Structures of beta-amyloid peptide 1-40, 1-42, and 1-55-the 672-726 fragment of APP-in a membrane environment with implications for interactions with gamma-secretase. J Am Chem Soc (2009) 0.98
Models of membrane-bound Alzheimer's Abeta peptide assemblies. Proteins (2010) 0.98
Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol. Cell Mol Neurobiol (2001) 0.95
Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. J Mol Biol (2011) 0.91
Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes. Biophys J (2013) 0.88
Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM. J Struct Biol (2012) 0.86
Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid beta peptide formation and reactive oxygen species generation. J Physiol (2002) 0.86
The amyloid beta ion channel hypothesis of Alzheimer's disease. Neuropsychiatr Dis Treat (2007) 0.86
Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein. Int J Alzheimers Dis (2011) 0.85
Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J (2008) 0.85
The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia. Int J Mol Sci (2013) 0.85
Pyruvate blocks zinc-induced neurotoxicity in immortalized hypothalamic neurons. Cell Mol Neurobiol (2002) 0.84
Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases. Cell Mol Neurobiol (2001) 0.81
Displacement currents associated with the insertion of Alzheimer disease amyloid beta-peptide into planar bilayer membranes. Biophys J (2000) 0.81
The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr Neuropharmacol (2006) 0.80
Neurosteroids block the increase in intracellular calcium level induced by Alzheimer’s β-amyloid protein in long-term cultured rat hippocampal neurons. Neuropsychiatr Dis Treat (2008) 0.80
Ultrastructural characterization of peptide-induced membrane fusion and peptide self-assembly in the lipid bilayer. Biophys J (1999) 0.80
Pore formation by human stefin B in its native and oligomeric states and the consequent amyloid induced toxicity. Front Mol Neurosci (2012) 0.79
Synergistic interactions between Alzheimer's Aβ40 and Aβ42 on the surface of primary neurons revealed by single molecule microscopy. PLoS One (2013) 0.79
α-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons. J Physiol (2014) 0.78
Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers. Front Physiol (2013) 0.77
Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission. Philos Trans R Soc Lond B Biol Sci (2015) 0.76
Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides. J Biol Chem (2016) 0.76
Structural evolution and membrane interactions of Alzheimer's amyloid-beta peptide oligomers: new knowledge from single-molecule fluorescence studies. Protein Sci (2014) 0.76
Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer's Aβ peptide ion channel. Cell Stress Chaperones (2014) 0.76
Ion Channel Formation by Amyloid-β42 Oligomers but not Amyloid-β40 in Cellular Membranes. J Biol Chem (2016) 0.75
Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design. Interface Focus (2017) 0.75
Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. Int J Alzheimers Dis (2011) 0.75
Comparison of the amyloid pore forming properties of rat and human Alzheimer's beta-amyloid peptide 1-42: Calcium imaging data. Data Brief (2016) 0.75
Platelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Brain Res Bull (2016) 0.75
Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer's disease study. BMB Rep (2015) 0.75
Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int (2017) 0.75
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science (1987) 8.29
The molecular pathology of Alzheimer's disease. Neuron (1991) 8.21
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature (1992) 7.02
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science (1990) 6.03
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron (1990) 4.15
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci (1992) 4.10
Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc Natl Acad Sci U S A (1993) 3.16
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell (1993) 2.89
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc Natl Acad Sci U S A (1993) 2.41
Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A (1991) 1.58
Alzheimer's disease: a cell biological perspective. Science (1992) 1.55
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels. Proc Natl Acad Sci U S A (1996) 1.49
Theoretical models of the ion channel structure of amyloid beta-protein. Biophys J (1994) 1.44
Identification and localization of ryanodine binding proteins in the avian central nervous system. Neuron (1990) 1.42
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. J Biol Chem (1993) 1.33
In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging (1993) 1.29
Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem Biophys Res Commun (1994) 1.27
beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease. Mol Cell Biochem (1994) 1.16
Three-dimensional visualization of the smooth endoplasmic reticulum in Purkinje cell dendrites. J Neurosci (1993) 1.15
Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging (1993) 1.09
Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res (1990) 1.06
Effect of beta amyloid peptides on neurons in hippocampal slice cultures. Neurobiol Aging (1993) 1.02
A new class of calcium channels activated by glucose in human pancreatic beta-cells. FEBS Lett (1990) 0.94
Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments. Trends Neurosci (1997) 0.91
Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system. Neuroscience (1993) 0.89
Immortalized GnRH neurons express large-conductance calcium-activated potassium channels. Neuroendocrinology (1996) 0.89
A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule". Biophys J (1994) 0.85
L-type Ca2+ channels mediate joint modulation by gamma-amino-butyric acid and glutamate of [Ca2+]i and neuropeptide secretion in immortalized gonadodropin-releasing hormone neurons. Neuroendocrinology (1995) 0.85
Kinetics and steady-state properties of the charged system controlling sodium conductance in the squid giant axon. J Physiol (1974) 8.77
Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol (1973) 8.53
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen (2000) 6.24
Calcium and potassium systems of a giant barnacle muscle fibre under membrane potential control. J Physiol (1973) 4.71
Destruction of the sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo. J Physiol (1976) 4.18
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell (1996) 3.81
Analysis of the potential-dependent changes in optical retardation in the squid giant axon. J Physiol (1971) 3.50
Potassium permeability activated by intracellular calcium ion concentration in the pancreatic beta-cell. J Physiol (1979) 3.33
The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon. J Physiol (1976) 3.27
Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet (2001) 3.21
Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. Proc Natl Acad Sci U S A (1993) 3.16
Sodium and potassium conductance changes during a membrane action potential. J Physiol (1970) 2.94
Sodium conductance activation without inactivation in pronase-perfused axons. Nat New Biol (1971) 2.78
The binding of tetrodotoxin to nerve membranes. J Physiol (1971) 2.74
Characteristics of the sodium gating current in the squid giant axon. J Physiol (1973) 2.49
Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behav Neurosci (1996) 2.46
Sodium influxes in internally perfused squid giant axon during voltage clamp. J Physiol (1969) 2.43
Effect of tetrodotoxin on the early outward currents in perfused giant axons. Proc Natl Acad Sci U S A (1967) 2.43
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc Natl Acad Sci U S A (1993) 2.41
Structural genomics projects in Japan. Nat Struct Biol (2000) 2.40
Analysis of the effects of calcium or magnesium on voltage-clamp currents in perfused squid axons bathed in solutions of high potassium. J Gen Physiol (1969) 2.19
Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron (1995) 2.17
Cyclic changes in potential and resistance of the beta-cell membrane induced by glucose in islets of Langerhans from mouse. J Physiol (1978) 2.11
Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha. Ann Neurol (1991) 2.03
Displacement currents in the node of Ranvier. Voltage and time dependence. Pflugers Arch (1975) 1.95
Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci (1995) 1.81
Simultaneous measurements of magnesium, calcium and sodium influxes in perfused squid giant axons under membrane potential control. J Physiol (1975) 1.80
The nature of the oscillatory behaviour in electrical activity from pancreatic beta-cell. Horm Metab Res Suppl (1980) 1.76
Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nat Genet (1996) 1.76
Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency. Hum Mutat (2000) 1.75
Mouse pancreatic beta-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization. J Physiol (1979) 1.71
Alternative forms of rat TrkC with different functional capabilities. Neuron (1993) 1.70
Development of the brainstem and cerebellum in autistic patients. J Autism Dev Disord (1995) 1.70
Small cell carcinoma of the stomach: a clinicopathologic study of 17 cases. Am J Gastroenterol (1991) 1.65
A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia (1981) 1.63
Adult-onset Krabbe disease with homozygous T1853C mutation in the galactocerebrosidase gene. Unusual MRI findings of corticospinal tract demyelination. Neurology (1997) 1.61
Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line. J Biol Chem (2000) 1.59
Electrical coupling between cells in islets of Langerhans from mouse. J Membr Biol (1984) 1.58
Entrapment of left renal vein in children with orthostatic proteinuria. Pediatr Nephrol (1990) 1.57
Urokinase type plasminogen activator receptor expression in colorectal neoplasms. Gut (1998) 1.50
Zn2+ interaction with Alzheimer amyloid beta protein calcium channels. Proc Natl Acad Sci U S A (1996) 1.49
The rate of action of tetrodotoxin on sodium conductance in the squid giant axon. Philos Trans R Soc Lond B Biol Sci (1975) 1.47
The topography of electrical synchrony among beta-cells in the mouse islet of Langerhans. Q J Exp Physiol (1984) 1.47
A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees. Proc Natl Acad Sci U S A (1996) 1.46
Properties of the Ca-activated K+ channel in pancreatic beta-cells. Cell Calcium (1983) 1.45
Theoretical models of the ion channel structure of amyloid beta-protein. Biophys J (1994) 1.44
Transduction of retrovirus-mediated NeoR gene into CD34+ cells purified from granulocyte colony-stimulating factor (G-CSF)-mobilized infant and cord blood. Exp Hematol (1997) 1.43
Relationship between GAD antibody and residual beta-cell function in children after overt onset of IDDM. Diabetes Care (1996) 1.42
Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemone. Biochim Biophys Acta (1976) 1.40
Fibrin glue sealing for the prevention of pancreatic fistulas following distal pancreatectomy. Arch Surg (1995) 1.40
Inhibitory effect of vacuolating toxin of Helicobacter pylori on enzyme secretion from rat pancreatic acini. Pancreas (1999) 1.39
Adult colorectal invagination associated with colonic cancer and established by fiberscopy of the sigmoid colon. Endoscopy (1996) 1.39
IgA nephropathy demonstrating clinico-serologic features of acute post-streptococcal glomerulonephritis. Clin Nephrol (1994) 1.38
Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. Infect Immun (1983) 1.37
Magnitude and modulation of pancreatic beta-cell gap junction electrical conductance in situ. J Membr Biol (1995) 1.36
A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. Am J Hum Genet (1991) 1.34
Blocking of potassium currents by pronase in perfused giant axons. Nature (1967) 1.33
Calcium channel activity of purified human synexin and structure of the human synexin gene. Proc Natl Acad Sci U S A (1989) 1.33
Interferon-alpha is effective in HTLV-I-associated myelopathy: a multicenter, randomized, double-blind, controlled trial. Neurology (1996) 1.32
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells (2000) 1.32
The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum. J Biol Chem (1991) 1.31
Randomized clinical trial of ultrasonic dissector or conventional division in distal pancreatectomy for non-fibrotic pancreas. Br J Surg (1999) 1.31
High helical propensity of the peptide fragments derived from beta-lactoglobulin, a predominantly beta-sheet protein. J Mol Biol (1995) 1.27
Sodium movements in perfused squid giant axons. Passive fluxes. J Gen Physiol (1968) 1.27
Complete agenesis of the dorsal pancreas. J Hepatobiliary Pancreat Surg (1999) 1.26
Gating currents in the node of Ranvier: voltage and time dependence. Philos Trans R Soc Lond B Biol Sci (1975) 1.25
3D-CT diagnosis for ingested foreign bodies. Am J Emerg Med (2000) 1.25
Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis. Brain Res Bull (2000) 1.25
An experimental approach to determine membrane charges in squid giant axons. J Gen Physiol (1968) 1.23
Regulation of calcium fluxes and their regulatory roles in pancreatic islets. Ann N Y Acad Sci (1978) 1.23
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis (1996) 1.22
Proceedings: Demonstration of a first-order voltage-dependent transition of the sodium activation gates. J Physiol (1974) 1.22
Ca2+-activated synexin forms highly selective, voltage-gated Ca2+ channels in phosphatidylserine bilayer membranes. Proc Natl Acad Sci U S A (1988) 1.21
Role of mast cell tryptase in renal interstitial fibrosis. J Am Soc Nephrol (2001) 1.20
Drug use pathways among high school students of Mexico. Addiction (1998) 1.20
Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. J Antibiot (Tokyo) (1980) 1.20
Concurrent occurrence of gastric adenocarcinoma and duodenal neuroendocrine cell carcinoma: a composite tumour or collision tumours ? Gut (2001) 1.19
Atrial natriuretic factor and isosorbide dinitrate modulate the gating of ATP-sensitive K+ channels in cultured vascular smooth muscle cells. Circ Res (1994) 1.19
Individual ionization constants of all the carboxyl groups in ribonuclease HI from Escherichia coli determined by NMR. Biochemistry (1994) 1.19
"Chemical aminoacylation" of tRNA's. J Biol Chem (1978) 1.19
On the relation between displacement currents and activation of the sodium conductance in the squid giant axon. Philos Trans R Soc Lond B Biol Sci (1975) 1.19
Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological features. Eur J Cancer (2001) 1.18
Effect of temperature and metabolic inhibitors on 45Ca outflow from squid giant axons. Biochim Biophys Acta (1968) 1.18
Clinical studies of multiple sclerosis in Japan: classical multiple sclerosis and Devic's disease. J Neurol Sci (1974) 1.17
Development of a black gram [Vigna mungo (L.) Hepper] linkage map and its comparison with an azuki bean [Vigna angularis (Willd.) Ohwi and Ohashi] linkage map. Theor Appl Genet (2006) 1.17
Glucose-induced oscillatory changes in extracellular ionized potassium concentration in mouse islets of Langerhans. Biophys J (1985) 1.17
Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels. Heart Vessels (1998) 1.17
beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease. Mol Cell Biochem (1994) 1.16
Improved human islet isolation using nicotinamide. Am J Transplant (2006) 1.16
Physiological roles of adenosine derivatives which are released during neurotransmission in mammalian brain. J Physiol (Paris) (1978) 1.16
Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett (2001) 1.16
A new antibiotic, ikarugamycin. J Antibiot (Tokyo) (1972) 1.16
Asymmetrical displacement currents in the membrane of frog myelinated nerve: early time course and effects of membrane potential. Pflugers Arch (1978) 1.16
A molecular basis for synexin-driven, calcium-dependent membrane fusion. J Exp Biol (1988) 1.13
Endogenous interleukin-8 (IL-8) surge in granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Blood (1999) 1.12
[Polymicrobial endocarditis caused by Streptococcus pneumoniae and Streptococcus pyogenes in a heroin addict carrying the human immunodeficiency virus]. Med Clin (Barc) (1991) 1.12